Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours
Open accessAbstract
When β-catenin signalling is disturbed from mid-gestation onwards lineage commitment is profoundly altered in postnatal mouse epidermis. We have investigated whether adult epidermis has the capacity forβ-catenin-induced lineage conversion without prior embryonic priming. We fused N-terminally truncated, stabilised β-catenin to the ligand-binding domain of a mutant oestrogen receptor (ΔNβ-cateninER).ΔNβ-cateninER was expressed in the epidermis of transgenic mice under the control of the keratin 14 promoter and β-catenin activity was induced in adult epidermis by topical application of 4-hydroxytamoxifen(4OHT). Within 7 days of daily 4OHT treatment resting hair follicles were recruited into the hair growth cycle and epithelial outgrowths formed from existing hair follicles and from interfollicular epidermis. The outgrowths expressed Sonic hedgehog, Patched and markers of hair follicle differentiation, indicative of de novo follicle formation. The interfollicular epidermal differentiation program was largely unaffected but after an initial wave of sebaceous gland duplication sebocyte differentiation was inhibited. A single application of 4OHT was as effective as repeated doses in inducing new follicles and growth of existing follicles. Treatment of epidermis with 4OHT for 21 days resulted in conversion of hair follicles to benign tumours resembling trichofolliculomas. The tumours were dependent on continuous activation of β-catenin and by 28 days after removal of the drug they had largely regressed. We conclude that interfollicular epidermis and sebaceous glands retain the ability to be reprogrammed in adult life and that continuousβ-catenin signalling is required to maintain hair follicle tumours.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TERT interacts with Brg-1, which binds β-catenin, and is recruited to Wnt target gene chromatin to enhance Wnt transcriptional output.
“TERT interacts with the chromatin remodeling protein Brg-1, which binds b-catenin, the central transactivator in the Wnt pathway.TERT is recruited to Wnt target gene chromatin in cells stimulated by Wnts and serves to enhance the transcriptional output of the Wnt program in this context (148,149).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [149]
TERT acts as a developmental regulator and modulates the Wnt signaling pathway.
“These observations indicated that TERT possesses properties of a developmental regulator and indeed TERT exerts these potent developmental effects as a modulator in the Wnt signaling pathway (149).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [149]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Identification of c- <i>MYC</i> as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566 · see citing works
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601 · see citing works
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183 · see citing works
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159 · see citing works
Morgenstern, J. P., & Land, H. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.12.3587 · Cited by 2,099 · see citing works
Controls of Hair Follicle Cycling
Stenn, K. S., & Paus, R. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.449 · Cited by 1,520 · see citing works
Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells
Wagers, A. J., Sherwood, R. I., Christensen, J. L., & Weissman, I. L. (2002) · Science · doi:10.1126/science.1074807 · Cited by 1,460 · see citing works
β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin
Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G., & Birchmeier, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00336-1 · Cited by 1,352 · see citing works
Wetering, M. L. V. D., Cavallo, R. A., Dooijes, D., van Beest, M., van Es, J. V., Loureiro, J., Ypma, A., Hursh, D., Jones, T. L., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,347 · see citing works
Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus
Peifer, M., & Polakis, P. (2000) · Science · doi:10.1126/science.287.5458.1606 · Cited by 1,253 · see citing works
Cell biology :a laboratory handbook.
Celis, J. E. (1994) · Cited by 1,199 · see citing works
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
Gat, U., DasGupta, R., Degenstein, L., & Fuchs, E. (1998) · Cell · doi:10.1016/s0092-8674(00)81631-1 · Cited by 1,089 · see citing works
WNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088 · see citing works
van Genderen, C., Okamura, R., Fariñas, I., Quo, R. G., Parslow, T., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 1,031 · see citing works
DasGupta, R., & Fuchs, E. V. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 995 · see citing works
The Promise and Perils of Wnt Signaling Through β-Catenin
Moon, R. T., Bowerman, B. A., Boutros, M., & Perrimon, N. (2002) · Science · doi:10.1126/science.1071549 · Cited by 970 · see citing works
Molecular Mechanisms Regulating Hair Follicle Development
Millar, S. E. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01670.x · Cited by 967 · see citing works
