Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, Brinda, Vacher, Coralie, Berger, Zdenek, Davies, Janet E, Luo, Shouqing, Oroz, Lourdes G, Scaravilli, Francesco, Easton, Douglas F, Duden, Rainer, O'Kane, Cahir J, Rubinsztein, David C·2004·Nature Genetics

Cited by (1,011)

Items 101–200 of 1,011

  1. Targeting protein prenylation for cancer therapy
    Berndt, Norbert, Hamilton, Andrew D., Sebti, Saïd M. · 2011 · Nature Reviews Cancer
  2. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
    Sovan Sarkar, Ethan O. Perlstein, Sara Imarisio, Sandra Pineau, Axelle Cordenier, Rebecca L. Maglathlin, John A Webster, Timothy A. Lewis, Cahir J. O’Kane, Stuart L. Schreiber et al. · 2007 · Nature Chemical Biology
  3. Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases
    Spencer, Brian, Potkar, Rewati, Trejo, Margarita, Rockenstein, Edward, Patrick, Christina, Gindi, Ryan, Adame, Anthony, Wyss-Coray, Tony, Masliah, Eliezer · 2009 · The Journal of Neuroscience
  4. Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
    Sarkar, S, Ravikumar, B, Floto, R A, Rubinsztein, D C · 2009 · Cell Death & Differentiation
  5. Autophagy: The spotlight for cellular stress responses
    Palaniyandi Ravanan, Ida Florance, Priti Talwar · 2017 · Life Sciences
  6. Lysosomal disorders: From storage to cellular damage
    Ballabio, Andrea, Gieselmann, Volkmar · 2009 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  7. Common mechanisms of amyloid oligomer pathogenesis in degenerative disease
    Glabe, Charles G. · 2006 · Neurobiology of Aging
  8. Enhancing Macroautophagy Protects against Ischemia/Reperfusion Injury in Cardiac Myocytes
    Hamacher-Brady, Anne, Brady, Nathan R., Gottlieb, Roberta A. · 2006 · Journal of Biological Chemistry
  9. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
    Barry Boland, Wai Haung Yu, Olga Corti, Bertrand Mollereau, Alexandre Henriques, Erwan Bézard, Greg Pastores, David Chaim Rubinsztein, Ralph A. Nixon, Michael R. Duchen et al. · 2018 · Nature Reviews Drug Discovery
  10. The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
    T. Pan, Seiji Kondo, Weidong Le, Joseph J. Jankovic · 2008 · Brain
  11. Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities
    Sarah J. Tabrizi, Michael D. Flower, Christopher A. Ross, Edward J. Wild · 2020 · Nature Reviews Neurology
  12. Autophagy and aging: keeping that old broom working
    Cuervo, Ana Maria · 2008 · Trends in Genetics
  13. Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease
    Lyndsay M. Murrow, Jayanta Debnath · 2012 · Annual Review of Pathology Mechanisms of Disease
  14. Fighting neurodegeneration with rapamycin: mechanistic insights
    Jordi Bové, Marta Martínez‐Vicente, Miquel Vila · 2011 · Nature reviews. Neuroscience
  15. Autophagy: Basic Principles and Relevance to Disease
    Kundu, Mondira, Thompson, Craig B. · 2008 · Annual Review of Pathology: Mechanisms of Disease
  16. Autophagy in health and disease: A comprehensive review
    Sarbari Saha, Debasna Pritimanjari Panigrahi, Shankargouda Patil, Sujit K. Bhutia · 2018 · Biomedicine & Pharmacotherapy
  17. Huntington’s Disease: Mechanisms of Pathogenesis and Therapeutic Strategies
    María Jiménez-Sánchez, Floriana Licitra, Benjamin R. Underwood, David Chaim Rubinsztein · 2016 · Cold Spring Harbor Perspectives in Medicine
  18. Autophagy and apoptosis: what is the connection?
    Jacob M. Gump, Andrew M. Thorburn · 2011 · Trends in Cell Biology
  19. Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
    Trond Lamark, Terje Johansen · 2012 · International Journal of Cell Biology
  20. Huntingtin and the molecular pathogenesis of Huntington's disease
    Christian Landles, Gillian P. Bates · 2004 · EMBO Reports
  21. Differential Effects of Endoplasmic Reticulum Stress-induced Autophagy on Cell Survival
    Wen‐Xing Ding, Hong‐Min Ni, Wentao Gao, Yi‐Feng Hou, Melissa A. Melan, Xiaoyun Chen, Donna Beer Stolz, Zhi-Ming Shao, Xiao‐Ming Yin · 2006 · Journal of Biological Chemistry
  22. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
    Shouqing Luo, David Chaim Rubinsztein · 2009 · Cell Death and Differentiation
  23. The pleiotropic role of autophagy: from protein metabolism to bactericide
    Noboru Mizushima · 2005 · Cell Death and Differentiation
  24. Mechanisms of neurodegeneration in Huntington’s disease
    Joana Gil‐Mohapel, Ana Cristina Rego · 2008 · European Journal of Neuroscience
  25. Repeat expansion disease: progress and puzzles in disease pathogenesis
    Albert R. La Spada, J. Paul Taylor · 2010 · Nature Reviews Genetics
  26. Autophagy and neurodegeneration: when the cleaning crew goes on strike
    Marta Martínez‐Vicente, Ana María Cuervo · 2007 · The Lancet Neurology
  27. The quest to slow ageing through drug discovery
    Partridge, Linda, Fuentealba, Matias, Kennedy, Brian K. · 2020 · Nature Reviews Drug Discovery
  28. siRNA Screening of the Kinome Identifies ULK1 as a Multidomain Modulator of Autophagy
