Cited by 140Endometriosis Research and TreatmentAntioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

Oxidative stress biomarkers in patients with endometriosis: systematic review

Carvalho, Luiz Fernando Pina, Samadder, Abhishek Neil, Agarwal, Ashok, Fernandes, Luiz Flávio C., Abrão, Mauricio S.·2012·Archives of Gynecology and Obstetrics

Abstract

Purpose Since the first description about oxygen toxicity made by Joseph Priestley, the oxidative stress has been enrolled as a key factor in the pathogenesis of endometriosis. Our aim was to review oxidative stress biomarkers measured in patients with endometriosis.Methods Relevant studies were identified by searches of the MEDLINE database from 1990 to March 2011 using endometriosis, free radical and oxidative stress as mesh terms. We only included manuscripts in English, and review articles were excluded. In addition, free radical chemistry and oxidative stress history were discussed.Results After inclusion and exclusion criteria, 19 articles were selected to be included in this systematic review. A total of 36 oxidative stress biomarkers (20 different markers) were measured in patients with endometriosis. Some of the markers were measured in more than one manuscript. They were arranged in five subgroups: Enzymatic activity (n = 3), Anions/free radicals (n = 5), Lipoperoxidation markers (n = 7), DNA Damage markers (n = 1), and Protein oxidation (n = 4). Of those 36 markers, 23 were found to be significantly higher in patients with endometriosis comparing with control patients.Conclusion Oxidative stress plays an important role in the pathogenesis and progression of endometriosis.

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Crossref · 10.1007/s00404-012-2439-7

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Authors
Carvalho, L. F. P., Samadder, A. N., Agarwal, A., Fernandes, L. F. C., & Abrão, M. S.
Affiliations
  • Cleveland Clinic (US)
  • Universidade de São Paulo (BR)
Corresponding author
Carvalho, Luiz Fernando Pina
Venue
Archives of Gynecology and Obstetrics
Published
2012-07-12
Volume
286
Issue
4
Pages
1033-1040
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
OpenAlex
W2063806095
Cited by
140
References
37
Citations by year
2026: 6 · 2025: 15 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 9 · 2020: 7 · 2019: 8 · 2018: 14 · 2017: 11 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 7 · 2012: 1
FWCI
1.39
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
endometriosis, oxidative stress, oxidative stress biomarkers, free radicals, lipid peroxidation, DNA damage, protein oxidation, antioxidant enzymes, endometriosis pathogenesis
MeSH terms
Endometriosis, Female, Humans, Biomarkers, Oxidative Stress

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