Rules for Making Human Tumor Cells
Hahn, W. C., & Weinberg, R. A. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021902 · Cited by 951 · see citing works
The secret life of the hair follicle
Hardy, M. H. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90350-d · Cited by 931 · see citing works
Littlewood, T. D., Hancock, D. C., Danielian, P. S., Parker, M. G., & Evan, G. I. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.10.1686 · Cited by 780 · see citing works
Sonic hedgehog signaling is essential for hair development
St‐Jacques, B., Dassule, H. R., Karavanova, I. D., Botchkarev, V. A., Li, J., Danielian, P. S., McMahon, J. A., Lewis, P. M., Paus, R., & McMahon, A. P. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70443-9 · Cited by 764 · see citing works
Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog
Oro, A. E., Higgins, K. M., Hu, Z., Bonifas, J. M., Epstein, E. H., & Scott, M. P. (1997) · Science · doi:10.1126/science.276.5313.817 · Cited by 707 · see citing works
Vasioukhin, V., Degenstein, L., Wise, B., & Fuchs, E. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.15.8551 · Cited by 691 · see citing works
A common human skin tumour is caused by activating mutations in β-catenin
Chan, E., Gat, U., McNiff, J. M., & Fuchs, E. (1999) · Nature Genetics · doi:10.1038/7747 · Cited by 612 · see citing works
Links between signal transduction, transcription and adhesion in epithelial bud development
Jamora, C., DasGupta, R., Kocieniewski, P., & Fuchs, E. V. (2003) · Nature · doi:10.1038/nature01458 · Cited by 567 · see citing works
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skinPreprint
Merrill, B. J., Gat, U., DasGupta, R., & Fuchs, E. V. (2001) · Genes & Development · doi:10.1101/gad.891401 · Cited by 559 · see citing works
New aspects of Wnt signaling pathways in higher vertebrates
Huelsken, J., & Birchmeier, W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00231-8 · Cited by 552 · see citing works
Funayama, N., Fagotto, F., McCrea, P. D., & Gumbiner, B. M. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.5.959 · Cited by 545 · see citing works
Wnt signaling maintains the hair-inducing activity of the dermal papillaPreprint
Kishimoto, J., Burgeson, R. E., & Morgan, B. A. (2000) · Genes & Development · doi:10.1101/gad.14.10.1181 · Cited by 535 · see citing works
Feedback control of intercellular signalling in development
Freeman, M. (2000) · Nature · doi:10.1038/35042500 · Cited by 534 · see citing works
Essential Role forSonic hedgehogduring Hair Follicle Morphogenesis
Chiang, C. C., Swan, R. Z., Grachtchouk, M. A., Bolinger, M., Litingtung, Y., Robertson, E. K., Cooper, M. K., Gaffield, W., Westphal, H., Beachy, P. A., et al. (1999) · Developmental Biology · doi:10.1006/dbio.1998.9103 · Cited by 497 · see citing works
Reddy, S., Andl, T., Bagasra, A., Lu, M. M., Epstein, D. J., Morrisey, E. E., & Millar, S. E. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00452-x · Cited by 489 · see citing works
Programming gene expression in developing epidermis
Byrne, C. R., Tainsky, M. A., & Fuchs, E. V. (1994) · Development · doi:10.1242/dev.120.9.2369 · Cited by 487 · see citing works
Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.Preprint
Zhou, P., Byrne, C. R., Jacobs, J., & Fuchs, E. V. (1995) · Genes & Development · doi:10.1101/gad.9.6.700 · Cited by 474 · see citing works
Lowell, S., Jones, P. H., Roux, I., Dunne, J., & Watt, F. M. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00451-6 · Cited by 443 · see citing works
Self-citationLabbé, E., Letamendı́a, A., & Attisano, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150152697 · Cited by 442 · see citing works
Braun, K. M., Niemann, C., Jensen, U. B., Sundberg, J. P., Silva-Vargas, V., & Watt, F. M. (2003) · Development · doi:10.1242/dev.00703 · Cited by 425 · see citing works
Self-citationKratochwil, K., Dull, M., Fariñas, I., Galcerán, J., & Grosschedl, R. (1996) · Genes & Development · doi:10.1101/gad.10.11.1382 · Cited by 425 · see citing works
Vassar, R. J., Rosenberg, M. J., Ross, S. R., Tyner, A. L., & Fuchs, E. V. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1563 · Cited by 368 · see citing works
Contribution of stem cells and differentiated cells to epidermal tumours
Owens, D. M., & Watt, F. M. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1096 · Cited by 346 · see citing works
Self-citationArnold, I., & Watt, F. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00154-3 · Cited by 341 · see citing works
Self-citationc-Myc promotes differentiation of human epidermal stem cells
Gandarillas, A., & Watt, F. M. (1997) · Genes & Development · doi:10.1101/gad.11.21.2869 · Cited by 326 · see citing works
Self-citationMcGowan, K. M., & Coulombe, P. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.469 · Cited by 319 · see citing works
Wnt/Beta-Catenin/Tcf Signaling: A Critical Pathway in Gastrointestinal Tumorigenesis
Kolligs, F. T., Bommer, G. T., & Göke, B. (2002) · Digestion · doi:10.1159/000066755 · Cited by 312 · see citing works
