A mouse model for Zellweger syndrome

Regulation of the mevalonate pathway

Goldstein, J. L., & Brown, M. S. (1990) · Nature · doi:10.1038/343425a0 · Cited by 5,394 · see citing works

Role of insulin-like growth factors in embryonic and postnatal growth

Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463 · see citing works

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281 · see citing works

Rapid separation of lipid classes in high yield and purity using bonded phase columns.

Kaluzny, M., Duncan, L. A., Merritt, M. V., & Epps, D. E. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34412-6 · Cited by 964 · see citing works

IGF-I is required for normal embryonic growth in mice.Preprint

Powell-Braxton, L., Hollingshead, P. G., Warburton, C., Dowd, M., Pitts-Meek, S., Dalton, D. K., Gillett, N. A., & Stewart, T. A. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2609 · Cited by 795 · see citing works

Peroxisomal and Mitochondrial Defects in the Cerebro-Hepato-Renal Syndrome

Goldfischer, S. L., Moore, C. L., Johnson, T., Spiro, A. J., Valsamis, M. P., Wisniewski, H. K., Ritch, R. H., Norton, W. T., Rapin, I., & Gartner, L. M. (1973) · Science · doi:10.1126/science.182.4107.62 · Cited by 791 · see citing works

The Metabolic Basis of Inherited Disease

Garland, J. T. (1990) · JAMA · doi:10.1001/jama.1990.03440180133052 · Cited by 658 · see citing works

Human PEX7 encodes the peroxisomal PTS2 receptor and is responsible for rhizomelic chondrodysplasia punctata

Braverman, N., Steel, G., Obie, C., Moser, A. B., Moser, H. W., Gould, S. J., & Valle, D. L. (1997) · Nature Genetics · doi:10.1038/ng0497-369 · Cited by 433 · see citing works

Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders

Dodt, G., Braverman, N., Wong, C., Moser, A. B., Moser, H. W., Watkins, P. A., Valle, D. L., & Gould, S. J. (1995) · Nature Genetics · doi:10.1038/ng0295-115 · Cited by 424 · see citing works

Peroxisomal Lipid Metabolism

Reddy, J. K., & Mannaerts, G. P. (1994) · Annual Review of Nutrition · doi:10.1146/annurev.nu.14.070194.002015 · Cited by 418 · see citing works

Protein Import into Peroxisomes and Biogenesis of the Organelle

Subramani, S. E. (1993) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.09.110193.002305 · Cited by 416 · see citing works

A unified nomenclature for peroxisome biogenesis factors.

Distel, B., Erdmann, R., Gould, S. J., Blobel, G., Crane, D. I., Cregg, J. M., Dodt, G., Fujiki, Y., Goodman, J. M., Just, W. W., et al. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.1.1 · Cited by 414 · see citing works

Techniques in diagnostic human biochemical genetics: A laboratory manual

Strange, R. C. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81025-h · Cited by 413 · see citing works

Severe plasmalogen deficiency in tissues of infants without peroxisomes (Zellweger syndrome)

Heymans, H. S. A., Schutgens, R. B. H., Tan, R., van den BOSCH, H., & Borst, P. (1983) · Nature · doi:10.1038/306069a0 · Cited by 348 · see citing works

Plasminogen activator inhibitor-1 gene-deficient mice. I. Generation by homologous recombination and characterization.

Carmeliet, P., Kieckens, L., Schoonjans, L., Neugeboren, B. I., Nuffelen, A. V., Prendergast, G. C., Cole, M. D., Bronson, R. T., Collen, D., & Mulligan, R. C. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116892 · Cited by 345 · see citing works

CYTOCHEMICAL LOCALIZATION OF PEROXIDATIC ACTIVITY OF CATALASE IN RAT HEPATIC MICROBODIES (PEROXISOMES)

Fahimi, H. D. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.43.2.275 · Cited by 290 · see citing works

Disorders of peroxisome biogenesis

Braverman, N., Dodt, G., Gould, S., & Valle, D. L. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.suppl_1.1791 · Cited by 283 · see citing works

Rhizomelic chondrodysplasia punctata is a peroxisomal protein targeting disease caused by a non-functional PTS2 receptor

Motley, A. M., Hettema, E. H., Hogenhout, E. M., Brites, P., ten Asbroek, A. L. M. A., Wijburg, F. A., Baas, F., Heijmans, H. S. A., Tabak, H. F., Wanders, R. J. A., et al. (1997) · Nature Genetics · doi:10.1038/ng0497-377 · Cited by 271 · see citing works

Rhizomelic chondrodysplasia punctata is caused by deficiency of human PEX7, a homologue of the yeast PTS2 receptor

Purdue, P. E., Zhang, J. W., Skoneczny, M., & Lazarow, P. B. (1997) · Nature Genetics · doi:10.1038/ng0497-381 · Cited by 265 · see citing works

Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.

