LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, Brendan K, Loh, Po-Ru, Finucane, Hilary K, Ripke, Stephan, Yang, Jian, Patterson, Nick, Daly, Mark J +2 more·2015·Nature Genetics

DOI 10.1038/ng.3211

Cited by (1,062)

Items 801–900 of 1,062

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Hakhamanesh Mostafavi, Jeffrey P. Spence, Sahin Naqvi, Jonathan K. Pritchard · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
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Ward, Joey, Lyall, Laura M., Bethlehem, Richard A. I., Ferguson, Amy, Strawbridge, Rona J., Lyall, Donald M., Cullen, Breda, Graham, Nicholas, Johnston, Keira J. A., Bailey, Mark E. S. et al. · 2019 · Translational Psychiatry
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McArthur, Evonne, Rinker, David C., Capra, John A. · 2021 · Nature Communications
Age-Dependent Pleiotropy Between General Cognitive Function and Major Psychiatric Disorders
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Loïc Yengo, Zhihong Zhu, Naomi R. Wray, Bruce S Weir, Jian Yang, Matthew R. Robinson, Peter M. Visscher · 2017 · Proceedings of the National Academy of Sciences
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Shouneng Peng, Maya A. Deyssenroth, Antonio Fabio Di Narzo, Haoxiang M. Cheng, Zhongyang Zhang, Luca Lambertini, Arno Ruusalepp, Jason Ciril Kovacic, Johan Björkegren, Carmen J. Marsit et al. · 2018 · PLoS Genetics
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Margaux L.A. Hujoel, Steven Gazal, Farhad Hormozdiari, Bryce van de Geijn, Alkes L. Price · 2019 · The American Journal of Human Genetics
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Mark J. Adams, William David Hill, David M. Howard, Hassan S. Dashti, Katrina A. S. Davis, Archie Campbell, Toni‐Kim Clarke, Ian J. Deary, Caroline Hayward, David John Porteous et al. · 2019 · International Journal of Epidemiology
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Jie Zheng, Marie‐Jo Brion, John P. Kemp, Nicole M. Warrington, Maria Carolina Borges, Gibran Hemani, Tom G. Richardson, Humaira Rasheed, Zhen Qiao, Philip Haycock et al. · 2020 · Journal of Bone and Mineral Research
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Polygenicity and Epistasis Underlie Fitness-Proximal Traits in the Caenorhabditis elegans Multiparental Experimental Evolution (CeMEE) Panel
Luke M. Noble, Ivo M. Chelo, Thiago Guzella, Bruno Afonso, David Riccardi, Patrick Ammerman, Adel Dayarian, Sara Carvalho, Anna B. Crist, Ania Pino-Querido et al. · 2017 · Genetics
Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis-regulatory elements
Anderson, Ashlyn G., Rogers, Brianne B., Loupe, Jacob M., Rodriguez-Nunez, Ivan, Roberts, Sydney C., White, Lauren M., Brazell, J. Nicholas, Bunney, William E., Bunney, Blynn G., Watson, Stanley J. et al. · 2023 · Cell Genomics
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Weihua Meng, Mark J. Adams, Harry L. Hébert, Ian J. Deary, Andrew Mark McIntosh, Blair H. Smith · 2018 · EBioMedicine
Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
Jodie N. Painter, Tracy A. O’Mara, Andrew P. Morris, Timothy H. T. Cheng, Maggie Gorman, Lynn M. Martin, Shirley Hodson, Angela Jones, Nicholas G. Martin, Scott D. Gordon et al. · 2018 · Cancer Medicine
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Alexandra S. Shadrina, Sodbo Sharapov, Tatiana Shashkova, Yakov A. Tsepilov · 2019 · PLoS Genetics
Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty
Gurmannat Kalra, Beatrice C. Milon, Alex M. Casella, Brian R. Herb, Elizabeth Humphries, Yang Song, Kevin P. Rose, Ronna P. Hertzano, Seth A. Ament · 2020 · PLoS Genetics
Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases
Adrien B. Georges, Min‐Lee Yang, Takiy-Eddine Berrandou, Mark K. Bakker, Ozan Dikilitas, Soto Romuald Kiando, Lijiang Ma, Benjamin A. Satterfield, Sebanti Sengupta, Mengyao Yu et al. · 2021 · Nature Communications
