Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S. W., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81369-0 · Cited by 3,073

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

Davies, S. W., Turmaine, M., Cozens, B. A., DiFiglia, M., Sharp, A. H., Ross, C. A., Scherzinger, E., Wanker, E. E., Mangiarini, L., & Bates, G. P. (1997) · Cell · doi:10.1016/s0092-8674(00)80513-9 · Cited by 2,188

TOR, a Central Controller of Cell Growth

Schmelzle, T., & Hall, M. N. (2000) · Cell · doi:10.1016/s0092-8674(00)00117-3 · Cited by 1,914

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

Saudou, F., Finkbeiner, S. M., Devys, D., & Greenberg, M. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81782-1 · Cited by 1,598

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

Webb, J. L., Ravikumar, B., Atkins, J., Skepper, J. N., & Rubinsztein, D. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300227200 · Cited by 1,429

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

Steffan, J. S., Bodai, L., Pallos, J., Poelman, M., McCampbell, A., Apostol, B. L., Kazantsev, A., Schmidt, E., Zhu, Y.-Z., Greenwald, M., et al. (2001) · Nature · doi:10.1038/35099568 · Cited by 1,228

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

Ravikumar, B. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.9.1107 · Cited by 1,099

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

Fingar, D. C., Salama, S., Tsou, C., Harlow, E., & Blenis, J. (2002) · Genes & Development · doi:10.1101/gad.995802 · Cited by 1,093

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

Kim, D., Sarbassov, D. D., Ali, S. M., Latek, R. R., Guntur, K., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00114-x · Cited by 992

Autophagy fails to prevent glucose deprivation/glucose reintroduction-induced neuronal death due to calpain-mediated lysosomal dysfunction in cortical neurons

Gerónimo‐Olvera, C., Montiel, T., Rincón-Heredia, R., Castro‐Obregón, S., & Massieu, L. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.299 · Cited by 64

Aberrant regulation of autophagy in mammalian diseases

Xie, W. D., & Zhou, J. Y. (2018) · Biology Letters · doi:10.1098/rsbl.2017.0540 · Cited by 66

Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction

Regan‐Klapisz, E., Sorokina, I., Voortman, J., de Keizer, P. L. J., Roovers, R. C., Verheesen, P., Urbé, S., Fallon, L., Fon, E. A., Verkleij, A. J., et al. (2005) · Journal of Cell Science · doi:10.1242/jcs.02571 · Cited by 64

Autophagy in neuroinflammatory diseases

Muller, S., Brun, S., René, F., Seze, J. D., Loeffler, J., & Jeltsch‐David, H. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.05.015 · Cited by 66

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

Aron, R., Pellegrini, P., Green, E. W., Maddison, D. C., Opoku-Nsiah, K., Oliveira, A. O., Wong, J. S., Daub, A. C., Giorgini, F., Muchowski, P. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05653-z · Cited by 64

Restoring autophagic flux attenuates cochlear spiral ganglion neuron degeneration by promoting TFEB nuclear translocation via inhibiting MTOR

Ye, B., Wang, Q., Hu, H., Shen, Y., Cui, F., Chen, P., Ma, Y., Wu, H., & Xiang, M. (2019) · Autophagy · doi:10.1080/15548627.2019.1569926 · Cited by 64

Exosome release and neuropathology induced by α-synuclein: new insights into protective mechanisms of Drp1 inhibition

Fan, R. Z., Guo, M. A., Luo, S., Cui, M., & Tieu, K. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0821-4 · Cited by 63

The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology

Lacombe, A., & Scorrano, L. (2024) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2024.02.001 · Cited by 65

Can autophagy protect against neurodegeneration caused by aggregate-prone proteins?

