Ghrelin, obesity and diabetes

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works

Abdominal obesity and metabolic syndrome

Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354 · see citing works

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · see citing works

Circulating Ghrelin Levels Are Decreased in Human Obesity

Tschöp, M. H., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, É., & Heiman, M. L. (2001) · Diabetes · doi:10.2337/diabetes.50.4.707 · Cited by 1,992 · see citing works

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works

Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake

Zhang, J. V., Ren, P.-G., Avsian-Kretchmer, O., Luo, C.-W., Rauch, R., Klein, C., & Hsueh, A. J. W. (2005) · Science · doi:10.1126/science.1117255 · Cited by 1,197 · see citing works

Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin

van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187 · see citing works

Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues.

Guan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185 · see citing works

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

Asakawa, A., Inui, A., Kaga, O., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.22158 · Cited by 1,175 · see citing works

The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats

Date, Y., Murakami, N., Toshinai, K., Matsukura, S., Niijima, A., Matsuo, H., Kangawa, K., & Nakazato, M. (2002) · Gastroenterology · doi:10.1053/gast.2002.35954 · Cited by 1,081 · see citing works

Expression of ghrelin receptor mRNA in the rat and the mouse brain

Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074 · see citing works

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

Erickson, J. C., Clegg, K. E., & Palmiter, R. D. (1996) · Nature · doi:10.1038/381415a0 · Cited by 1,009 · see citing works

Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite

Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984 · see citing works

Ghrelin controls hippocampal spine synapse density and memory performance

Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1656 · Cited by 828 · see citing works

Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

Sun, Y., Wang, P., Zheng, H., & Smith, R. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305930101 · Cited by 743 · see citing works

Ghrelin, a Natural GH Secretagogue Produced by the Stomach, Induces Hyperglycemia and Reduces Insulin Secretion in Humans

Broglio, F., Arvat, E., Benso, A. S., Gottero, C., Muccioli, G., Papotti, M. G., van der Lely, A. J., Deghenghi, R., & Ghigo, E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.8098 · Cited by 720 · see citing works

Post-prandial decrease of circulating human ghrelin levels

Tschöp, M., Wawarta, R., Riepl, R. L., Friedrich, S., Bidlingmaier, M., Landgraf, R., & Folwaczny, C. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03351037 · Cited by 699 · see citing works

Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure

Banks, W. A., Tschöp, M., Robinson, S. M., & Heiman, M. L. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034827 · Cited by 691 · see citing works

Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related Protein

Chen, H. Y., Trumbauer, M. E., Chen, A. S., Weingarth, D. T., Adams, J. R., Frazier, E. G., Shen, Z., Marsh, D. J., Feighner, S. D., Guan, X.-M., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1596 · Cited by 667 · see citing works

Mice lacking ghrelin receptors resist the development of diet-induced obesity

Zigman, J. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26002 · Cited by 654 · see citing works

Deletion of Ghrelin Impairs neither Growth nor Appetite

Sun, Y., Ahmed, S., & Smith, R. G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.7973-7981.2003 · Cited by 644 · see citing works

Ghrelin Is Present in Pancreatic α-Cells of Humans and Rats and Stimulates Insulin Secretion

Date, Y., Nakazato, M., Hashiguchi, S., Dezaki, K., Mondal, M. S., Hosoda, H., Kojima, M., Kangawa, K., Arima, T., Matsuo, H., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.1.124 · Cited by 572 · see citing works

Food Fails to Suppress Ghrelin Levels in Obese Humans

English, P., Ghatei, M. A., Malik, I., Bloom, S. R., & Wilding, J. P. H. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8738 · Cited by 535 · see citing works

High constitutive signaling of the ghrelin receptor–identification of a potent inverse agonist

Holst, B., Cygankiewicz, A., Jensen, T. H., Ankersen, M., & Schwartz, T. W. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0069 · Cited by 515 · see citing works

Insulin Regulates Plasma Ghrelin Concentration

Saad, M. F., Bernaba, B., Hwu, C., Jinagouda, S. D., Fahmi, S., Kogosov, E., & Boyadjian, R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.8.8879 · Cited by 512 · see citing works

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference

Wortley, K. E., Anderson, K. D., García, K., Murray, J. D., Malinova, L., Liu, R., Moncrieffe, M., Thabet, K., Cox, H. J., Yancopoulos, G. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402763101 · Cited by 471 · see citing works

Ghrelin action in the brain controls adipocyte metabolism

Theander-Carrillo, C. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25811 · Cited by 465 · see citing works

The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas

Wierup, N., Svensson, H., Mulder, H., & Sundler, F. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(02)00067-8 · Cited by 457 · see citing works

Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers

Lawrence, C. B., Snape, A. C., Baudoin, F., & Luckman, S. M. (2002) · Endocrinology · doi:10.1210/endo.143.1.8561 · Cited by 436 · see citing works

Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in Mice

Qian, S., Chen, H., Weingarth, D. T., Trumbauer, M. E., Novi, D. E., Guan, X.-M., Yu, H., Shen, Z., Feng, Y., Frazier, E. G., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.14.5027-5035.2002 · Cited by 430 · see citing works

GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin

Holst, B., Egerod, K. L., Schild, E., Vickers, S. P., Cheetham, S. C., Gerlach, L., Storjohann, L., Stidsen, C. E., Jones, R., Beck‐Sickinger, A. G., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0933 · Cited by 429 · see citing works

Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens

Naleid, A. M., Grace, M. K., Cummings, D. E., & Levine, A. S. (2005) · Peptides · doi:10.1016/j.peptides.2005.04.025 · Cited by 409 · see citing works

Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity

Yıldız, B. O., Suchard, M. A., Wong, M., McCann, S. M., & Licinio, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403465101 · Cited by 385 · see citing works

Absence of ghrelin protects against early-onset obesity

Wortley, K. E. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26003 · Cited by 375 · see citing works

Genetics and Pathophysiology of Human Obesity

Cummings, D. E., & Schwartz, M. W. (2003) · Annual Review of Medicine · doi:10.1146/annurev.med.54.101601.152403 · Cited by 371 · see citing works

Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice.

