Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline
Open accessAbstract
Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult-generated neurons in the development of chronic seizures or associated cognitive deficits remains to be determined. Here we show that the ablation of adult neurogenesis before pilocarpine-induced acute seizures in mice leads to a reduction in chronic seizure frequency. We also show that ablation of neurogenesis normalizes epilepsy-associated cognitive deficits. Remarkably, the effect of ablating adult neurogenesis before acute seizures is long lasting as it suppresses chronic seizure frequency for nearly 1 year. These findings establish a key role of neurogenesis in chronic seizure development and associated memory impairment and suggest that targeting aberrant hippocampal neurogenesis may reduce recurrent seizures and restore cognitive function following a pro-epileptic brain insult.
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Inhibiting adult neurogenesis reduces the frequency of chronic seizures along with seizure-related cognitive decline as well as stroke-induced cognitive decline.
“In fact, inhibiting adult neurogenesis reduces the frequency of chronic seizures along with seizure-related cognitive decline (Cho et al., 2015) as well as stroke-induced cognitive decline (Cuartero et al., 2019).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Cho et al., 2015
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Cites
Modification of seizure activity by electrical stimulation: II. Motor seizure
Racine, R. J. (1972) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(72)90177-0 · Cited by 7,141 · see citing works
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369 · see citing works
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139 · see citing works
The novel object recognition memory: neurobiology, test procedure, and its modifications
Antunes, M., & Biala, G. (2012) · Cognitive Processing · doi:10.1007/s10339-011-0430-z · Cited by 2,390 · see citing works
Parent, J. M., Yu, T. W., Leibowitz, R. T., Geschwind, D. H., Sloviter, R. S., & Lowenstein, D. H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-10-03727.1997 · Cited by 1,853 · see citing works
ADULT NEUROGENESIS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
Ming, G., & Song, H. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.051804.101459 · Cited by 1,829 · see citing works
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works
When Is the Hippocampus Involved in Recognition Memory?
Barker, G. R. I., & Warburton, E. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6413-10.2011 · Cited by 818 · see citing works
Chang, B. S., & Lowenstein, D. H. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022308 · Cited by 730 · see citing works
Pitkänen, A., & Sutula, T. P. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00073-x · Cited by 638 · see citing works
Scharfman, H. E., Goodman, J. H., & Sollas, A. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06144.2000 · Cited by 605 · see citing works
Self-citationObject recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval
Winters, B. D., Saksida, L. M., & Bussey, T. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.004 · Cited by 574 · see citing works
Mesial Temporal Lobe Epilepsy: What Have We Learned?
Engel, J. (2001) · The Neuroscientist · doi:10.1177/107385840100700410 · Cited by 558 · see citing works
Zeng, L., Rensing, N. R., & Wong, M. L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0066-09.2009 · Cited by 526 · see citing works
The neurobiology of cognitive disorders in temporal lobe epilepsy
Bell, B. D., Lin, J. J., Seidenberg, M., & Hermann, B. P. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.3 · Cited by 480 · see citing works
Neurod1 is essential for the survival and maturation of adult-born neurons
Gao, Z., Ure, K., Ables, J. L., Lagace, D. C., Nave, K.-A., Goebbels, S., Eisch, A. J., & Hsieh, J. (2009) · Nature Neuroscience · doi:10.1038/nn.2385 · Cited by 473 · see citing works
Self-citationAstrocytes in the Epileptic Brain
Wetherington, J. P., Serrano, G. E., & Dingledine, R. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.002 · Cited by 391 · see citing works
Aberrant seizure‐induced neurogenesis in experimental temporal lobe epilepsy
Parent, J. M., Elliott, R. C., Pleasure, S. J., Barbaro, N. M., & Lowenstein, D. H. (2005) · Annals of Neurology · doi:10.1002/ana.20699 · Cited by 363 · see citing works