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Margaret A. Taub, Matthew P. Conomos, Rebecca Keener, Kruthika Raman Iyer, Joshua S. Weinstock, Lisa R. Yanek, John Lane, Tyne W. Miller‐Fleming, Jennifer A. Brody, Laura M. Raffield et al. · 2022 · Cell Genomics
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Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling
Katerina Zorina-Lichtenwalter, Carmen I. Bango, Lukas Van Oudenhove, Marta Čeko, Martin A. Lindquist, Andrew David Grotzinger, Matthew C. Keller, Naomi P. Friedman, Tor Dessart Wager · 2023 · Pain
Analysis across Taiwan Biobank, Biobank Japan, and UK Biobank identifies hundreds of novel loci for 36 quantitative traits
Chia‐Yen Chen, Tzu‐Ting Chen, Yen‐Chen Anne Feng, Mingrui Yu, Shu‐Chin Lin, Ryan J. Longchamps, Shi‐Heng Wang, Yi‐Hsiang Hsu, Hwai‐I Yang, Po‐Hsiu Kuo et al. · 2023 · Cell Genomics
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder
Nora I. Strom, Zachary F. Gerring, Marco Galimberti, Dongmei Yu, Matthew Halvorsen, Abdel Abdellaoui, Cristina Rodriguez‐Fontenla, Julia Sealock, Tim B. Bigdeli, Jonathan R. I. Coleman et al. · 2025 · Nature Genetics
Analysis of Shared Heritability in Common Disorders of the Brain
2016
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences 1
Richard Karlsson Linnér, Pietro Biroli, Edward L. Kong, S. Fleur W. Meddens, Robbee Wedow, Mark Alan Fontana, Maël P. Lebreton, Abdel Abdellaoui, Anke R. Hammerschlag, Michel Guillaume Nivard et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
The distribution of common-variant effect sizes
O’Connor, Luke J. · 2021 · Nature Genetics
Comparative genetic architectures of schizophrenia in East Asian and European populations
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Chia-Yen Chen, Zhiqiang Li, Alicia R. Martin, Julien Bryois, Xixian Ma, Héléna A. Gaspar, Masashi Ikeda, Beben Benyamin, Brielin C. Brown et al. · 2019 · Lancaster EPrints (Lancaster University)
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context
Apolline Gallois, Joel Mefford, Arthur Ko, Amaury Vaysse, Hanna Julienne, Mika Ala‐Korpela, Markku Laakso, Noah Zaitlen, Päivi Pajukanta, Hugues Aschard · 2019 · Nature Communications
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Masaru Koido, Eri Kawakami, Junko Fukumura, Yui Noguchi, Momoko Ohori, Yasunori Nio, Paola Nicoletti, Guruprasad Padur Aithal, Ann K. Daly, Paul Brent Watkins et al. · 2020 · Nature Medicine
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Natalie R. van Zuydam, Alexander I. Stiby, Moustafa Abdalla, Erin E. Austin, Emma H. Dahlström, Stela McLachlan, Efthymia Vlachopoulou, Emma Ahlqvist, Chen Di Liao, Niina Sandholm et al. · 2021 · Circulation Genomic and Precision Medicine
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Alice Williamson, Dougall M. Norris, Xianyong Yin, K. Alaine Broadaway, Anne H. Moxley, Swarooparani Vadlamudi, Emma P Wilson, Anne Jackson, Vasudha Ahuja, Mette Korre Andersen et al. · 2023 · Nature Genetics
Multi-PGS enhances polygenic prediction by combining 937 polygenic scores
Clara Albiñana, Zhihong Zhu, Andrew Joseph Schork, Andrés Ingason, Hugues Aschard, Isabell Brikell, Cynthia Marie Bulik, Liselotte Vogdrup Petersen, Esben Agerbo, Jakob Grove et al. · 2023 · Nature Communications
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Daniel B. Rosoff, Lucas A. Mavromatis, Andrew S. Bell, Josephin Wagner, Jeesun Jung, Riccardo Emilio Marioni, George Davey Smith, Steve Horvath, Falk W. Lohoff · 2023 · Nature Aging
Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes
Varun Warrier, Eva-Maria Stauffer, Qin Qin Huang, Emilie M. Wigdor, Eric A. W. Slob, Jakob Seidlitz, Lisa Ronan, Sofie Louise Valk, Travis T. Mallard, Andrew David Grotzinger et al. · 2023 · Nature Genetics
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Konstantinos Hatzikotoulas, Andreas Roposch, Andrew M. Wainwright, Tim N. Theologis, Nicholas M.P. Clarke, Jonathan S. M. Dwyer, Aresh Hashemi-Nejad, Nigel Kiely, Marcos Katchburian, Nicholas Nicolaou et al. · 2018 · Communications Biology
