LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

Cited by (1,062)

Items 1,001–1,062 of 1,062

1. Genome-wide association study of febrile seizures implicates fever response and neuronal excitability genes
   Line Skotte, João Fadista, Jonas Bybjerg‐Grauholm, Vivek Appadurai, Michael S. Hildebrand, Thomas Folkmann Hansen, Karina Banasik, Jakob Grove, Clara Albiñana, Frank Geller et al. · 2021 · Brain
2. Genome-wide association meta-analysis identifies 29 new acne susceptibility loci
   Brittany L. Mitchell, Jake R. Saklatvala, Nick Dand, Fiona A. Hagenbeek, Xin Li, Josine L. Min, Laurent F. Thomas, Meike Bartels, Jouke‐Jan Hottenga, Michelle K. Lupton et al. · 2022 · Nature Communications
3. Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases
   Yasumizu, Yoshiaki, Takeuchi, Daiki, Morimoto, Reo, Takeshima, Yusuke, Okuno, Tatsusada, Kinoshita, Makoto, Morita, Takayoshi, Kato, Yasuhiro, Wang, Min, Motooka, Daisuke et al. · 2024 · Cell Genomics
4. Shared genetic etiology between anxiety disorders and psychiatric and related intermediate phenotypes
   Ohi, Kazutaka, Otowa, Takeshi, Shimada, Mihoko, Sasaki, Tsukasa, Tanii, Hisashi · 2020 · Psychological Medicine
5. Association of accelerometer-derived sleep measures with lifetime psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank
   Wainberg, Michael, Jones, Samuel E., Beaupre, Lindsay Melhuish, Hill, Sean L., Felsky, Daniel, Rivas, Manuel A., Lim, Andrew S. P., Ollila, Hanna M., Tripathy, Shreejoy J. · 2021 · PLOS Medicine
6. An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes
   Tylee, Daniel S., Lee, Yu Kyung, Wendt, Frank R., Pathak, Gita A., Levey, Daniel F., De Angelis, Flavio, Gelernter, Joel, Polimanti, Renato · 2022 · JAMA Psychiatry
7. Genomic relationships across psychiatric disorders including substance use disorders
   Abdellaoui, Abdel, Smit, Dirk J.A., van den Brink, Wim, Denys, Damiaan, Verweij, Karin J.H. · 2021 · Drug and Alcohol Dependence
8. Genetic research in autism spectrum disorders
   Robinson, Elise B., Neale, Benjamin M., Hyman, Steven E. · 2015 · Current Opinion in Pediatrics
9. Shades of complexity: New perspectives on the evolution and genetic architecture of human skin
   Quillen, Ellen E., Norton, Heather L., Parra, Esteban J., Lona‐Durazo, Frida, Ang, Khai C., Illiescu, Florin Mircea, Pearson, Laurel N., Shriver, Mark D., Lasisi, Tina, Gokcumen, Omer et al. · 2019 · American Journal of Physical Anthropology
10. Genetic comorbidity between major depression and cardio‐metabolic traits, stratified by age at onset of major depression
    Hagenaars, Saskia P., Coleman, Jonathan R. I., Choi, Shing Wan, Gaspar, Héléna, Adams, Mark J., Howard, David M., Hodgson, Karen, Traylor, Matthew, Air, Tracy M., Andlauer, Till F. M. et al. · 2020 · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
11. Efficient cross-trait penalized regression increases prediction accuracy in large cohorts using secondary phenotypes
    Chung, Wonil, Chen, Jun, Turman, Constance, Lindstrom, Sara, Zhu, Zhaozhong, Loh, Po-Ru, Kraft, Peter, Liang, Liming · 2019 · Nature Communications
12. Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies
    Zhao, Bingxin, Ibrahim, Joseph G, Li, Yun, Li, Tengfei, Wang, Yue, Shan, Yue, Zhu, Ziliang, Zhou, Fan, Zhang, Jingwen, Huang, Chao et al. · 2019 · Cerebral Cortex
13. Genome‐wide analyses of aggressiveness in attention‐deficit hyperactivity disorder
    Brevik, Erlend J., van Donkelaar, Marjolein M. J., Weber, Heike, Sánchez‐Mora, Cristina, Jacob, Christian, Rivero, Olga, Kittel‐Schneider, Sarah, Garcia‐Martínez, Iris, Aebi, Marcel, van Hulzen, Kimm et al. · 2016 · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
14. Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study
    Fang, Si, Yarmolinsky, James, Gill, Dipender, Bull, Caroline J., Perks, Claire M., the PRACTICAL Consortium, Davey Smith, George, Gaunt, Tom R., Richardson, Tom G. · 2023 · PLOS Medicine
15. Efficient variance components analysis across millions of genomes
    Pazokitoroudi, Ali, Wu, Yue, Burch, Kathryn S., Hou, Kangcheng, Zhou, Aaron, Pasaniuc, Bogdan, Sankararaman, Sriram · 2020 · Nature Communications
16. PICALM Alzheimer’s risk allele causes aberrant lipid droplets in microglia
    Kozlova, Alena, Zhang, Siwei, Sudwarts, Ari, Zhang, Hanwen, Smirnou, Stanislau, Byeon, Seul Kee, Thapa, Christina, Sun, Xiaotong, Stephenson, Kimberley, Zhao, Xiaojie et al. · 2025 · Nature
17. Genome-wide association studies identify<i>PRKCB</i>as a novel genetic susceptibility locus for primary biliary cholangitis in the Japanese population
    Kawashima, Minae, Hitomi, Yuki, Aiba, Yoshihiro, Nishida, Nao, Kojima, Kaname, Kawai, Yosuke, Nakamura, Hitomi, Tanaka, Atsushi, Zeniya, Mikio, Hashimoto, Etsuko et al. · 2017 · Human Molecular Genetics
18. Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis
    Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Aradottir, Kristrun, Feenstra, Bjarke, Sigurdsson, Asgeir, Stefansdottir, Lilja, Kristinsdottir, Anna M., Zink, Florian, Halldorsson, Gisli H., Munk Nielsen, Nete et al. · 2016 · Nature Communications
19. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
    Demontis, Ditte, Walters, Raymond K., Rajagopal, Veera M., Waldman, Irwin D., Grove, Jakob, Als, Thomas D., Dalsgaard, Søren, Ribasés, Marta, Bybjerg-Grauholm, Jonas, Bækvad-Hansen, Maria et al. · 2021 · Nature Communications
20. Family-GWAS reveals effects of environment and mating on genetic associations
    Tan, Tammy, Jayashankar, Hariharan, Guan, Junming, Nehzati, Seyed Moeen, Mir, Mahdi, Bennett, Michael, Agerbo, Esben, Ahlskog, Rafael, de Andrade Anapaz, Ville Pinto, Benonisdottir, Stefania et al. · 2024
21. Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a <scp>Genome‐Wide</scp> Association <scp>Meta‐Analysis</scp> Followed by Mendelian Randomization
    Zheng, Jie, Wheeler, Eleanor, Pietzner, Maik, Andlauer, Till F. M., Yau, Michelle S., Hartley, April E., Brumpton, Ben Michael, Rasheed, Humaira, Kemp, John P., Frysz, Monika et al. · 2023 · Arthritis &amp; Rheumatology
22. Multi-trait association studies discover pleiotropic loci between Alzheimer’s disease and cardiometabolic traits