Jessberger, S., Zhao, C., Toni, N., Clemenson, G. D., Li, Y., & Gage, F. H. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2002-07.2007 · Cited by 360 · see citing works
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline
Jessberger, S., Nakashima, K., Clemenson, G. D., Mejia, E., Mathews, E. A., Ure, K., Ogawa, S., Sinton, C. M., Gage, F. H., & Hsieh, J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0110-07.2007 · Cited by 353 · see citing works
Self-citationMorgan, R. J., & Soltesz, I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801372105 · Cited by 347 · see citing works
Hattiangady, B., Rao, M. S. R., & Shetty, A. K. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.08.008 · Cited by 303 · see citing works
Cognitive prognosis in chronic temporal lobe epilepsy
Hermann, B. P., Seidenberg, M., Dow, C., Jones, J. E., Rutecki, P. A., Bhattacharya, A., & Bell, B. D. (2006) · Annals of Neurology · doi:10.1002/ana.20872 · Cited by 299 · see citing works
Jung, K., Chu, K., Lee, S., Kim, J., Sinn, D.-I., Kim, J., Park, D.-K., Lee, J., Kim, S. U., Kim, M., et al. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.02.016 · Cited by 293 · see citing works
Excessive activation of mTOR in postnatally generated granule cells is sufficient to cause epilepsy
Pun, R. Y. K., Rolle, I. J., LaSarge, C. L., Hosford, B. E., Rosen, J. M., Uhl, J. D., Schmeltzer, S. N., Faulkner, C., Bronson, S. L., Murphy, B. L., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.002 · Cited by 266 · see citing works
Reactive astrocytes express the embryonic intermediate neurofilament nestin
Clarke, S. R., Shetty, A. K., Bradley, J. L., & Turner, D. A. (1994) · Neuroreport · doi:10.1097/00001756-199410000-00011 · Cited by 256 · see citing works
Jakubs, K., Nanobashvili, A., Bonde, S., Ekdahl, C. T., Kokaia, Z., Kokaia, M., & Lindvall, O. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.004 · Cited by 250 · see citing works
Biochemical, Molecular and Epigenetic Mechanisms of Valproic Acid Neuroprotection
Monti, B., Polazzi, E., & Contestabile, A. (2009) · Current Molecular Pharmacology · doi:10.2174/1874467210902010095 · Cited by 241 · see citing works
Buckmaster, P. S., & Lew, F. H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4852-10.2011 · Cited by 236 · see citing works
Jin, K., Wang, X., Xie, L., Mao, X. O., & Greenberg, D. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000154107 · Cited by 225 · see citing works
Kron, M. M., Zhang, H., & Parent, J. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5655-09.2010 · Cited by 208 · see citing works
Niibori, Y., Yu, T., Epp, J. R., Akers, K. G., Josselyn, S. A., & Frankland, P. W. (2012) · Nature Communications · doi:10.1038/ncomms2261 · Cited by 195 · see citing works
Walter, C., Murphy, B. L., Pun, R. Y. K., Spieles-Engemann, A. L., & Danzer, S. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0431-07.2007 · Cited by 189 · see citing works
Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus
Lacefield, C. O., Itskov, V., Reardon, T., Hen, R., & Gordon, J. A. (2012) · Hippocampus · doi:10.1002/hipo.20860 · Cited by 188 · see citing works
In Vivo Intracellular Analysis of Granule Cell Axon Reorganization in Epileptic Rats
Buckmaster, P. S., & Dudek, F. E. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.712 · Cited by 182 · see citing works
Yu, T., Zhang, G., Liebl, D. J., & Kernie, S. G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4629-08.2008 · Cited by 180 · see citing works
Self-citationThe dentate gyrus as a filter or gate: a look back and a look ahead
Hsu, D. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63032-5 · Cited by 177 · see citing works
Cognitive Outcomes in Patients with Chronic Temporal Lobe Epilepsy
Helmstaedter, C., & Kockelmann, E. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00702.x · Cited by 176 · see citing works
Jung, K., Chu, K., Kim, M., Jeong, S., Song, Y., Lee, S., Kim, J. Y., Lee, S. K., & Roh, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03412.x · Cited by 171 · see citing works
Kralic, J. E., Ledergerber, D., & Fritschy, J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04386.x · Cited by 151 · see citing works
Blaiss, C. A., Yu, T., Zhang, G., Chen, J., Dimchev, G. A., Parada, L. F., Powell, C. M., & Kernie, S. G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5265-10.2011 · Cited by 148 · see citing works
Self-citationReview: Epilepsy as an Example of Neural Plasticity