Carroll, J. M., Romero, M. R., & Watt, F. M. (1995) · Cell · doi:10.1016/0092-8674(95)90211-2 · Cited by 303 · see citing works
Self-citationNiemann, C., Owens, D. M., Hülsken, J., Birchmeier, W., & Watt, F. M. (2002) · Development · doi:10.1242/dev.129.1.95 · Cited by 298 · see citing works
Self-citationTCF/LEF factors earn their wings
Clevers, H. C., & van de Wetering, M. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01305-x · Cited by 292 · see citing works
The ins and outs of APC and β‐catenin nuclear transport
Henderson, B. R., & Fagotto, F. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf181 · Cited by 287 · see citing works
At the Roots of a Never-Ending Cycle
Fuchs, E. V., Merrill, B. J., Jamora, C., & DasGupta, R. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00022-3 · Cited by 272 · see citing works
Stem-cell hierarchy in skin cancer
Pérez‐Losada, J., & Balmain, A. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1095 · Cited by 270 · see citing works
Van Mater, D., Kolligs, F. T., Dlugosz, A. A., & Fearon, E. R. (2003) · Genes & Development · doi:10.1101/gad.1076103 · Cited by 263 · see citing works
Revest, J., Spencer‐Dene, B., Kerr, K., Moerlooze, L. D., Rosewell, I. R., & Dickson, C. (2001) · Developmental Biology · doi:10.1006/dbio.2000.0144 · Cited by 262 · see citing works
Sato, N., Leopold, P. L., & Crystal, R. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7691 · Cited by 253 · see citing works
Stem cell fate and patterning in mammalian epidermis
Watt, F. M. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00211-2 · Cited by 251 · see citing works
Self-citationZhu, A. J., Haase, I., & Watt, F. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6728 · Cited by 245 · see citing works
Self-citationThe secret life of the hair follicle
Hardy, M. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90044-5 · Cited by 244 · see citing works
Wnt-3A/β-Catenin Signaling Induces Transcription from the LEF-1 Promoter
Filali, M. S., Cheng, N., Abbott, D., Leontiev, V. V., & Engelhardt, J. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107977200 · Cited by 241 · see citing works
Zhu, A. J., & Watt, F. M. (1999) · Development · doi:10.1242/dev.126.10.2285 · Cited by 240 · see citing works
Self-citationHair cycle regulation of Hedgehog signal reception
Oro, A. E., & Higgins, K. M. (2003) · Developmental Biology · doi:10.1016/s0012-1606(02)00042-8 · Cited by 228 · see citing works
Damalas, A., Kahan, S., Shtutman, M. S., Ben‐Ze'ev, A., & Oren, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4912 · Cited by 206 · see citing works
TCF: Lady Justice Casting the Final Verdict on the Outcome of Wnt Signalling
Brantjes, H., Barker, N., van Es, J. H., & Clevers, H. C. (2002) · Biological Chemistry · doi:10.1515/bc.2002.027 · Cited by 202 · see citing works
Designer skin: lineage commitment in postnatal epidermis
Niemann, C., & Watt, F. M. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02263-8 · Cited by 201 · see citing works
Self-citationNiemann, C., Undén, A. B., Lyle, S. R., Zouboulis, C. C., Toftgård, R., & Watt, F. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834202100 · Cited by 184 · see citing works
Self-citationEllis, T., Gambardella, L., Horcher, M., Tschanz, S. A., Capol, J., Bertram, P. G., Jochum, W., Barrandon, Y., & Busslinger, M. (2001) · Genes & Development · doi:10.1101/gad.200101 · Cited by 177 · see citing works
Melief, C. J. M. (2003) · European Journal of Immunology · doi:10.1002/eji.200324341 · Cited by 177 · see citing works
Wang, X., Zinkel, S. S., Polonsky, K. S., & Fuchs, E. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.219 · Cited by 160 · see citing works
Zhu, A. J., & Watt, F. M. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.13.3013 · Cited by 159 · see citing works
Self-citationKusakabe, T., Maeda, M., Hoshi, N., Sugino, T., Watanabe, K., Fukuda, T., & Suzuki, T. (2000) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540004800505 · Cited by 157 · see citing works
Filipe, M. I., & Lake, B. D. (1990) · Medical Entomology and Zoology · Cited by 143 · see citing works
O’Guin, W. M., Sun, T., & Manabe, M. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12494172 · Cited by 114 · see citing works
Stem-cell “plasticity”: befuddled by the muddle
Goodell, M. A. (2003) · Current Opinion in Hematology · doi:10.1097/00062752-200305000-00003 · Cited by 106 · see citing works
Callahan, C. A., & Oro, A. E. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00230-6 · Cited by 83 · see citing works
Poulsom, R., Longcroft, J. M., Jeffery, R. E., Rogers, L. A., & Steel, J. H. (1998) · PubMed · Cited by 81 · see citing works
DasGupta, R., Rhee, H. H., & Fuchs, E. V. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200204134 · Cited by 80 · see citing works
p19ARF‐independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes
Roper, E. A., Weinberg, W. C., Watt, F. M., & Land, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve020 · Cited by 59 · see citing works
Self-citationPlastic adult stem cells: will they graduate from the school of hard knocks?