Sun, Y.-X., Asnicar, M., Saha, P., Chan, L., & Smith, R. G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.004 · Cited by 368 · see citing works

Endogenous Ghrelin in Pancreatic Islets Restricts Insulin Release by Attenuating Ca2+ Signaling in β-Cells

Dezaki, K., Hosoda, H., Kakei, M., Hashiguchi, S., Watanabe, M., Kangawa, K., & Yada, T. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3142 · Cited by 366 · see citing works

Non-Acylated Ghrelin Counteracts the Metabolic But Not the Neuroendocrine Response to Acylated Ghrelin in Humans

Broglio, F., Gottero, C., Prodam, F., Gauna, C., Muccioli, G., Papotti, M., Abribat, T., van der Lely, A. J., & Ghigo, E. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031964 · Cited by 355 · see citing works

Expression of Ghrelin and of the GH Secretagogue Receptor by Pancreatic Islet Cells and Related Endocrine Tumors

Volante, M., Allìa, E., Gugliotta, P., Funaro, A., Broglio, F., Deghenghi, R., Muccioli, G., Ghigo, E., & Papotti, M. G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8279 · Cited by 354 · see citing works

High Circulating Ghrelin: A Potential Cause for Hyperphagia and Obesity in Prader-Willi Syndrome

DelParigi, A., Tschöp, M. H., Heiman, M. L., Salbe, A. D., de Courten, B. V., Sell, S. M., Bunt, J. C., & Tataranni, P. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020871 · Cited by 348 · see citing works

Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study

Murray, C. D., Martin, N. M., Patterson, M., Taylor, S. A., Ghatei, M. A., Kamm, M. A., Johnston, C., Bloom, S. R., & Emmanuel, A. V. (2005) · Gut · doi:10.1136/gut.2005.069088 · Cited by 320 · see citing works

Dose-Dependent Inhibition by Ghrelin of Insulin Secretion in the Mouse

Reimer, M. K., Pacini, G., & Åhrén, B. (2003) · Endocrinology · doi:10.1210/en.2002-220819 · Cited by 316 · see citing works

Ultradian Rhythmicity of Ghrelin Secretion in Relation with GH, Feeding Behavior, and Sleep-Wake Patterns in Rats

Tolle, V., Bassant, M., Zizzari, P., Poindessous‐Jazat, F., Tomasetto, C., Epelbaum, J., & Bluet‐Pajot, M. (2002) · Endocrinology · doi:10.1210/endo.143.4.8712 · Cited by 305 · see citing works

Hyperphagic Effects of Brainstem Ghrelin Administration

Faulconbridge, L. F., Cummings, D. E., Kaplan, J. M., & Grill, H. J. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2260 · Cited by 302 · see citing works

Acylated and Unacylated Ghrelin Promote Proliferation and Inhibit Apoptosis of Pancreatic β-Cells and Human Islets: Involvement of 3′,5′-Cyclic Adenosine Monophosphate/Protein Kinase A, Extracellular Signal-Regulated Kinase 1/2, and Phosphatidyl Inositol 3-Kinase/Akt Signaling

Granata, R., Settanni, F., Biancone, L., Trovato, L., Nano, R., Bertuzzi, F., Destefanis, S., Annunziata, M., Martinetti, M., Catapano, F., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0266 · Cited by 294 · see citing works

Ghrelin Levels Correlate with Insulin Levels, Insulin Resistance, and High-Density Lipoprotein Cholesterol, But Not with Gender, Menopausal Status, or Cortisol Levels in Humans

Purnell, J. Q., Weigle, D. S., Breen, P. A., & Cummings, D. E. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030513 · Cited by 274 · see citing works

Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin.

Nishi, Y., Hiejima, H., Hosoda, H., Kaiya, H., Mori, K., Fukue, Y., Yanase, T., Nawata, H., Kangawa, K., & Kojima, M. (2005) · Endocrinology · doi:10.1210/en.2004-0695 · Cited by 267 · see citing works

Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents

Nogueiras, R., Pfluger, P. T., Tovar, S. A., Arnold, M., Mitchell, S. E., Morris, A., Pérez–Tilve, D., Vazquez, M. J., Wiedmer, P., Castañeda, T. R., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0915 · Cited by 265 · see citing works

Ghrelin regulates mitochondrial-lipid metabolism gene expression and tissue fat distribution in liver and skeletal muscle.

Barazzoni, R., Bosutti, A., Stebel, M., Cattin, M. R., Roder, E., Visintin, L., Cattin, L., Biolo, G., Zanetti, M., & Guarnieri, G. (2005) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00115.2004 · Cited by 250 · see citing works

Structural Divergence of Human Ghrelin

Hosoda, H., Kojima, M., Mizushima, T., Shimizu, S., & Kangawa, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205366200 · Cited by 243 · see citing works

Blockade of Pancreatic Islet–Derived Ghrelin Enhances Insulin Secretion to Prevent High-Fat Diet–Induced Glucose Intolerance

Dezaki, K., Sone, H., Koizumi, M., Nakata, M., Kakei, M., Nagai, H., Hosoda, H., Kangawa, K., & Yada, T. (2006) · Diabetes · doi:10.2337/db06-0878 · Cited by 242 · see citing works

Gut Vagal Afferents Are Not Necessary for the Eating-Stimulatory Effect of Intraperitoneally Injected Ghrelin in the Rat

Arnold, M., Mura, A., Langhans, W., & Geary, N. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2606-06.2006 · Cited by 233 · see citing works

Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats

Tang-Christensen, M., Vrang, N., Ortmann, S., Bidlingmaier, M., Horvath, T. L., & Tschöp, M. (2004) · Endocrinology · doi:10.1210/en.2004-0529 · Cited by 226 · see citing works

Obestatin does not activate orphan G protein-coupled receptor GPR39

Lauwers, E., Landuyt, B., Arckens, L., Schoofs, L., & Luyten, W. H. M. L. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.141 · Cited by 225 · see citing works

Vaccination against weight gain

Zorrilla, E. P., Iwasaki, S., Moss, J. A., Chang, J. Y., Otsuji, J., Inoue, K., Meijler, M. M., & Janda, K. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605376103 · Cited by 224 · see citing works

Hypothalamic growth hormone secretagogue receptor regulates growth hormone secretion, feeding, and adiposity.