Scharfman, H. E. (2002) · The Neuroscientist · doi:10.1177/107385840200800211 · Cited by 136 · see citing works
Self-citationYoung hippocampal neurons are critical for recent and remote spatial memory in adult mice
Goodman, T. H., Trouche, S. G., Massou, I., Verret, L., Zerwas, M., Roullet, P., & Rampon, C. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.047 · Cited by 136 · see citing works
McCloskey, D. P., Hintz, T. M., Pierce, J. P., & Scharfman, H. E. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05101.x · Cited by 114 · see citing works
Self-citationEctopic Granule Cells of the Rat Dentate Gyrus
Scharfman, H. E., Goodman, J. H., & McCloskey, D. P. (2006) · Developmental Neuroscience · doi:10.1159/000096208 · Cited by 109 · see citing works
Self-citationHeterogeneous Integration of Adult-Generated Granule Cells into the Epileptic Brain
Murphy, B. L., Pun, R. Y. K., Yin, H., Faulkner, C., Loepke, A. W., & Danzer, S. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2728-10.2011 · Cited by 102 · see citing works
Functional Implications of Seizure-Induced Neurogenesis
Scharfman, H. E. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-6376-8_14 · Cited by 100 · see citing works
Self-citationPierce, J. P., Melton, J. T., Punsoni, M., McCloskey, D. P., & Scharfman, H. E. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.007 · Cited by 97 · see citing works
Self-citationSuppression of Adult Neurogenesis Increases the Acute Effects of Kainic Acid
Iyengar, S. S., LaFrancois, J. J., Friedman, D. J., Drew, L., Denny, C. A., Burghardt, N. S., Wu, M. V., Hsieh, J., Hen, R., & Scharfman, H. E. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.11.009 · Cited by 90 · see citing works
Self-citationSinger, B. H., Gamelli, A., Fuller, C. L., Temme, S. J., Parent, J. M., & Murphy, G. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015425108 · Cited by 88 · see citing works
Scharfman, H. E., & Pierce, J. P. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03480.x · Cited by 74 · see citing works
Self-citationThe Influence of Ectopic Migration of Granule Cells into the Hilus on Dentate Gyrus-CA3 Function
Myers, C. E., Bermudez‐Hernandez, K., & Scharfman, H. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068208 · Cited by 74 · see citing works
Self-citationPekcec, A., Fuest, C., Mühlenhoff, M., Gerardy‐Schahn, R., & Potschka, H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05172.x · Cited by 66 · see citing works
Zhan, R., Timofeeva, O., & Nadler, J. V. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00663.2010 · Cited by 65 · see citing works
Ledergerber, D., Fritschy, J., & Kralic, J. E. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.02.010 · Cited by 61 · see citing works
Cameron, M. C., Zhan, R., & Nadler, J. V. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22623 · Cited by 58 · see citing works
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy
Thind, K. K., Ribak, C. E., & Buckmaster, P. S. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21745 · Cited by 54 · see citing works
Region‐specific plasticity in the epileptic rat brain: A hippocampal and extrahippocampal analysis
Jung, K., Chu, K., Lee, S., Kim, J., Kang, K., Song, E., Kim, S., Park, H.-K., Kim, M., Lee, S. K., et al. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01718.x · Cited by 53 · see citing works
Szabadics, J., Varga, C., Brunner, J., Chen, K., & Soltész, I. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5602-09.2010 · Cited by 49 · see citing works
Manning, E. E., Ransome, M. I., Burrows, E. L., & Hannan, A. J. (2010) · Hippocampus · doi:10.1002/hipo.20900 · Cited by 47 · see citing works
Raedt, R., Boon, P., Persson, A., Alborn, A., Boterberg, T., Dycke, A. V., Linder, B., Smedt, T. D., Wadman, W. J., Ben‐Menachem, E., et al. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01146.x · Cited by 45 · see citing works
Modulation of neurogenesis by targeted hippocampal irradiation fails to affect kindling progression
Pekcec, A., Lüpke, M., Baumann, R., Seifert, H., & Potschka, H. (2010) · Hippocampus · doi:10.1002/hipo.20802 · Cited by 40 · see citing works
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Research works printed but not linked: 1
- Ribak C. E. et al. in Jasper’s Basic Mechanisms of the Epilepsies eds Noebels J. L., Avoli M., Rogawski M. A., Olsen R. W., Delgado-Escueta A. V. National Center for Biotechnology Information (2012). 22787592
Cited by
Sorted by citations