Alison, M. R., Poulsom, R., Otto, W. R., Vig, P., Brittan, M., Direkze, N. C., Preston, S. L., & Wright, N. A. (2003) · Journal of Cell Science · doi:10.1242/jcs.00269 · Cited by 58 · see citing works
Sundberg, J. P., Sundberg, B. A., & Beamer, W. G. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199709)20:1 · Cited by 38 · see citing works
Weng, Z., Xin, M., Pablo, L., Grueneberg, D. A., Hagel, M., Bain, G., Müller, T. H., & Papkoff, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m105331200 · Cited by 35 · see citing works
Cultivation and Retroviral Infection of Human Epidermal Keratinocytes
Watt, F. M., Simon, B. M., & Prowse, D. M. (2006) · Cell Biology · doi:10.1016/b978-012164730-8/50017-4 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
1 of the 80 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Swift, S., Lorens, J., Achacosa, P. and Nolan, G. P. (1999). In Current Protocols in Immunology, vol. 1 (ed. J. E. Coligan, A. M. Kruisbeek, D. H. Marguilies, E. M. Shevach and W. Strober), pp. 17C, 1-17. New York: Wiley.
Cited by
Sorted by citations
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works
Wnt signalling in stem cells and cancer
Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666 · see citing works
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783 · see citing works
Moore, K. A., & Lemischka, I. R. (2006) · Science · doi:10.1126/science.1110542 · Cited by 1,541 · see citing works
Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270 · see citing works
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064 · see citing works
The Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119 · see citing works
Scratching the surface of skin development
Fuchs, E. (2007) · Nature · doi:10.1038/nature05659 · Cited by 930 · see citing works
Epidermal Stem Cells of the Skin
Blanpain, C., & Fuchs, E. V. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104357 · Cited by 845 · see citing works
Hochedlinger, K., Yamada, Y., Beard, C., & Jaenisch, R. (2005) · Cell · doi:10.1016/j.cell.2005.02.018 · Cited by 841 · see citing works
Telomeres and telomerase in cancer
Artandi, S. E., & DePinho, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp268 · Cited by 823 · see citing works
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration
Greco, V., Chen, T., Rendl, M., Schober, M., Pasolli, H. A., Stokes, N., dela Cruz-Racelis, J., & Fuchs, E. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2008.12.009 · Cited by 800 · see citing works
Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
Plikus, M. V., Mayer, J. A., de la Cruz, D., Baker, R. E., Maini, P. K., Maxson, R. E., & Chuong, C. (2008) · Nature · doi:10.1038/nature06457 · Cited by 768 · see citing works
Telomerase modulates Wnt signalling by association with target gene chromatin
Park, J.-I., Venteicher, A. S., Hong, J. Y., Choi, J., Jun, S., Shkreli, M., Chang, W., Meng, Z., Cheung, P., Ji, H., et al. (2009) · Nature · doi:10.1038/nature08137 · Cited by 707 · see citing works
Beyond tumorigenesis: cancer stem cells in metastasis
Li, F., Tiede, B., Massagué, J., & Kang, Y.-B. (2007) · Cell Research · doi:10.1038/sj.cr.7310118 · Cited by 651 · see citing works
Epithelial Stem Cells: Turning over New Leaves
Blanpain, C., Horsley, V., & Fuchs, E. V. (2007) · Cell · doi:10.1016/j.cell.2007.01.014 · Cited by 593 · see citing works
Samuel, M. S., Lopez, J. I., McGhee, E. J., Croft, D. R., Strachan, D., Timpson, P., Munro, J., Schröder, E., Zhou, J., Brunton, V. G., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.008 · Cited by 542 · see citing works
Alonso, L. C., & Fuchs, E. V. (2006) · Journal of Cell Science · doi:10.1242/jcs.02793 · Cited by 557 · see citing works
Androgenetic alopecia: a review
Lolli, F., Pallotti, F., Rossi, A., Fortuna, M. C., Caro, G., Lenzi, A., Sansone, A., & Lombardo, F. P. (2017) · Endocrine · doi:10.1007/s12020-017-1280-y · Cited by 539 · see citing works
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
Martínez, P., & Blasco, M. A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3025 · Cited by 530 · see citing works
Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis
Jensen, K. B., Collins, C. A., Nascimento, E. M., Tan, D. W., Frye, M., Itami, S., & Watt, F. M. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.04.014 · Cited by 523 · see citing works
Self-citationCancer stem cells versus phenotype‐switching in melanoma
Hoek, K. S., & Goding, C. R. (2010) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2010.00757.x · Cited by 494 · see citing works
Epithelial stem cells, wound healing and cancer
Arwert, E. N., Hoste, E., & Watt, F. M. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3217 · Cited by 442 · see citing works
Self-citationSkin stem cells: rising to the surface
Fuchs, E. V. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708185 · Cited by 431 · see citing works
Vidal, V., Chaboissier, M., Lützkendorf, S., Cotsarelis, G., Mill, P., Hui, C., Ortonne, N., Ortonne, J. P., & Schedl, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.064 · Cited by 427 · see citing works
β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
Enshell‐Seijffers, D., Lindon, C., Kashiwagi, M., & Morgan, B. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.01.016 · Cited by 408 · see citing works
NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells
Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H., & Fuchs, E. (2008) · Cell · doi:10.1016/j.cell.2007.11.047 · Cited by 424 · see citing works
β-catenin activation is necessary and sufficient to specify the dorsal dermal fate in the mouse
Atit, R., Sgaier, S. K., Mohamed, O. A., Taketo, M. M., Dufort, D., Joyner, A. L., Niswander, L., & Conlon, R. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.449 · Cited by 400 · see citing works
“…Wnt signal transduction in the epidermis is necessary for the development of hair and feathers (Chang et al., 2004; Huelsken et al., 2001; Lo Celso et al., 2004; Silva-Vargas et al., 2005), and it has been suggested that the dermal condensations participating in early stages of hair…”
BackgroundSignaling Involved in Hair Follicle Morphogenesis and Development
Pisal, R. V., Dev, K., Diaz, D. C., Qureshi, W. M. S., Filip, S., & Mokrý, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15011647 · Cited by 391 · see citing works
Defining the impact of β-catenin/Tcf transactivation on epithelial stem cellsPreprint
Lowry, W. E., Blanpain, C., Nowak, J. A., Guasch, G., Lewis, L. E., & Fuchs, E. V. (2005) · Genes & Development · doi:10.1101/gad.1324905 · Cited by 392 · see citing works
Mesenchymal–epithelial interactions during hair follicle morphogenesis and cycling
Sennett, R., & Rendl, M. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.011 · Cited by 387 · see citing works
Continuous tooth generation in mouse is induced by activated epithelial Wnt/β-catenin signaling
Järvinen, E., Salazar‐Ciudad, I., Birchmeier, W., Taketo, M. M., Jernvall, J., & Thesleff, I. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607289103 · Cited by 379 · see citing works
Choi, J., Southworth, L. K., Sarin, K. Y., Venteicher, A. S., Ma, W., Chang, W., Cheung, P., Jun, S., Artandi, M. K., Shah, N., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.0040010 · Cited by 336 · see citing works
In search of the “hair cycle clock”: a guided tour
Paus, R., & Foitzik, K. (2004) · Differentiation · doi:10.1111/j.1432-0436.2004.07209004.x · Cited by 324 · see citing works
The Basement Membrane of Hair Follicle Stem Cells Is a Muscle Cell Niche
Fujiwara, H., Ferreira, M. M., Donati, G., Marciano, D. K., Linton, J. M., Sato, Y., Hartner, A., Sekiguchi, K., Reichardt, L. F., & Watt, F. M. (2011) · Cell · doi:10.1016/j.cell.2011.01.014 · Cited by 317 · see citing works
Self-citationA family business: stem cell progeny join the niche to regulate homeostasis
Hsu, Y., & Fuchs, E. V. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3272 · Cited by 307 · see citing works
Bisson, I., & Prowse, D. M. (2009) · Cell Research · doi:10.1038/cr.2009.43 · Cited by 309 · see citing works
Self-citationRegeneration of Dermis: Scarring and Cells Involved
Rippa, A. L., Kalabusheva, E. P., & Vorotelyak, E. A. (2019) · Cells · doi:10.3390/cells8060607 · Cited by 301 · see citing works
