The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis
Open accessAbstract
Although many vertebrate organs, such as kidneys, lungs and liver, are composed of epithelial tubules, little is known of the mechanisms that establish the length or diameter of these tubules. In the kidney, defects in the establishment or maintenance of tubule diameter are associated with one of the most common inherited human disorders, polycystic kidney disease. Here we show that attenuation of Wnt9b signaling during kidney morphogenesis affects the planar cell polarity of the epithelium and leads to tubules with significantly increased diameter. Although previous studies showed that polarized cell divisions maintain the diameter of postnatal kidney tubules, we find that cell divisions are randomly oriented during embryonic development. Our data suggest that diameter is established during early morphogenetic stages by convergent extension processes and maintained by polarized cell divisions. Wnt9b, signaling through the non-canonical Rho/Jnk branch of the Wnt pathway, is necessary for both of these processes.
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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
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Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
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Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
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Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine · doi:10.1038/nm.2667 · Cited by 747
Ciliopathies: an expanding disease spectrum
Waters, A. M., & Beales, P. L. (2011) · Pediatric Nephrology · doi:10.1007/s00467-010-1731-7 · Cited by 676
Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis
Goddard, L. M., Duchemin, A.-L., Ramalingan, H., Wu, B., Chen, M., Bamezai, S., Yang, J., Li, L., Morley, M. P., Wang, T., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.09.023 · Cited by 156
Self-citationSculpting Organs: Mechanical Regulation of Tissue Development
Nelson, C. M., & Gleghorn, J. P. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150043 · Cited by 130
Metadata
- Authors
- Karner, C. M., Chirumamilla, R., Aoki, S., Igarashi, P., Wallingford, J. B., & Carroll, T. J.
- Venue
- Nature Genetics
- Published
- 2009-06-21
- Volume
- 41
- Issue
- 7
- Pages
- 793-799
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2046518908
- Cited by
- 373
- References
- 10
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Karner, C. M., Chirumamilla, R., Aoki, S., Igarashi, P., Wallingford, J. B., & Carroll, T. J. (2009). Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nature Genetics. https://doi.org/10.1038/ng.400
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