Devinsky, O., Vezzani, A., O'Brien, T. J., Jetté, N., Scheffer, I. E., de Curtis, M., & Perucca, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.24 · Cited by 967 · see citing works
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works
Long, Q., Upadhya, D., Hattiangady, B., Kim, D.-K., An, S. Y., Shuai, B., Prockop, D. J., & Shetty, A. K. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703920114 · Cited by 401 · see citing works
Microglia–Neuron Communication in Epilepsy
Eyo, U. B., Murugan, M., & Wu, L. (2016) · Glia · doi:10.1002/glia.23006 · Cited by 290 · see citing works
Formation and integration of new neurons in the adult hippocampus
Denoth‐Lippuner, A., & Jessberger, S. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00433-z · Cited by 274 · see citing works
Adult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236 · see citing works
The effects of microglia‐ and astrocyte‐derived factors on neurogenesis in health and disease
Araki, T., Ikegaya, Y., & Koyama, R. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14969 · Cited by 208 · see citing works
Amanollahi, M., Jameie, M., Heidari, A., & Rezaei, N. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03102-z · Cited by 200 · see citing works
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy
Colasante, G., Qiu, Y., Massimino, L., Berardino, C. D., Cornford, J. H., Snowball, A., Weston, M., Jones, S. P., Giannelli, S. G., Lieb, A., et al. (2020) · Brain · doi:10.1093/brain/awaa045 · Cited by 138 · see citing works
Assessments of dentate gyrus function: discoveries and debates
Borzello, M., Ramirez, S., Treves, A., Lee, I., Scharfman, H. E., Stark, C. E. L., Knierim, J. J., & Rangel, L. M. (2023) · Nature reviews. Neuroscience · doi:10.1038/s41583-023-00710-z · Cited by 138 · see citing works
Self-citationOrtega, S. B., Torres, V. O., Latchney, S. E., Whoolery, C. W., Noorbhai, I., Poinsatte, K., Selvaraj, U. M., Benson, M. A., Meeuwissen, A., Plautz, E. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913292117 · Cited by 137 · see citing works
Self-citationThe Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review
Nakhal, M. M., Yassin, L. K., Alyaqoubi, R., Saeed, S., Alderei, A., Alhammadi, A., Alshehhi, M., Almehairbi, A., Houqani, S. A., BaniYas, S., et al. (2024) · Life · doi:10.3390/life14101234 · Cited by 134 · see citing works
Notch: an interactive player in neurogenesis and disease
Zhang, R., Engler, A., & Taylor, V. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2641-9 · Cited by 130 · see citing works
Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice
Cuartero, M. I., de la Parra, J., Pérez-Ruiz, A., Bravo-Ferrer, I., Durán-Laforet, V., García-Culebras, A., García-Segura, J. M., Dhaliwal, J., Frankland, P. W., Lizasoain, I., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120412 · Cited by 128 · see citing works
Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis
Yun, S., Reynolds, R. P., Masiulis, I., & Eisch, A. J. (2016) · Nature Medicine · doi:10.1038/nm.4218 · Cited by 127 · see citing works
Self-citationThe long and short term effects of motherhood on the brain
Duarte‐Guterman, P., Leuner, B., & Galea, L. A. M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.02.004 · Cited by 127 · see citing works
Kaur, H., Patro, I. K., Tikoo, K., & Sandhir, R. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.009 · Cited by 126 · see citing works
Upadhya, D., Hattiangady, B., de Castro, O. W., Shuai, B., Kodali, M., Attaluri, S., Bates, A. A., Dong, Y. W., Zhang, S., Prockop, D. J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1814185115 · Cited by 126 · see citing works
Semple, B. D., Zamani, A., Rayner, G., Shultz, S. R., & Jones, N. C. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.07.018 · Cited by 123 · see citing works
Neuronal replacement therapy: previous achievements and challenges ahead
Grade, S., & Götz, M. (2017) · npj Regenerative Medicine · doi:10.1038/s41536-017-0033-0 · Cited by 115 · see citing works
Yu, C. J., Deng, X., & Xu, D. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106249 · Cited by 112 · see citing works
Christian, C. A., Reddy, D. S., Maguire, J., & Forcelli, P. A. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.017392 · Cited by 105 · see citing works
RNA-binding proteins balance brain function in health and disease
Schieweck, R., Ninkovic, J., & Kiebler, M. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00047.2019 · Cited by 104 · see citing works
