Wallace, Douglas C.

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 3,185

Mitochondrial diseases in man and mouse

Wallace, D. C. (1999) · Science

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 3,060

Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy

Wallace, D. C., Singh, G., Lott, M. T., Hodge, J. A., Schurr, T. G., Lezza, A. M. S., Elsas, L. J., & Nikoskelainen, E. K. (1988) · Science

Mitochondrial Function and PathologyHereditary Neurological Disorders

Cited by 2,440

Mitochondria and cancer

Wallace, D. C. (2012) · Nature Reviews Cancer

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

Cited by 2,404

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 1,789

Extension of murine life span by overexpression of catalase targeted to mitochondria

Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 1,724

Maternal inheritance of human mitochondrial DNA.

Giles, R. E., Blanc, H., Cann, H. M., & Wallace, D. C. (1980) · Proceedings of the National Academy of Sciences

Forensic and Genetic ResearchMitochondrial Function and Pathology

Cited by 1,365

Diseases of the mitochondrial DNA

Wallace, D. C. (1992) · Annual Review of Biochemistry

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 1,319

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

Kokoszka, J. E., Waymire, K. G., Levy, S. E., Sligh, J. E., Cai, J., Jones, D. P., MacGregor, G. R., & Wallace, D. C. (2004) · Nature

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,086

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Flint Beal, M., & Wallace, D. C. (1992) · Nature Genetics

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 890

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 757

Mitochondrial disease in superoxide dismutase 2 mutant mice

Melov, S., Coskun, P., Patel, M., Tuinstra, R., Cottrell, B., Jun, A. S., Zastawny, T. H., Dizdaroglu, M., Goodman, S. I., Huang, T.-T., et al. (1999) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 581

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

Coskun, P. E., Beal, M. F., & Wallace, D. C. (2004) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 556

A mouse model of mitochondrial disease reveals germline selection against severe mtDNA mutations

Fan, W., Waymire, K. G., Narula, N., Li, P., Rocher, C., Coskun, P. E., Vannan, M. A., Narula, J., MacGregor, G. R., & Wallace, D. C. (2008) · Science

Mitochondrial Function and PathologyEvolution and Genetic Dynamics

Cited by 466

The basal proton conductance of mitochondria depends on adenine nucleotide translocase content

Brand, M. D., Pakay, J. L., Ocloo, A., Kokoszka, J., Wallace, D. C., Brookes, P. S., & Cornwall, E. J. (2005) · Biochemical Journal

Mitochondrial Function and PathologyATP Synthase and ATPases Research

Cited by 410

The clinical characteristics of pedigrees of Leber’s hereditary optic neuropathy with the 11778 mutation

Newman, N. J., Lott, M. T., & Wallace, D. C. (1991) · American Journal of Ophthalmology

Mitochondrial Function and PathologyGlaucoma and retinal disorders

Cited by 403

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

da Silveira, W. A., Fazelinia, H., Rosenthal, S. B., Laiakis, E. C., Kim, M. S., Meydan, C., Kidane, Y., Rathi, K. S., Smith, S. M., Stear, B., et al. (2020) · Cell

Spaceflight effects on biologySpace exploration and regulation

Cited by 402

A mitochondrial bioenergetic etiology of disease

Wallace, D. C. (2013) · Journal of Clinical Investigation

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 342

Marked changes in mitochondrial DNA deletion levels in Alzheimer brains

Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., McKee, A. C., Beal, M. F., Graham, B. H., & Wallace, D. C. (1994) · Genomics

Mitochondrial Function and PathologyAlzheimer's disease research and treatments

Cited by 309

Mitochondrial DNA variation and cancer

Kopinski, P. K., Singh, L. N., Zhang, S., Lott, M. T., & Wallace, D. C. (2021) · Nature reviews. Cancer

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

Cited by 301

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress

Picard, M., McManus, M. J., Gray, J. D., Nasca, C., Moffat, C., Kopinski, P. K., Seifert, E. L., McEwen, B. S., & Wallace, D. C. (2015) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyStress Responses and Cortisol

Cited by 293

Phylogenetic analysis of Leber's hereditary optic neuropathy mitochondrial DNA's indicates multiple independent occurrences of the common mutations

Brown, M. D., Torroni, A., Reckord, C. L., & Wallace, D. C. (1995) · Human Mutation

Mitochondrial Function and PathologyForensic and Genetic Research

Cited by 256

Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene

Esposito, L. A., Kokoszka, J. E., Waymire, K. G., Cottrell, B., MacGregor, G. R., & Wallace, D. C. (2000) · Free Radical Biology and Medicine

Redox biology and oxidative stressSelenium in Biological Systems

Cited by 228

The ADP/ATP translocase drives mitophagy independent of nucleotide exchange

Hoshino, A., Wang, W.-J., Wada, S., McDermott-Roe, C., Evans, C. S., Gosis, B., Morley, M. P., Rathi, K. S., Li, J., Li, K., et al. (2019) · Nature

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 228