Ravikumar, B., & Rubinsztein, D. C. (2004) · Neuroreport · doi:10.1097/00001756-200411150-00001 · Cited by 64

A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy

Li, Y., Zhao, Y., Hu, J. N., Xiao, J., Qu, L., Wang, Z., Ma, D., & Chen, Y. (2012) · Autophagy · doi:10.4161/auto.22742 · Cited by 66

p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity

Luo, S., Mizuta, H., & Rubinsztein, D. C. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm362 · Cited by 66

Genipin alleviates sepsis‐induced liver injury by restoring autophagy

Cho, H., Kim, S., Choi, J.-W., & Lee, S. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13397 · Cited by 63

Activation of the AMPK-ULK1 pathway plays an important role in autophagy during prion infection

Fan, X., Tian, C., Wang, H., Xu, Y., Ren, K., Zhang, B., Chen, G., Shi, Q., Meng, G., Zhang, L.-B., et al. (2015) · Scientific Reports · doi:10.1038/srep14728 · Cited by 63

Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases

Lim, M., Jeung, I. C., Jeong, J., Yoon, S., Lee, S., Park, J., Kang, Y.-S., Lee, H., Park, Y., Lee, H. G., et al. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.09.018 · Cited by 63

It’s a Cell-Eat-Cell World

Oczypok, E. A., Oury, T. D., & Chu, C. T. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.017 · Cited by 65

Investigating the Role of Reactive Oxygen Species in Regulating Autophagy

Gibson, S. B. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-405881-1.00013-6 · Cited by 65

FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels

Elcocks, H., Brazel, A. J., McCarron, K. R., Kaulich, M., Husnjak, K., Mortiboys, H., Clague, M. J., & Urbé, S. (2023) · The EMBO Journal · doi:10.15252/embj.2022112799 · Cited by 64

Autophagy sustains the replication of porcine reproductive and respiratory virus in host cells

Liu, Q., Qin, Y., Zhou, L., Kou, Q., Guo, X., Ge, X., Yang, H., & Hu, H. (2012) · Virology · doi:10.1016/j.virol.2012.03.022 · Cited by 63

Trifluoperazine rescues human dopaminergic cells from wild-type α-synuclein-induced toxicity

Höllerhage, M., Goebel, J. N., de Andrade, A., Hildebrandt, T., Dolga, A. M., Culmsee, C., Oertel, W. H., Hengerer, B., & Höglinger, G. U. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.027 · Cited by 66

Resveratrol Triggers Protective Autophagy Through the Ceramide/Akt/mTOR Pathway in Melanoma B16 Cells

Wang, M., Yu, T., Zhu, C., Sun, H. Y., Qiu, Y., Zhu, X., & Li, J. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2013.878738 · Cited by 62

Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy

Li, X., Chang, R., Liu, X., & Li, S. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s58470 · Cited by 62

Excitotoxic glutamate insults block autophagic flux in hippocampal neurons

Kulbe, J. R., Levy, J. M. M., Coultrap, S. J., Thorburn, A. M., & Bayer, K. U. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.032 · Cited by 62

Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases

Xu, Y., Tian, C., Wang, S.-B., Xie, W.-L., Guo, Y., Zhang, J., Shi, Q., Chen, C., & Dong, X. (2012) · Autophagy · doi:10.4161/auto.21482 · Cited by 66

Caloric restriction and the precision-control of autophagy: A strategy for delaying neurodegenerative disease progression

Ntsapi, C., & Loos, B. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.07.014 · Cited by 65

Mechanical Stress-Dependent Autophagy Component Release via Extracellular Nanovesicles in Tumor Cells

Wang, K., Wei, Y., Liu, W., Liu, L., Guo, Z. G., Fan, C., Wang, L., Hu, J., & Li, B. (2019) · ACS Nano · doi:10.1021/acsnano.9b00587 · Cited by 65

Correction of Huntington’s Disease Phenotype by Genistein-Induced Autophagy in the Cellular Model

Pierzynowska, K., Gaffke, L., Hać, A., Mantej, J., Niedziałek, N., Brokowska, J., & Węgrzyn, G. (2018) · NeuroMolecular Medicine · doi:10.1007/s12017-018-8482-1 · Cited by 62

Amino Acid Regulation of Autophagosome Formation

Meijer, A. J. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-157-4_5 · Cited by 64

Walnut diet reduces accumulation of polyubiquitinated proteins and inflammation in the brain of aged rats

Poulose, S. M., Bielinski, D. F., & Shukitt‐Hale, B. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.009 · Cited by 61

Phosphorylation of NBR1 by GSK3 modulates protein aggregation

Nicot, A.-S., Verso, F. L., Ratti, F., Pilot‐Storck, F., Streichenberger, N., Sandri, M., Schaeffer, L., & Goillot, E. (2014) · Autophagy · doi:10.4161/auto.28479 · Cited by 61