    The VA Million Veteran Program, Bone, William P., Siewert, Katherine M., Jha, Anupama, Klarin, Derek, Damrauer, Scott M., Chang, Kyong-Mi, Tsao, Philip S., Assimes, Themistocles L., Ritchie, Marylyn D. et al. · 2021 · Alzheimer's Research &amp; Therapy
23. Combining genome-wide association studies highlight novel loci involved in human facial variation
    Xiong, Ziyi, Gao, Xingjian, Chen, Yan, Feng, Zhanying, Pan, Siyu, Lu, Haojie, Uitterlinden, Andre G., Nijsten, Tamar, Ikram, Arfan, Rivadeneira, Fernando et al. · 2022 · Nature Communications
24. Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways
    Jansen, Philip R., Watanabe, Kyoko, Stringer, Sven, Skene, Nathan, Bryois, Julien, Hammerschlag, Anke R., de Leeuw, Christiaan A., Benjamins, Jeroen, Muñoz-Manchado, Ana B., Nagel, Mats et al. · 2018
25. Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations
    Koller, Dora, Wendt, Frank R., Pathak, Gita A., De Lillo, Antonella, De Angelis, Flavio, Cabrera-Mendoza, Brenda, Tucci, Serena, Polimanti, Renato · 2022 · BMC Biology
26. Concepts and Misconceptions about the Polygenic Additive Model Applied to Disease
    Visscher, Peter M., Wray, Naomi R. · 2015 · Human Heredity
27. Assessment and visualization of phenome-wide causal relationships using genetic data: an application to dental caries and periodontitis
    Haworth, Simon, Kho, Pik Fang, Holgerson, Pernilla Lif, Hwang, Liang-Dar, Timpson, Nicholas J., Rentería, Miguel E., Johansson, Ingegerd, Cuellar-Partida, Gabriel · 2021 · European Journal of Human Genetics
28. Multi-Ancestry Meta-Analysis yields novel genetic discoveries and ancestry-specific associations
    Turley, Patrick, Martin, Alicia R., Goldman, Grant, Li, Hui, Kanai, Masahiro, Walters, Raymond K., Jala, Jonathan B., Lin, Kuang, Millwood, Iona Y., Carey, Caitlin E. et al. · 2021
29. No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy
    Fjell, Anders M., Sørensen, Øystein, Wang, Yunpeng, Amlien, Inge K., Baaré, William F. C., Bartrés-Faz, David, Bertram, Lars, Boraxbekk, Carl-Johan, Brandmaier, Andreas M., Demuth, Ilja et al. · 2023 · Nature Human Behaviour
30. An Atlas of Gene Regulatory Elements in Adult Mouse Cerebrum
    Li, Yang Eric, Preissl, Sebastian, Hou, Xiaomeng, Zhang, Ziyang, Zhang, Kai, Fang, Rongxin, Qiu, Yunjiang, Poirion, Olivier, Li, Bin, Liu, Hanqing et al. · 2020
31. A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores
    Kang, Moonil, Ang, Ting Fang Alvin, Devine, Sherral A., Sherva, Richard, Mukherjee, Shubhabrata, Trittschuh, Emily H., Gibbons, Laura E., Scollard, Phoebe, Lee, Michael, Choi, Seo-Eun et al. · 2023 · Molecular Neurodegeneration
32. Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes risk
    Chiou, Joshua, Zeng, Chun, Cheng, Zhang, Han, Jee Yun, Schlichting, Michael, Huang, Serina, Wang, Jinzhao, Sui, Yinghui, Deogaygay, Allison, Okino, Mei-Lin et al. · 2019
33. How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID)
    Kennedy, Hannah L., Dinkler, Lisa, Kennedy, Martin A., Bulik, Cynthia M., Jordan, Jennifer · 2022 · Journal of Eating Disorders