Wiemer, E. A. C., Nuttley, W. M., Bertolaet, B. L., Li, X., Francke, U., Wheelock, M. J., Anné, U. K., Johnson, K. R., & Subramani, S. E. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.1.51 · Cited by 185 · see citing works

The mechanism of arrest of neuronal migration in the Zellweger malformation: An hypothesis based upon cytoarchitectonic analysis

Evrard, P., Caviness, V. S., Prats-Vinas, J., & Lyon, G. (1978) · Acta Neuropathologica · doi:10.1007/bf00689761 · Cited by 175 · see citing works

Identification and Characterization of the Putative Human Peroxisomal C-terminal Targeting Signal Import Receptor

Fransen, M., Brees, C., Baumgart‐Vogt, E., VANHOOREN, J. C. T., Baes, M. I., Mannaerts, G. P., & Veldhoven, P. P. V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7731 · Cited by 174 · see citing works

Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultured human adherent cells

Veldhoven, P. P. V., & Bell, R. M. (1988) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(88)90030-6 · Cited by 155 · see citing works

The Tetratricopeptide Repeat Domain of the PAS10 Protein of Saccharomyces cerevisiae Is Essential for Binding the Peroxisomal Targeting Signal -SKL

Brocard, C., Kragler, F., Simon, M. M., Schuster, T., & Hartig, A. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2564 · Cited by 142 · see citing works

Mevalonic Acid Is Limiting for N-Linked Glycosylation and Translocation of the Insulin-like Growth Factor-1 Receptor to the Cell Surface

Carlberg, M., Dricu, A., Blegen, H., Wang, M., Hjertman, M., Zickert, P., Höög, A., & Larsson, O. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17453 · Cited by 136 · see citing works

Cerebro-hepato-renal syndrome

Passarge, E., & McAdams, A. J. (1967) · The Journal of Pediatrics · doi:10.1016/s0022-3476(67)80205-1 · Cited by 135 · see citing works

Peroxisomes: Biology and Importance in Toxicology and Medicine

Lake, R. (2007) · Cited by 131 · see citing works

Identification of three distinct peroxisomal protein import defects in patients with peroxisome biogenesis disorders

Slawecki, M. L., Dodt, G., Steinberg, S., Moser, A. B., Moser, H. W., & Gould, S. J. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.5.1817 · Cited by 120 · see citing works

Differential protein import deficiencies in human peroxisome assembly disorders.

Motley, A. M., Hettema, E. H., Distel, B., & Tabak, H. F. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.125.4.755 · Cited by 118 · see citing works

Protein Translocation into Peroxisomes

Subramani, S. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32483 · Cited by 94 · see citing works

Presence of peroxisomal membrane proteins in liver and fibroblasts from patients with the Zellweger syndrome and related disorders: evidence for the existence of peroxisomal ghosts.

Wiemer, E. A. C., Brul, S., Ww, J., DRIEL, R. V., Brouwer-Kelder, E. M., van den Berg, M., Weijers, P. J., Schutgens, R. B. H., van den BOSCH, H., & Schram, A. W. (1989) · PubMed · Cited by 81 · see citing works

Peroxisomes : biology and role in toxicology and disease

Reddy, J. K., Suga, T., Mannaerts, G. P., Lazarow, P. B., & Subramani, S. E. (1996) · New York Academy of Sciences eBooks · Cited by 72 · see citing works

The pathology of peroxisomal disorders with pathogenetic considerations.

Powers, J. M. (1995) · PubMed · Cited by 72 · see citing works

PRESIDENTIAL ADDRESS: The Pathology of Peroxisomal Disorders with Pathogenetic Considerations

Powers, J. M. (1995) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199509000-00014 · Cited by 67 · see citing works

Histochemical characteristics of the striated inclusions of adrenoleukodystrophy

Johnson, A. B., Schaumburg, H. H., & Powers, J. M. (1976) · Journal of Histochemistry & Cytochemistry · doi:10.1177/24.6.59773 · Cited by 66 · see citing works

Biogenesis of peroxisomes: immunocytochemical investigation of peroxisomal membrane proteins in proliferating rat liver peroxisomes and in catalase-negative membrane loops.

Baumgart‐Vogt, E., Völkl, A., Hashimoto, T., & Fahimi, H. D. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.6.2221 · Cited by 65 · see citing works

Mitochondrial and peroxisomal beta oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver.