Neuroprotective therapy in Parkinson's disease and motor complications: A search for a pathogenesis-targeted, disease-modifying strategy

Olanow, C. W., & Jankovic, J. J. (2005) · Movement Disorders · doi:10.1002/mds.20457 · Cited by 61

Autophagy function and its relationship to pathology, clinical applications, drug metabolism and toxicity

Petibone, D. M., Majeed, W., & Casciano, D. A. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3393 · Cited by 63

Autophagy, Metabolic Disease, and Pathogenesis of Heart Dysfunction

Wang, F., Jia, J., & Rodrigues, B. B. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.01.002 · Cited by 62

Augmenting brain metabolism to increase macro- and chaperone-mediated autophagy for decreasing neuronal proteotoxicity and aging

Loos, B., Klionsky, D. J., & Wong, E. S. P. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.001 · Cited by 64

Apelin/APJ system: A novel promising target for neurodegenerative diseases

Luo, H., Han, L., & Xu, J. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29001 · Cited by 61

Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress

Patel, P. H., & Tamanoi, F. (2006) · Journal of Cell Science · doi:10.1242/jcs.03199 · Cited by 61

Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye

Wang, B., Peng, L., Ouyang, H., Wang, L., He, D., Zhong, J., Xiao, Y., Deng, Y., Li, M., Li, S., et al. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27072 · Cited by 61

Autophagy Induction Rescues Toxicity Mediated by Proteasome Inhibition

Rubinsztein, D. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.005 · Cited by 61

Current Management of Tuberous Sclerosis Complex

Krueger, D., & Franz, D. (2008) · Paediatric drugs · doi:10.2165/00148581-200810050-00004 · Cited by 68

Amyotrophic lateral sclerosis pathogenesis: a journey through the secretory pathway

Nassif, M., Matus, S., Castillo, K., & Hetz, C. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2991 · Cited by 60

mTOR Enhances Foam Cell Formation by Suppressing the Autophagy Pathway

Wang, X., Li, L., Niu, X., Dang, X., Li, P., Li, Q., Bi, X., Gao, Y., Hu, Y., Li, M., et al. (2014) · DNA and Cell Biology · doi:10.1089/dna.2013.2164 · Cited by 60

Proteostasis disturbance in amyotrophic lateral sclerosis

Medinas, D. B., Valenzuela, V., & Hetz, C. A. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx274 · Cited by 67

Proteostasis of Huntingtin in Health and Disease

Koyuncu, S., Fatima, A., Gutiérrez-García, R., & Vı́lchez, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071568 · Cited by 61

New insights into autophagy in hepatocellular carcinoma: mechanisms and therapeutic strategies.

Yang, S., Yang, L., Li, X., Li, B., Li, Y., Zhang, X., Ma, Y., Peng, X., Jin, H., & Li, H. (2019) · PubMed Central · Cited by 60

mTOR in health and in sickness

Liko, D., & Hall, M. N. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1326-7 · Cited by 60

The stress-responsive protein REDD1 and its pathophysiological functions

Kim, J., Kwon, Y., & Kim, Y. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01056-3 · Cited by 71

Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy

Nisoli, I., Chauvin, J., Napoletano, F., Calamita, P., Zanin, V., Fanto, M., & Charroux, B. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.31 · Cited by 61

RNAi Screening in Drosophila Cells Identifies New Modifiers of Mutant Huntingtin Aggregation

Doumanis, J., Wada, K., Kino, Y., Moore, A. W., & Nukina, N. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007275 · Cited by 59

Chromosomal profiles of gene expression in Huntington's disease

Anderson, A. N., Roncaroli, F., Hodges, A., Deprez, M., & Turkheimer, F. (2007) · Brain · doi:10.1093/brain/awm312 · Cited by 59

Is autophagy a double-edged sword for the heart?

