LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, Brendan K, Loh, Po-Ru, Finucane, Hilary K, Ripke, Stephan, Yang, Jian, Patterson, Nick, Daly, Mark J +2 more·2015·Nature Genetics
DOI 10.1038/ng.3211
Cited by (1,062)
Items 201–300 of 1,062
- Characterizing mutagenic effects of recombination through a sequence-level genetic mapBjarni V. Halldórsson, Gunnar Pálsson, Ólafur Andri Stefánsson, Hákon Jónsson, Marteinn Thor Hardarson, Hannes P. Eggertsson, Bjarni Gunnarsson, Ásmundur Oddsson, Gisli Hreinn Halldorsson, Florian Zink et al. · 2019 · Science
- Identification of 55,000 Replicated DNA Methylation QTLAllan F. McRae, Riccardo Emilio Marioni, Sonia H Shah, Jian Yang, Joseph E. Powell, Sarah E. Harris, Jude Gibson, Anjali K. Henders, Lisa M. Bowdler, Jodie N. Painter et al. · 2018 · Scientific Reports
- Functionally informed fine-mapping and polygenic localization of complex trait heritabilityWeissbrod, Omer, Hormozdiari, Farhad, Benner, Christian, Cui, Ran, Ulirsch, Jacob, Gazal, Steven, Schoech, Armin P., van de Geijn, Bryce, Reshef, Yakir, Márquez-Luna, Carla et al. · 2020 · Nature Genetics
- Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK BiobankZhaozhong Zhu, Yanjun Guo, Huwenbo Shi, Cong-Lin Liu, Ronald Allan M. Panganiban, Wonil Chung, Luke Jen O’Connor, Blanca E. Himes, Steven Gazal, Kohei Hasegawa et al. · 2019 · Journal of Allergy and Clinical Immunology
- Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traitsHang Zhou, Julia Sealock, Sandra Sanchez‐Roige, Toni‐Kim Clarke, Daniel F. Levey, Zhongshan Cheng, Boyang Li, Renato A Polimanti, Rachel L. Kember, Rachel Vickers‐Smith et al. · 2020 · Nature Neuroscience
- Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel diseaseThe UK-PSC Consortium, Ji, Sun-Gou, The International IBD Genetics Consortium, The International PSC Study Group, Juran, Brian D, Mucha, Sören, Folseraas, Trine, Jostins, Luke, Melum, Espen, Kumasaka, Natsuhiko et al. · 2017 · Nature Genetics
- Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive errorMilly S. Tedja, Robert Wojciechowski, Pirro G. Hysi, Nicholas Eriksson, Nicholas A. Furlotte, Virginie J. M. Verhoeven, Adriana I. Iglesias, Magda A. Meester‐Smoor, Stuart W. J. Tompson, Qiao Fan et al. · 2018 · Nature Genetics
- Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex TraitsHuwenbo Shi, Nicholas Mancuso, Sarah J. Spendlove, Bogdan Paşaniuc · 2017 · The American Journal of Human Genetics
- RICOPILI: Rapid Imputation for COnsortias PIpeLIneLam, Max, Awasthi, Swapnil, Watson, Hunna J, Goldstein, Jackie, Panagiotaropoulou, Georgia, Trubetskoy, Vassily, Karlsson, Robert, Frei, Oleksander, Fan, Chun-Chieh, De Witte, Ward et al. · 2020 · Bioinformatics
- Common variants in Alzheimer’s disease and risk stratification by polygenic risk scoresde Rojas, Itziar, Moreno-Grau, Sonia, Tesi, Niccolo, Grenier-Boley, Benjamin, Andrade, Victor, Jansen, Iris E., Pedersen, Nancy L., Stringa, Najada, Zettergren, Anna, Hernández, Isabel et al. · 2021 · Nature Communications
- Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortiaMETASTROKE Consortium, International Consortium for Blood Pressure GWAS, Hagenaars, S P, SpiroMeta Consortium, CHARGE Consortium Pulmonary Group, CHARGE Consortium Aging and Longevity Group, Harris, S E, Davies, G, Hill, W D, Liewald, D C M, Ritchie, S J, Marioni, R E et al. · 2016 · Molecular Psychiatry
- Reduced signal for polygenic adaptation of height in UK BiobankBerg, Jeremy J, Harpak, Arbel, Sinnott-Armstrong, Nasa, Joergensen, Anja Moltke, Mostafavi, Hakhamanesh, Field, Yair, Boyle, Evan August, Zhang, Xinjun, Racimo, Fernando, Pritchard, Jonathan K et al. · 2019 · eLife
- Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traitsJacqueline M. Lane, Jingjing Liang, Irma Vlasac, Simon George Anderson, David A. Bechtold, Jack Bowden, Richard Emsley, Shubhroz Gill, Max A. Little, Annemarie Ida Luik et al. · 2016 · Nature Genetics
- Common genetic associations between age-related diseasesHandan Melike Dönertaş, Daniel K. Fabian, Matías Fuentealba, Linda Partridge, Janet M. Thornton · 2021 · Nature Aging
- Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific EffectsCarolina Medina‐Gómez, John P. Kemp, Katerina Trajanoska, Jian’an Luan, Alessandra Chesi, Tarunveer S. Ahluwalia, Dennis Owen Mook-Kanamori, Annelies C. Ham, Fernando Pires Hartwig, Daniel S. Evans et al. · 2018 · The American Journal of Human Genetics
- Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucomaAnthony P. Khawaja, Jessica N. Cooke Bailey, Nicholas J. Wareham, Robert A. Scott, Mark J. Simcoe, Robert P. Igo, Yeunjoo E. Song, Robert Wojciechowski, Ching‐Yu Cheng, Peng Tee Khaw et al. · 2018 · Nature Genetics
- Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction.Karlsson Linnér, Richard, Mallard, Travis T., Barr, Peter B., Sanchez-Roige, Sandra, Madole, James W., Driver, Morgan N., Poore, Holly E., de Vlaming, Ronald, Grotzinger, Andrew D., Tielbeek, Jorim J. et al. · 2021 · Nature Neuroscience
- Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolismSapkota, Yadav, Steinthorsdottir, Valgerdur, Morris, Andrew P., Fassbender, Amelie, Rahmioglu, Nilufer, De Vivo, Immaculata, Buring, Julie E., Zhang, Futao, Edwards, Todd L., Jones, Sarah et al. · 2017 · Nature Communications
- Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studiesMilton Pividori, Nathan Schoettler, Dan L. Nicolae, Carole Ober, Hae Kyung Im · 2019 · The Lancet Respiratory Medicine
- A large-scale genome-wide association study meta-analysis of cannabis use disorderEmma C. Johnson, Ditte Demontis, Thorgeir Elís Thorgeirsson, Raymond Kenney Walters, Renato A Polimanti, Alexander S. Hatoum, Sandra Sanchez‐Roige, Sarah E. Paul, Frank R. Wendt, Toni-Kim Clarke et al. · 2020 · The Lancet Psychiatry
- Genome-wide association analysis identifies three new susceptibility loci for childhood body mass indexFelix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J.P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Møller, Eskil et al. · 2016 · Human Molecular Genetics
- Fast and accurate long-range phasing in a UK Biobank cohortLoh, Po-Ru, Palamara, Pier Francesco, Price, Alkes L · 2016 · Nature Genetics
- Common genetic variants contribute to risk of rare severe neurodevelopmental disordersNiemi, Mari E. K., Martin, Hilary C., Rice, Daniel L., Gallone, Giuseppe, Gordon, Scott, Kelemen, Martin, McAloney, Kerrie, McRae, Jeremy, Radford, Elizabeth J., Yu, Sui et al. · 2018 · Nature
- Transethnic Genetic-Correlation Estimates from Summary StatisticsBrown, Brielin C., Ye, Chun Jimmie, Price, Alkes L., Zaitlen, Noah · 2016 · The American Journal of Human Genetics
- Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanismsCornelis Blauwendraat, Karl Heilbron, Costanza Ludovica Vallerga, Sara Bandrés‐Ciga, Rainer von Coelln, Lasse Pihlstrøm, Javier Simón‐Sánchez, Claudia Schulte, Manu Sharma, Lynne Krohn et al. · 2019 · Movement Disorders
- Systematic differences in discovery of genetic effects on gene expression and complex traitsMostafavi, Hakhamanesh, Spence, Jeffrey P., Naqvi, Sahin, Pritchard, Jonathan K. · 2023 · Nature Genetics
- Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseasesMineto Ota, Yasuo Nagafuchi, Hiroaki Hatano, Kazuyoshi Ishigaki, Chikashi Terao, Yusuke Takeshima, Haruyuki Yanaoka, Satomi Kobayashi, Mai Okubo, Harumi Shirai et al. · 2021 · Cell
- Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopiaPirro G. Hysi, Hélène Choquet, Anthony P. Khawaja, Robert Wojciechowski, Milly S. Tedja, Jie Yin, Mark J. Simcoe, Karina Patasova, Omar A. Mahroo, Khanh K. Thai et al. · 2020 · Nature Genetics
- Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factorsHUNT All-In Stroke, Mark K. Bakker, China Kadoorie Biobank Collaborative Group, The ICAN Study Group, CADISP Group, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators, Rick A. A. van der Spek, Wouter van Rheenen, Sandrine Morel, Romain Bourcier et al. · 2020 · Nature Genetics
- Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysisAndrew David Grotzinger, Travis T. Mallard, Wonuola A. Akingbuwa, Hill Fung Ip, Mark J. Adams, Cathryn M. Lewis, Andrew Mark McIntosh, Jakob Grove, Søren Dalsgaard, Klaus‐Peter Lesch et al. · 2022 · Nature Genetics
- Erratum: Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligenceSuzanne Sniekers, Sven Stringer, Kyoko Watanabe, Philip R. Jansen, Jonathan R. I. Coleman, Eva M. L. Krapohl, Erdogan Taskesen, Anke R. Hammerschlag, Aysu Okbay, Delilah Zabaneh et al. · 2017 · Nature Genetics
- Index and biological spectrum of human DNase I hypersensitive sitesMeuleman, Wouter, Muratov, Alexander, Rynes, Eric, Halow, Jessica, Lee, Kristen, Bates, Daniel, Diegel, Morgan, Dunn, Douglas, Neri, Fidencio, Teodosiadis, Athanasios et al. · 2020 · Nature
- Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adultsMariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary Furlan Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, David Hadley et al. · 2017 · PLoS Genetics
- Whole-genome sequencing reveals host factors underlying critical COVID-19Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, Alex Stuckey, Christopher A. Odhams, Susan Walker, Clark D Russell, Tomas Malinauskas, Yang Wu, Jonathan Edward Millar et al. · 2022 · Nature
- Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analysesThomas D. Als, Mitja Kurki, Jakob Grove, Georgios Voloudakis, Karen Therrien, Elisa M. Tasanko, Trine Tollerup Nielsen, Joonas Naamanka, Kumar Veerapen, Daniel F. Levey et al. · 2023 · Nature Medicine
- Can the impact of childhood adiposity on disease risk be reversed? A Mendelian randomization study.Richardson, Tom G., Sanderson, Eleanor, Elsworth, Benjamin, Tilling, Kate, Davey Smith, George · 2019
- Multivariate genome-wide analyses of the well-being spectrumBIOS consortium, Baselmans, Bart M. L., Social Science Genetic Association Consortium, Jansen, Rick, Ip, Hill F., van Dongen, Jenny, Abdellaoui, Abdel, van de Weijer, Margot P., Bao, Yanchun, Smart, Melissa et al. · 2019 · Nature Genetics
- Genome-wide analysis identifies 12 loci influencing human reproductive behaviorNicola Barban, LifeLines Cohort Study, Rick Jansen, Ronald de Vlaming, Ahmad Vaez, Jornt J. Mandemakers, Felix C. Tropf, Xia Shen, James F. Wilson, Daniel I. Chasman et al. · 2016 · Nature Genetics
- Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritisEleni Zengini, Konstantinos Hatzikotoulas, Ioanna Tachmazidou, Julia Steinberg, Fernando Pires Hartwig, Lorraine Southam, Sophie Hackinger, Cindy Germaine Boer, Unnur Styrkársdóttir, Arthur Gilly et al. · 2018 · Nature Genetics
