The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.
The Yeast Deletion Collection: A Decade of Functional Genomics
Open accessAbstract
The yeast deletion collections comprise >21,000 mutant strains that carry precise start-to-stop deletions of ∼6000 open reading frames. This collection includes heterozygous and homozygous diploids, and haploids of both MATa and MATα mating types. The yeast deletion collection, or yeast knockout (YKO) set, represents the first and only complete, systematically constructed deletion collection available for any organism. Conceived during the Saccharomyces cerevisiae sequencing project, work on the project began in 1998 and was completed in 2002. The YKO strains have been used in numerous laboratories in >1000 genome-wide screens. This landmark genome project has inspired development of numerous genome-wide technologies in organisms from yeast to man. Notable spinoff technologies include synthetic genetic array and HIPHOP chemogenomics. In this retrospective, we briefly describe the yeast deletion project and some of its most noteworthy biological contributions and the impact that these collections have had on the yeast research community and on genomics in general.
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Cited by
Generating Single Cell–Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9
Giuliano, C. J., Lin, A., Girish, V., & Sheltzer, J. M. (2019) · Current Protocols in Molecular Biology · doi:10.1002/cpmb.100 · Cited by 130
Paralog buffering contributes to the variable essentiality of genes in cancer cell lines
De Kegel, B., & Ryan, C. J. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008466 · Cited by 92
Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications
Caldara, M., & Marmiroli, N. (2021) · Pharmaceuticals · doi:10.3390/ph14090915 · Cited by 54
Yeast toxicogenomics: Lessons from a eukaryotic cell model and cell factory
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An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes
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Metadata
- Authors
- Giaever, G., & Nislow, C.
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-06-01
- Volume
- 197
- Issue
- 2
- Pages
- 451-465
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2099636105
- Cited by
- 481
- References
- 106
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
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