Catenins: Keeping Cells from Getting Their Signals Crossed
Pérez‐Moreno, M., & Fuchs, E. V. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.010 · Cited by 295 · see citing works
Tcf3 Governs Stem Cell Features and Represses Cell Fate Determination in Skin
Nguyen, H., Rendl, M., & Fuchs, E. V. (2006) · Cell · doi:10.1016/j.cell.2006.07.036 · Cited by 287 · see citing works
Wnt signalling: variety at the core
Hoppler, S., & Kavanagh, C. (2007) · Journal of Cell Science · doi:10.1242/jcs.03363 · Cited by 279 · see citing works
Wnt Signaling in Skin Development, Homeostasis, and Disease
Lim, X., & Nusse, R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008029 · Cited by 268 · see citing works
Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis
Estrach, S., Ambler, C. A., Celso, C. L., Hozumi, K., & Watt, F. M. (2006) · Development · doi:10.1242/dev.02644 · Cited by 254 · see citing works
Self-citationComparative regenerative mechanisms across different mammalian tissues
Iismaa, S. E., Kaidonis, X., Nicks, A. M., Bogush, N., Kikuchi, K., Naqvi, N., Harvey, R. P., Husain, A., & Graham, R. M. (2018) · npj Regenerative Medicine · doi:10.1038/s41536-018-0044-5 · Cited by 256 · see citing works
Morgan, B. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015180 · Cited by 243 · see citing works
Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration
Myung, P. S., Takeo, M., Ito, M., & Atit, R. P. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.230 · Cited by 242 · see citing works
Silva-Vargas, V., Celso, C. L., Giangreco, A., Ofstad, T. A., Prowse, D. M., Braun, K. M., & Watt, F. M. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.013 · Cited by 237 · see citing works
Self-citationWnt/beta-Catenin Signaling and Small Molecule Inhibitors
Voronkov, A. E., & Krauss, S. J. K. (2012) · Current Pharmaceutical Design · doi:10.2174/138161213804581837 · Cited by 224 · see citing works
Wnt signaling through canonical and non-canonical pathways: Recent progress
Widelitz, R. B. (2005) · Growth Factors · doi:10.1080/08977190500125746 · Cited by 218 · see citing works
Nijhof, J. G. W., Braun, K. M., Giangreco, A., van Pelt, C., Kawamoto, H., Boyd, R. L., Willemze, R., Mullenders, L. H. F., Watt, F. M., de Gruijl, F. R., et al. (2006) · Development · doi:10.1242/dev.02443 · Cited by 211 · see citing works
Self-citationThe Hair Follicle as an Estrogen Target and Source
Ohnemus, U., Uenalan, M., Inzunza, J., Gustafsson, J.-A., & Paus, R. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0020 · Cited by 205 · see citing works
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
Nguyen, H., Merrill, B. J., Polak, L., Nikolova, M., Rendl, M., Shaver, T. M., Pasolli, H. A., & Fuchs, E. V. (2009) · Nature Genetics · doi:10.1038/ng.431 · Cited by 201 · see citing works
Yang, S. H., Andl, T., Grachtchouk, V., Wang, A., Liu, J., Syu, L.-J., Ferris, J., Wang, T. S., Glick, A. B., Millar, S. E., et al. (2008) · Nature Genetics · doi:10.1038/ng.192 · Cited by 195 · see citing works
Activation of β-catenin signaling programs embryonic epidermis to hair follicle fate
Zhang, Y., Andl, T., Yang, S. H., Teta, M., Liu, F., Seykora, J. T., Tobias, J. W., Piccolo, S., Schmidt‐Ullrich, R., Nagy, A., et al. (2008) · Development · doi:10.1242/dev.017459 · Cited by 193 · see citing works
The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate
Blanco, S., Kurowski, A., Nichols, J., Watt, F. M., Benitah, S. A., & Frye, M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002403 · Cited by 193 · see citing works
Self-citationMacrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells
Castellana, D., Paus, R., & Pérez‐Moreno, M. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1002002 · Cited by 189 · see citing works
Epidermal stem cell diversity and quiescence
Watt, F. M., & Jensen, K. B. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900033 · Cited by 187 · see citing works
Self-citationHairy tale of signaling in hair follicle development and cycling
Lee, J., & Tumbar, T. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.003 · Cited by 188 · see citing works
What does the concept of the stem cell niche really mean today?