- Contribution of genetics to visceral adiposity and its relation to cardiovascular and metabolic diseaseTorgny Karlsson, Mathias Rask‐Andersen, Gang Pan, Julia Höglund, Claes Wadelius, Weronica E. Ek, Åsa Johansson · 2019 · Nature Medicine
- A genome‐wide association study of the frailty index highlights brain pathways in ageingJanice L. Atkins, Juulia Jylhävä, Nancy L. Pedersen, Patrik K. E. Magnusson, Yi Lu, Yunzhang Wang, Sara Hägg, David R. Melzer, Dylan M. Williams, Luke C. Pilling · 2021 · Aging Cell
- Organization of the human intestine at single-cell resolutionJohn W. Hickey, Winston R. Becker, Stephanie A. Nevins, Aaron M. Horning, Almudena Espín-Pérez, Chenchen Zhu, Bokai Zhu, Bei Wei, Roxanne Chiu, Derek C. Chen et al. · 2023 · Nature
- Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly DistinctManuel A. R. Ferreira, Riddhima Mathur, Judith M. Vonk, Agnieszka Szwajda, Ben Michael Brumpton, Raquel Granell, Bronwyn K. Brew, Vilhelmina Ullemar, Yi Lu, Yunxuan Jiang et al. · 2019 · The American Journal of Human Genetics
- Common and rare variant associations with clonal haematopoiesis phenotypesKessler, Michael D., Damask, Amy, O’Keeffe, Sean, Banerjee, Nilanjana, Li, Dadong, Watanabe, Kyoko, Marketta, Anthony, Van Meter, Michael, Semrau, Stefan, Horowitz, Julie et al. · 2022 · Nature
- Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK BiobankLane, Jacqueline M., Vlasac, Irma, Anderson, Simon G., Kyle, Simon D., Dixon, William G., Bechtold, David A., Gill, Shubhroz, Little, Max A., Luik, Annemarie, Loudon, Andrew et al. · 2016 · Nature Communications
- Polygenic scoring accuracy varies across the genetic ancestry continuumYi Ding, Kangcheng Hou, Ziqi Xu, Aditya Pimplaskar, Ella Petter, Kristin M. Boulier, Florian Privé, Bjarni Jóhann Vilhjálmsson, Loes M. Olde Loohuis, Bogdan Paşaniuc · 2023 · Nature
- A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligenceHill, W. D., Marioni, R. E., Maghzian, O., Ritchie, S. J., Hagenaars, S. P., McIntosh, A. M., Gale, C. R., Davies, G., Deary, I. J. · 2019 · Molecular Psychiatry
- The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditionsNilüfer Rahmioğlu, Sally Mortlock, Marzieh Ghiasi, Peter Loof Møller, Lilja Stefánsdóttir, Geneviève Galarneau, Constance Turman, Rebecca Danning, Matthew H. Law, Yadav Sapkota et al. · 2023 · Nature Genetics
- The causal effects of education on health outcomes in the UK BiobankDavies, Neil M., Dickson, Matt, Davey Smith, George, van den Berg, Gerard J., Windmeijer, Frank · 2018 · Nature Human Behaviour
- Exploiting the GTEx resources to decipher the mechanisms at GWAS lociAlvaro Barbeira, Rodrigo Bonazzola, Eric R. Gamazon, Yanyu Liang, YoSon Park, Sarah Kim-Hellmuth, Gao T. Wang, Zhuoxun Jiang, Dan Zhou, Farhad Hormozdiari et al. · 2021 · Genome biology
- Discovery and prioritization of variants and genes for kidney function in >1.2 million individualsKira J. Stanzick, Yong Li, Pascal Schlosser, Mathias Gorski, Matthias Wuttke, Laurent F. Thomas, Humaira Rasheed, Bryce X. Rowan, Sarah E. Graham, Brett R. Vanderweff et al. · 2021 · Nature Communications
- Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviourJones, Samuel E., van Hees, Vincent T., Mazzotti, Diego R., Marques-Vidal, Pedro, Sabia, Séverine, van der Spek, Ashley, Dashti, Hassan S., Engmann, Jorgen, Kocevska, Desana, Tyrrell, Jessica et al. · 2019 · Nature Communications
- Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and ClassificationDapas, Matthew, Dunaif, Andrea · 2022 · Endocrine Reviews
- Quantifying genetic effects on disease mediated by assayed gene expression levelsDouglas W. Yao, Luke Jen O’Connor, Alkes L. Price, Alexander Gusev · 2020 · Nature Genetics
