LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, Brendan K, Loh, Po-Ru, Finucane, Hilary K, Ripke, Stephan, Yang, Jian, Patterson, Nick, Daly, Mark J +2 more·2015·Nature Genetics
DOI 10.1038/ng.3211
Cited by (1,062)
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- Examining the role of common variants in rare neurodevelopmental conditionsQin Qin Huang, Emilie M. Wigdor, Daniel Shiloh Malawsky, Patrick H. Campbell, Kaitlin E. Samocha, V. Kartik Chundru, Petr Danecek, Sarah Lindsay, Thomas Marchant, Mahmoud Koko et al. · 2024 · Nature
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- Estimation of Parental Effects Using Polygenic ScoresJared V. Balbona, Yongkang Kim, Matthew C. Keller · 2021 · Behavior Genetics
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- Using three-dimensional regulatory chromatin interactions from adult and fetal cortex to interpret genetic results for psychiatric disorders and cognitive traitsPaola Giusti‐Rodríguez, Patrick F. Sullivan · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
- GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architectureMatoba, Nana, Akiyama, Masato, Ishigaki, Kazuyoshi, Kanai, Masahiro, Takahashi, Atsushi, Momozawa, Yukihide, Ikegawa, Shiro, Ikeda, Masashi, Iwata, Nakao, Hirata, Makoto et al. · 2019 · Nature Human Behaviour
- Genetic association study of childhood aggression across raters, instruments, and ageIp, Hill F., van der Laan, Camiel M., Krapohl, Eva M. L., Brikell, Isabell, Sánchez-Mora, Cristina, Nolte, Ilja M., St Pourcain, Beate, Bolhuis, Koen, Palviainen, Teemu, Zafarmand, Hadi et al. · 2021 · Translational Psychiatry
- The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome‐wide association studiesLee, James J., McGue, Matt, Iacono, William G., Chow, Carson C. · 2018 · Genetic Epidemiology
- A genome-wide association study for extremely high intelligenceZabaneh, D, Krapohl, E, Gaspar, H A, Curtis, C, Lee, S H, Patel, H, Newhouse, S, Wu, H M, Simpson, M A, Putallaz, M et al. · 2018 · Molecular Psychiatry
- Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSAJūlı́us Guðmundsson, Jon Karl Sigurdsson, Lilja Stefánsdóttir, Bjarni Agnar Agnarsson, Helgi J. Ísaksson, Ólafur Andri Stefánsson, Sigurjon Axel Gudjonsson, Daniel Fannar Gudbjartsson, Gísli Másson, Michael L. Frigge et al. · 2018 · Nature Communications
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- Discovery of genomic loci of the human cerebral cortex using genetically informed brain atlasesCarolina Makowski, Dennis van der Meer, Weixiu Dong, Hao Wang, Yan Wu, Jingjing Zou, Cin Liu, Sara B. Rosenthal, Donald J. Hagler, Chun Chieh Fan et al. · 2022 · Science
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- Analysis of genetic dominance in the UK BiobankDuncan S. Palmer, Wei Zhou, Liam E. Abbott, Emilie M. Wigdor, Nikolas A. Baya, Claire L. Churchhouse, Cotton Seed, Timothy Poterba, Daniel A. King, Masahiro Kanai et al. · 2023 · Science
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- Adiposity and sex-specific cancer riskMathias Rask‐Andersen, Emma L. Ivansson, Julia Höglund, Weronica E. Ek, Torgny Karlsson, Åsa Johansson · 2023 · Cancer Cell
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- Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndromeSanghyeon Park, Soyeon Kim, Beomsu Kim, Dan Say Kim, Jaeyoung Kim, Yeeun Ahn, Hyejin Kim, Minku Song, Injeong Shim, Sang‐Hyuk Jung et al. · 2024 · Nature Genetics
- Genetic epidemiology of eating disordersCynthia Marie Bulik, Susan C. Kleiman, Zeynep Yılmaz · 2016 · Current Opinion in Psychiatry
- Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion responseQ S Li, C Tian, Guy R. Seabrook, Wayne Curtis Drevets, Vaibhav A. Narayan · 2016 · Translational Psychiatry
- Polygenic risk for schizophrenia and measured domains of cognition in individuals with psychosis and controlsRebecca Shafee, Pranav Nanda, Jaya L. Padmanabhan, Neeraj Tandon, Ney Alliey‐Rodriguez, Sreeja S. Kalapurakkel, Daniel J. Weiner, Raquel E. Gur, Richard S.E. Keefe, Scot Kristian Hill et al. · 2018 · Translational Psychiatry
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- Mixed Model with Correction for Case-Control Ascertainment Increases Association PowerTristan J. Hayeck, Noah Zaitlen, Po‐Ru Loh, Bjarni Jóhann Vilhjálmsson, Samuela J Pollack, Alexander Gusev, Jian Yang, Guo‐Bo Chen, Michael Edward Goddard, Peter M. Visscher et al. · 2015 · The American Journal of Human Genetics
- Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic AneurysmsFemke N. G. van ’t Hof, Ynte Marije Ruigrok, Cue Hyunkyu Lee, Stephan Ripke, Graig Anderson, Mariza de Andrade, Annette F. Baas, Jan D. Blankensteijn, Erwin P. Böttinger, Matthew J. Bown et al. · 2016 · Journal of the American Heart Association
- Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weightLiang‐Dar Hwang, Debbie A. Lawlor, Rachel M. Freathy, David M. Evans, Nicole M. Warrington · 2019 · International Journal of Epidemiology
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- Quality Control Procedures for Genome‐Wide Association StudiesVan Q. Truong, Jakob Woerner, Tess Cherlin, Yuki Bradford, Anastasia Lucas, Chelsea C. Okeh, Manu Shivakumar, Daniel H. Hui, Rachit Kumar, Milton Pividori et al. · 2022 · Current Protocols
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