Lander, A. D., Kimble, J. E., Clevers, H. C., Fuchs, E. V., Montarras, D., BUCKINGHAM, M. E., Calof, A. L., Trumpp, A., & Óskarsson, T. (2012) · BMC Biology · doi:10.1186/1741-7007-10-19 · Cited by 175 · see citing works
Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately
Shi, Y., Shu, B., Yang, R., Xu, Y., Xing, B., Liu, J., Chen, L., Qi, S., Liu, X., Wang, P., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0103-4 · Cited by 179 · see citing works
Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis
Clayton, R. W., Göbel, K., Niessen, C. M., Paus, R., Steensel, M. A. M. V., & Lim, X. (2019) · British Journal of Dermatology · doi:10.1111/bjd.17981 · Cited by 181 · see citing works
Lung Cancer and Lung Stem Cells
Giangreco, A., Groot, K. R., & Janes, S. M. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200607-984pp · Cited by 170 · see citing works
Kim, H., Wu, J., Ye, S., Tai, C.-I., Zhou, X., Yan, H., Li, P., Pera, M. F., & Ying, Q.-L. (2013) · Nature Communications · doi:10.1038/ncomms3403 · Cited by 165 · see citing works
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
Espada, J., Varela, I., Flores, I., Ugalde, A. P., Cadiñanos, J., Pendás, A. M., Stewart, C. L., Tryggvason, K., Blasco, M. A., Freije, J. M. P., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801096 · Cited by 163 · see citing works
Teulière, J., Faraldo, M. M., Deugnier, M., Shtutman, M. S., Ben‐Ze'ev, A., Thiery, J. P., & Glukhova, M. A. (2004) · Development · doi:10.1242/dev.01583 · Cited by 162 · see citing works
Wnt signaling induces epithelial differentiation during cutaneous wound healing
Fathke, C., Wilson, L., Shah, K. V., Kim, B., Hocking, A. M., Moon, R. T., & Isik, F. F. (2006) · BMC Cell Biology · doi:10.1186/1471-2121-7-4 · Cited by 161 · see citing works
Rogers, G. E. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00512.x · Cited by 160 · see citing works
Dissecting the Heterogeneity of Skin Gene Expression Patterns in Systemic Sclerosis
Assassi, S., Swindell, W. R., Wu, M., Tan, F., Khanna, D., Furst, D. E., Tashkin, D. P., Jahan-Tigh, R. R., Mayes, M. D., Gudjonsson, J. E., et al. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39289 · Cited by 152 · see citing works
Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin
Collins, C. A., Kretzschmar, K., & Watt, F. M. (2011) · Development · doi:10.1242/dev.064592 · Cited by 152 · see citing works
Self-citationMaintenance and Repair of the Bronchiolar Epithelium
Stripp, B. R., & Reynolds, S. D. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200711-167dr · Cited by 151 · see citing works
Correction of aberrant growth preserves tissue homeostasis
Brown, S., Pineda, C. M., Xin, T., Boucher, J. D., Suozzi, K. C., Park, S., Matte-Martone, C. C., Gonzalez, D. G., Rytlewski, J. A., Beronja, S., et al. (2017) · Nature · doi:10.1038/nature23304 · Cited by 151 · see citing works
Donati, G., Proserpio, V., Lichtenberger, B. M., Natsuga, K., Sinclair, R. D., Fujiwara, H., & Watt, F. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312880111 · Cited by 149 · see citing works
Self-citationHairless triggers reactivation of hair growth by promoting Wnt signaling
Beaudoin, G. M. J., Sisk, J. M., Coulombe, P. A., & Thompson, C. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507609102 · Cited by 149 · see citing works
Vitamin D receptor is essential for normal keratinocyte stem cell function
Cianferotti, L., Cox, M. K., Skorija, K., & Demay, M. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702884104 · Cited by 148 · see citing works
Wnt/β-catenin signaling in adult mammalian epithelial stem cells
Kretzschmar, K., & Clevers, H. C. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.05.015 · Cited by 144 · see citing works
Lin, W., Xiang, L., Shi, H., Zhang, J., Jiang, L., Cai, P., Lin, Z., Lin, B., Huang, Y., Zhang, H., et al. (2015) · BioMed Research International · doi:10.1155/2015/730139 · Cited by 146 · see citing works
Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells
Veltri, A., Lang, C. M. R., & Lien, W. (2017) · Stem Cells · doi:10.1002/stem.2723 · Cited by 147 · see citing works
Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation
Rognoni, E., Widmaier, M., Jakobson, M., Ruppert, R., Ussar, S., Katsougkri, D., Böttcher, R. T., Lai-Cheong, J. E., Rifkin, D. B., McGrath, J. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3490 · Cited by 140 · see citing works
Pálmer, H. G., Anjos‐Afonso, F., Carmeliet, G., Takeda, H., & Watt, F. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001483 · Cited by 140 · see citing works
Self-citationRognoni, E., Gomez, C., Pisco, A. O., Rawlins, E. L., Simons, B. D., Watt, F. M., & Driskell, R. R. (2016) · Development · doi:10.1242/dev.131797 · Cited by 137 · see citing works
Self-citationThe Development of Archosaurian First-Generation Teeth in a Chicken Mutant