Gurusamy, N., & Das, D. K. (2009) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.96.2009.3.2 · Cited by 59

Huntington's disease: An update of therapeutic strategies

Kumar, A., Singh, S. K., Kumar, V., Kumar, D., Agarwal, S., & Rana, M. K. (2014) · Gene · doi:10.1016/j.gene.2014.11.022 · Cited by 62

Strategies for Treatment in Alexander Disease

Messing, A., Daniels, C. M. L., & Hagemann, T. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.013 · Cited by 60

p62 Plays a Protective Role in the Autophagic Degradation of Polyglutamine Protein Oligomers in Polyglutamine Disease Model Flies

Saitoh, Y., Fujikake, N., Okamoto, Y., Popiel, H. A., Hatanaka, Y., Ueyama, M., Suzuki, M., Gaumer, S., Murata, M., Wada, K., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.590281 · Cited by 55

The altered autophagy mediated by TFEB in animal and cell models of amyotrophic lateral sclerosis.

Chen, Y., Liu, H., Guan, Y., Wang, Q., Zhou, F., Jie, L., Ju, J., Pu, L., Du, H., & Wang, X. (2015) · PubMed · Cited by 59

Transcription factor EB: an emerging drug target for neurodegenerative disorders

Song, J., Liu, J., Jiang, Y., Wang, Z., & Li, M. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.10.013 · Cited by 59

Protein Transduction Domain-mediated Delivery of QBP1 Suppresses Polyglutamine-induced Neurodegeneration In Vivo

Popiel, H. A., Nagai, Y., Fujikake, N., & Toda, T. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300045 · Cited by 59

Recent progress in the role of autophagy in neurological diseases

Meng, T., Lin, S., Zhuang, H., Huang, H., He, Z., Hu, Y., Gong, Q., & Feng, D. (2019) · Cell Stress · doi:10.15698/cst2019.05.186 · Cited by 58

Inhibition of autophagy enhances the effects of the AKT inhibitor MK‐2206 when combined with paclitaxel and carboplatin in BRAF wild‐type melanoma

Rebecca, V. W., Massaro, R. R., Fedorenko, I. V., Sondak, V. K., Anderson, A. R. A., Kim, E., Amaravadi, R. K., Maria‐Engler, S. S., Messina, J. L., Gibney, G. T., et al. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12227 · Cited by 58

Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice

Li, M., Huang, Y., Ma, A. A. K., Lin, E., & Diamond, M. I. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.011 · Cited by 68

Neurodegenerative pathways as targets for acquired epilepsy therapy development

Casillas-Espinosa, P. M., Ali, I. Y., & O'Brien, T. J. (2020) · Epilepsia Open · doi:10.1002/epi4.12386 · Cited by 59

Autophagy regulation by acetylation—implications for neurodegenerative diseases

Son, S. M., Park, S. J., Fernandez-Estévez, M., & Rubinsztein, D. C. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00556-4 · Cited by 59

Autophagy in Glomerular Health and Disease

Hartleben, B., Wanner, N., & Huber, T. B. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.11.007 · Cited by 58

High-Content Chemical and RNAi Screens for Suppressors of Neurotoxicity in a Huntington's Disease Model

Schulte, J., Sepp, K. J., Wu, C., Hong, P., & Littleton, J. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023841 · Cited by 63

Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos?

Cortés, C. J., & Spada, A. R. L. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.03.010 · Cited by 61

Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy

Piras, A., Schiaffino, L., Boido, M., Valsecchi, V., Guglielmotto, M., Amicis, E. D., Puyal, J., Garcerá, A., Tamagno, E., Soler, R. M., et al. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0086-4 · Cited by 60

Increased translation as a novel pathogenic mechanism in Huntington’s disease

Creus‐Muncunill, J., Badillos-Rodríguez, R., García-Forn, M., Masana, M., Barriga, G. G.-D., Guisado-Corcoll, A., Alberch, J., Malagelada, C., Delgado-Garcia, J. M., Gruart, A., et al. (2019) · Brain · doi:10.1093/brain/awz230 · Cited by 60

Molecular mechanisms of mitophagy and its roles in neurodegenerative diseases

Li, X., Huang, L., Lan, J., Feng, X., Li, P., Wu, L., & Peng, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105240 · Cited by 57

Molecular Pathogenesis of Protein Misfolding Diseases: Pathological Molecular Environments Versus Quality Control Systems Against Misfolded Proteins

Naiki, H., & Nagai, Y. (2009) · The Journal of Biochemistry · doi:10.1093/jb/mvp119 · Cited by 57

Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease

Schneider, L. E., & Zhang, J. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-14 · Cited by 59

CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation

Mishra, S. K., Gao, Y., Deng, Y., Chalfant, C. E., Hinchcliffe, E. H., & Brown, R. E. (2017) · Autophagy · doi:10.1080/15548627.2017.1393129 · Cited by 57