Vanhove, G. F., Veldhoven, P. P. V., Vanhoutte, F., Parmentier, G. G., Eyssen, H., & Mannaerts, G. P. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54282-4 · Cited by 59 · see citing works

Early Neurogenesis and Teratogenesis in Whole Mouse Embryo Cultures. Histochemical, Immunocytological and Ultrastructural Study of the Premigratory Neuronal-glial Units in Normal Mouse Embryo and in Mouse Embryos Influenced by Cocaine and Retinoic Acid

Gressèns, P., Gofflot, F., Maele‐Fabry, G. V., Misson, J., Gadisseux, J., Evrard, P., & PICARD, J. J. (1992) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199203000-00010 · Cited by 56 · see citing works

Electron Microscopic Cytochemistry and Immunocytochemistry in Biomedicine

Ogawa, K., & Barka, T. (1992) · Cited by 53 · see citing works

Structural and Chemical Alterations in the Cerebral Maldevelopment of Fetal Cerebro-Hepato-Renal (Zellweger) Syndrome

Powers, J. M., Tummons, R. C., Caviness, V. S., Moser, A. B., & Moser, H. W. (1989) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198905000-00005 · Cited by 49 · see citing works

A method for the quantitative determination of glycerolipids containing O-alkyl and O-alk-1-enyl moieties

Blank, M. L., Cress, E. A., Piantadosi, C. A., & Snyder, F. F. C. (1975) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(75)90007-7 · Cited by 48 · see citing works

CEREBRO-HEPATO-RENAL SYNDROME. REPORT OF A CASE WITH HISTOCHEMICAL AND ULTRASTRUCTURAL OBSERVATIONS

Agamanolis, D. P., Robinson, H. B., & TIMMONS, G. D. (1976) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197605000-00002 · Cited by 47 · see citing works

Immunolocalization of a 43 kDa peroxisomal membrane protein in the liver of patients with generalized peroxisomal disorders.

Espeel, M., Roels, F., Girós, M., Mandel, H., Peltier, A., Poggi, F., Poll‐The, B. T., Smeitink, J. A. M., Maldergem, L. V., & Santos, M. J. (1995) · PubMed · Cited by 21 · see citing works

The Visualization of Peroxisomal Proteins Containing a C-Terminal Targeting Sequence on Western Blot by Using the Biotinylated PTS1-Receptor

Fransen, M., Brees, C., Veldhoven, P. P. V., & Mannaerts, G. P. (1996) · Analytical Biochemistry · doi:10.1006/abio.1996.0423 · Cited by 16 · see citing works

Activity measurements of acyl‐CoA oxidases in human liver

Veldhoven, P. P. V. (1995) · Journal of Inherited Metabolic Disease · doi:10.1007/bf00711435 · Cited by 14 · see citing works

Morphology of Peroxisomes in Light- and Electron Microscopy

Baumgart‐Vogt, E. (1994) · Springer eBooks · doi:10.1007/978-3-642-87807-7_4 · Cited by 11 · see citing works

Cell and tissue heterogeneity in peroxisomal patients

Roels, F., Espeel, M., Mandel, H., Poggi, F., Smeitink, J. A. M., Toorman, J., Kerckaert, I., Poll‐The, B. T., Schutgens, R. B. H., Wanders, R., et al. (1995) · Ghent University Academic Bibliography (Ghent University) · Cited by 11 · see citing works

Assay of dihydroxyacetone phosphate acyltransferase with 32P-labeled substrate

Jones, K. M., & Hajra, A. K. (1994) · Clinical Chemistry · doi:10.1093/clinchem/40.6.946 · Cited by 9 · see citing works

Functions and biogenesis of peroxisomes in relation to human disease

Wanders, R. J. A., Schutgens, R. B. H., Tabak, H. F., & van Wetenschappen, K. N. A. (1995) · North-Holland eBooks · Cited by 8 · see citing works

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

Ishihara, N., Nomura, M., Jofuku, A., Kato, H., Suzuki, S. O., Masuda, K., Otera, H., Nakanishi, Y., Nonaka, I., Goto, Y.-I., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1907 · Cited by 1,066 · see citing works

Biochemistry of mammalian peroxisomes revisited

Wanders, R. J. A., & Waterham, H. R. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133329 · Cited by 995 · see citing works

Peroxisomes and oxidative stress

Schrader, M., & Fahimi, H. D. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.09.006 · Cited by 838 · see citing works

CENTRAL NERVOUS SYSTEM NEURONAL MIGRATION

Hatten, M. E. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.511 · Cited by 797 · see citing works

Role of peroxisomes in ros/rns-metabolism: Implications for human disease

Fransen, M., Nordgren, M., Wang, B., & Apanasets, O. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.001 · Cited by 644 · see citing works

Functions and biosynthesis of plasmalogens in health and disease

Brites, P., Waterham, H. R., & Wanders, R. J. A. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2003.12.010 · Cited by 415 · see citing works

Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes

Kassmann, C. M., Lappe-Siefke, C., Baes, M., Brügger, B., Mildner, A., Werner, H. B., Natt, O., Michaelis, T., Prinz, M., Frahm, J., et al. (2007) · Nature Genetics · doi:10.1038/ng2070 · Cited by 357 · see citing works

Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

Veldhoven, P. P. V. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r005959 · Cited by 328 · see citing works

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

Chrast, R., Saher, G., Nave, K.-A., & Verheijen, M. H. G. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009761 · Cited by 314 · see citing works

Genetic Analysis of Indole-3-butyric Acid Responses inArabidopsis thalianaReveals Four Mutant Classes

Zolman, B. K., Yoder, A. R., & Bartel, B. (2000) · Genetics · doi:10.1093/genetics/156.3.1323 · Cited by 290 · see citing works

Human Brain Malformations and Their Lessons for Neuronal Migration

Ross, M. E., & Walsh, C. A. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1041 · Cited by 235 · see citing works

The ether lipid-deficient mouse: Tracking down plasmalogen functions

Gorgas, K., Teigler, A., Komljenovic, D., & Just, W. W. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.038 · Cited by 231 · see citing works

Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice

Rodemer, C., Thai, T.-P., Brügger, B., Kaercher, T., Werner, H. B., Nave, K., Wieland, F., Gorgas, K., & Just, W. W. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg191 · Cited by 225 · see citing works

Peroxisomes Are Oxidative Organelles

Antonenkov, V. D., Grunau, S., Ohlmeier, S., & Hiltunen, J. K. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2996 · Cited by 223 · see citing works

Peroxisomal disorders I: biochemistry and genetics of peroxisome biogenesis disorders

Wanders, R. J. A., & Waterham, H. R. (2004) · Clinical Genetics · doi:10.1111/j.1399-0004.2004.00329.x · Cited by 220 · see citing works

Redox interplay between mitochondria and peroxisomes

Lismont, C., Nordgren, M., Van Veldhoven, P. P., & Fransen, M. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00035 · Cited by 214 · see citing works

Mitochondrial Alterations Caused by Defective Peroxisomal Biogenesis in a Mouse Model for Zellweger Syndrome (PEX5 Knockout Mouse)

Baumgart, E., Vanhorebeek, I., Grabenbauer, M., Borgers, M., Declercq, P. E., Fahimi, H. D., & Baes, M. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62534-5 · Cited by 210 · see citing works

Peroxisomal Disorders: Genotype, Phenotype, Major Neuropathologic Lesions, and Pathogenesis

Powers, J. M., & Moser, H. W. (1998) · Brain Pathology · doi:10.1111/j.1750-3639.1998.tb00139.x · Cited by 208 · see citing works

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

Chang, C.-L., Weigel, A. V., Ioannou, M. S., Pasolli, H. A., Xu, C. S., Peale, D. R., Shtengel, G., Freeman, M., Hess, H. F., Blackstone, C., et al. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201902061 · Cited by 206 · see citing works

Peroxisome Biogenesis Disorders

Grønborg, S. W., Gould, S. J., & Valle, D. L. (2003) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.4.070802.110424 · Cited by 203 · see citing works

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

Ivashchenko, O., Veldhoven, P. P. V., Brees, C., Ho, Y.-S., Terlecky, S. R., & Fransen, M. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-11-0919 · Cited by 199 · see citing works

Peroxisomes in brain development and function

Berger, J., Dorninger, F., Forss-Petter, S., & Kunze, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.12.005 · Cited by 194 · see citing works

Inactivation of the Peroxisomal Multifunctional Protein-2 in Mice Impedes the Degradation of Not Only 2-Methyl-branched Fatty Acids and Bile Acid Intermediates but Also of Very Long Chain Fatty Acids

Baes, M. I., Huyghe, S., Carmeliet, P., Declercq, P. E., Collen, D., Mannaerts, G. P., & Veldhoven, P. P. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001994200 · Cited by 194 · see citing works

An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes

Braverman, N. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.8.1195 · Cited by 190 · see citing works

Peroxisome Dynamics in Cultured Mammalian Cells

Huybrechts, S. J., Veldhoven, P. P. V., Brees, C., Mannaerts, G. P., Los, G. V., & Fransen, M. (2009) · Traffic · doi:10.1111/j.1600-0854.2009.00970.x · Cited by 180 · see citing works

Mammalian peroxisomes and reactive oxygen species

Schrader, M., & Fahimi, H. D. (2004) · Histochemistry and Cell Biology · doi:10.1007/s00418-004-0673-1 · Cited by 177 · see citing works

Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities†

Dirkx, R., Vanhorebeek, I., Martens, K., Schad, A., Grabenbauer, M., Fahimi, D., Declercq, P., Van Veldhoven, P. P., & Baes, M. (2005) · Hepatology · doi:10.1002/hep.20628 · Cited by 174 · see citing works

PEX11β Deficiency Is Lethal and Impairs Neuronal Migration but Does Not Abrogate Peroxisome Function