Harris, M. P., Hasso, S. M., Ferguson, M. W. J., & Fallon, J. F. (2006) · Current Biology · doi:10.1016/j.cub.2005.12.047 · Cited by 132 · see citing works
Conditional Stabilization ofβ-Catenin Expands the Pool of Lung Stem Cells
Reynolds, S. D., Zemke, A. C., Giangreco, A., Brockway, B., Teisanu, R. M., Drake, J. A., Mariani, T. J., Di, Y. P., Taketo, M. M., & Stripp, B. R. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0053 · Cited by 132 · see citing works
Närhi, K. M., Järvinen, E., Birchmeier, W., Taketo, M. M., Mikkola, M. L., & Thesleff, I. (2008) · Development · doi:10.1242/dev.016550 · Cited by 132 · see citing works
Modulation of Hair Growth with Small Molecule Agonists of the Hedgehog Signaling Pathway
Paladini, R. D., Saleh, J., Qian, C., Xu, G.-X., & Rubin, L. L. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23867.x · Cited by 130 · see citing works
Pearton, D. J., Yang, Y., & Dhouailly, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500344102 · Cited by 129 · see citing works
Miller, S. J., Lavker, R. M., & Sun, T. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.07.003 · Cited by 128 · see citing works
Celso, C. L., Berta, M., Braun, K. M., Frye, M., Lyle, S. R., Zouboulis, C. C., & Watt, F. M. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0651 · Cited by 120 · see citing works
Self-citationNeuroendocrinology and neurobiology of sebaceous glands
Clayton, R. W., Langan, E. A., Ansell, D. M., de Vos, I. J. H. M., Göbel, K., Schneider, M. R., Picardo, M., Lim, X., Steensel, M. A. M. V., & Paus, R. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12579 · Cited by 123 · see citing works
β-Catenin Activation Regulates Tissue Growth Non–Cell Autonomously in the Hair Stem Cell Niche
Deschene, E. R., Myung, P. S., Rompolas, P., Zito, G., Sun, T. Y., Taketo, M. M., Saotome, I., & Greco, V. (2014) · Science · doi:10.1126/science.1248373 · Cited by 117 · see citing works
Lichtenberger, B. M., Mastrogiannaki, M., & Watt, F. M. (2016) · Nature Communications · doi:10.1038/ncomms10537 · Cited by 117 · see citing works
Self-citationPark, H.-J., Zhang, N., & Park, D. K. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.03.028 · Cited by 116 · see citing works
Immune modulation of hair follicle regeneration
Rahmani, W. M., Sinha, S., & Biernaskie, J. A. (2020) · npj Regenerative Medicine · doi:10.1038/s41536-020-0095-2 · Cited by 113 · see citing works
Gomez, C., Chua, W., Miremadi, A., Quist, S., Headon, D. J., & Watt, F. M. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.04.001 · Cited by 107 · see citing works
Self-citationRegenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4
Chen, C., Murray, P. J., Jiang, T. X., Plikus, M. V., Chang, Y.-T., Lee, O. K., Widelitz, R. B., & Chuong, C. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.139 · Cited by 107 · see citing works
Development and Homeostasis of the Skin EpidermisPreprint
Sotiropoulou, P., & Blanpain, C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008383 · Cited by 103 · see citing works
Richman, J. M., & Handrigan, G. R. (2011) · genesis · doi:10.1002/dvg.20721 · Cited by 103 · see citing works
Collins, C. A., & Watt, F. M. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.08.034 · Cited by 99 · see citing works
Self-citationHair growth-promoting activity of hot water extract of Thuja orientalis
Zhang, N., Park, D. K., & Park, H.-J. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-9 · Cited by 97 · see citing works
Kandyba, E. E., & Kobielak, K. (2013) · Stem Cells · doi:10.1002/stem.1599 · Cited by 95 · see citing works
Petersson, M., Brylka, H., Kraus, A., John, S., Rappl, G., Schettina, P., & Niemann, C. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.199 · Cited by 93 · see citing works
- Authors
- Celso, C. L., Prowse, D. M., & Watt, F. M.
- Affiliations
- Cancer Research UK (GB)
- Corresponding author
- Watt, Fiona M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-04-15
- Volume
- 131
- Issue
- 8
- Pages
- 1787-1799
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1980344438
- Cited by
- 339
- References
- 80
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 7 · 2020: 12 · 2019: 10 · 2018: 11 · 2017: 24 · 2016: 7 · 2015: 10 · 2014: 19 · 2013: 20 · 2012: 25
- FWCI
- 19.86
- Type
- journal article
- Language
- en
- Open access
- green
- uhra.herts.ac.uk
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion)
- Funders
- Cancer Research UK
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- β-catenin signaling, hair follicle regeneration, epidermis, lineage conversion, trichofolliculoma, hair follicle tumor, sebaceous glands, Sonic hedgehog, Patched, 4-hydroxytamoxifen, keratin 14 promoter, tumor regression
- MeSH terms
- Animals, Cytoskeletal Proteins, Epidermis, Mice, Transgenic, Promoter Regions, Genetic, Skin Neoplasms, Time Factors, Signal Transduction, Trans-Activators, Hair Follicle, beta Catenin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
