The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
ParaHydrogen Induced Polarization of 13C carboxylate resonance in acetate and pyruvate
Open accessAbstract
The advent of nuclear spins hyperpolarization techniques represents a breakthrough in the field of medical diagnoses by magnetic resonance imaging. Dynamic nuclear polarization (DNP) is the most widely used method, and hyperpolarized metabolites such as [1-13C]-pyruvate are shown to report on status of tumours. Parahydrogen-induced polarization (PHIP) is a chemistry-based technique, easier to handle and much less expensive in respect to DNP, with significantly shorter polarization times. Its main limitation is the availability of unsaturated precursors for the target substrates; for instance, acetate and pyruvate cannot be obtained by direct incorporation of the parahydrogen molecule. Herein we report a method that allows us to achieve hyperpolarization in this kind of molecule by means of a tailored precursor containing a hydrogenable functionality that, after polarization transfer to the target 13C moiety, is cleaved to obtain the metabolite of interest. The reported procedure can be extended to a number of other biologically relevant substrates. Compounds such as acetate and pyruvate are useful probes for MRI, but their hyperpolarization relies on difficult and expensive dynamic nuclear polarization techniques. Here, the authors show how parahydrogen-induced polarization can be used to quickly and inexpensively hyperpolarize these compounds.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR
Ardenkjær-Larsen, J. H., Fridlund, B., Gram, A., Hansson, G., Hansson, L., Lerche, M. H., Servin, R., Thaning, M., & Golman, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733835100 · Cited by 2,861
Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer
Adams, R. W., Aguilar, J. A., Atkinson, K. D., Cowley, M. J., Elliott, P. I. P., Duckett, S. B., Green, G. G. R., Khazal, I. G., López-Serrano, J., & Williamson, D. C. (2009) · Science · doi:10.1126/science.1168877 · Cited by 1,031
Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate
Gallagher, F. A., Kettunen, M. I., Day, S. E., Hu, D.-E., Ardenkjær-Larsen, J. H., Zandt, R. I. ‘., Jensen, P. R., Karlsson, M., Golman, K., Lerche, M. H., et al. (2008) · Nature · doi:10.1038/nature07017 · Cited by 849
Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681
Golman, K., in ‘t Zandt, R., & Thaning, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601319103 · Cited by 659
Parahydrogen induced polarization
Natterer, J., & Bargon, J. (1997) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/s0079-6565(97)00007-1 · Cited by 589
Barrell, M. J., Campaña, A. G., von Delius, M., Geertsema, E. M., & Leigh, D. A. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201006633 · Cited by 521
New approaches for imaging tumour responses to treatment
Brindle, K. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2289 · Cited by 460
Gallagher, F. A., Kettunen, M. I., Hu, D.-E., Jensen, P. R., Zandt, R. I. ‘., Karlsson, M., Gisselsson, A., Nelson, S. K., Witney, T. H., Bohndiek, S. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911447106 · Cited by 301
Towards hyperpolarized 13C-succinate imaging of brain cancer
Bhattacharya, P., Chekmenev, E. Y., Perman, W. H., Harris, K. C., Lin, A. P., Norton, V. A., Tan, C. T., Ross, B. D., & Weitekamp, D. P. (2007) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2007.01.017 · Cited by 214
Spontaneous Transfer of Para hydrogen Derived Spin Order to Pyridine at Low Magnetic Field
Atkinson, K. D., Cowley, M. J., Elliott, P. I. P., Duckett, S. B., Green, G. G. R., López-Serrano, J., & Whitwood, A. C. (2009) · Journal of the American Chemical Society · doi:10.1021/ja903601p · Cited by 198
PASADENA Hyperpolarization of Succinic Acid for MRI and NMR Spectroscopy
Chekmenev, E. Y., Hövener, J., Norton, V. A., Harris, K., Batchelder, L. S., Bhattacharya, P., Ross, B. D., & Weitekamp, D. P. (2008) · Journal of the American Chemical Society · doi:10.1021/ja7101218 · Cited by 184
Transfer of para-hydrogen spin order into polarization by diabatic field cycling
Jóhannesson, H., Axelsson, O., & Karlsson, M. G. (2004) · Comptes Rendus Physique · doi:10.1016/j.crhy.2004.02.001 · Cited by 155
A hyperpolarized equilibrium for magnetic resonance
Hövener, J., Schwaderlapp, N., Lickert, T., Duckett, S. B., Mewis, R. E., Highton, L. A. R., Kenny, S. M., Green, G. G. R., Leibfritz, D., Korvink, J. G., et al. (2013) · Nature Communications · doi:10.1038/ncomms3946 · Cited by 149
Kinetic Modeling of Hyperpolarized 13C Label Exchange between Pyruvate and Lactate in Tumor Cells
Witney, T. H., Kettunen, M. I., & Brindle, K. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237727 · Cited by 148
Imaging pH with hyperpolarized 13C
Gallagher, F. A., Kettunen, M. I., & Brindle, K. M. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1742 · Cited by 101
Shchepin, R. V., Coffey, A. M., Waddell, K. W., & Chekmenev, E. Y. (2014) · Analytical Chemistry · doi:10.1021/ac500952z · Cited by 93
Auxin-Binding Protein 1 is a negative regulator of the SCFTIR1/AFB pathway
Tromas, A., Paque, S., Stierlé, V., Quettier, A., Müller, P., Lechner, E., Genschik, P., & Perrot‐Rechenmann, C. (2013) · Nature Communications · doi:10.1038/ncomms3496 · Cited by 85
Hetero-NMR Enhancement via Parahydrogen Labeling
Barkemeyer, J., Haake, M., & Bargon, J. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00115a028 · Cited by 82
PASADENA Hyperpolarized 13C Phospholactate
Shchepin, R. V., Coffey, A. M., Waddell, K. W., & Chekmenev, E. Y. (2012) · Journal of the American Chemical Society · doi:10.1021/ja210639c · Cited by 72
Natterer, J., Schedletzky, O., Barkemeyer, J., Bargon, J., & Glaser, S. J. (1998) · Journal of Magnetic Resonance · doi:10.1006/jmre.1998.1421 · Cited by 65
Kennedy, B. W. C., Kettunen, M. I., Hu, D., & Brindle, K. M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja300222e · Cited by 52
13C hyperpolarization of a barbituric acid derivative via parahydrogen induced polarization
Roth, M., Koch, A., Kindervater, P., Bargon, J., Spiess, H. W., & Münnemann, K. (2010) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2010.01.016 · Cited by 41
Cited by
Parahydrogen‐Based Hyperpolarization for Biomedicine
Hövener, J., Pravdivtsev, A. N., Kidd, B., Bowers, C. R., Glöggler, S., Kovtunov, K. V., Plaumann, M., Katz‐Brull, R., Buckenmaier, K., Jerschow, A., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201711842 · Cited by 346
Self-citationImaging cancer metabolism using magnetic resonance
Brindle, K. M. (2024) · npj Imaging · doi:10.1038/s44303-023-00004-0 · Cited by 22
Metadata
- Authors
- Reineri, F., Boi, T., & Aime, S.
- Venue
- Nature Communications
- Published
- 2015-01-05
- Volume
- 6
- Issue
- 1
- Pages
- 5858-5858
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1985587922
- Cited by
- 296
- References
- 23
- FWCI
- 10.33
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