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Alexander I. Young, Fabian L. Wauthier, Peter Donnelly · 2018 · Nature Genetics
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David M. Brazel, Yu Jiang, Jordan M. Hughey, Valérie Turcot, Xiaowei Zhan, Jian Gong, Chiara Batini, J. Dylan Weissenkampen, Mengzhen Liu, Daniel R. Barnes et al. · 2018 · Biological Psychiatry
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Oliver Pain, Andrew J. Pocklington, Peter Holmans, Nicholas J. Bray, Heath O’Brien, Lynsey S. Hall, Antonio F. Pardiñas, Michael C. O’Donovan, Michael John Owen, Richard Anney · 2019 · Biological Psychiatry
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Natalia Trpchevska, Maxim B. Freidin, Linda Broer, Berthe C. Oosterloo, Shuyang Yao, Yitian Zhou, Barbara Vona, Charles E. Bishop, Argyro J. Bizaki-Vallaskangas, Barbara Canlon et al. · 2022 · The American Journal of Human Genetics
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Rachel Shujuan Chong, Hengtong Li, Alex Jia Yang Cheong, Qiao Fan, Victor Koh, Raghavan Lavanya, Monisha Esther Nongpiur, Ching‐Yu Cheng · 2022 · Ophthalmology
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Patrícia Pelufo Silveira, Irina Pokhvisneva, David M. Howard, Michael Joseph Meaney · 2023 · Molecular Psychiatry
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Eleanor Davyson, Xueyi Shen, Danni A. Gadd, Elena Bernabeu, Robert Francis Hillary, Daniel L. McCartney, Mark J. Adams, Riccardo Emilio Marioni, Andrew Mark McIntosh · 2023 · Biological Psychiatry
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Lei Sun, Zhong Wang, Tianyuan Lu, Teri A. Manolio, Andrew D. Paterson · 2023 · The American Journal of Human Genetics
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Linda Kachuri, Thomas J. Hoffmann, Yu Jiang, Sonja I. Berndt, John P. Shelley, Kerry Roe Schaffer, Mitchell J. Machiela, Neal D. Freedman, Wen‐Yi Huang, Shengchao A. Li et al. · 2023 · Nature Medicine
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Priya Gupta, Marco Galimberti, Yue Liu, Sarah Beck, Aliza P. Wingo, Thomas S. Wingo, Keyrun Adhikari, Henry R. Kranzler, VA Million Veteran Program, Murray B. Stein et al. · 2024 · Nature Human Behaviour
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Sterenborg, Rosalie B. T. M., Steinbrenner, Inga, Li, Yong, Bujnis, Melissa N., Naito, Tatsuhiko, Marouli, Eirini, Galesloot, Tessel E., Babajide, Oladapo, Andreasen, Laura, Astrup, Arne et al. · 2024 · Nature Communications
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R. M. Maier, Peter M. Visscher, Matthew R. Robinson, Naomi R. Wray · 2017 · Psychological Medicine
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Gloria Hoi‐Yee Li, Ching‐Lung Cheung, Philip Chun-Ming Au, K. C. B. Tan, Ian Chi Kei Wong, Pak Chung Sham · 2019 · International Journal of Epidemiology
Redefining tissue specificity of genetic regulation of gene expression in the presence of allelic heterogeneity
Marios Arvanitis, Karl Tayeb, Benjamin J. Strober, Alexis J. Battle · 2022 · The American Journal of Human Genetics
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups
Manuel Mattheisen, Jakob Grove, Thomas D. Als, Joanna Martin, Georgios Voloudakis, Sandra Melanie Meier, Ditte Demontis, Jaroslav M. Bendl, Raymond Kenney Walters, Caitlin E. Carey et al. · 2022 · Nature Genetics
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Zi-Kun Yang, Chen Wang, Lin-Xi Liu, Atlas Khan, Annie J Lee, B. Vardarajan, R. Mayeux, Krzysztof Kiryluk, I. Ionita-Laza · 2023 · Nature Genetics
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Haonan Zeng, Wenjing Zhang, Qing Lin, Yahui Gao, Jinyan Teng, Zhiting Xu, Xiaodian Cai, Zhanming Zhong, Jun Wu, Yuqiang Liu et al. · 2023 · Nucleic Acids Research
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Carl Veller, Graham Coop · 2024 · PLoS Biology
Bayesian association scan reveals loci associated with human lifespan and linked biomarkers
