Neurod1 is essential for the survival and maturation of adult-born neurons
Open accessAbstract
The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.
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Wnt target NEUROD1 is important for adult neurogenesis and the survival and maturation of adult-born neurons.
“Wnt target NEUROD1 is important for adult neurogenesis and the survival and maturation of adult-born neurons [54, 64].”
From CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease (2026) · cites this paper as [64]
The paper’s Abstract reports that Neurod1 is required for the survival and maturation of adult-born neurons and identifies it as a regulator of adult neurogenesis. Our copy does not identify Neurod1 as a Wnt target (searched: “Wnt target Neurod1” and “Wnt”), so that part of the sentence is not supported by this source. (LLM, conf=0.86)
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- Authors
- Gao, Z., Ure, K., Ables, J. L., Lagace, D. C., Nave, K.-A., Goebbels, S., Eisch, A. J., & Hsieh, J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- University of Ottawa (CA)
- Max Planck Society (DE)
- Corresponding author
- Hsieh, Jenny
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2009-08-23
- Volume
- 12
- Issue
- 9
- Pages
- 1090-1092
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3365543
- OpenAlex
- W2077599130
- Cited by
- 473
- References
- 0
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 26 · 2023: 29 · 2022: 36 · 2021: 30 · 2020: 36 · 2019: 28 · 2018: 21 · 2017: 28 · 2016: 23 · 2015: 29 · 2014: 30 · 2013: 31 · 2012: 27
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institute on Drug Abuse (R21DA023701, K02DA023555, R01DA016765)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- NeuroD1, adult neurogenesis, adult-born neurons, neuronal survival, neuronal maturation, hippocampus, olfactory bulb, transcription factors, inducible gene deletion
- MeSH terms
- Animals, Astrocytes, Cell Differentiation, Cell Survival, Cells, Cultured, Hippocampus, Mice, Transgenic, Neurons, Olfactory Bulb, Time Factors, Mice, Knockout, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Adult Stem Cells, Neurogenesis
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