Shuto, Y., Shibasaki, T., Otagiri, A., Kuriyama, H., Ohata, H., Tamura, H., Kamegai, J., Sugihara, H., Oikawa, S., & Wakabayashi, I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213300 · Cited by 220 · see citing works

Delayed Short-Term Secretory Regulation of Ghrelin in Obese Animals: Evidenced by a Specific RIA for the Active Form of Ghrelin

Ariyasu, H., Takaya, K., Hosoda, H., Iwakura, H., Ebihara, K., Mori, K., Ogawa, Y., Hosoda, K., Akamizu, T., Kojima, M., et al. (2002) · Endocrinology · doi:10.1210/en.2002-220225 · Cited by 214 · see citing works

Role of the Duodenum and Macronutrient Type in Ghrelin Regulation

Overduin, J., Frayo, R. S., Grill, H. J., Kaplan, J. M., & Cummings, D. E. (2004) · Endocrinology · doi:10.1210/en.2004-0609 · Cited by 208 · see citing works

Ghrelin Uses Gαi2 and Activates Voltage-Dependent K+ Channels to Attenuate Glucose-Induced Ca2+ Signaling and Insulin Release in Islet β-Cells

Dezaki, K., Kakei, M., & Yada, T. (2007) · Diabetes · doi:10.2337/db07-0345 · Cited by 183 · see citing works

Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats

Yasuda, T., Masaki, T., Kakuma, T., & Yoshimatsu, H. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00789-4 · Cited by 167 · see citing works

GH-Releasing Peptide-2 Increases Fat Mass in Mice Lacking NPY: Indication for a Crucial Mediating Role of Hypothalamic Agouti-Related Protein

Tschöp, M. H., Statnick, M. A., Suter, T. M., & Heiman, M. L. (2002) · Endocrinology · doi:10.1210/endo.143.2.8633 · Cited by 150 · see citing works

Obestatin acts in brain to inhibit thirst

Samson, W. K., White, M. M., Price, C. J., & Ferguson, A. V. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00395.2006 · Cited by 148 · see citing works

Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus

Olszewski, P. K., Li, D., Grace, M. K., Billington, C. J., Kotz, C. M., & Levine, A. S. (2003) · Peptides · doi:10.1016/s0196-9781(03)00105-0 · Cited by 146 · see citing works

Cell Biology of the Ghrelin Receptor

Camiña, J. P. (2005) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2005.01379.x · Cited by 146 · see citing works

Circulating ghrelin concentrations are lowered by intravenous glucose or hyperinsulinemic euglycemic conditions in rodents

McCowen, K. C., Maykel, J. A., Bistrian, B. R., & Ling, P. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.175r007 · Cited by 143 · see citing works

Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice

Salehi, A. A., de la Cour, C. D., Håkanson, R., & Lundquist, I. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2003.12.001 · Cited by 140 · see citing works

Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat

Bresciani, E., Rapetti, D., Donà, F., Bulgarelli, I., Tamiazzo, L., Locatelli, V., & Torsello, A. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03344175 · Cited by 138 · see citing works

Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss

Perreault, M., Istrate, N., Wang, L., Nichols, A., Tozzo, E., & Stricker‐Krongrad, A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802640 · Cited by 132 · see citing works

Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats

Seoane, L. M., Al–Massadi, O., Pazos, Y., Pagotto, U., & Casanueva, F. F. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03344174 · Cited by 130 · see citing works

Ghrelin is an orexigenic and metabolic signaling peptide in the arcuate and paraventricular nuclei

Currie, P. J., Mirza, A., Fuld, R., Park, D., & Vasselli, J. R. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00756.2004 · Cited by 125 · see citing works

Hypothalamic paraventricular injections of ghrelin: effect on feeding and c-Fos immunoreactivity

Olszewski, P. K., Grace, M. K., Billington, C. J., & Levine, A. S. (2003) · Peptides · doi:10.1016/s0196-9781(03)00159-1 · Cited by 123 · see citing works

Obestatin alters sleep in rats

Szentirmai, É., & Krueger, J. M. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.053 · Cited by 119 · see citing works

Distribution and biological activity of obestatin in the rat

Dun, S. L., Brailoiu, G. C., Brailoiu, E., Yang, J., Chang, J. K., & Dun, N. J. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06944 · Cited by 108 · see citing works

Synaptic Plasticity in Energy Balance Regulation

Horvath, T. L. (2006) · Obesity · doi:10.1038/oby.2006.314 · Cited by 104 · see citing works

Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice

de la Cour, C. D., Lindqvist, A., Egecioglu, E., Tung, Y. C. L., Surve, V. V., Ohlsson, C., Jansson, J.-O., Erlanson‐Albertsson, C., Dickson, S. L., & Håkanson, R. (2005) · Gut · doi:10.1136/gut.2004.058578 · Cited by 102 · see citing works

Growth hormone receptor deficiency results in blunted ghrelin feeding response, obesity, and hypolipidemia in mice

Egecioglu, E., Bjursell, M., Ljungberg, A., Dickson, S. L., Kopchick, J. J., Bergström, G. M. L., Svensson, L., Oscarsson, J., Törnell, J., & Bohlooly‐Y, M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00181.2005 · Cited by 101 · see citing works

Ghrelin prevents development of diabetes at adult age in streptozotocin-treated newborn rats

Irako, T., Akamizu, T., Hosoda, H., Iwakura, H., Ariyasu, H., Tojo, Κ., Tajima, N., & Kangawa, K. (2006) · Diabetologia · doi:10.1007/s00125-006-0226-3 · Cited by 88 · see citing works

Gut–Brain Axis: Regulation of Glucose Metabolism

Heijboer, A. C., Pijl, H., van den Hoek, A. M., Havekes, L. M., Romijn, J. A., & Corssmit, E. P. M. (2006) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2006.01492.x · Cited by 86 · see citing works

Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor

Gauna, C., Delhanty, P. J. D., van Aken, M. O., Janssen, J. A. M. J. L., Themmen, A. P. N., Hofland, L. J., Culler, M. D., Broglio, F., Ghigo, E., & van der Lely, A. J. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.040 · Cited by 86 · see citing works

Relationship between Ghrelin and Energy Expenditure in Healthy Young Women

St-Pierre, D. H., Karelis, A. D., Cianflone, K., Conus, F., Mignault, D., RABASA-LHORET, R. P. R., St-Onge, M., Tremblay-Lebeau, A., & Poehlman, É. T. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0613 · Cited by 84 · see citing works

Ghrelin, a Novel Growth Hormonereleasing Peptide, in the Treatment of Cardiopulmonaryassociated Cachexia

Nagaya, N., Kojima, M., & Kangawa, K. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1402 · Cited by 72 · see citing works