Luo, Q., Xian, P., Wang, T., Wu, S., Sun, T., Wang, W., Wang, B., Yang, H., Yang, Y., Wang, H., et al. (2021) · Theranostics · doi:10.7150/thno.58632 · Cited by 104 · see citing works
You, J. C., Muralidharan, K., Park, J. W., Petrof, I., Pyfer, M. S., Corbett, B. F., LaFrancois, J. J., Zheng, Y., Zhang, X., Mohila, C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4413 · Cited by 102 · see citing works
Self-citationAn Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy
Botterill, J. J., Lu, Y.-L., LaFrancois, J. J., Bernstein, H. L., Alcantara‐Gonzalez, D., Jain, S. S., Leary, P., & Scharfman, H. E. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.100 · Cited by 99 · see citing works
Self-citationNeuberger, E. J., Swietek, B., Corrubia, L., Prasanna, A., & Santhakumar, V. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.07.015 · Cited by 97 · see citing works
Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits
Zhou, Q., Nemes, A. D., Lee, D., Ro, E. J., Zhang, J., Nowacki, A. S., Dymecki, S. M., Najm, I., & Suh, H. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95731 · Cited by 97 · see citing works
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy
Ammothumkandy, A., Rāviņa, K., Wolseley, V., Tartt, A. N., Yu, P.-N., Corona, L., Zhang, N., Nune, G. C., Kalayjian, L. A., Mann, J. J., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01044-2 · Cited by 95 · see citing works
Current Understanding of the Neural Stem Cell Niches
Llorente, V., Velarde, P., Desco, M., & Gómez‐Gaviro, M. V. (2022) · Cells · doi:10.3390/cells11193002 · Cited by 94 · see citing works
Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections
Mo, M., Eyo, U. B., Xie, M., Peng, J., Bosco, D. B., Umpierre, A. D., Zhu, X., Tian, D., Xu, P., & Wu, L. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0487-19.2019 · Cited by 93 · see citing works
Lybrand, Z. R., Goswami, S., Zhu, J., Jarzabek, V., Merlock, N., Aktar, M., Smith, C., Zhang, L., Varma, P., Cho, K., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21649-8 · Cited by 91 · see citing works
Self-citationMishra, V., Shuai, B., Kodali, M., Shetty, G. A., Hattiangady, B., Rao, X., & Shetty, A. K. (2015) · Scientific Reports · doi:10.1038/srep17807 · Cited by 89 · see citing works
Cho, K., & Jang, H. (2020) · Scientific Reports · doi:10.1038/s41598-019-56958-y · Cited by 88 · see citing works
Self-citationLi, Y., Abdourahman, A., Tamm, J. A., Pehrson, A. L., Sánchez, C., & Gulinello, M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.05.013 · Cited by 79 · see citing works
Lösing, P., Niturad, C. E., Harrer, M., zu Reckendorf, C. M., Schatz, T., Sinske, D., Lerche, H., Maljevic, S., & Knöll, B. (2017) · Molecular Brain · doi:10.1186/s13041-017-0310-2 · Cited by 79 · see citing works
Wnt/β-catenin signaling as a potential target for novel epilepsy therapies
Hodges, S. L., & Lugo, J. N. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.07.002 · Cited by 75 · see citing works
Ablation of Newly Generated Hippocampal Granule Cells Has Disease-Modifying Effects in Epilepsy
Hosford, B. E., Liska, J. P., & Danzer, S. C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1371-16.2016 · Cited by 73 · see citing works
The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex
Tee, A. R., Sampson, J. R., Pal, D. K., & Bateman, J. M. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.01.040 · Cited by 73 · see citing works
microRNAs in the pathophysiology of epilepsy
Brennan, G. P., & Henshall, D. C. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.01.017 · Cited by 73 · see citing works
Buckmaster, P. S., Abrams, E., & Wen, X. (2017) · The Journal of Comparative Neurology · doi:10.1002/cne.24226 · Cited by 72 · see citing works
Bosch, C., Masachs, N., Exposito-Alonso, D., Martínez, A., Teixeira, C. M., Fernaud, I., Pujadas, L., Ulloa, F., Comella, J. X., DeFelipe, J., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw216 · Cited by 70 · see citing works
Normal and epilepsy-associated pathologic function of the dentate gyrus
Dengler, C. G., & Coulter, D. A. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.04.005 · Cited by 70 · see citing works
MicroRNA‐induced silencing in epilepsy: Opportunities and challenges for clinical application
Tiwari, D., Peariso, K., & Groß, C. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24582 · Cited by 70 · see citing works
Function and Dysfunction of Adult Hippocampal Neurogenesis in Regeneration and Disease
