The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
Open accessAbstract
Single-layered embryonic skin either stratifies to form epidermis or responds to Wnt signaling (stabilized β-catenin) to form hair follicles. Postnatally, stem cells continue to differentially use Wnt signaling in long-term tissue homeostasis. We have discovered that embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors. Using loss-of-function studies and transcriptional analyses, we uncovered consequences to the absence of Tcf3 and Tcf4 in skin that only partially overlap with those caused by β-catenin deficiency. We established roles for Tcf3 and Tcf4 in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that Tcf proteins have both Wnt-dependent and Wnt-independent roles in lineage determination.
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Cites
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis
Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564
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Self-citationFOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
Essers, M. A., Weijzen, S., de Vries‐Smits, A. M., Saarloos, I., de Ruiter, N. D., Bos, J. L., & Burgering, B. M. T. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600476 · Cited by 798
Augmented Wnt signaling in a mammalian model of accelerated aging
Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., Chen, J., Malide, D., Rovira, I. I., Schimel, D., Kuo, C. J., et al. (2007) · Science · doi:10.1126/science.1143578 · Cited by 755
Celso, C. L., Prowse, D. M., & Watt, F. M. (2004) · Development · doi:10.1242/dev.01052 · Cited by 339
Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R. (2003) · Genes & Development · doi:10.1101/gad.1076103 · Cited by 263
Cited by
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
Clevers, H., Loh, K. M., & Nusse, R. (2014) · Science · doi:10.1126/science.1248012 · Cited by 1,364
Yap1 acts downstream of α-catenin to control epidermal proliferation
Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036
TCF/LEFs and Wnt Signaling in the Nucleus
Cadigan, K. M., & Waterman, M. L. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007906 · Cited by 760
Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
Sennett, R., & Rendl, M. (2012) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2012.08.011 · Cited by 388
Self-citationInterfollicular Epidermal Stem Cells Self-Renew via Autocrine Wnt Signaling
Lim, X., Tan, S. H., Koh, W. L. C., Chau, R. M. W., Yan, K. S., Kuo, C. J., van Amerongen, R., Klein, A. M., & Nusse, R. (2013) · Science · doi:10.1126/science.1239730 · Cited by 347
Metadata
- Authors
- Nguyen, H., Merrill, B. J., Polak, L., Nikolova, M., Rendl, M., Shaver, T. M., Pasolli, H. A., & Fuchs, E.
- Venue
- Nature Genetics
- Published
- 2009-08-30
- Volume
- 41
- Issue
- 10
- Pages
- 1068-1075
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2090327931
- Cited by
- 201
- References
- 6
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- green
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