IA-2β, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion

Doi, A., Shono, T., Nishi, M., Furuta, H., Sasaki, H., & Nanjo, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502470102 · Cited by 71 · see citing works

Ghrelin as a Potential Anti-Obesity Target

Horváth, T. L., Castañeda, T. R., Tang‐Christensen, M., Pagotto, U., & Tschöp, M. H. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033454748 · Cited by 68 · see citing works

Obestatin – a ghrelin‐associated peptide that does not hold its promise to suppress food intake and motility

Gourcerol, G., & Taché, Y. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00916.x · Cited by 66 · see citing works

Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress

Kineman, R. D., Gahete, M. D., & Luque, R. M. (2007) · Journal of Molecular Endocrinology · doi:10.1677/jme-06-0026 · Cited by 63 · see citing works

Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat

Sibilia, V., Bresciani, E., Lattuada, N., Rapetti, D., Locatelli, V., Luca, V. D., Donà, F., Netti, C., Torsello, A., & GUIDOBONO, F. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03349204 · Cited by 57 · see citing works

Is ghrelin a signal for the development of metabolic systems?

Grove, K. L. (2005) · Journal of Clinical Investigation · doi:10.1172/jci27211 · Cited by 57 · see citing works

Changes in 24-h area-under-the-curve ghrelin values following diet-induced weight loss are associated with loss of fat-free mass, but not with changes in fat mass, insulin levels or insulin sensitivity

Purnell, J. Q., Cummings, D., & Weigle, D. S. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803401 · Cited by 36 · see citing works

Growth Hormone Secretagogue (Ghrelin-) Receptors - A Complex Drug Target for the Regulation of Body Weight

Nogueiras, R., Pérez–Tilve, D., Wortley, K. E., & Tschöp, M. H. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706777452227 · Cited by 27 · see citing works

Ghrelin: A Link between Eating Disorders, Obesity and Reproduction

Gottero, C., Broglio, F., Prodam, F., Destefanis, S., Bellone, S., Benso, A. S., Gauna, C., Arvat, E., van der Lely, A. J., & Ghigo, E. (2004) · Nutritional Neuroscience · doi:10.1080/10284150400017363 · Cited by 19 · see citing works

GHRH and GH secretagogues: clinical perspectives and safety.

Aimaretti, G., Baldelli, R., Corneli, G., Bellone, S., Rovere, S., Croce, C. G., Ragazzoni, F., Giordano, R., Arvat, E., Bona, G., et al. (2004) · PubMed · Cited by 14 · see citing works

Ghrelin and GHS on cardiovascular applications/functions

Isgaard, J., & Johansson, I. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03347578 · Cited by 12 · see citing works

Central Control of Body Weight and Appetite

Woods, S. C., & D’Alessio, D. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1630 · Cited by 460 · see citing works

Brain Regulation of Appetite and Satiety

Ahima, R. S., & Antwi, D. A. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2008.08.005 · Cited by 387 · see citing works

Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass

Korner, J., Inabnet, W., Febres, G., Conwell, I. M., McMahon, D. J., Salas, R., Taveras, C., Schrope, B., & Bessler, M. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.79 · Cited by 338 · see citing works

Ghrelin

Pradhan, G., Samson, S. L., & Sun, Y. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328365b9be · Cited by 294 · see citing works

Fasting plasma levels of nesfatin-1 in patients with type 1 and type 2 diabetes mellitus and the nutrient-related fluctuation of nesfatin-1 level in normal humans

Li, Q., Wang, H.-Y., Chen, X., Guan, H., & Jiang, Z. (2009) · Regulatory Peptides · doi:10.1016/j.regpep.2009.11.003 · Cited by 193 · see citing works

Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span

Dixit, V. D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108028 · Cited by 158 · see citing works

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius

Hisadome, K., Reimann, F. M., Gribble, F. M., & Trapp, S. (2010) · Diabetes · doi:10.2337/db10-0128 · Cited by 150 · see citing works

Endocannabinoid signaling and food addiction

D’Addario, C., Bonaventura, M. V. M. D., Pucci, M., Romano, A., Gaetani, S., Ciccocioppo, R., Cifani, C., & Maccarrone, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.08.008 · Cited by 123 · see citing works

The role of the endocannabinoid system in the neuroendocrine regulation of energy balance

Bermúdez‐Silva, F. J., Cardinal, P., & Cota, D. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408458 · Cited by 117 · see citing works

Predictive Factors of Type 2 Diabetes Remission 1 Year After Bariatric Surgery: Impact of Surgical Techniques

Robert, M., Ferrand-Gaillard, C., Disse, E., Espalieu, P., Simon, C., Laville, M., Gouillat, C., & Thivolet, C. H. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0868-4 · Cited by 106 · see citing works

Recent Advances in Obesity: Genetics and Beyond

Cheung, W. W., & Mao, P. (2012) · ISRN Endocrinology · doi:10.5402/2012/536905 · Cited by 103 · see citing works

Polymersomes conjugated with des-octanoyl ghrelin and folate as a BBB-penetrating cancer cell-targeting delivery system

Chen, Y., Chiang, C., Chen, L., Liang, P., Hsieh, W., & Lin, W.-L. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.042 · Cited by 98 · see citing works

Acylated and nonacylated ghrelin levels and their associations with insulin resistance in obese and normal weight children with metabolic syndrome

Pacifico, L., Poggiogalle, E., Costantino, F., Anania, C., Ferraro, F., Chiarelli, F., & Chiesa, C. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0375 · Cited by 97 · see citing works

Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats

Hu, X., Li, Y., Li, C., Fu, Y., Cai, F., Chen, Q., & Li, D. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.01.011 · Cited by 95 · see citing works

A Focused Review of the Metabolic Side-Effects of Clozapine

Yuen, J. W. Y., Kim, D. D., Procyshyn, R. M., Panenka, W. J., Honer, W. G., & Barr, A. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.609240 · Cited by 92 · see citing works

Recessive Isolated Growth Hormone Deficiency and Mutations in the Ghrelin Receptor

Pantel, J., Legendre, M., Nivot, S., Morisset‐Lopez, S., Luton, M., Bouc, Y. L., Epelbaum, J., & Amselem, S. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1327 · Cited by 91 · see citing works

Obesity Epidemic

Hurt, R. T., Frazier, T. H., McClave, S. A., & Kaplan, L. M. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607111415110 · Cited by 91 · see citing works