Peng, L., & Bonaguidi, M. A. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.09.004 · Cited by 67 · see citing works
ApoE Regulates the Development of Adult Newborn Hippocampal Neurons
Tensaouti, Y., Stephanz, E. P., Yu, T., & Kernie, S. G. (2018) · eNeuro · doi:10.1523/eneuro.0155-18.2018 · Cited by 67 · see citing works
Self-citationChen, K.-N., Guan, Q.-W., Yin, X., Wang, Z., Zhou, H., & Mao, X. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.268 · Cited by 66 · see citing works
REST regulation of gene networks in adult neural stem cells
Mukherjee, S., Brulet, R., Zhang, L., & Hsieh, J. (2016) · Nature Communications · doi:10.1038/ncomms13360 · Cited by 63 · see citing works
Self-citationWoitke, F., Ceangă, M., Rudolph, M., Niv, F., Witte, O. W., Redecker, C., Kunze, A., & Keiner, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183463 · Cited by 62 · see citing works
The Ever-Changing Morphology of Hippocampal Granule Neurons in Physiology and Pathology
Llorens-Martı́n, M., Rábano, A., & Ávila, J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00526 · Cited by 61 · see citing works
Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury
Sun, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.017 · Cited by 60 · see citing works
Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy
Cao, D., Zhou, X., Guo, Q., Xiang, M.-Y., Bao, M., He, B., & Mao, X. (2024) · Biomarker Research · doi:10.1186/s40364-024-00687-6 · Cited by 59 · see citing works
Epilepsy-associated alterations in hippocampal excitability
Navidhamidi, M., Ghasemi, M., & Mehranfard, N. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0059 · Cited by 59 · see citing works
Bekenstein, U., Mishra, N., Milikovsky, D. Z., Hanin, G., Zelig, D., Sheintuch, L., Berson, A., Greenberg, D., Friedman, A., & Soreq, H. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701201114 · Cited by 59 · see citing works
The Dentate Gyrus and Temporal Lobe Epilepsy: An “Exciting” Era
Scharfman, H. E. (2019) · Epiliepsy currents/Epilepsy currents · doi:10.1177/1535759719855952 · Cited by 58 · see citing works
Self-citationFitzsimons, C. P., Herbert, J., Schouten, M., Meijer, O. C., Lucassen, P. J., & Lightman, S. L. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.05.001 · Cited by 58 · see citing works
PTEN deletion increases hippocampal granule cell excitability in male and female mice
Santos, V. R., Pun, R. Y. K., Arafa, S. R., LaSarge, C. L., Rowley, S. D., Khademi, S., Bouley, T., Holland, K. D., Garcia‐Cairasco, N., & Danzer, S. C. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.014 · Cited by 57 · see citing works
Circuit-based interventions in the dentate gyrus rescue epilepsy-associated cognitive dysfunction
Kahn, J. B., Port, R. G., Yue, C., Takano, H., & Coulter, D. A. (2019) · Brain · doi:10.1093/brain/awz209 · Cited by 57 · see citing works
Neuroregenerative gene therapy to treat temporal lobe epilepsy in a rat model
Zheng, J., Li, T., Qi, S., Qin, B., Yu, J., & Chen, G. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102198 · Cited by 55 · see citing works
Mechanisms of epileptogenesis and preclinical approach to antiepileptogenic therapies
Łukawski, K., Andres‐Mach, M., Czuczwar, M., Łuszczki, J. J., Kruszyński, K., & Czuczwar, S. J. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.07.012 · Cited by 54 · see citing works
Sparks, F. T., Liao, Z., Li, W., Grosmark, A., Soltész, I., & Losonczy, A. (2020) · Nature Communications · doi:10.1038/s41467-020-19969-2 · Cited by 53 · see citing works
Beyond sex differences: short- and long-term effects of pregnancy on the brain
Puri, T. A., Richard, J. E., & Galea, L. A. M. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.03.010 · Cited by 53 · see citing works
de Castro, O. W., Upadhya, D., Kodali, M., & Shetty, A. K. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00603 · Cited by 51 · see citing works
Treating Brain Disorders by Targeting Adult Neural Stem Cells
Bao, H., & Song, J. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.10.001 · Cited by 51 · see citing works
Singh, T., & Goel, R. K. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03274-5 · Cited by 51 · see citing works
Zhang, X., Wei, X., Mei, Y., Wang, D., Wang, J., Zhang, Y., Li, X., Gu, Y., Peng, G., & Sun, B. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.11.003 · Cited by 49 · see citing works
Traumatic Brain Injury and Stem Cell: Pathophysiology and Update on Recent Treatment Modalities
