Cited by 1,789Mitochondrial Function and PathologyMetabolism and Genetic DisordersRedox biology and oxidative stress

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Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Yibing, Huang, Ting-Ting, Carlson, Elaine J., Melov, Simon, Ursell, Philip C., Olson, Jean L., Noble, Linda J., Yoshimura, Midori P., Berger, Christoph, Chan, Pak H., Wallace, Douglas C., Epstein, Charles J.·1995·Nature Genetics

DOI 10.1038/ng1295-376

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Abstract

The Sod2 gene for Mn-superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of defense against superoxide produced as a byproduct of oxidative phosphorylation, was inactivated by homologous recombination. Homozygous mutant mice die within the first 10 days of life with a dilated cardiomyopathy, accumulation of lipid in liver and skeletal muscle, and metabolic acidosis. Cytochemical analysis revealed a severe reduction in succinate dehydrogenase (complex II) and aconitase (a TCA cycle enzyme) activities in the heart and, to a lesser extent, in other organs. These findings indicate that MnSOD is required for normal biological function of tissues by maintaining the integrity of mitochondrial enzymes susceptible to direct inactivation by superoxide.

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Authors: Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., Wallace, D. C., & Epstein, C. J.
Affiliations: University of California, San Francisco (US)
Emory University (US)
Children's Medical Research Institute (AU)
ORCID: Li, Yibing
Huang, Ting-Ting
Melov, Simon
Berger, Christoph
Wallace, Douglas C.
Epstein, Charles J.
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 1995-12
Volume: 11
Issue: 4
Pages: 376-381
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng1295-376
OpenAlex: W2094655287
Cited by: 1,789
References: 32
Citations by year: 2026: 20 · 2025: 35 · 2024: 23 · 2023: 31 · 2022: 32 · 2021: 48 · 2020: 39 · 2019: 36 · 2018: 42 · 2017: 52 · 2016: 58 · 2015: 62 · 2014: 102 · 2013: 87 · 2012: 101
FWCI: 9.79
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P30AG010130, AG-10130, AG-13154, AG-08938, P01AG008938, R01AG013154)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: manganese superoxide dismutase, dilated cardiomyopathy, neonatal lethality, mitochondrial superoxide, oxidative phosphorylation, succinate dehydrogenase, complex II, aconitase, TCA cycle, lipid accumulation, metabolic acidosis, Sod2 knockout mice
MeSH terms: Acidosis, Animals, Animals, Newborn, Base Sequence, Cardiomyopathy, Dilated, Electron Transport Complex IV, Genes, Lethal, Homozygote, Lipids, Liver, Mice, Mutant Strains, Mitochondria, Heart, Mitochondria, Muscle, Molecular Sequence Data, Succinate Dehydrogenase, Superoxide Dismutase, Lipid Peroxidation, Sequence Deletion, Gene Targeting, Muscle, Skeletal, Mice

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Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

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