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Cited by 202

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression

Open access
Tan, Youhua, Tajik, Arash, Chen, Junwei, Jia, Qiong, Chowdhury, Farhan, Wang, Lili, Chen, Junjian, Zhang, Shuang, Hong, Ying, Yi, Haiying, Wu, Douglas C., Zhang, Yuejin, Wei, Fuxiang, Poh, Yeh-Chuin, Seong, Jihye, Singh, Rishi, Lin, Li-Jung, Doğanay, Sultan, Li, Yong, Jia, Haibo, Ha, Taekjip, Wang, Yingxiao, Huang, Bo, Wang, Ning·2014·Nature Communications
DOI 10.1038/ncomms5619
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Abstract

Tumour-repopulating cells (TRCs) are a self-renewing, tumorigenic subpopulation of cancer cells critical in cancer progression. However, the underlying mechanisms of how TRCs maintain their self-renewing capability remain elusive. Here we show that relatively undifferentiated melanoma TRCs exhibit plasticity in Cdc42-mediated mechanical stiffening, histone 3 lysine residue 9 (H3K9) methylation, Sox2 expression and self-renewal capability. In contrast to differentiated melanoma cells, TRCs have a low level of H3K9 methylation that is unresponsive to matrix stiffness or applied forces. Silencing H3K9 methyltransferase G9a or SUV39h1 elevates the self-renewal capability of differentiated melanoma cells in a Sox2-dependent manner. Mechanistically, H3K9 methylation at the Sox2 promoter region inhibits Sox2 expression that is essential in maintaining self-renewal and tumorigenicity of TRCs both in vitro and in vivo. Taken together, our data suggest that 3D soft-fibrin-matrix-mediated cell softening, H3K9 demethylation and Sox2 gene expression are essential in regulating TRC self-renewal. Soft 3D gels can promote the growth of tumour-repopulating cells, a self-renewing subpopulation of cancer cells critical in cancer progression. Here, the authors investigate the mechanism behind this phenomenon and show that the histone 3 lysine residue 9 methylation and Sox2 are controlling this process.

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Metadata

Authors
Tan, Y., Tajik, A., Chen, J., Jia, Q., Chowdhury, F., Wang, L., Chen, J., Zhang, S., Hong, Y., Yi, H., Wu, D. C., Zhang, Y., Wei, F., Poh, Y.-C., Seong, J., Singh, R., Lin, L.-J., Doğanay, S., Li, Y., Jia, H., Ha, T., Wang, Y., Huang, B., & Wang, N.
Venue
Nature Communications
Publisher
Springer Science and Business Media LLC
Published
2014-08-06
Volume
5
Issue
1
Pages
4619-4619
ISSN
2041-1723 (ISSN-L)
DOI
10.1038/ncomms5619
OpenAlex
W2043999650
Cited by
202
References
8
FWCI
6.03
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. https://app.cochat.ai/papers/10.1038/ncomms5619
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Tan, Y., Tajik, A., Chen, J., Jia, Q., Chowdhury, F., Wang, L., Chen, J., Zhang, S., Hong, Y., Yi, H., Wu, D. C., Zhang, Y., Wei, F., Poh, Y.-C., Seong, J., Singh, R., Lin, L.-J., Doğanay, S., Li, Y., . . . Wang, N. (2014). Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. Nature Communications. https://doi.org/10.1038/ncomms5619

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