Clinically Precedented Protein Kinases: Rationale for Their Use in Neurodegenerative Disease

Benn, C., & Dawson, L. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00242 · Cited by 59

The protein phosphatase PP2A-B′ subunit Widerborst is a negative regulator of cytoplasmic activated Akt and lipid metabolism inDrosophila

Vereshchagina, N., Ramel, M., Bitoun, E., & WILSON, C. G. (2008) · Journal of Cell Science · doi:10.1242/jcs.035220 · Cited by 59

Primary cilia and autophagic dysfunction in Huntington’s disease

Kaliszewski, M., Knott, A. B., & Bossy-Wetzel, E. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.80 · Cited by 55

Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential

Wu, N., Zheng, W., Zhou, Y., Tian, Y., Tang, M., Feng, X., Ashrafizadeh, M., Wang, Y. Z., Niu, X., Tambuwala, M. M., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102428 · Cited by 59

SIRT 2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors

Inoue, T., Nakayama, Y., Li, Y., Matsumori, H., Takahashi, H., Kojima, H., Wanibuchi, H., Katoh, M., & Oshimura, M. (2014) · FEBS Journal · doi:10.1111/febs.12810 · Cited by 57

Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells

Liang, C., Li, H., Zhou, H., Zhang, S., Liu, Z., Zhou, Q., & Sun, F. (2011) · Oncology Reports · doi:10.3892/or.2011.1593 · Cited by 57

PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins

Magnaudeix, A., Wilson, C. M., Page, G., Bauvy, C., Codogno, P., Lévêque, P., Labrousse, F., Delage-Corre, M., Yardin, C., & Terro, F. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.026 · Cited by 57

The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

Davies, J. E., Sarkar, S., & Rubinsztein, D. C. (2007) · BMC Biochemistry · doi:10.1186/1471-2091-8-s1-s2 · Cited by 56

The mTOR signaling pathway as a treatment target for intracranial neoplasms

Pachow, D., Wick, W., Gutmann, D. H., & Mawrin, C. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou164 · Cited by 57

Fangchinoline Induces Apoptosis, Autophagy and Energetic Impairment in Bladder Cancer

Fan, B., Zhang, X., Ma, Y., & Zhang, A. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000481698 · Cited by 56

Huntington’s disease: the coming of age

Pandey, M., & Rajamma, U. (2018) · Journal of Genetics · doi:10.1007/s12041-018-0957-1 · Cited by 56

Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1

Wong, M., Ganapathy, A. S., Suchanec, E., Laidler, L. L., Ma, T., & Nighot, P. K. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00246.2018 · Cited by 57

SCAMP5 Links Endoplasmic Reticulum Stress to the Accumulation of Expanded Polyglutamine Protein Aggregates via Endocytosis Inhibition

Noh, J.-Y., Lee, H., Song, S., Kim, N. S., Im, W., Kim, M., Seo, H., Chung, C.-W., Chang, J.-W., Ferrante, R. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807620200 · Cited by 56

Polyglutamine Toxicity Is Controlled by Prion Composition and Gene Dosage in Yeast

Gong, H., Romanova, N. V., Allen, K., Chandramowlishwaran, P., Gokhale, K., Newnam, G. P., Mieczkowski, P. A., Sherman, M. Y., & Chernoff, Y. O. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002634 · Cited by 55

Lacritin Rescues Stressed Epithelia via Rapid Forkhead Box O3 (FOXO3)-associated Autophagy That Restores Metabolism

Wang, N., Zimmerman, K., Raab, R. W., McKown, R. L., Hutnik, C. M. L., Talla, V., Tyler, M. F., Lee, J. K., & Laurie, G. W. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436584 · Cited by 58

Drosophila as a model system to study autophagy

Zirin, J. D., & Perrimon, N. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0223-y · Cited by 56

Reversible Acetylation Regulates Salt-inducible Kinase (SIK2) and Its Function in Autophagy*

Yang, F.-C., Tan, B. C., Chen, W.-H., Lin, Y.-H., Huang, J.-Y., Chang, H.-Y., Sun, H.-Y., Hsu, P., Liou, G., Shen, J., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.431239 · Cited by 55