- Novel genetic loci associated with hippocampal volumeHibar, Derrek P., Adams, Hieab H. H., Jahanshad, Neda, Chauhan, Ganesh, Stein, Jason L., Hofer, Edith, Renteria, Miguel E., Bis, Joshua C., Arias-Vasquez, Alejandro, Ikram, M. Kamran et al. · 2017 · Nature Communications
- Predicting Polygenic Risk of Psychiatric DisordersAlicia R. Martin, Mark J. Daly, Elise Robinson, Steven E. Hyman, Benjamin M. Neale · 2018 · Biological Psychiatry
- Landscape and Regulation of m6A and m6Am Methylome across Human and Mouse TissuesJune Liu, Kai Li, Jiabin Cai, Mingchang Zhang, Xiaoting Zhang, Xushen Xiong, Haowei Meng, Xizhan Xu, Zhibin Huang, Jinying Peng et al. · 2019 · Molecular Cell
- Investigating the genetic architecture of noncognitive skills using GWAS-by-subtractionPerline Demange, Margherita Malanchini, Travis T. Mallard, Pietro Biroli, Simon R. Cox, Andrew David Grotzinger, Elliot M. Tucker–Drob, Abdel Abdellaoui, Louise Arseneault, Elsje van Bergen et al. · 2021 · Nature Genetics
- Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study DataStephen Burgess, Christopher N. Foley, Verena Zuber · 2018 · Annual Review of Genomics and Human Genetics
- Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapiesMark J. Adams, Fabian Streit, Xiangrui Meng, Swapnil Awasthi, Brett N. Adey, Karmel W. Choi, V. Kartik Chundru, Jonathan R. I. Coleman, Bart Ferwerda, Jerome C. Foo et al. · 2025 · Cell
- New loci for body fat percentage reveal link between adiposity and cardiometabolic disease riskYingchang Lu, Felix R. Day, Stefan Gustafsson, Martin L. Buchkovich, Jianbo Na, Veronique A. Bataille, Diana L. Cousminer, Zari Dastani, Alexander Drong, Tõnu Esko et al. · 2016 · Nature Communications
- Identification of nine new susceptibility loci for endometrial cancerTracy A. O’Mara, Dylan M. Glubb, Frédéric C. Amant, Daniela Annibali, Katie A. Ashton, John Attia, Paul Livermore Auer, Matthias W. Beckmann, Amanda Black, Manjeet K. Bolla et al. · 2018 · Nature Communications
- High-definition likelihood inference of genetic correlations across human complex traitsNing Zheng, Yudi Pawitan Y, Xia Shen · 2020 · Nature Genetics
- Multi-ancestry genome-wide association meta-analysis of Parkinson’s diseaseJonggeol Jeffrey Kim, Dan Vitale, Diego Véliz Otani, Michelle Mulan Lian, Karl Heilbron, Stella W. Aslibekyan, Adam Auton, Elizabeth Babalola, Robert K. Bell, Jessica Bielenberg et al. · 2023 · Nature Genetics
- Multiethnic polygenic risk scores improve risk prediction in diverse populationsCarla Márquez‐Luna, Po‐Ru Loh, Alkes L. Price · 2017 · Genetic Epidemiology
- Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traitsHammerschlag, Anke R, Stringer, Sven, de Leeuw, Christiaan A, Sniekers, Suzanne, Taskesen, Erdogan, Watanabe, Kyoko, Blanken, Tessa F, Dekker, Kim, te Lindert, Bart H W, Wassing, Rick et al. · 2017 · Nature Genetics
- Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohortsSara R. Rashkin, Rebecca E. Graff, Linda Kachuri, Khanh K. Thai, Stacey Alexeeff, Maruta A. Blatchins, Taylor B. Cavazos, Douglas A. Corley, Nima C. Emami, Joshua Hoffman et al. · 2020 · Nature Communications
- Deconstructing the sources of genotype-phenotype associations in humansYoung, Alexander I., Benonisdottir, Stefania, Przeworski, Molly, Kong, Augustine · 2019 · Science
- Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traitsZhang, Yan, Qi, Guanghao, Park, Ju-Hyun, Chatterjee, Nilanjan · 2018 · Nature Genetics
- Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effectRafik Tadros, Catherine Francis, Xiao Yun Xu, Alexa M.C. Vermeer, Andrew Robert Harper, Roy Huurman, Ken Kelu Bisabu, Roddy Walsh, Edgar T. Hoorntje, Wouter P. te Rijdt et al. · 2021 · Nature Genetics
- Anorexia nervosaJanet L. Treasure, Stephan Zipfel, Nadia Micali, Tracey D. Wade, Eric M. Stice, Angélica Medeiros Claudino, Ulrike H Schmidt, Guido Frank, Cynthia Marie Bulik, Elisabet Wentz · 2015 · Nature Reviews Disease Primers
- Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disordersChris Q. Eijsbouts, Tenghao Zheng, Nicholas Alexander Kennedy, Ferdinando Bonfiglio, Carl A. Anderson, Loukas Moutsianas, Jo Holliday, Jingchunzi Shi, Suyash Shringarpure, Michelle Agee et al. · 2021 · Nature Genetics
- Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetesIrene Miguel-Escalada, Sílvia Bonàs‐Guarch, Inês Cebola, Joan Ponsa-Cobas, Julen Mendieta-Esteban, Goutham Atla, Biola M. Javierre, Delphine Rolando, Irene Farabella, Claire C. Morgan et al. · 2019 · Nature Genetics
- Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studiesQibin Qi, Jun Li, Bing Yu, Jee‐Young Moon, Jin Choul Chai, Jordi Merino, Jie Hu, Miguel Ruiz‐Canela, Casey M. Rebholz, Zheng Wang et al. · 2021 · Gut
- Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulationTeumer, Alexander, Chaker, Layal, Groeneweg, Stefan, Li, Yong, Di Munno, Celia, Barbieri, Caterina, Schultheiss, Ulla T., Traglia, Michela, Ahluwalia, Tarunveer S., Akiyama, Masato et al. · 2018 · Nature Communications
- Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population HistoryLiu, Siyang, Huang, Shujia, Chen, Fang, Zhao, Lijian, Yuan, Yuying, Francis, Stephen Starko, Fang, Lin, Li, Zilong, Lin, Long, Liu, Rong et al. · 2018 · Cell
- Long-read sequencing of 3,622 Icelanders provides insight into the role of structural variants in human diseases and other traitsDoruk Beyter, Helga Ingimundardóttir, Ásmundur Oddsson, Hannes P. Eggertsson, Eyþór Björnsson, Hákon Jónsson, Bjarni A. Atlason, Snædís Kristmundsdóttir, Svenja Mehringer, Marteinn Thor Hardarson et al. · 2021 · Nature Genetics
- Genetic architecture of 11 organ traits derived from abdominal MRI using deep learningYi Liu, Nicolas Basty, Brandon J. Whitcher, Jimmy David Bell, Elena P. Sorokin, Nick van Bruggen, Elizabeth Louise Thomas, Madeleine Cule · 2021 · eLife
- Item-level analyses reveal genetic heterogeneity in neuroticismMats Nagel, Kyoko Watanabe, Sven Stringer, Daniëlle Posthuma, Sophie van der Sluis · 2018 · Nature Communications
- Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chancesPaul R. H. J. Timmers, Ninon Mounier, Kristi Läll, Krista Fischer, Ning Zheng, Xiao Feng, Andrew D. Bretherick, David W. Clark, Mawussé D. T. Agbessi, Habibul Ahsan et al. · 2019 · eLife
- Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and geneticsAmanda M. Buch, Conor M. Liston · 2020 · Neuropsychopharmacology
- Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex TraitsNicholas Mancuso, Huwenbo Shi, Pagé C. Goddard, Gleb Kichaev, Alexander Gusev, Bogdan Paşaniuc · 2017 · The American Journal of Human Genetics
- Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA statusPaul Lyons, James E. Peters, Federico Alberici, James Liley, Richard Coulson, William John Astle, Chiara Baldini, Francesco Bonatti, Maria Cinta Cid, Heather Elding et al. · 2019 · Nature Communications
- Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architectureZhang, Qian, Sidorenko, Julia, Couvy-Duchesne, Baptiste, Marioni, Riccardo E., Wright, Margaret J., Goate, Alison M., Marcora, Edoardo, Huang, Kuan-lin, Porter, Tenielle, Laws, Simon M. et al. · 2020 · Nature Communications
- GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortiumTrampush, J W, Yang, M L Z, Yu, J, Knowles, E, Davies, G, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K et al. · 2017 · Molecular Psychiatry
- Genome-wide association study of multisite chronic pain in UK BiobankKeira J.A. Johnston, Mark J. Adams, Barbara I. Nicholl, Joey Ward, Rona J. Strawbridge, Amy Ferguson, Andrew Mark McIntosh, Mark E.S. Bailey, Daniel J. Smıth · 2019 · PLoS Genetics
- The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank studyYu‐Fang Pei, Yaozhong Liu, Xiaolin Yang, Hong Zhang, Gui-Juan Feng, Xin‐Tong Wei, Lei Zhang · 2020 · Communications Biology
- A compendium of genetic regulatory effects across pig tissuesJinyan Teng, Yahui Gao, Hongwei Holly Yin, Zhonghao Bai, Shuli Liu, Haonan Zeng, Lijing Bai, Zexi Cai, Bingru Zhao, Xiujin Li et al. · 2024 · Nature Genetics
- Extreme Polygenicity of Complex Traits Is Explained by Negative SelectionO'Connor, Luke J., Schoech, Armin P., Hormozdiari, Farhad, Gazal, Steven, Patterson, Nick, Price, Alkes L. · 2019 · The American Journal of Human Genetics
- Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathyPirruccello, James P., Bick, Alexander, Wang, Minxian, Chaffin, Mark, Friedman, Samuel, Yao, Jie, Guo, Xiuqing, Venkatesh, Bharath Ambale, Taylor, Kent D., Post, Wendy S. et al. · 2020 · Nature Communications
- Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive SymptomsNils Kappelmann, Janine Arloth, Marios K. Georgakis, Darina Czamara, Nicolas Rost, Symen Ligthart, Golam Mohammed Khandaker, Elisabeth B. Binder · 2020 · JAMA Psychiatry
- Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation studyKaterina Trajanoska, John A. Morris, Ling Oei, Hou-Feng Zheng, David M. Evans, Douglas P. Kiel, Claes Ohlsson, John Brent Richards, Fernando Rivadeneira · 2018 · BMJ
- Thinking About the Evolution of Complex Traits in the Era of Genome-Wide Association StudiesGuy Sella, Nick Barton · 2019 · Annual Review of Genomics and Human Genetics
- Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scoresOmer Weissbrod, Masahiro Kanai, Huwenbo Shi, Steven Gazal, Wouter J. Peyrot, Amit V. Khera, Yukinori Okada, The Biobank Japan Project, Koichi Matsuda, Yuji Yamanashi et al. · 2022 · Nature Genetics
- Population structure in genetic studies: Confounding factors and mixed modelsJae Hoon Sul, Lana S. Martin, Eleazar Eskin · 2018 · PLoS Genetics
- The variant call format provides efficient and robust storage of GWAS summary statisticsMatthew Lyon, Shea J. Andrews, Benjamin Elsworth, Tom R. Gaunt, Gibran Hemani, Edoardo M. Marcora · 2021 · Genome biology
- Genetic correlates of social stratification in Great BritainAbdellaoui, Abdel, Hugh-Jones, David, Yengo, Loic, Kemper, Kathryn E., Nivard, Michel G., Veul, Laura, Holtz, Yan, Zietsch, Brendan P., Frayling, Timothy M., Wray, Naomi R. et al. · 2019 · Nature Human Behaviour
- Genetic architecture of subcortical brain structures in 38,851 individualsClaudia Liliana Satizábal, Hieab H.H. Adams, Derrek P. Hibar, Charles C. White, Maria J. Knol, Jason L. Stein, Markus R. Scholz, Muralidharan Sargurupremraj, Neda Jahanshad, Gennady V. Roshchupkin et al. · 2019 · Nature Genetics
- Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated lociSmith, D J, Escott-Price, V, Davies, G, Bailey, M E S, Colodro-Conde, L, Ward, J, Vedernikov, A, Marioni, R, Cullen, B, Lyall, D et al. · 2016 · Molecular Psychiatry
- SumHer better estimates the SNP heritability of complex traits from summary statisticsSpeed, Doug, Balding, David J. · 2019 · Nature Genetics