Reis, C., Gospodarev, V. V., Reis, H., Wilkinson, M., Gaio, J., Araujo, C., Chen, S., & Zhang, J. H. (2017) · Stem Cells International · doi:10.1155/2017/6392592 · Cited by 48 · see citing works
Novel therapeutic targets for epilepsy intervention
Kambli, L., Bhatt, L. K., Oza, M. J., & Prabhavalkar, K. S. (2017) · Seizure · doi:10.1016/j.seizure.2017.07.014 · Cited by 47 · see citing works
Impact of rapamycin on status epilepticus induced hippocampal pathology and weight gain
Hester, M. S., Hosford, B. E., Santos, V. R., Singh, S. P., Rolle, I. J., LaSarge, C. L., Liska, J. P., Garcia‐Cairasco, N., & Danzer, S. C. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.03.015 · Cited by 47 · see citing works
Sakai, A., Matsuda, T., Doi, H., Nagaishi, Y., Kato, K., & Nakashima, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716479115 · Cited by 46 · see citing works
Godale, C. M., & Danzer, S. C. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00298 · Cited by 46 · see citing works
Cannabinoid Actions on Neural Stem Cells: Implications for Pathophysiology
Rodrigues, R. S., Lourenço, D. M., Paulo, S. L., Mateus, J. M., Ferreira, M. F., Mouro, F. M., Moreira, J. B., Ribeiro, F. F., Sebastião, A. M., & Xapelli, S. (2019) · Molecules · doi:10.3390/molecules24071350 · Cited by 45 · see citing works
Qu, Z., Su, F., Qi, X., Sun, J., Wang, H., Qiao, Z., Zhao, H., & Zhu, Y. (2017) · Cell Biochemistry and Function · doi:10.1002/cbf.3306 · Cited by 45 · see citing works
Liu, Q., Shen, C., Dai, Y., Tang, T. A., Hou, C., Yang, H., Wang, Y., Xu, J., Lu, Y., Wang, Y., et al. (2024) · Biomarker Research · doi:10.1186/s40364-024-00636-3 · Cited by 43 · see citing works
Jain, S. S., LaFrancois, J. J., Botterill, J. J., Alcantara‐Gonzalez, D., & Scharfman, H. E. (2019) · Hippocampus · doi:10.1002/hipo.23062 · Cited by 43 · see citing works
Self-citationAdult Neurogenesis in the Development of Epilepsy
Danzer, S. C. (2019) · Epiliepsy currents/Epilepsy currents · doi:10.1177/1535759719868186 · Cited by 43 · see citing works
Transcriptional regulation of neural stem cell expansion in the adult hippocampus
Guo, N., McDermott, K. D., Shih, Y.-T., Zanga, H., Ghosh, D., Herber, C., Coleman, J., Zagouras, A., Meara, W. R., Wong, L. P., et al. (2022) · eLife · doi:10.7554/elife.72195 · Cited by 42 · see citing works
Jang, H., Kim, J., Jeong, K. H., Lim, S. C., Kim, S.-Y., & Cho, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040859 · Cited by 42 · see citing works
Self-citationβ‐catenin signaling modulates the tempo of dendritic growth of adult‐born hippocampal neurons
Heppt, J., Wittmann, M., Schäffner, I., Billmann, C., Zhang, J., Weisenhorn, D. M. V., Prakash, N., Wurst, W., Taketo, M. M., & Lie, D. C. (2020) · The EMBO Journal · doi:10.15252/embj.2020104472 · Cited by 42 · see citing works
miRNA-Mediated Regulation of Adult Hippocampal Neurogenesis; Implications for Epilepsy
Bielefeld, P., Mooney, C., Henshall, D. C., & Fitzsimons, C. P. (2016) · Brain Plasticity · doi:10.3233/bpl-160036 · Cited by 41 · see citing works
Bielefeld, P., Durá, I., Danielewicz, J., Lucassen, P. J., Baekelandt, V., Abrous, D. N., Encinas, J. M., & Fitzsimons, C. P. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112032 · Cited by 41 · see citing works
Alves, M., García, L. D. D., Conte, G., Jimenez-Mateos, E. M., D’Orsi, B., Sanz‐Rodriguez, A., Prehn, J. H. M., Henshall, D. C., & Engel, T. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0089-19.2019 · Cited by 40 · see citing works
Wu, Y., Wang, Y., Wu, Y., Li, T., & Wang, W. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.08.009 · Cited by 40 · see citing works
Hamilton, L. K., & Fernandes, K. J. L. (2017) · Biology of the Cell · doi:10.1111/boc.201700037 · Cited by 40 · see citing works
Scharfman, H. E., & Myers, C. E. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.09.005 · Cited by 39 · see citing works
Self-citationExperimental Cerebral Malaria Spreads along the Rostral Migratory Stream
Hoffmann, A., Pfeil, J., Alfonso, J., Kurz, F. T., Sahm, F., Heiland, S., Monyer, H., Bendszus, M., Mueller, A., Helluy, X., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005470 · Cited by 39 · see citing works
Hu, J.-J., Yang, X., Luo, W.-D., Han, S. H., Yin, J., Liu, W., He, X., & Peng, B. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.01.022 · Cited by 39 · see citing works
de la Parra, J., Cuartero, M. I., Pérez‐Ruíz, A., García‐Culebras, A., Martín, R., Sánchez‐Prieto, J., García-Segura, J. M., Lizasoaín, I., & Moro, M. Á. (2018) · eNeuro · doi:10.1523/eneuro.0370-17.2018 · Cited by 39 · see citing works