Li, X., Baumgart, E., Morrell, J. C., Jimenez-Sanchez, G., Valle, D., & Gould, S. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4358-4365.2002 · Cited by 165 · see citing works

From peroxisomal disorders to common neurodegenerative diseases – the role of ether phospholipids in the nervous system

Dorninger, F., Forss‐Petter, S., & Berger, J. (2017) · FEBS Letters · doi:10.1002/1873-3468.12788 · Cited by 162 · see citing works

Central role of peroxisomes in isoprenoid biosynthesis

Kovacs, W. J., Olivier, L. M., & Krisans, S. K. (2002) · Progress in Lipid Research · doi:10.1016/s0163-7827(02)00002-4 · Cited by 156 · see citing works

Pexophagy: The Selective Degradation of Peroxisomes

Till, A., Lakhani, R., Burnett, S. F., & Subramani, S. E. (2012) · International Journal of Cell Biology · doi:10.1155/2012/512721 · Cited by 156 · see citing works

Loss-or gain-of-function mutations in ACOX1 cause axonal loss via different mechanisms

Chung, H.-L., Wangler, M. F., Marcogliese, P. C., Jo, J., Ravenscroft, T. A., Zuo, Z., Duraine, L., Sadeghzadeh, S., Li-Kroeger, D., Schmidt, R. E., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.021 · Cited by 154 · see citing works

Human disorders of cortical development: from past to present

Francis, F., Meyer, G., Fallet‐Bianco, C., Moreno, S., Kappeler, C., Socorro, A. C., Tuy, F. P. D., Beldjord, C., & Chelly, J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04649.x · Cited by 152 · see citing works

Pex12 Interacts with Pex5 and Pex10 and Acts Downstream of Receptor Docking in Peroxisomal Matrix Protein Import

Chang, C., Warren, D. S., Sacksteder, K. A., & Gould, S. J. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.4.761 · Cited by 150 · see citing works

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

Wang, B., Veldhoven, P. P. V., Brees, C., Rubio, N., Nordgren, M., Apanasets, O., Kunze, M., Baes, M. I., Agostinis, P., & Fransen, M. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.08.173 · Cited by 141 · see citing works

Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNSPreprint

Rice, D. S., & Curran, T. (1999) · Genes & Development · doi:10.1101/gad.13.21.2758 · Cited by 142 · see citing works

Import of proteins into peroxisomes

Hettema, E. H., Distel, B., & Tabak, H. F. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00087-7 · Cited by 136 · see citing works

Metabolic and molecular aspects of ethanolamine phospholipid biosynthesis: the role of CTP:phosphoethanolamine cytidylyltransferase (Pcyt2)

Bakovic, M., Fullerton, M. D., & Michel, V. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-006 · Cited by 129 · see citing works

New directions for neuronal migration

Pearlman, A. L., Faust, P. L., Hatten, M. E., & Brunstrom, J. E. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80007-x · Cited by 124 · see citing works

Deletion of the Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Auxiliary Subunit TRIP8b Impairs HippocampalIhLocalization and Function and Promotes Antidepressant Behavior in Mice

Lewis, A. S., Vaidya, S. P., Blaiss, C. A., Liu, Z., Stoub, T. R., Brager, D. H., Chen, X., Bender, R. A., Estep, C. M., Popov, A. B., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0936-11.2011 · Cited by 123 · see citing works

Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata

Brites, P. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg236 · Cited by 116 · see citing works

Mechanisms and Disturbances of Neuronal Migration

Gressèns, P. (2000) · Pediatric Research · doi:10.1203/00006450-200012000-00004 · Cited by 116 · see citing works

Identification and Characterization of the Human Orthologue of Yeast Pex14p

Will, G. K., Soukupova, M., Hong, X., Erdmann, K. S., Kiel, J. A. K. W., Dodt, G., Kunau, W., & Erdmann, R. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2265 · Cited by 116 · see citing works

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

Hulshagen, L., Krysko, O., Bottelbergs, A., Huyghe, S., Klein, R., Van Veldhoven, P. P., De Deyn, P. P., D'Hooge, R., Hartmann, D., & Baes, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4968-07.2008 · Cited by 115 · see citing works

Domain Mapping of Human PEX5 Reveals Functional and Structural Similarities to Saccharomyces cerevisiae Pex18p and Pex21p

Dodt, G., Warren, D. S., Becker, E., Rehling, P., & Gould, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106932200 · Cited by 115 · see citing works

Be different—The diversity of peroxisomes in the animal kingdom

Islinger, M., Cardoso, M. J., & Schrader, M. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.03.013 · Cited by 115 · see citing works

Characterization of Peroxisomal Pex5p from Rat Liver

Gouveia, A., Reguenga, C., Oliveira, M. E., Sá-Miranda, C., & Azevedo, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004366200 · Cited by 114 · see citing works

Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon–carbon bond cleavage during α-oxidation of 3-methyl-branched fatty acids

Foulon, V., Antonenkov, V. D., Croes, K., Waelkens, E., Mannaerts, G. P., Veldhoven, P. P. V., & Casteels, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10039 · Cited by 114 · see citing works

Plasmalogens participate in very-long-chain fatty acid-induced pathology

Brites, P., Mooyer, P. A. W., el Mrabet, L., Waterham, H. R., & Wanders, R. J. A. (2008) · Brain · doi:10.1093/brain/awn295 · Cited by 112 · see citing works

Peroxisome biogenesis and peroxisome biogenesis disorders

Fujiki, Y. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01667-7 · Cited by 112 · see citing works

<i>Pex13</i>Inactivation in the Mouse Disrupts Peroxisome Biogenesis and Leads to a Zellweger Syndrome Phenotype

Maxwell, M., Bjorkman, J., Nguyen, T., Sharp, P., Finnie, J., Paterson, C., Tonks, I., Paton, B. C., Kay, G. F., & Crane, D. I. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5947-5957.2003 · Cited by 110 · see citing works

Breakdown of 2-Hydroxylated Straight Chain Fatty Acids via Peroxisomal 2-Hydroxyphytanoyl-CoA Lyase

Foulon, V., Sniekers, M., Huysmans, E., Asselberghs, S., Mahieu, V., Mannaerts, G. P., Veldhoven, P. P. V., & Casteels, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413362200 · Cited by 107 · see citing works

Progeric Effects of Catalase Inactivation in Human Cells

Koepke, J. I., Wood, C. S., Terlecky, L. J., Walton, P. A., & Terlecky, S. R. (2008) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2008.06.004 · Cited by 101 · see citing works

Peroxisomes and cancer: The role of a metabolic specialist in a disease of aberrant metabolism

Dahabieh, M. S., Pietro, E. D., Jangal, M., Gonçalves, C., Witcher, M., Braverman, N., & Rincon, S. V. D. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.07.004 · Cited by 96 · see citing works

From death receptor to reactive oxygen species and c‐Jun N‐terminal protein kinase: the receptor‐interacting protein 1 odyssey

Temkin, V., & Karin, M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00560.x · Cited by 96 · see citing works

G enetically A ltered M ouse M odels: the G ood, the B ad, and the U gly

Thyagarajan, T., Totey, S. M., Danton, M. J. S., & Kulkarni, A. B. (2003) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130301400302 · Cited by 92 · see citing works

Peroxisomal multifunctional protein-2: The enzyme, the patients and the knockout mouse model.

Huyghe, S., Mannaerts, G. P., Baes, M., & Van Veldhoven, P. P. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.006 · Cited by 91 · see citing works

Neocortical and cerebellar developmental abnormalities in conditions of selective elimination of peroxisomes from brain or from liver

Krysko, O., Hulshagen, L., Janssen, A., Schütz, G., Klein, R., De Bruycker, M., Espeel, M., Gressens, P., & Baes, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21097 · Cited by 90 · see citing works

Aging, Age-Related Diseases and Peroxisomes

Fransen, M., Nordgren, M., Wang, B., Apanasets, O., & Veldhoven, P. P. V. (2013) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-6889-5_3 · Cited by 90 · see citing works

The importance of ether-phospholipids: A view from the perspective of mouse models

da Silva, T. F., Sousa, V., Malheiro, A. R., & Brites, P. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.05.014 · Cited by 86 · see citing works

The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress

Walton, P. A., Brees, C., Lismont, C., Apanasets, O., & Fransen, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.07.013 · Cited by 85 · see citing works

The Cytosolic DnaJ-like Protein Djp1p Is Involved Specifically in Peroxisomal Protein Import

Hettema, E. H., Ruigrok, C. C. M., Koerkamp, M. J. A. G., van den Berg, M., Tabak, H. F., Distel, B., & Braakman, I. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.2.421 · Cited by 85 · see citing works

The surprising complexity of peroxisome biogenesis

Olsen, L. J. (1998) · Plant Molecular Biology · doi:10.1023/a:1006092830670 · Cited by 84 · see citing works

Pathogenesis of migration disorders

Gressèns, P. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000218228.73678.e1 · Cited by 83 · see citing works

Peroxisome biogenesis disorders: the role of peroxisomes and metabolic dysfunction in developing brain

Faust, P. L., Banka, D., Siriratsivawong, R., Ng, V. G., & Wikander, T. M. (2005) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-005-7059-y · Cited by 82 · see citing works

Optimized protocols for the simultaneous preparation of primary neuronal cultures of the neocortex, hippocampus and cerebellum from individual newborn (P0.5) C57Bl/6J mice

Ahlemeyer, B., & Baumgart‐Vogt, E. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.05.022 · Cited by 82 · see citing works

