The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
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“elimination of p53 aggravates the phenotypes of some progeroid mutant mice”
From The Hallmarks of Aging (2013) · cites this paper as Ruzankina et al., 2009
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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232
Senescence of Activated Stellate Cells Limits Liver Fibrosis
Krizhanovsky, V., Yon, M., Dickins, R. A., Hearn, S., Simon, J., Miething, C., Yee, H., Zender, L., & Lowe, S. W. (2008) · Cell · doi:10.1016/j.cell.2008.09.015 · Cited by 2,027
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459
ATR and ATRIP: Partners in Checkpoint Signaling
Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985
Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80762-x · Cited by 979
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951
Self-citationSenescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
Brown, E. J., & Baltimore, D. (2003) · Genes & Development · doi:10.1101/gad.1067403 · Cited by 511
Self-citationDelayed ageing through damage protection by the Arf/p53 pathway
Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302 · cited 1×
“Occupancy of tissues by genetically unstable cells might delay tissue renewal either by obstructing competent progenitors from interacting with key environmental cues or by causing the generation of secreted factor”
Flagged first, then by citations
Research works printed but not linked: 18
- Wlodarski, P. et al. Role of p53 in hematopoietic recovery after cytotoxic treatment. Blood 91, 2998–3006 (1998). · DOI
- Frank, K.M. et al. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol. Cell 5, 993–1002 (2000). · DOI
- Gao, Y. et al. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature 404, 897–900 (2000). · DOI
- Hakem, R., de la Pompa, J.L., Elia, A., Potter, J. & Mak, T.W. Partial rescue of Brca1 (5–6) early embryonic lethality by p53 or p21 null mutation. Nat. Genet. 16, 298–302 (1997). · DOI
- Lim, D.S. & Hasty, P. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol. Cell. Biol. 16, 7133–7143 (1996). · DOI
- Lim, D.S. et al. Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol. Cell. Biol. 20, 3772–3780 (2000). · DOI
- Xu, Y., Yang, E.M., Brugarolas, J., Jacks, T. & Baltimore, D. Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm−/− mice. Mol. Cell. Biol. 18, 4385–4390 (1998). · DOI
- Xu, X. et al. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat. Genet. 28, 266–271 (2001). · DOI
- Botchkarev, V.A. et al. p53 is essential for chemotherapy-induced hair loss. Cancer Res. 60, 5002–5006 (2000).
- Orii, K.E., Lee, Y., Kondo, N. & McKinnon, P.J. Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc. Natl. Acad. Sci. USA 103, 10017–10022 (2006). · DOI
- Maier, B. et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev. 18, 306–319 (2004). · DOI · Paper page
- Paulsen, R.D. & Cimprich, K.A. The ATR pathway: fine-tuning the fork. DNA Repair (Amst.) 6, 953–966 (2007). · DOI
- Ruzankina, Y. et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 1, 113–126 (2007). · DOI
- Zhou, B.B. & Bartek, J. Targeting the checkpoint kinases: chemosensitization versus chemoprotection. Nat. Rev. Cancer 4, 216–225 (2004). · DOI
- Nghiem, P., Park, P.K., Kim Ys, Y.S., Desai, B.N. & Schreiber, S.L. ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J. Biol. Chem. 277, 4428–4434 (2002). · DOI
- Morris, R.J. et al. Capturing and profiling adult hair follicle stem cells. Nat. Biotechnol. 22, 411–417 (2004). · DOI · Paper page
- Greco, V. et al. A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell 4, 155–169 (2009). · DOI · Paper page
- Blanpain, C., Lowry, W.E., Geoghegan, A., Polak, L. & Fuchs, E. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118, 635–648 (2004). · DOI · Paper page
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Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Causes and consequences of replication stress
Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079
Toledo, L. I., Murga, M., Zur, R., Soria, R., Rodriguez, A., Martinez, S., Oyarzabal, J., Pastor, J., Bischoff, J. R., & Fernandez-Capetillo, O. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2076 · Cited by 465
Mechanisms that Regulate Stem Cell Aging and Life Span
Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.001 · Cited by 320
Metadata
- Authors
- Ruzankina, Y., Schoppy, D. W., Asare, A., Clark, C. E., Vonderheide, R. H., & Brown, E. J.
- Venue
- Nature Genetics
- Published
- 2009-08-30
- Volume
- 41
- Issue
- 10
- Pages
- 1144-1149
- ISSN
- 1061-4036
- 1546-1718
- PMC
- PMC2823374
- Cited by
- 97
- References
- 15
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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