Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus
Open accessAbstract
Throughout the adult life of most mammals, new neurons are continuously generated in the dentate gyrus of the hippocampal formation. Recent work has documented specific cognitive deficits after elimination of adult hippocampal neurogenesis in rodents, suggesting that these neurons may contribute to information processing in hippocampal circuits. Young adult-born neurons exhibit enhanced excitability and have altered capacity for synaptic plasticity in hippocampal slice preparations in vitro. Still, little is known about the effect of adult-born granule cells on hippocampal activity in vivo. To assess the impact of these new neurons on neural circuits in the dentate, we recorded perforant-path evoked responses and spontaneous network activity from the dentate gyrus of urethane-anesthetized mice whose hippocampus had been focally X-irradiated to eliminate the population of young adult-born granule cells. After X-irradiation, perforant-path responses were reduced in magnitude. In contrast, there was a marked increase in the amplitude of spontaneous γ-frequency bursts in the dentate gyrus and hilus, as well as increased synchronization of dentate neuron firing to these bursts. A similar increase in gamma burst amplitude was also found in animals in which adult neurogenesis was eliminated using the GFAP:TK pharmacogenetic ablation technique. These data suggest that young neurons may inhibit or destabilize recurrent network activity in the dentate and hilus. This unexpected result yields a new perspective on how a modest number of young adult-generated granule cells may modulate activity in the larger population of mature granule cells, rather than acting solely as independent encoding units.
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Adult-generated neurons in the hippocampus modulate neuronal oscillations; their elimination by focal irradiation or transgenic means increases rhythmic firing.
“Studies have shown that adult-generated neurons in the hippocampus have the ability to modulate neuronal oscillations in that their elimination by focal irradiation or by transgenic means increases rhythmic firing (36).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [36]
New neurons may be involved in modulating neuronal oscillations in the hippocampus.
“New neurons may be involved in modulating neuronal oscillations in the hippocampus as ablation of neurogenesis destabilizes network activity in vivo (36).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [36]
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- Authors
- Lacefield, C. O., Itskov, V., Reardon, T., Hen, R., & Gordon, J. A.
- Affiliations
- New York State Psychiatric Institute (US)
- Columbia University (US)
- Corresponding author
- Hen, René
- Gordon, Joshua A.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2010-09-29
- Volume
- 22
- Issue
- 1
- Pages
- 106-116
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- PMC
- PMC3282563
- OpenAlex
- W2050305231
- Cited by
- 188
- References
- 47
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 11 · 2022: 10 · 2021: 13 · 2020: 13 · 2019: 15 · 2018: 5 · 2017: 13 · 2016: 15 · 2015: 16 · 2014: 14 · 2013: 16 · 2012: 11
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH081968, R01MH068542)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- adult hippocampal neurogenesis, dentate gyrus granule cells, perforant path, hilus, hippocampal circuitry, spontaneous network activity
- MeSH terms
- Animals, Cytoplasmic Granules, Male, Mice, Inbred C57BL, Mice, Transgenic, Nerve Net, Neural Pathways, Neuronal Plasticity, Neurons, Dentate Gyrus, Mice, Neurogenesis
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