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Cited by 298

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

Open access
Global BPgen Consortium, den Hoed, Marcel, CARDIoGRAM Consortium, PR GWAS Consortium, QRS GWAS Consortium, QT-IGC Consortium, CHARGE-AF Consortium, Eijgelsheim, Mark, Esko, Tõnu, Brundel, Bianca J J M, Peal, David S, Evans, David M, Nolte, Ilja M, Segrè, Ayellet V, Holm, Hilma, Handsaker, Robert E, Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, Bochud, Murielle, Boucher, Gabrielle, Cornelis, Marilyn C, Gudbjartsson, Daniel, Hadley, David, van der Harst, Pim, Hayward, Caroline, den Heijer, Martin, Igl, Wilmar, Jackson, Anne U, Kutalik, Zoltán, Luan, Jian'an, Kemp, John P, Kristiansson, Kati, Ladenvall, Claes, Lorentzon, Mattias, Montasser, May E, Njajou, Omer T, O'Reilly, Paul F, Padmanabhan, Sandosh, St. Pourcain, Beate, Rankinen, Tuomo, Salo, Perttu, Tanaka, Toshiko, Timpson, Nicholas J, Vitart, Veronique, Waite, Lindsay, Wheeler, William, Zhang, Weihua, Draisma, Harmen H M, Feitosa, Mary F, Kerr, Kathleen F, Lind, Penelope A, Mihailov, Evelin, Onland-Moret, N Charlotte, Song, Ci, Weedon, Michael N, Xie, Weijia, Yengo, Loic, Absher, Devin, Albert, Christine M, Alonso, Alvaro, Arking, Dan E, de Bakker, Paul I W, Balkau, Beverley, Barlassina, Cristina, Benaglio, Paola, Bis, Joshua C, Bouatia-Naji, Nabila, Brage, Søren, Chanock, Stephen J, Chines, Peter S, Chung, Mina, Darbar, Dawood, Dina, Christian, Dörr, Marcus, Elliott, Paul, Felix, Stephan B, Fischer, Krista, Fuchsberger, Christian, de Geus, Eco J C, Goyette, Philippe, Gudnason, Vilmundur, Harris, Tamara B, Hartikainen, Anna-Liisa, Havulinna, Aki S, Heckbert, Susan R, Hicks, Andrew A, Hofman, Albert, Holewijn, Suzanne, Hoogstra-Berends, Femke, Hottenga, Jouke-Jan, Jensen, Majken K, Johansson, Åsa, Junttila, Juhani, Kääb, Stefan, Kanon, Bart, Ketkar, Shamika, Khaw, Kay-Tee, Knowles, Joshua W, Kooner, Angrad S, Kors, Jan A, Kumari, Meena, Milani, Lili, Laiho, Päivi, Lakatta, Edward G, Langenberg, Claudia, Leusink, Maarten, Liu, Yongmei, Luben, Robert N, Lunetta, Kathryn L, Lynch, Stacey N, Markus, Marcello R P, Marques-Vidal, Pedro, Leach, Irene Mateo, McArdle, Wendy L, McCarroll, Steven A, Medland, Sarah E, Miller, Kathryn A, Montgomery, Grant W, Morrison, Alanna C, Müller-Nurasyid, Martina, Navarro, Pau, Nelis, Mari, O'Connell, Jeffrey R, O'Donnell, Christopher J, Ong, Ken K, Newman, Anne B, Peters, Annette, Polasek, Ozren, Pouta, Anneli, Pramstaller, Peter P, Psaty, Bruce M, Rao, Dabeeru