The V471A Polymorphism in Autophagy-Related Gene ATG7 Modifies Age at Onset Specifically in Italian Huntington Disease Patients

Metzger, S., Walter, C., Rieß, O., Roos, R. A. C., Nielsen, J. E., Craufurd, D., REGISTRY Investigators of the European Huntington’s Disease Network, & Nguyen, H. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068951 · Cited by 55

Autophagy: a potential therapeutic target in lung diseases

Nakahira, K., & Choi, A. M. K. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00072.2013 · Cited by 57

Autophagy in Alzheimer’s disease

Moreira, P. I., Santos, R. X., Zhu, X., Lee, H.-G., Smith, M. A., Casadesus, G., & Perry, G. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.84 · Cited by 55

Activation of ER Stress and Autophagy Induced by TDP-43 A315T as Pathogenic Mechanism and the Corresponding Histological Changes in Skin as Potential Biomarker for ALS with the Mutation

Wang, X., Zhou, S. Y., Ding, X., Ma, M., Zhang, J., Zhou, Y., Wu, E., & Teng, J. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.12657 · Cited by 59

Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice

Bayram-Weston, Z., Jones, L., Dunnett, S. B., & Brooks, S. P. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.07.009 · Cited by 60

Chaperons moléculaires et repliement des protéines : L’exemple de certaines protéines de choc thermique

Arrigo, A. (2005) · médecine/sciences · doi:10.1051/medsci/2005216-7619 · Cited by 55

α-Synuclein levels modulate Huntington's disease in mice

Corrochano, S., Renna, M., Carter, S., Chrobot, N., Kent, R., Stewart, M. E., Cooper, J. F., Brown, S. D. M., Rubinsztein, D. C., & Acevedo‐Arozena, A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr477 · Cited by 54

Selective Autophagy by Close Encounters of the Ubiquitin Kind

Vainshtein, A., & Grumati, P. (2020) · Cells · doi:10.3390/cells9112349 · Cited by 59

Autophagy in Multiple Sclerosis: Two Sides of the Same Coin

Misrielal, C., Mauthe, M., Reggiori, F., & Eggen, B. J. L. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.603710 · Cited by 56

Pathogenesis of Huntington’s Disease: An Emphasis on Molecular Pathways and Prevention by Natural Remedies

Irfan, Z., Khanam, S., Karmakar, V., Firdous, S. M., Khier, B. S. I. A. E., Khan, I., Rehman, M. U., & Khan, A. (2022) · Brain Sciences · doi:10.3390/brainsci12101389 · Cited by 54

Gangliosides induce autophagic cell death in astrocytes

Hwang, J., Lee, S., Lee, J. T., Kwon, T. K., Kim, D. R., Kim, H., Park, H., & Suk, K. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00563.x · Cited by 54

Regulation and Functional Significance of Autophagy in Respiratory Cell Biology and Disease

Patel, A. S., Morse, D., & Choi, A. M. K. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0282tr · Cited by 54

Rhes Deletion Is Neuroprotective in the 3-Nitropropionic Acid Model of Huntington's Disease

Mealer, R. G., Subramaniam, S., & Snyder, S. H. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3730-12.2013 · Cited by 54

Gene networks: Dissecting pathways in retinal development and disease

Gregory, C. Y., Wallace, V. A., & Gregory-Evans, K. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.10.003 · Cited by 54

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

Sarkar, S., Ravikumar, B., Floto, R. A., & Rubinsztein, D. C. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.110 · Cited by 578

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model

Roscic, A., Baldo, B., Crochemore, C., Marcellin, D., & Paganetti, P. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07435.x · Cited by 92

Rapamycin alleviates toxicity of different aggregate-prone proteins

Berger, Z., Ravikumar, B., Menzies, F. M., Oroz, L. G., Underwood, B. R., Pangalos, M. N., Schmitt, I., Wullner, U., Evert, B. O., O'Kane, C. J., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi458 · Cited by 657

alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet

Berger, Z., Ravikumar, B., Menzies, F. M., Garcia-Oroz, L., Underwood, B. R., Pangalos, M. N., Schmitt, I., Wullner, U., Evert, B. O., O’Kane, C. J., et al. (2015)

Potential therapeutics targeting on autophagy for Huntington disease

Zheng-hong, Q. (2011)