Role of ghrelin axis in colorectal cancer: A novel association

Waseem, T., Javaid-ur-Rehman, Ahmad, F., Azam, M. A., & Qureshi, M. A. (2008) · Peptides · doi:10.1016/j.peptides.2008.03.020 · Cited by 84 · see citing works

Metabolic effects of overnight continuous infusion of unacylated ghrelin in humans

Benso, A. S., St-Pierre, D. H., Prodam, F., Gramaglia, E., Granata, R., van der Lely, A. J., Ghigo, E., & Broglio, F. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0982 · Cited by 82 · see citing works

Lipid Sensing and Insulin Resistance in the Brain

Yue, J. T. Y., & Lam, T. K. T. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.013 · Cited by 82 · see citing works

Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats

Strassburg, S., Anker, S. D., Castañeda, T. R., Burget, L., Pérez–Tilve, D., Pfluger, P. T., Nogueiras, R., Halem, H. A., Dong, J. Z., Culler, M. D., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00040.2008 · Cited by 69 · see citing works

The neurological effects of ghrelin in brain diseases: Beyond metabolic functions

Jiao, Q., Du, X., Li, Y., Gong, B., Shi, L., Tang, T., & Jiang, H. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.010 · Cited by 62 · see citing works

The effects of obesity on asthma: immunometabolic links

Miethe, S., Guarino, M., Alhamdan, F., Simon, H., Renz, H. E., Dufour, J., Potaczek, D. P., & Garn, H. (2018) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.4304 · Cited by 62 · see citing works

Orphan GPCRs and Neuromodulation

Civelli, O. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.009 · Cited by 61 · see citing works

Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting

Hoddy, K. K., Gibbons, C., Kroeger, C. M., Trepanowski, J. F., Barnosky, A., Bhutani, S., Gabel, K., Finlayson, G., & Varady, K. A. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.03.011 · Cited by 60 · see citing works

Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling

Stevanović, D., Trajković, V., Müller-Lühlhoff, S., Brandt, E., Abplanalp, W. A., Bumke‐Vogt, C., Liehl, B., Wiedmer, P., Janjetović, K., Starcevic, V. P., et al. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.08.009 · Cited by 60 · see citing works

Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a

Casanueva, F. F., Camiña, J. P., Carreira, M. C., Pazos, Y., Varga, J. L., & Schally, A. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811680106 · Cited by 57 · see citing works

A Scientific Perspective of Personalised Gene-Based Dietary Recommendations for Weight Management

Drabsch, T., & Holzapfel, C. (2019) · Nutrients · doi:10.3390/nu11030617 · Cited by 51 · see citing works

Comparative Study of Diabetes Mellitus Resolution According to Reconstruction Type After Gastrectomy in Gastric Cancer Patients with Diabetes Mellitus

Lee, W., Ahn, S. H., Lee, J. H., Park, D. J., Lee, H., Kim, H., & Yang, H.-K. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0580-1 · Cited by 49 · see citing works

Adipose Tissue Hormones and Appetite and Body Weight Regulators an Insulin Resistance / Гормоны Жировой Ткани И Регуляторы Аппетита И Массы Тела При Инсулиновой Резистентности

Koleva, D. I., Orbetzova, M. M., & Atanassova, P. K. (2013) · Folia Medica · doi:10.2478/folmed-2013-0002 · Cited by 48 · see citing works

The Potential Benefits and Adverse Effects of Phytic Acid Supplement in Streptozotocin-Induced Diabetic Rats

Omoruyi, F. O., Budiaman, A., Eng, Y., Olumese, F. E., Hoesel, J. L., Ejilemele, A., & Okorodudu, A. O. (2013) · Advances in Pharmacological Sciences · doi:10.1155/2013/172494 · Cited by 47 · see citing works

Ghrelin-mediated appetite regulation in the central nervous system

Kirsz, K., & Zieba, D. A. (2011) · Peptides · doi:10.1016/j.peptides.2011.04.010 · Cited by 47 · see citing works

An Evaluation of Acylated Ghrelin and Obestatin Levels in Childhood Obesity and Their Association with Insulin Resistance, Metabolic Syndrome, and Oxidative Stress

Razzaghy‐Azar, M., Nourbakhsh, M., Pourmoteabed, A. R., Nourbakhsh, M., Ilbeigi, D., & Khosravi, M. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5070061 · Cited by 43 · see citing works

Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status.

Caminos, J. E., Bravo, S. B., Garcés, M. F., González, C. R., Cepeda, L. A., González, A. C., Nogueiras, R., Gallego, R., García‐Caballero, T., Cordido, F., et al. (2009) · PubMed · doi:10.14670/hh-24.979 · Cited by 43 · see citing works

Ghrelin Gene Products in Acute and Chronic Inflammation

Prodam, F., & Filigheddu, N. (2014) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-014-0287-9 · Cited by 42 · see citing works

New Frontiers for the Use of IP6 and Inositol Combination in Treating Diabetes Mellitus: A Review

Omoruyi, F. O., Stennett, D., Foster, S. R., & Dilworth, L. (2020) · Molecules · doi:10.3390/molecules25071720 · Cited by 42 · see citing works

Ghrelin forms in the modulation of energy balance and metabolism

Cappellari, G. G., & Barazzoni, R. (2018) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-018-0599-6 · Cited by 40 · see citing works

Leptin and ghrelin dynamics: unraveling their influence on food intake, energy balance, and the pathophysiology of type 2 diabetes mellitus

Vijayashankar, U., Ramashetty, R., Rajeshekara, M., Vishwanath, N., Yadav, A. K., Prashant, A., & Lokeshwaraiah, R. (2024) · Journal of Diabetes and Metabolic Disorders · doi:10.1007/s40200-024-01418-2 · Cited by 35 · see citing works

Elevation of Fasting Ghrelin in Healthy Human Subjects Consuming a High-Salt Diet: A Novel Mechanism of Obesity?