C, Ring, Susan M, Rossin, Elizabeth J, Rudan, Diana, Sanna, Serena, Scott, Robert A, Sehmi, Jaban S, Sharp, Stephen, Shin, Jordan T, Singleton, Andrew B, Smith, Albert V, Soranzo, Nicole, Spector, Tim D, Stewart, Chip, Stringham, Heather M, Tarasov, Kirill V, Uitterlinden, André G, Vandenput, Liesbeth, Hwang, Shih-Jen, Whitfield, John B, Wijmenga, Cisca, Wild, Sarah H, Willemsen, Gonneke, Wilson, James F, Witteman, Jacqueline C M, Wong, Andrew, Wong, Quenna, Jamshidi, Yalda, Zitting, Paavo, Boer, Jolanda M A, Boomsma, Dorret I, Borecki, Ingrid B, van Duijn, Cornelia M, Ekelund, Ulf, Forouhi, Nita G, Froguel, Philippe, Hingorani, Aroon, Ingelsson, Erik, Kivimaki, Mika, Kronmal, Richard A, Kuh, Diana, Lind, Lars, Martin, Nicholas G, Oostra, Ben A, Pedersen, Nancy L, Quertermous, Thomas, Rotter, Jerome I, van der Schouw, Yvonne T, Verschuren, W M Monique, Walker, Mark, Albanes, Demetrius, Arnar, David O, Assimes, Themistocles L, Bandinelli, Stefania, Boehnke, Michael, de Boer, Rudolf A, Bouchard, Claude, Caulfield, W L Mark, Chambers, John C, Curhan, Gary, Cusi, Daniele, Eriksson, Johan, Ferrucci, Luigi, van Gilst, Wiek H, Glorioso, Nicola, de Graaf, Jacqueline, Groop, Leif, Gyllensten, Ulf, Hsueh, Wen-Chi, Hu, Frank B, Huikuri, Heikki V, Hunter, David J, Iribarren, Carlos, Isomaa, Bo, Jarvelin, Marjo-Riitta, Jula, Antti, Kähönen, Mika, Kiemeney, Lambertus A, van der Klauw, Melanie M, Kooner, Jaspal S, Kraft, Peter, Iacoviello, Licia, Lehtimäki, Terho, Lokki, Marja-Liisa L, Mitchell, Braxton D, Navis, Gerjan, Nieminen, Markku S, Ohlsson, Claes, Poulter, Neil R, Qi, Lu, Raitakari, Olli T, Rimm, Eric B, Rioux, John D, Rizzi, Federica, Rudan, Igor, Salomaa, Veikko, Sever, Peter S, Shields, Denis C, Shuldiner, Alan R, Sinisalo, Juha, Stanton, Alice V, Stolk, Ronald P, Strachan, David P, Tardif, Jean-Claude, Thorsteinsdottir, Unnur, Tuomilehto, Jaako, van Veldhuisen, Dirk J, Virtamo, Jarmo, Viikari, Jorma, Vollenweider, Peter, Waeber, Gérard, Widen, Elisabeth, Cho, Yoon Shin, Olsen, Jesper V, Visscher, Peter M, Willer, Cristen, Franke, Lude, Erdmann, Jeanette, Thompson, John R, Pfeufer, Arne, Sotoodehnia, Nona, Newton-Cheh, Christopher, Ellinor, Patrick T, Stricker, Bruno H Ch, Metspalu, Andres, Perola, Markus, Beckmann, Jacques S, Smith, George Davey, Stefansson, Kari, Wareham, Nicholas J, Munroe, Patricia B, Sibon, Ody C M, Milan, David J, Snieder, Harold, Samani, Nilesh J, Loos, Ruth J F·2013·Nature Genetics
DOI 10.1038/ng.2610
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Abstract

Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and confirmed associations with all 7 previously established loci. Experimental downregulation of gene expression in Drosophila melanogaster and Danio rerio identified 20 genes at 11 loci that are relevant for heart rate regulation and highlight a role for genes involved in signal transmission, embryonic cardiac development and the pathophysiology of dilated cardiomyopathy, congenital heart failure and/or sudden cardiac death. In addition, genetic susceptibility to increased heart rate is associated with altered cardiac conduction and reduced risk of sick sinus syndrome, and both heart rate–increasing and heart rate–decreasing variants associate with risk of atrial fibrillation. Our findings provide fresh insights into the mechanisms regulating heart rate and identify new therapeutic targets.

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Research works printed but not linked: 38

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Cited by

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Metadata

Authors
Global BPgen Consortium, den Hoed, M., CARDIoGRAM Consortium, PR GWAS Consortium, QRS GWAS Consortium, QT-IGC Consortium, CHARGE-AF Consortium, Eijgelsheim, M., Esko, T., Brundel, B. J. J. M., Peal, D. S., Evans, D. M., Nolte, I. M., Segrè, A. V., Holm, H., Handsaker, R. E., Westra, H.-J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J. H., Kim, Y. J., Go, M. J., Almgren, P., Bochud, M., Boucher, G., Cornelis, M. C., Gudbjartsson, D., Hadley, D., van der Harst, P., Hayward, C., den Heijer, M., Igl, W., Jackson, A. U., Kutalik, Z., Luan, J., Kemp, J. P., Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M. E., Njajou, O. T., O'Reilly, P. F., Padmanabhan, S., St. Pourcain, B., Rankinen, T., Salo, P., Tanaka, T., Timpson, N. J., Vitart, V., Waite, L., Wheeler, W., Zhang, W., Draisma, H. H. M., Feitosa, M. F., Kerr, K. F., Lind, P. A., Mihailov, E., Onland-Moret, N. C., Song, C., Weedon, M. N., Xie, W., Yengo, L., Absher, D., Albert, C. M., Alonso, A., Arking, D. E., de Bakker, P. I. W., Balkau, B., Barlassina, C., Benaglio, P., Bis, J. C., Bouatia-Naji, N., Brage, S., Chanock, S. J., Chines, P. S., Chung, M., Darbar, D., Dina, C., Dörr, M., Elliott, P., Felix, S. B., Fischer, K., Fuchsberger, C., de Geus, E. J. C., Goyette, P., Gudnason, V., Harris, T. B., Hartikainen, A.-L., Havulinna, A. S., Heckbert, S. R., Hicks, A. A., Hofman, A., Holewijn, S., Hoogstra-Berends, F., Hottenga, J.-J., Jensen, M. K., Johansson, Å., Junttila, J., Kääb, S., Kanon, B., Ketkar, S., Khaw, K.-T., Knowles, J. W., Kooner, A. S., Kors, J. A., Kumari, M., Milani, L., Laiho, P., Lakatta, E. G., Langenberg, C., Leusink, M., Liu, Y., Luben, R. N., Lunetta, K. L., Lynch, S. N., Markus, M. R. P., Marques-Vidal, P., Leach, I. M., McArdle, W. L., McCarroll, S. A., Medland, S. E., Miller, K. A., Montgomery, G. W., Morrison, A. C., Müller-Nurasyid, M., Navarro, P., Nelis, M., O'Connell, J. R., O'Donnell, C. J., Ong, K. K., Newman, A. B., Peters, A., Polasek, O., Pouta, A., Pramstaller, P. P., Psaty, B. M., Rao, D. C., Ring, S. M., Rossin, E. J., Rudan, D., Sanna, S., Scott, R. A., Sehmi, J. S., Sharp, S., Shin, J. T., Singleton, A. B., Smith, A. V., Soranzo, N., Spector, T. D., Stewart, C., Stringham, H. M., Tarasov, K. V., Uitterlinden, A. G., Vandenput, L., Hwang, S.-J., Whitfield, J. B., Wijmenga, C., Wild, S. H., Willemsen, G., Wilson, J. F., Witteman, J. C. M., Wong, A., Wong, Q., Jamshidi, Y., Zitting, P., Boer, J. M. A., Boomsma, D. I., Borecki, I. B., van Duijn, C. M., Ekelund, U., Forouhi, N. G., Froguel, P., Hingorani, A., Ingelsson, E., Kivimaki, M., Kronmal, R. A., Kuh, D., Lind, L., Martin, N. G., Oostra, B. A., Pedersen, N. L., Quertermous, T., Rotter, J. I., van der Schouw, Y. T., Verschuren, W. M. M., Walker, M., Albanes, D., Arnar, D. O., Assimes, T. L., Bandinelli, S., Boehnke, M., de Boer, R. A., Bouchard, C., Caulfield, W. L. M., Chambers, J. C., Curhan, G., Cusi, D., Eriksson, J., Ferrucci, L., van Gilst, W. H., Glorioso, N., de Graaf, J., Groop, L., Gyllensten, U., Hsueh, W.-C., Hu, F. B., Huikuri, H. V., Hunter, D. J., Iribarren, C., Isomaa, B., Jarvelin, M.-R., Jula, A., Kähönen, M., Kiemeney, L. A., van der Klauw, M. M., Kooner, J. S., Kraft, P., Iacoviello, L., Lehtimäki, T., Lokki, M.-L. L., Mitchell, B. D., Navis, G., Nieminen, M. S., Ohlsson, C., Poulter, N. R., Qi, L., Raitakari, O. T., Rimm, E. B., Rioux, J. D., Rizzi, F., Rudan, I., Salomaa, V., Sever, P. S., Shields, D. C., Shuldiner, A. R., Sinisalo, J., Stanton, A. V., Stolk, R. P., Strachan, D. P., Tardif, J.-C., Thorsteinsdottir, U., Tuomilehto, J., van Veldhuisen, D. J., Virtamo, J., Viikari, J., Vollenweider, P., Waeber, G., Widen, E., Cho, Y. S., Olsen, J. V., Visscher, P. M., Willer, C., Franke, L., Erdmann, J., Thompson, J. R., Pfeufer, A., Sotoodehnia, N., Newton-Cheh, C., Ellinor, P. T., Stricker, B. H. C., Metspalu, A., Perola, M., Beckmann, J. S., Smith, G. D., Stefansson, K., Wareham, N. J., Munroe, P. B., Sibon, O. C. M., Milan, D. J., Snieder, H., Samani, N. J., & Loos, R. J. F.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2013-04-14
Volume
45
Issue
6
Pages
621-631
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.2610
OpenAlex
W1992911777
Cited by
298
References
15
FWCI
17.58
Type
journal article
Language
en
Open access
bronze
Licence
www.springer.com/tdm (tdm)

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