Aaron F. McDaid, Peter K. Joshi, Eleonora Porcu, Andrea Komljenović, Hao Li, Vincenzo Sorrentino, Maria Litovchenko, Roel P. J. Bevers, Sina Rüeger, Alexandre Reymond et al. · 2017 · Nature Communications
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Roseann Elizabeth Peterson, Na Cai, Andy W. Dahl, Tim B. Bigdeli, Alexis C. Edwards, Bradley Todd Webb, Silviu‐Alin Bacanu, Noah Zaitlen, Jonathan Flint C, Kenneth S. Kendler · 2018 · American Journal of Psychiatry
A Robust Method Uncovers Significant Context-Specific Heritability in Diverse Complex Traits
Andy W. Dahl, Khiem Nguyen, Na Cai, Michael J. Gandal, Jonathan Flint C, Noah Zaitlen · 2020 · The American Journal of Human Genetics
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Marios Arvanitis, Emmanouil Tampakakis, Yanxiao Zhang, Wei Wang, Adam Auton, Michelle Agee, Stella W. Aslibekyan, Robert K. Bell, Katarzyna Bryc, Sarah Clark et al. · 2020 · Nature Communications
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Ammar J. Alsheikh, Sabrina Wollenhaupt, Emily A. King, Jonas Reeb, Sujana Ghosh, Lindsay R. Stolzenburg, Saleh Tamim, Jozef Lazar, J. Wade Davis, Howard J. Jacob · 2022 · BMC Medical Genomics
Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder
Veera Manikandan Rajagopal, Jinjie Duan, Laura Vilar‐Ribó, Jakob Grove, Tetyana Zayats, Josep Antoni Ramos‐Quiroga, F. Kyle Satterstrom, María Soler Artigas, Jonas Bybjerg‐Grauholm, Marie Bækvad‐Hansen et al. · 2022 · Nature Genetics
The hepato-ovarian axis: genetic evidence for a causal association between non-alcoholic fatty liver disease and polycystic ovary syndrome
Dong Liu, Xue Gao, Xiong‐Fei Pan, Tao Zhou, Cairong Zhu, Fei Li, Jian‐Gao Fan, Giovanni Targher, Jian Zhao · 2023 · BMC Medicine
The genetic architecture and evolution of the human skeletal form
Eucharist Kun, Emily M. Javan, Olivia S. Smith, Faris F. Gulamali, Javier de la Fuente, Brianna I. Flynn, Kushal Vajrala, Zoe D. Trutner, Prakash Jayakumar, Elliot M. Tucker–Drob et al. · 2023 · Science
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Rósa B. Þórólfsdóttir, Garðar Sveinbjörnsson, Patrick Sulem, Jonas Bille Nielsen, Stefan Jonsson, Gisli Hreinn Halldorsson, Páll Melsted, Erna V. Ivarsdottir, Olafur B. Davidsson, Ragnar P. Kristjansson et al. · 2018 · Communications Biology
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Xikun Han, Kaiah Steven, Ayub Qassim, Henry N. Marshall, Cameron Bean, Michael Tremeer, Jiyuan An, Owen M. Siggs, Puya Gharahkhani, Jamie E. Craig et al. · 2021 · The American Journal of Human Genetics
Exploring the Relationship Between Schizophrenia and Cardiovascular Disease: A Genetic Correlation and Multivariable Mendelian Randomization Study
Rada R Veeneman, Jentien M. Vermeulen, Abdel Abdellaoui, Eleanor C. M. Sanderson, Robyn E. Wootton, Rafik Tadros, Connie R. Bezzina, Damiaan A J P Denys, Marcus Robert Munafo, Karin J. H. Verweij et al. · 2021 · Schizophrenia Bulletin
Research Review: How to interpret associations between polygenic scores, environmental risks, and phenotypes
Jean‐Baptiste Pingault, Andrea G. Allegrini, Tracy Odigie, Leonard Frach, Jessie R. Baldwin, Frühling Vesta Rijsdijk, Frank Dudbridge · 2022 · Journal of Child Psychology and Psychiatry
Genome-wide study on 72,298 individuals in Korean biobank data for 76 traits
Nam, Kisung, Kim, Jangho, Lee, Seunggeun · 2022 · Cell Genomics
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Chachrit Khunsriraksakul, Qinmengge Li, Havell Markus, Matthew T. Patrick, Renan Sauteraud, Daniel McGuire, Xingyan Wang, Chen Wang, Lida Wang, Siyuan Chen et al. · 2023 · Nature Communications
The Critical Needs and Challenges for Genetic Architecture Studies in Africa
Martin, Alicia R, Teferra, Solomon, Möller, Marlo, Hoal, Eileen G, Daly, Mark J · 2018 · Current Opinion in Genetics & Development
CHIMGEN: a Chinese imaging genetics cohort to enhance cross-ethnic and cross-geographic brain research