Zhang, Y., Li, F., Liu, F., Chu, C., Wang, Y., Wang, D., Guo, T., Wang, J., Guan, G., Ren, K., et al. (2016) · Nutrients · doi:10.3390/nu8060323 · Cited by 39 · see citing works

Ion Channels in Obesity: Pathophysiology and Potential Therapeutic Targets

Vasconcelos, L. H. C., de Souza, I. L. L., Pinheiro, L. S., & da Silva, B. A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00058 · Cited by 36 · see citing works

Nanomedicine for obesity treatment

Zhang, Y., Yu, J., Qiang, L., & Gu, Z. (2018) · Science China Life Sciences · doi:10.1007/s11427-017-9257-1 · Cited by 36 · see citing works

Diabetes Remission After LRYGBP With and Without Fundus Resection: a Randomized Clinical Trial

Kehagias, D., Lampropoulos, C., Georgopoulos, N., Habeos, I., Kalavrizioti, D., Vamvakas, S., Davoulou, P., & Kehagias, I. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06857-z · Cited by 32 · see citing works

Type 2 diabetes mellitus coincident with pulmonary or latent tuberculosis results in modulation of adipocytokines

Kumar, N. P., Nair, D., Banurekha, V. V., Dolla, C., Kumaran, P., Sridhar, R., & Babu, S. (2016) · Cytokine · doi:10.1016/j.cyto.2015.12.026 · Cited by 34 · see citing works

Fetal Growth Restriction and Its Metabolism-Related Long-Term Outcomes—Underlying Mechanisms and Clinical Implications

Răileanu, A. A., Miron, I. C., Lupu, A., Bozomitu, L. I., Săsăran, M. O., Russu, R., Rosu, S. T., Nedelcu, A. H., Șalaru, D. L., Baciu, G., et al. (2025) · Nutrients · doi:10.3390/nu17030555 · Cited by 32 · see citing works

Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease

Berthold, H. K., Giannakidou, E., Krone, W., Trégouët, D., & Gouni‐Berthold, I. (2009) · Hypertension Research · doi:10.1038/hr.2009.194 · Cited by 31 · see citing works

Endocrine and Metabolic Actions of Ghrelin

Gasco, V., Beccuti, G., Marotta, F., Benso, A., Granata, R., Broglio, F., & Ghigo, E. (2010) · Endocrine Development · doi:10.1159/000262531 · Cited by 30 · see citing works

Gastric Bypass Surgery May Improve Beta Cell Apoptosis with Ghrelin Overexpression in Patients with BMI ≥ 32.5 kg/m2

Yang, J. Z., Feng, X., Zhong, S.-Z., Wang, Y., & Liu, J. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1135-4 · Cited by 27 · see citing works

Acylated and unacylated ghrelin levels in normal weight and obese children: influence of puberty and relationship with insulin, leptin and adiponectin levels.

Bellone, S., Prodam, F., Savastio, S., Rienzo, F. D., Demarchi, I., Trovato, L., Petri, A., Rapa, A., Aimaretti, G., & Bona, G. (2012) · PubMed · doi:10.3275/7761 · Cited by 27 · see citing works

Therapeutic applications of ghrelin to cachexia utilizing its appetite-stimulating effect

Akamizu, T., & Kangawa, K. (2011) · Peptides · doi:10.1016/j.peptides.2011.05.018 · Cited by 27 · see citing works

Systematic Review of Ghrelin Response to Food Intake in Pediatric Age, From Neonates to Adolescents

Prodam, F., Monzani, A., Ricotti, R., Marolda, A., Bellone, S., Aimaretti, G., Roccio, M., & Bona, G. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4010 · Cited by 27 · see citing works

Does the pituitary somatotrope play a primary role in regulating GH output in metabolic extremes?

Luque, R. M., Gahete, M. D., Córdoba‐Chacón, J., Childs, G. V., & Kineman, R. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05913.x · Cited by 27 · see citing works

Serum Nesfatin-1 Level in Healthy Subjects with Weight-Related Abnormalities and Newly Diagnosed Patients with Type 2 Diabetes Mellitus; a Case-Control Study

Samani, S. (2019) · Acta Endocrinologica (Bucharest) · doi:10.4183/aeb.2019.69 · Cited by 27 · see citing works

Expression of a mutant prohibitin from the aP2 gene promoter leads to obesity-linked tumor development in insulin resistance-dependent manner

Ande, S. R., Nguyen, K. H., Padilla‐Meier, G. P., Nyomba, B. L. G., & Mishra, S. (2016) · Oncogene · doi:10.1038/onc.2015.501 · Cited by 26 · see citing works

Both ghrelin deletion and unacylated ghrelin overexpression preserve muscles in aging mice

Agosti, E., Feudis, M. D., Angelino, E., Belli, R., Teixeira, M. A., Zaggia, I., Tamiso, E., Raiteri, T., Scircoli, A., Ronzoni, F., et al. (2020) · Aging · doi:10.18632/aging.103802 · Cited by 26 · see citing works

Metabolic hormones mediate cognition

Ghosh‐Swaby, O. R., Reichelt, A. C., Sheppard, P. A. S., Davies, J. S., Bussey, T. J., & Saksida, L. M. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.101009 · Cited by 25 · see citing works

Obesity-induced thymic involution and cancer risk

Lagou, M. K., & Karagiannis, G. S. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.04.008 · Cited by 25 · see citing works

Polymersomes conjugated with des-octanoyl ghrelin for the delivery of therapeutic and imaging agents into brain tissues

Chen, Y., Chiang, C., Chen, L., Liao, S.-C., Hsieh, W., & Lin, W.-L. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.051 · Cited by 25 · see citing works

Consumption of vitamin D-fortified yogurt drink increased leptin and ghrelin levels but reduced leptin to ghrelin ratio in type 2 diabetes patients: a single blind randomized controlled trial

Hajimohammadi, M., Shab‐Bidar, S., & Neyestani, T. R. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1397-z · Cited by 23 · see citing works

Obestatin Levels Are Associated With C-Peptide and Antiinsulin Antibodies at the Onset, Whereas Unacylated and Acylated Ghrelin Levels Are Not Predictive of Long-Term Metabolic Control in Children With Type 1 Diabetes

Prodam, F., Cadario, F., Bellone, S., Trovato, L., Moia, S., Pozzi, E., Savastio, S., & Bona, G. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3294 · Cited by 22 · see citing works

Fiber intake predicts ghrelin levels in overweight and obese postmenopausal women

St-Pierre, D. H., RABASA-LHORET, R. P. R., Lavoie, M.-È., Karelis, A. D., Strychar, I. M., Doucet, É., & Coderre, L. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0018 · Cited by 21 · see citing works

Current and potential roles of ghrelin in clinical practice

Angelidis, G., Valotassiou, V. J., & Georgoulias, P. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03350350 · Cited by 20 · see citing works

Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptor in Bilayer Membranes

Schrottke, S., Kaiser, A., Vortmeier, G., Els‐Heindl, S., Worm, D. J., Bosse, M., Schmidt, P. M., Scheidt, H. A., Beck‐Sickinger, A. G., & Huster, D. (2017) · Scientific Reports · doi:10.1038/srep46128 · Cited by 20 · see citing works

The Effect of Ghrelin and Estradiol on Mean Concentration of Thyroid Hormones

Kordi, F., & Khazali, H. (2014) · Intern J Endocrinol Metab · doi:10.5812/ijem.17988 · Cited by 18 · see citing works

A review on ghrelin and fish reproduction

Zhong, H., Hu, Y., & Yu, F. (2021) · Reproduction and Breeding · doi:10.1016/j.repbre.2021.07.004 · Cited by 16 · see citing works

Obestatin protects and reverses nonalcoholic fatty liver disease and its associated insulin resistance in rats via inhibition of food intake, enhancing hepatic adiponectin signaling, and blocking ghrelin acylation

Khaleel, E. F., & Abdel‐Aleem, G. A. (2018) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2018.1437638 · Cited by 15 · see citing works

Altered Systemic Adipokine Levels in Pulmonary Tuberculosis and Changes following Treatment

Moideen, K., Kumar, N. P., Nair, D., Banurekha, V. V., & Babu, S. (2018) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.18-0206 · Cited by 15 · see citing works

Ghrelin mediated regulation of neurosynaptic transmitters in depressive disorders

Masule, M. V., Rathod, S., Agrawal, Y. O., Patil, C. R., Nakhate, K. T., Ojha, S. K., Goyal, S. N., & Mahajan, U. B. (2022) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2022.100113 · Cited by 14 · see citing works

Unacylated, acylated ghrelin and obestatin levels are differently inhibited by oral glucose load in pediatric obesity: Association with insulin sensitivity and metabolic alterations

Prodam, F., Trovato, L., Demarchi, I., Busti, A., Petri, A., Moia, S., Walker, G. E., Aimaretti, G., Bona, G., & Bellone, S. (2011) · e-SPEN the European e-Journal of Clinical Nutrition and Metabolism · doi:10.1016/j.eclnm.2011.04.001 · Cited by 13 · see citing works

Cross-Talk between Obesity and Diabetes: Introducing Polyphenols as an Effective Phytomedicine to Combat the Dual Sword Diabesity

Shah, M. A., Haris, M. N., Faheem, H. I., Hamid, A., Yousaf, R., Rasul, A., Shah, G. M., Khalil, A. A. K., Wahab, A., Khan, H. Z., et al. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220628123224 · Cited by 13 · see citing works

Immunohistochemical evidence of association between ghrelin expression and tumor growth in esophageal carcinoma.

Omoto, I., Matsumoto, M., Uchikado, Y., Kita, Y., Sakurai, T., Sasaki, K., Setoyama, T., Okumura, H., Owaki, T., Ishigami, S., et al. (2014) · PubMed · Cited by 13 · see citing works

Obesity alters inflammatory response in the pathology of asthma (Review)

Qin, Z., Yang, H. B., Liu, J., Li, D., Wang, Y., Chen, Y., & Huang, C. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5266 · Cited by 12 · see citing works

Low ghrelin level is associated with poor control and bad prognosis parameters in obese diabetic patients

Al-Hakeim, H., & Ali, M. M. (2012) · Journal of Diabetology · doi:10.4103/2078-7685.198026 · Cited by 12 · see citing works

Gut hormone activity of children born to women with and without gestational diabetes

Chandler-Laney, P. C., Bush, N. C., Rouse, D. J., Mancuso, M., & Gower, B. A. (2013) · Pediatric Obesity · doi:10.1111/j.2047-6310.2012.00140.x · Cited by 12 · see citing works

Influence of age, gender, and glucose tolerance on fasting and fed acylated ghrelin in Prader Willi syndrome

Prodam, F., Bellone, S., Grugni, G., Crinò, A., Ragusa, L., Franzese, A., Battista, E. D., Corrias, A., Walker, G. E., Rapa, A., et al. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2008.12.002 · Cited by 12 · see citing works

HIGH-FIBER DIET PROMOTES METABOLIC, HORMONAL, AND SATIETY EFFECTS IN OBESE WOMEN ON A SHORT-TERM CALORIC RESTRICTION

Triffoni‐Melo, A. D. T., de Castro, M., Jordão, A. A., Leandro‐Merhi, V. A., Dick‐de‐Paula, I., & Garcia, R. W. D. (2023) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803.202302022-96 · Cited by 11 · see citing works

Risk of Fat Mass- and Obesity-Associated Gene-Dependent Obesogenic Programming by Formula Feeding Compared to Breastfeeding

Melnik, B. C., Weiskirchen, R., Stremmel, W., John, S. M., & Schmitz, G. (2024) · Nutrients · doi:10.3390/nu16152451 · Cited by 11 · see citing works

The structure and function of the ghrelin receptor coding for drug actions

Shiimura, Y., Im, D., Tany, R., Asada, H., Kise, R., Kurumiya, E., Wakasugi-Masuho, H., Yasuda, S., Matsui, K., Kishikawa, J.-I., et al. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-024-01481-6 · Cited by 9 · see citing works

An exploratory double‐blind, randomized, placebo‐controlled study to assess the efficacy of CitruSlim on body composition and lipid parameters in obese individuals

Hancke, J. L., Srivastava, S., Cáceres, D., Burgos, R. A., & Alarcón, P. (2021) · Phytotherapy Research · doi:10.1002/ptr.7331 · Cited by 8 · see citing works

Modulators of the ghrelin system as potential treatments for obesity and diabetes

Carpino, P. A., & Ho, G. (2008) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.18.11.1253 · Cited by 8 · see citing works

Ghrelin Levels in Basal Conditions and During Glucose Tolerance Test in Prediabetic and Diabetic Patients

Bounias, I., Pouliliou, S., Tripsianis, G., Antonoglou, C., Papazoglou, A., Maltezos, E., & Papazoglou, D. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0746-4014 · Cited by 4 · see citing works

Personality traits in substance use disorders and obesity when compared to healthy controls

Ramirez, V., Wiers, C. E., Wang, G., & Volkow, N. D. (2020) · Addiction · doi:10.1111/add.15062 · Cited by 7 · see citing works

Changes in ghrelin and asymmetrical dimethylarginine in obese Mexican adolescents after six-month lifestyle intervention

