The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity
Open accessAbstract
Cells respond to stimuli by changes in various processes, including signaling pathways and gene expression. Efforts to identify components of these responses increasingly depend on mRNA profiling and genetic library screens. By comparing the results of these two assays across various stimuli, we found that genetic screens tend to identify response regulators, whereas mRNA profiling frequently detects metabolic responses. We developed an integrative approach that bridges the gap between these data using known molecular interactions, thus highlighting major response pathways. We used this approach to reveal cellular pathways responding to the toxicity of alpha-synuclein, a protein implicated in several neurodegenerative disorders including Parkinson's disease. For this we screened an established yeast model to identify genes that when overexpressed alter alpha-synuclein toxicity. Bridging these data and data from mRNA profiling provided functional explanations for many of these genes and identified previously unknown relations between alpha-synuclein toxicity and basic cellular pathways.
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Cited by
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Self-citationNetwork propagation: a universal amplifier of genetic associations
Cowen, L., Ideker, T., Raphael, B. J., & Sharan, R. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.38 · Cited by 657
Integrative approaches for finding modular structure in biological networks
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Metadata
- Authors
- Yeger-Lotem, E., Riva, L., Su, L. J., Gitler, A. D., Cashikar, A. G., King, O. D., Auluck, P. K., Geddie, M. L., Valastyan, J. S., Karger, D. R., Lindquist, S., & Fraenkel, E.
- Venue
- Nature Genetics
- Published
- 2009-02-22
- Volume
- 41
- Issue
- 3
- Pages
- 316-323
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2136303131
- Cited by
- 286
- References
- 107
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- green
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- Yeger-Lotem, E., Riva, L., Su, L. J., Gitler, A. D., Cashikar, A. G., King, O. D., Auluck, P. K., Geddie, M. L., Valastyan, J. S., Karger, D. R., Lindquist, S., & Fraenkel, E. (2009). Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nature Genetics. https://doi.org/10.1038/ng.337
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