Cited by 456Epilepsy research and treatmentNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline

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Cho, Kyung-Ok, Lybrand, Zane R., Ito, Naoki, Brulet, Rebecca, Tafacory, Farrah, Zhang, Ling, Good, Levi, Ure, Kerstin +5 more·2015·Nature Communications

Abstract

Acute seizures after a severe brain insult can often lead to epilepsy and cognitive impairment. Aberrant hippocampal neurogenesis follows the insult but the role of adult-generated neurons in the development of chronic seizures or associated cognitive deficits remains to be determined. Here we show that the ablation of adult neurogenesis before pilocarpine-induced acute seizures in mice leads to a reduction in chronic seizure frequency. We also show that ablation of neurogenesis normalizes epilepsy-associated cognitive deficits. Remarkably, the effect of ablating adult neurogenesis before acute seizures is long lasting as it suppresses chronic seizure frequency for nearly 1 year. These findings establish a key role of neurogenesis in chronic seizure development and associated memory impairment and suggest that targeting aberrant hippocampal neurogenesis may reduce recurrent seizures and restore cognitive function following a pro-epileptic brain insult.

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  • Inhibiting adult neurogenesis reduces the frequency of chronic seizures along with seizure-related cognitive decline as well as stroke-induced cognitive decline.

    “In fact, inhibiting adult neurogenesis reduces the frequency of chronic seizures along with seizure-related cognitive decline (Cho et al., 2015) as well as stroke-induced cognitive decline (Cuartero et al., 2019).”

    From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Cho et al., 2015

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  1. Ribak C. E. et al. in Jasper’s Basic Mechanisms of the Epilepsies eds Noebels J. L., Avoli M., Rogawski M. A., Olsen R. W., Delgado-Escueta A. V. National Center for Biotechnology Information (2012). 22787592

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Authors
Cho, K.-O., Lybrand, Z. R., Ito, N., Brulet, R., Tafacory, F., Zhang, L., Good, L., Ure, K., Kernie, S. G., Birnbaum, S. G., Scharfman, H. E., Eisch, A. J., & Hsieh, J.
Affiliations
  • The University of Texas Southwestern Medical Center (US)
  • Kitasato University (JP)
  • Baylor College of Medicine (US)
  • Columbia University Irving Medical Center (US)
  • Nathan Kline Institute for Psychiatric Research (US)
Corresponding author
Hsieh, Jenny
Venue
Nature Communications
Published
2015-03-26
Volume
6
Issue
1
Pages
6606-6606
ISSN
2041-1723 (ISSN-L)
OpenAlex
W2155852776
Cited by
451
References
63
Citations by year
2026: 22 · 2025: 37 · 2024: 49 · 2023: 34 · 2022: 37 · 2021: 52 · 2020: 51 · 2019: 48 · 2018: 31 · 2017: 51 · 2016: 29 · 2015: 10
FWCI
32.77
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • National Aeronautics and Space Administration
  • Welch Foundation (I-1660)
  • American Heart Association
  • University of Texas Southwestern Medical Center
  • National Institutes of Health
  • National Institute on Aging (K02AG041815, R01AG032383)
  • National Heart, Lung, and Blood Institute (T32HL007360)
  • National Institute of Mental Health (R21MH094715)
  • National Institute on Drug Abuse (R21DA023701, K02DA023555, R01DA016765)
  • National Institute of General Medical Sciences (T32GM083831)
  • National Institute of Neurological Disorders and Stroke (R01NS038572, R01NS048192, R01NS081203, R01NS076775)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
hippocampal neurogenesis, epilepsy, chronic seizures, pilocarpine-induced seizures, cognitive impairment, memory impairment, brain injury, seizure suppression, therapeutic target
MeSH terms
Doublecortin Domain Proteins, Animals, Cognition Disorders, Disease Models, Animal, Epilepsy, Epilepsy, Temporal Lobe, Hippocampus, Immunohistochemistry, Mice, Transgenic, Microtubule-Associated Proteins, Nerve Tissue Proteins, Neurons, Neuropeptides, Pilocarpine, Muscarinic Agonists, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Neurogenesis, Neural Stem Cells

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