34. A selection pressure landscape for 870 human polygenic traits
    Song, Weichen, Shi, Yueqi, Wang, Weidi, Pan, Weihao, Qian, Wei, Yu, Shunying, Zhao, Min, Lin, Guan Ning · 2021 · Nature Human Behaviour
35. Mendelian imputation of parental genotypes for genome-wide estimation of direct and indirect genetic effects
    Young, Alexander I., Nehzati, Seyed Moeen, Lee, Chanwook, Benonisdottir, Stefania, Cesarini, David, Benjamin, Daniel J., Turley, Patrick, Kong, Augustine · 2020
36. Enrichment of schizophrenia heritability in both neuronal and glia cell regulatory elements
    Tansey, Katherine E., Hill, Matthew J. · 2018 · Translational Psychiatry
37. Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new independent variants
    Alemany, Silvia, Soler-Artigas, María, Cabana-Domínguez, Judit, Fakhreddine, Dana, Llonga, Natalia, Vilar-Ribó, Laura, Rodríguez-Urrutia, Amanda, Palacio, Judit, González-Castro, Ana María, Lobo, Beatriz et al. · 2023 · Journal of Translational Medicine
38. No support for the hereditarian hypothesis of the <scp>Black–White</scp> achievement gap using polygenic scores and tests for divergent selection
    Bird, Kevin A. · 2021 · American Journal of Physical Anthropology
39. GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
    Dashti, Hassan S, Jones, Samuel E, Wood, Andrew R, Lane, Jacqueline M, van Hees, Vincent T., Wang, Heming, Rhodes, Jessica A, Song, Yanwei, Patel, Krunal, Anderson, Simon G et al. · 2018
40. Shared genetic architectures of educational attainment in East Asian and European populations
    Chen, Tzu-Ting, Kim, Jaeyoung, Lam, Max, Chuang, Yi-Fang, Chiu, Yen-Ling, Lin, Shu-Chin, Jung, Sang-Hyuk, Kim, Beomsu, Kim, Soyeon, Cho, Chamlee et al. · 2024 · Nature Human Behaviour
41. Population phenomena inflate genetic associations of complex social traits
    Morris, Tim T., Davies, Neil M., Hemani, Gibran, Smith, George Davey · 2020 · Science Advances
42. mGWAS-Explorer: Linking SNPs, Genes, Metabolites, and Diseases for Functional Insights
    Chang, Le, Zhou, Guangyan, Ou, Huiting, Xia, Jianguo · 2022 · Metabolites
43. Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits
    Johnson, Ruth, Burch, Kathryn S., Hou, Kangcheng, Paciuc, Mario, Pasaniuc, Bogdan, Sankararaman, Sriram · 2021 · PLoS Computational Biology
44. Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability
    Bai, Dongsheng, Cao, Zhenkun, Attada, Nivedita, Song, Jinghui, Zhu, Chenxu · 2025 · Nature Methods
45. Genetic and environmental determinants of stressful life events and their overlap with depression and neuroticism
    Clarke, Toni-Kim, Zeng, Yanni, Navrady, Lauren, Xia, Charley, Haley, Chris, Campbell, Archie, Navarro, Pau, Amador, Carmen, Adams, Mark J., Howard, David M. et al. · 2018 · Wellcome Open Research
46. Evaluating the Correlations Between Osteoporosis and Lifestyle-Related Factors Using Transcriptome-Wide Association Study
    Du, Yanan, Li, Ping, Wen, Yan, Liang, Xiao, Liu, Li, Cheng, Bolun, Ding, Miao, Zhao, Yan, Ma, Mei, Zhang, Lu et al. · 2020 · Calcified Tissue International