Anticonvulsant and Neuroprotective Effects of Paeonol in Epileptic Rats
Liu, D., Agbo, E., Zhang, S.-H., & Zhu, J. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02874-6 · Cited by 39 · see citing works
Bistable Firing Pattern in a Neural Network Model
Protachevicz, P. R., Borges, F. S., Lameu, E. L., Ji, P., Iarosz, K. C., Kihara, A. H., Caldas, I. L., Junior, J. D. S., Baptista, M. S., Macau, E. E. N., et al. (2019) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2019.00019 · Cited by 39 · see citing works
Danzer, S. C. (2017) · Brain Plasticity · doi:10.3233/bpl-170056 · Cited by 38 · see citing works
Chavoshinezhad, S., Kouchesfahani, H. M., Ahmadiani, A., & Dargahi, L. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109661 · Cited by 38 · see citing works
Rao, S. B., Kirschen, G. W., Szczurkowska, J., Antonio, A. D., Wang, J., Ge, S., & Shelly, M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1217-17.2017 · Cited by 37 · see citing works
Zhang, L., Yan, J., Liu, Q., Xie, Z., & Jiang, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-42991-4 · Cited by 37 · see citing works
Self-citationAltered Synaptic Drive onto Birthdated Dentate Granule Cells in Experimental Temporal Lobe Epilepsy
Althaus, A. L., Moore, S. J., Zhang, H., Du, X., Murphy, G. G., & Parent, J. M. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0654-18.2019 · Cited by 36 · see citing works
Engel, T., Smith, J., & Alves, M. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s287740 · Cited by 36 · see citing works
Microglial contributions to aberrant neurogenesis and pathophysiology of epilepsy
Victor, T. R., & Tsirka, S. E. (2020) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2020.02 · Cited by 35 · see citing works
SARS-CoV-2-Mediated Neuropathogenesis, Deterioration of Hippocampal Neurogenesis and Dementia
Radhakrishnan, R. K., & Kandasamy, M. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175221078418 · Cited by 35 · see citing works
Brulet, R., Zhu, J., Aktar, M., Hsieh, J., & Cho, K. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.005 · Cited by 33 · see citing works
Self-citationWu, T., Yu, G., Xiao, J., Yan, C., Kurihara, H., Li, Y.-F., So, K., & He, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.04.011 · Cited by 33 · see citing works
- Authors
- Cho, K.-O., Lybrand, Z. R., Ito, N., Brulet, R., Tafacory, F., Zhang, L., Good, L., Ure, K., Kernie, S. G., Birnbaum, S. G., Scharfman, H. E., Eisch, A. J., & Hsieh, J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Kitasato University (JP)
- Baylor College of Medicine (US)
- Columbia University Irving Medical Center (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Corresponding author
- Hsieh, Jenny
- ORCID
- Venue
- Nature Communications
- Published
- 2015-03-26
- Volume
- 6
- Issue
- 1
- Pages
- 6606-6606
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4375780
- OpenAlex
- W2155852776
- Cited by
- 451
- References
- 63
- Citations by year
- 2026: 22 · 2025: 37 · 2024: 49 · 2023: 34 · 2022: 37 · 2021: 52 · 2020: 51 · 2019: 48 · 2018: 31 · 2017: 51 · 2016: 29 · 2015: 10
- FWCI
- 32.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Aeronautics and Space Administration
- Welch Foundation (I-1660)
- American Heart Association
- University of Texas Southwestern Medical Center
- National Institutes of Health
- National Institute on Aging (K02AG041815, R01AG032383)
- National Heart, Lung, and Blood Institute (T32HL007360)
- National Institute of Mental Health (R21MH094715)
- National Institute on Drug Abuse (R21DA023701, K02DA023555, R01DA016765)
- National Institute of General Medical Sciences (T32GM083831)
- National Institute of Neurological Disorders and Stroke (R01NS038572, R01NS048192, R01NS081203, R01NS076775)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hippocampal neurogenesis, epilepsy, chronic seizures, pilocarpine-induced seizures, cognitive impairment, memory impairment, brain injury, seizure suppression, therapeutic target
- MeSH terms
- Doublecortin Domain Proteins, Animals, Cognition Disorders, Disease Models, Animal, Epilepsy, Epilepsy, Temporal Lobe, Hippocampus, Immunohistochemistry, Mice, Transgenic, Microtubule-Associated Proteins, Nerve Tissue Proteins, Neurons, Neuropeptides, Pilocarpine, Muscarinic Agonists, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Neurogenesis, Neural Stem Cells
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