Qiang Xu, Lining Guo, Jingliang Cheng, Meiyun Wang, Zuojun Geng, Wenzhen Zhu, Bing Zhang, Weihua Liao, Shijun Qiu, Hui Zhang et al. · 2019 · Molecular Psychiatry
Shared genetic risk between eating disorder‐ and substance‐use‐related phenotypes: Evidence from genome‐wide association studies
Melissa A. Munn‐Chernoff, Emma C. Johnson, Yi‐Ling Chou, Jonathan R. I. Coleman, Laura M. Thornton, Raymond Kenney Walters, Zeynep Yılmaz, Jessica H. Baker, Christopher Hübel, Scott D. Gordon et al. · 2020 · Addiction Biology
Dissecting clinical heterogeneity of bipolar disorder using multiple polygenic risk scores
Brandon J. Coombes, Matej Markota, J. John Mann, Colin L. Colby, Eli A. Stahl, Ardesheer Talati, Jyotishman Pathak, Myrna M. Weissman, Susan L. McElroy, Mark A. Frye et al. · 2020 · Translational Psychiatry
Leveraging phenotypic variability to identify genetic interactions in human phenotypes
Andrew R. Marderstein, Emily Davenport, Scott Kulm, Cristopher V. Van Hout, Olivier Elemento, Andrew G. Clark · 2020 · The American Journal of Human Genetics
Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies
Ning Shang, Atlas Khan, Fernanda C. G. Polubriaginof, Francesca Zanoni, Karla Mehl, David A. Fasel, Paul E. Drawz, Robert J. Caroll, Joshua C. Denny, Matthew A. Hathcock et al. · 2021 · npj Digital Medicine
A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank
Guiying Dong, Jianfeng Feng, Fengzhu Sun, Jingqi Chen, Xing‐Ming Zhao · 2021 · Genome Medicine
Causal effect of COVID‐19 on Alzheimer's disease: A Mendelian randomization study
Ancha V. Baranova, Hongbao Cao, Fuquan Zhang · 2022 · Journal of Medical Virology
Genetic architecture of heart failure with preserved versus reduced ejection fraction
Jacob Joseph, Chang Liu, Qin Hui, Krishna G. Aragam, Zeyuan Wang, BRIAN R. CHAREST, Jennifer E. Huffman, Jacob M. Keaton, Todd L. Edwards, Serkalem Demissie et al. · 2022 · Nature Communications
CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
Sandra Sanchez‐Roige, Mariela V. Jennings, Hayley H. A. Thorpe, Jazlene E. Mallari, Lieke C van der Werf, Sevim B. Bianchi, Yuye Huang, Calvin Lee, Travis T. Mallard, Samuel A. Barnes et al. · 2023 · Translational Psychiatry
Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression
Jerry Guintivano, Enda M. Byrne, Jacqueline Kiewa, Shuyang Yao, Anna E. Bauer, Karolina A. Åberg, Mark J. Adams, Archie I Campbell, Megan L. Campbell, Karmel W. Choi et al. · 2023 · American Journal of Psychiatry
Genetically low vitamin D concentrations and myopic refractive error: a Mendelian randomization study
Gabriel Cuéllar-Partida, Katie M Williams, Seyhan Yazar, Jeremy A. Guggenheim, Alex William Hewitt, Cathy Williams, Jie Jin Wang, Pik Fang Kho, Seang‐Mei Saw, Ching‐Yu Cheng et al. · 2017 · International Journal of Epidemiology
Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases
Jiyuan An, Puya Gharahkhani, Matthew H. Law, Jue‐Sheng Ong, Xikun Han, Catherine M. Olsen, Rachel Ε. Neale, John Lai, Tom L. Vaughan, Ines Gockel et al. · 2019 · Nature Communications
Estimating cross‐population genetic correlations of causal effect sizes
Galinsky, Kevin J., Reshef, Yakir A., Finucane, Hilary K., Loh, Po‐Ru, Zaitlen, Noah, Patterson, Nick J., Brown, Brielin C., Price, Alkes L. · 2019 · Genetic Epidemiology
Testing structural models of psychopathology at the genomic level
Irwin D. Waldman, Holly E. Poore, Justin M. Luningham, Jingjing Yang · 2020 · World Psychiatry
Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities
Benedetta Izzi, Alfonsina Tirozzi, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Marc Hoylaerts, Licia Iacoviello, Alessandro Gialluisi · 2020 · International Journal of Molecular Sciences
PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics
Cue Hyunkyu Lee, Huwenbo Shi, Bogdan Paşaniuc, Eleazar Eskin, Buhm Han · 2020 · The American Journal of Human Genetics
Association between uric acid and risk of venous thromboembolism in East Asian populations: a cohort and Mendelian randomization study
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