Properties of the Ubiquitin-Pex5p Thiol Ester Conjugate

Grou, C. P. O., Carvalho, A. F., Pinto, M. P., Huybrechts, S. J., Sá-Miranda, C., Fransen, M., & Azevedo, J. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808978200 · Cited by 82 · see citing works

Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent apoptosis pathway

Tanaka, H., Okazaki, T., Aoyama-Ishiwatari, S., Yokota, M., Koike, M., Okada, Y., Fujiki, Y., & Gotoh, Y. (2019) · Journal of Cell Science · doi:10.1242/jcs.224766 · Cited by 81 · see citing works

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

Peeters, A., Shinde, A. B., Dirkx, R., Smet, J., Bock, K. D., Espeel, M., Vanhorebeek, I., Vanlander, A. V., Coster, R. V., Carmeliet, P., et al. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.11.017 · Cited by 80 · see citing works

The Peroxisome in Oxidative Stress

Dansen, T. B., & WIRTZ, K. W. A. (2001) · IUBMB Life · doi:10.1080/152165401753311762 · Cited by 77 · see citing works

Emerging roles of mitochondria in the evolution, biogenesis, and function of peroxisomes

Mohanty, A., & McBride, H. M. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00268 · Cited by 76 · see citing works

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

Fourcade, S., Ferrer, I., & Pujol, A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.041 · Cited by 77 · see citing works

Impairment of peroxisomal biogenesis in human colon carcinoma

Lauer, C. (1999) · Carcinogenesis · doi:10.1093/carcin/20.6.985 · Cited by 75 · see citing works

Organelle interplay in peroxisomal disorders

Thoms, S., Grønborg, S. W., & Gärtner, J. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.05.002 · Cited by 74 · see citing works

Recent insights into peroxisome biogenesis and associated diseases

Fujiki, Y., Abe, Y., Imoto, Y., Tanaka, A. J., Okumoto, K., Honsho, M., Tamura, S., Miyata, N., Yamashita, T., Chung, W. K., et al. (2020) · Journal of Cell Science · doi:10.1242/jcs.236943 · Cited by 72 · see citing works

Abnormal cerebellar histogenesis in <i>PEX2</i> Zellweger mice reflects multiple neuronal defects induced by peroxisome deficiency

Faust, P. L. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10699 · Cited by 71 · see citing works

Differential expression of peroxisomal matrix and membrane proteins during postnatal development of mouse brain

Ahlemeyer, B., Neubert, I., Kovacs, W. J., & Baumgart‐Vogt, E. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21448 · Cited by 68 · see citing works

The biogenesis protein PEX14 is an optimal marker for the identification and localization of peroxisomes in different cell types, tissues, and species in morphological studies

Grant, P. S., Ahlemeyer, B., Karnati, S., Berg, T., Stelzig, I., Nenicu, A., Kuchelmeister, K., Crane, D. I., & Baumgart‐Vogt, E. (2013) · Histochemistry and Cell Biology · doi:10.1007/s00418-013-1133-6 · Cited by 68 · see citing works

Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism

Chen, H., Liu, Z., & Huang, X. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp518 · Cited by 67 · see citing works

PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress

Müller, C. C., Nguyen, T. H., Ahlemeyer, B., Meshram, M., Santrampurwala, N., Cao, S., Sharp, P. C., Fietz, P. B., Baumgart‐Vogt, E., & Crane, D. I. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004622 · Cited by 67 · see citing works

Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies

Baes, M. I., & Veldhoven, P. P. V. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.03.003 · Cited by 66 · see citing works

Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues

Janssen, A., Gressens, P., Grabenbauer, M., Baumgart, E., Schad, A., Vanhorebeek, I., Brouwers, A., Declercq, P. E., Fahimi, D., Evrard, P., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09732.2003 · Cited by 65 · see citing works

Analysis of Human Pex19p's Domain Structure by Pentapeptide Scanning Mutagenesis

Fransen, M., Vastiau, I., Brees, C., Brys, V., Mannaerts, G. P., & Veldhoven, P. P. V. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.01.013 · Cited by 65 · see citing works

Disturbed Cholesterol Homeostasis in a Peroxisome-Deficient PEX2 Knockout Mouse Model

Kovacs, W. J., Shackelford, J. E., Tape, K. N., Richards, M. J., Faust, P. L., Fliesler, S. J., & Krisans, S. K. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.1.1-13.2004 · Cited by 63 · see citing works

Human peroxisomal disorders

Depreter, M., Espeel, M., & Roels, F. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10330 · Cited by 63 · see citing works

Peroxisomal Stress Response and Inter-Organelle Communication in Cellular Homeostasis and Aging

Kim, J., & Bai, H. (2022) · Antioxidants · doi:10.3390/antiox11020192 · Cited by 64 · see citing works