47. Shared genetic architecture between hypothyroidism and rheumatoid arthritis: a large-scale cross-trait analysis.
    Liu, Ruiyan, Shang, Xin, Fu, Yu, Wang, Ying, Wang, Ping, Yan, Shuxun · 2024 · Molecular Immunology
48. The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits
    Antón-Galindo, Ester, Cabana-Domínguez, Judit, Torrico, Bàrbara, Corominas, Roser, Cormand, Bru, Fernàndez-Castillo, Noèlia · 2023 · Frontiers in Psychiatry
49. Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)
    Sanchez-Roige, Sandra, Palmer, Abraham A., Fontanillas, Pierre, Elson, Sarah L., The 23andMe Research Team, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Adams, Mark J., Howard, David M., Edenberg, Howard J., Davies, Gail et al. · 2018
50. Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction
    Small, Aeron M., Yang, Ta-Yu, Itoh, Shinsuke, Thériault, Sébastien, Dufresne, Line, Kurosawa, Ryo, Komuro, Issei, Matsuda, Koichi, Vy, Ha My T., Farber-Eger, Eric H. et al. · 2026 · Nature Genetics
51. Epidemiology of hypertensive disorders in pregnancy
    Stuart, Jennifer J., Gray, Kathryn J., Rich-Edwards, Janet W., Roberts, James M. · 2022 · Chesley's Hypertensive Disorders in Pregnancy
52. Evidence of causal effect of major depression on alcohol dependence: Findings from the Psychiatric Genomics Consortium
    Polimanti, Renato, Peterson, Roseann E., Ong, Jue-Sheng, MacGregor, Stuart, Edwards, Alexis C., Clarke, Toni-Kim, Frank, Josef, Gerring, Zachary, Gillespie, Nathan A., Lind, Penelope A. et al. · 2018
53. Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies
    de Vlaming, Ronald, Okbay, Aysu, Rietveld, Cornelius A., Johannesson, Magnus, Magnusson, Patrik K. E., Uitterlinden, André G., van Rooij, Frank J. A., Hofman, Albert, Groenen, Patrick J. F., Thurik, A. Roy et al. · 2017 · PLOS Genetics
54. Consensus meta-analysis of genome-wide association studies for Alzheimer’s disease and related dementias
    EADB, Bellenguez, Céline, Castillo Morales, Atahualpa, Amin, Najaf, van der Lee, Sven J., Muntaner, Manon, Parveen, Kayenat, Küçükali, Fahri, Grenier-Boley, Benjamin, Heikkinen, Sami et al. · 2026 · Nature Genetics
55. Real-life helping behaviours in North America: A genome-wide association approach.
    Primes, Georg, Fieder, Martin · 2018 · PLoS ONE
56. The hidden genetic and microbial networks connecting neuropsychiatric and digestive disorders
    Xiong, Jiayi, Xu, Tiantian, Wang, Zheng, Huang, Yuanfeng, Zhang, Shiyu, Yang, Guang, Yang, Jiaqi, Gao, Shuo, Wang, Tianyang, Jian, Xingxing et al. · 2025 · Computational and Structural Biotechnology Journal
57. Genetic influences on neurodevelopmental disorders and their overlap with co-occurring conditions in childhood and adolescence: A meta-analysis
    Gidziela, Agnieszka, Ahmadzadeh, Yasmin I., Michelini, Giorgia, Allegrini, Andrea G., Agnew-Blais, Jessica, Lau, Lok Yan, Duret, Megan, Procopio, Francesca, Daly, Emily, Ronald, Angelica et al. · 2022
58. Novel estimators for family-based genome-wide association studies increase power and robustness
    Guan, Junming, Nehzati, Seyed Moeen, Benjamin, Daniel J., Young, Alexander I. · 2022
59. Effects of introgressed Neanderthal alleles on present-day brain morphology
    Zeloni, Roberta, Amaolo, Alessandro, Morez Jacobs, Adeline, Zapparoli, Ettore, Akl, Yara, Shafie, Mahan, Huerta-Sanchez, Emilia, Pizzagalli, Fabrizio, Provero, Paolo, Pagani, Luca et al. · 2026 · bioRxiv
60. Whole‐Genome Sequencing and Single‐Cell Transcriptomics Identify Human Leukocyte Antigen Loci and a <i>COG5</i> Variant in Aortic Dissection
    Lin, Jinran, Wu, Shishi, Lin, Chenhao, Jin, Shilin, Chen, Lu, Luo, Jingchun, Xu, Shuhua, Jin, Li, Yu, Mengyao, Zheng, Yan et al. · 2026 · Journal of the American Heart Association
61. Choice of phenotype scale is critical in biobank-based G × E tests
    Costantino, Manuela, Fonseca, Renée, Liu, Zhengtong, Huang, Zhenhong, Sankararaman, Sriram, Mathieson, Iain, Dahl, Andy · 2026 · Cell Genomics
62. Exploration of the genetic architecture of ANCA-associated vasculitis
    Byun, Jinyoung, Shaw, Vikram R., Zhu, Catherine, Han, Younghun, Sun, Ryan, Zhang, Zhihui, Xiao, Xiangjun, Pinder, Benjamin D., Zhang, Jinyi, Tadesse, Yohannes et al. · 2026 · eBioMedicine