Huang, F., Del-Rio-Navarro, B. E., Ontiveros, J. A. P., Ruíz-Bedolla, E., Navarro-Olivos, E., Villafaña, S., Bravo, G., & Hong, E. (2012) · Endocrine · doi:10.1007/s12020-012-9808-7 · Cited by 7 · see citing works

Unlocking The Molecular Basis Of Obesity

Gómez‐Ambrosi, J., & Frühbeck, G. (2007) · Future Lipidology · doi:10.2217/17460875.2.6.577 · Cited by 7 · see citing works

The metabolic response to the activation of the β- adrenergic receptor by salbutamol is amplified by acylated ghrelin

St-Pierre, D. H., Benso, A. S., Gramaglia, E., Prodam, F., Lucatello, B. G., Gigliardi, V. R., Olivetti, I., Tomelini, M., & Broglio, F. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03346604 · Cited by 6 · see citing works

Biomarkers of growth and carbohydrate metabolism in neonatal rats supplemented with fish oil and/or antioxidants during intermittent hypoxia

Galetaki, D. M., Cai, C. L., Bhatia, K., Chin, V. L., Aranda, J. V., & Beharry, K. D. A. (2022) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2022.101513 · Cited by 5 · see citing works

Effect of Continuous Positive Airway Pressure on Changes of Plasma/Serum Ghrelin and Evaluation of These Changes between Adults with Obstructive Sleep Apnea and Controls: A Meta-Analysis

Golshah, A., Imani, M. M., Sadeghi, M., Chalkhooshg, M. K., Brühl, A. B., Bahmani, L. S., & Brand, S. (2023) · Life · doi:10.3390/life13010149 · Cited by 5 · see citing works

Energy Balance Regulation

Richard, D., & Timofeeva, E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374387-9.00024-6 · Cited by 4 · see citing works

Hormones and Gastrointestinal Function of Newborns

Prodam, F., Bellone, S., Ricotti, R., Monzani, A., Genoni, G., Giglione, E., & Bona, G. (2016) · Springer eBooks · doi:10.1007/978-3-319-18159-2_184-1 · Cited by 3 · see citing works

The Role And Place Of Ghrelin In The Pathology Of Diseases Of The Gastrointestinal Tract

Kudryavtsev, A. A. (2019) · Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini · doi:10.15407/internalmed2019.02.090 · Cited by 3 · see citing works

Are Peripheral Biomarkers Determinants of Eating Styles in Childhood and Adolescence Obesity? A Cross-Sectional Study

Desdentado, L., Navarrete, J., Folgado-Alufre, M., de Blas, A., Navarro‐Siurana, J., Ponce, F., Molinari, G., Jimeno-Martínez, A., Rupérez, A. I., Bueno, G., et al. (2022) · Nutrients · doi:10.3390/nu14020305 · Cited by 3 · see citing works

Central Regulation of Appetite and Satiety Behavior

Lee, E. B., & Ahima, R. S. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_67 · Cited by 3 · see citing works

Obesity: Causes, consequences, and disease risks for service personnel

Mansoor, S., Hameed, A., Anjum, R., Maqbool, I., Masoodi, M., Maqbool, K., Dar, Z. A., Hamadani, A., & Mahmoud, A. E. D. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821556-2.00004-9 · Cited by 3 · see citing works

Adipokines Play Important Role in Cell Proliferation and Anti-proliferation

Maurya, S. K., Bhattacharya, N., Bhattacharya, A., & Senapati, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-1846-8_4 · Cited by 1 · see citing works

Ghrelin Regulation in Epilepsy

Prodam, F., Bellone, S., Ricotti, R., Genoni, G., Caputo, M., & Bo, G. (2011) · InTech eBooks · doi:10.5772/21680 · Cited by 1 · see citing works

Hyperghrelinemia in the patients presenting with Prader-Willi syndrome

Bogova, E. A., Волеводз, Н. Н., Ilyin, А. V., & Peterkova, V. A. (2014) · Problems of Endocrinology · doi:10.14341/probl201460330-37 · Cited by 1 · see citing works

The Stress Response of Critical Illness: Metabolic and Hormonal Aspects, Hormonal Regulation, Particular Clinical Situations “Morbid Obesity”

Coëffier, M., & Tamion, F. (2016) · Springer eBooks · doi:10.1007/978-3-319-27687-8_18 · Cited by 1 · see citing works

Plasma levels of obestatin and ghrelin and obestatin/ghrelin ratio in obese patients

Sfar, M., Jemaa, H. B., Kallel, A., Ben‐Mahrez, K., Feki, M., & Slama, F. B. (2022) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2022.14.1.0320 · Cited by 1 · see citing works

Children Obesity, Glucose Tolerance, Ghrelin, and Prader-Willi Syndrome

Bellone, S., Busti, A., Belcastro, S., Aimaretti, G., Bona, G., & Prodam, F. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374995-6.10018-0 · Cited by 1 · see citing works

Hormones and Gastrointestinal Function

Prodam, F., Bellone, S., Savastio, S., Busti, A., Guidi, C., Monzani, A., & Bona, G. (2012) · Springer eBooks · doi:10.1007/978-88-470-1405-3_43

Serum resistin a biomarker of type II diabetes development

Moshtaghi‐Kashanian, G., Forohar, D., & Sanjari, M. (2010) · Caspian journal of internal medicine

“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”

Gupta, D., Ogden, S. B., Shankar, K., Varshney, S., & Zigman, J. M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101128 · Cited by 53 · see citing works

Novel factors as therapeutic targets to treat diabetes. Focus on leptin and ghrelin

Gómez, R., Lago, F., Gómez-Reino, J. J., & Gualillo, O. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902914834 · Cited by 14 · see citing works

Ghrelin function in human obesity and type 2 diabetes: a concise review

Churm, R., Davies, J. S., Stephens, J. W., & Prior, S. L. (2017) · Obesity Reviews · doi:10.1111/obr.12474 · Cited by 58 · see citing works

Ghrelin and Metabolic Disorders

Ukkola, O. H. (2009) · Current Protein and Peptide Science · doi:10.2174/138920309787315220 · Cited by 57 · see citing works

Ghrelin and Obesity-An Update

Gandhi, M., & Swaminathan, S. (2017) · International Journal of Pharmaceutical and Clinical Research · doi:10.25258/ijpcr.v9i1.8263 · Cited by 3 · see citing works