The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder

Hiebler, S., Masuda, T., Hacia, J. G., Moser, A. B., Faust, P. L., Liu, A., Chowdhury, N., Huang, N., Lauer, A., Bennett, J., et al. (2014) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2014.01.008 · Cited by 60 · see citing works

Selective pathological changes of the periaqueductal gray matter in Alzheimer's disease

Parvizi, J., Hoesen, G. W. V., & Damásio, A. R. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200009)48:3 · Cited by 70 · see citing works

Cerebral MRI as a valuable diagnostic tool in Zellweger spectrum patients

Weller, S., Rosewich, H., & Gärtner, J. (2008) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-008-0856-3 · Cited by 58 · see citing works

Role of PEX5 ubiquitination in maintaining peroxisome dynamics and homeostasis

Wang, W., & Subramani, S. E. (2017) · Cell Cycle · doi:10.1080/15384101.2017.1376149 · Cited by 58 · see citing works

Deletion of a single allele of thePex11βgene is sufficient to cause oxidative stress, delayed differentiation and neuronal death in mouse brain

Ahlemeyer, B., Gottwald, M., & Baumgart‐Vogt, E. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007708 · Cited by 57 · see citing works

Trypanosoma bruceiglycosomal ABC transporters: identification and membrane targeting

Yernaux, C., Fransen, M., Brees, C., Lorenzen, S., & Michels, P. A. M. (2006) · Molecular Membrane Biology · doi:10.1080/09687860500460124 · Cited by 57 · see citing works

Peroxisomes in cardiomyocytes and the peroxisome / peroxisome proliferator-activated receptor-loop

Colasante, C., Chen, J., Ahlemeyer, B., & Baumgart‐Vogt, E. (2015) · Thrombosis and Haemostasis · doi:10.1160/th14-06-0497 · Cited by 56 · see citing works

Docosahexaenoic Acid Deficit Is Not a Major Pathogenic Factor in Peroxisome-Deficient Mice

Janssen, A., Baes, M. I., Gressèns, P., Mannaerts, G. P., Declercq, P. E., & Veldhoven, P. P. V. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780005 · Cited by 53 · see citing works

Unbalanced lipolysis results in lipotoxicity and mitochondrial damage in peroxisome-deficient Pex19 mutants

Bülow, M. H., Wingen, C., Senyilmaz, D., Gosejacob, D., Sociale, M., Bauer, R., Schulze, H., Sandhoff, K., Teleman, A. A., Hoch, M., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-08-0535 · Cited by 52 · see citing works

C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal

Amery, L., Brees, C., Baes, M. I., Setoyama, C., Miura, R., Mannaerts, G. P., & Veldhoven, P. P. V. (1998) · Biochemical Journal · doi:10.1042/bj3360367 · Cited by 52 · see citing works

Revisiting the neuropathogenesis of Zellweger syndrome

Crane, D. I. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.02.007 · Cited by 51 · see citing works

Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis

Hogenboom, S., Romeijn, G. J., Houten, S. M., Baes, M. I., Wanders, R. J. A., & Waterham, H. R. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30191-7 · Cited by 51 · see citing works

Peroxisome biogenesis and human peroxisome-deficiency disorders

Fujiki, Y. (2016) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.92.463 · Cited by 51 · see citing works

Current Cytochemical Techniques for the Investigation of Peroxisomes: A Review

Fahimi, H. D., & Baumgart‐Vogt, E. (1999) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549904701001 · Cited by 49 · see citing works

<i>Pex13</i>Inactivation in the Mouse Disrupts Peroxisome Biogenesis and Leads to a Zellweger Syndrome Phenotype

Maxwell, M., Bjorkman, J., Nguyen, T., Sharp, P., Finnie, J., Paterson, C., Tonks, I., Paton, B. C., Kay, G. F., & Crane, D. I. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5947-5957.2003 · Cited by 110 · see citing works

PEX11β Deficiency Is Lethal and Impairs Neuronal Migration but Does Not Abrogate Peroxisome Function

Li, X., Baumgart, E., Morrell, J. C., Jimenez-Sanchez, G., Valle, D., & Gould, S. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4358-4365.2002 · Cited by 165 · see citing works

Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a model for Zellweger syndrome, a human neuronal migration disorder

Faust, P. L., & Hatten, M. E. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.5.1293 · Cited by 157 · see citing works

The Right Diet for Heart Failure

Mitter, S. S., Vedanthan, R., & Fuster, V. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2017.10.004

Une approche moléculaire des cavernomes cérébraux de l'enfant

Husson, I., Mas, C., Dommergues, M.-A., Sebag, G. H., Elmaleh, M., Evrard, P., & Simonneau, M. (1998) · Archives de Pédiatrie · doi:10.1016/s0929-693x(99)80043-8