    Chan, Edmond Y.W., Kir, Serkan, Tooze, Sharon A. · 2007 · Journal of Biological Chemistry
  29. Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
    Zavodszky, Eszter, Seaman, Matthew N.J., Moreau, Kevin, Jimenez-Sanchez, Maria, Breusegem, Sophia Y., Harbour, Michael E., Rubinsztein, David C. · 2014 · Nature Communications
  30. mTOR Signaling in Disease
    Dazert, Eva, Hall, Michael N · 2011 · Current Opinion in Cell Biology
  31. Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease
    Cristina Malagelada, Zong Hao Jin, Vernice R. Jackson-Lewis, Serge Przedborski, Lloyd A. Greene · 2010 · Journal of Neuroscience
  32. Dynein mutations impair autophagic clearance of aggregate-prone proteins
    Ravikumar, Brinda, Acevedo-Arozena, Abraham, Imarisio, Sara, Berger, Zdenek, Vacher, Coralie, O'Kane, Cahir J, Brown, Steve D M, Rubinsztein, David C · 2005 · Nature Genetics
  33. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
    Shibata, Mamoru, Lu, Tao, Furuya, Tsuyoshi, Degterev, Alexei, Mizushima, Noboru, Yoshimori, Tamotsu, MacDonald, Marcy, Yankner, Bruce, Yuan, Junying · 2006 · Journal of Biological Chemistry
  34. Mitophagy and Neuroprotection
    Guofeng Lou, Konstantinos Palikaras, Sofie Lautrup, Morten Scheibye‐Knudsen, Nektarios Tavernarakis, Evandro Fei Fang · 2019 · Trends in Molecular Medicine
  35. Control of autophagy as a therapy for neurodegenerative disease
    Harry Harris, David Chaim Rubinsztein · 2011 · Nature Reviews Neurology
  36. Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury
    Silvia Carloni, Giuseppe Buonocore, Walter Balduini · 2008 · Neurobiology of Disease
  37. Autophagy in neurodegenerative diseases: pathogenesis and therapy
    Fang Guo, Xinyao Liu, Huaibin Cai, Weidong Le · 2017 · Brain Pathology
  38. Regulation of Autophagy by Extracellular Signal-Regulated Protein Kinases During 1-Methyl-4-Phenylpyridinium-Induced Cell Death
    Jian-hui Zhu, Craig Horbinski, Fengli Guo, Simon C. Watkins, Yasuo Uchiyama, Charleen T. Chu · 2007 · American Journal Of Pathology
  39. Amino acids and mTORC1: from lysosomes to disease
    Efeyan, Alejo, Zoncu, Roberto, Sabatini, David M. · 2012 · Trends in Molecular Medicine
  40. The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective
    Martini-Stoica, Heidi, Xu, Yin, Ballabio, Andrea, Zheng, Hui · 2016 · Trends in Neurosciences
  41. Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism
    Chan, Edmond Y. W., Longatti, Andrea, McKnight, Nicole C., Tooze, Sharon A. · 2009 · Molecular and Cellular Biology
  42. The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
    Maria Filimonenko, Pauline Isakson, Kim D. Finley, Monique R. Anderson, Hyun Jeong, Thomas J Melia, Bryan J. Bartlett, Katherine M. Myers, Hanne C. G. Birkeland, Trond Lamark et al. · 2010 · Molecular Cell
  43. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
    Palmieri, Michela, Pal, Rituraj, Nelvagal, Hemanth R., Lotfi, Parisa, Stinnett, Gary R., Seymour, Michelle L., Chaudhury, Arindam, Bajaj, Lakshya, Bondar, Vitaliy V., Bremner, Laura et al. · 2017 · Nature Communications
  44. Regulation of membrane traffic by phosphoinositide 3-kinases
    Karine Lindmo, Harald Stenmark · 2006 · Journal of Cell Science
  45. Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes
    Claudia Puri, Maurizio Renna, Carla F. Bento, Kévin Moreau, David Chaim Rubinsztein · 2013 · Cell
  46. Drosophila as a Model for Human Neurodegenerative Disease
    Julide Bilen, Nancy M. Bonini · 2005 · Annual Review of Genetics
  47. Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
    Hyunkyung Jeong, Florian Then, Thomas James Melia, Joseph R. Mazzulli, Libin Cui, Jeffrey N. Savas, Cindy Voisine, Paolo Paganetti, Naoko Tanese, Anne C. Hart et al. · 2009 · Cell
  48. Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition
    Shinji Saiki, Yukiko Sasazawa, Yoko Imamichi, Sumihiro Kawajiri, Takahiro Fujimaki, Isei Tanida, Hiroki Kobayashi, Fumiaki Sato, Shigeto Sato, Ken-Ichi Ishikawa et al. · 2011 · Autophagy
  49. How autophagy controls the intestinal epithelial barrier
    Elisabeth G. Foerster, Tapas Mukherjee, Liliane Cabral-Fernandes, Juliana Dutra Barbosa da Rocha, Stephen E. Girardin, Dana J. Philpott · 2021 · Autophagy
  50. Huntington's disease: from pathology and genetics to potential therapies
    Imarisio, Sara, Carmichael, Jenny, Korolchuk, Viktor, Chen, Chien-Wen, Saiki, Shinji, Rose, Claudia, Krishna, Gauri, Davies, Janet E., Ttofi, Evangelia, Underwood, Benjamin R. et al. · 2008 · Biochemical Journal
  51. Free Radicals in Cross Talk Between Autophagy and Apoptosis
    Vitaliy O. Kaminskyy, Boris Zhivotovsky · 2013 · Antioxidants and Redox Signaling
  52. Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder
    Chiu, Chi-Tso, Wang, Zhifei, Hunsberger, Joshua G., Chuang, De-Maw · 2013 · Pharmacological Reviews
  53. Targeting mammalian target of rapamycin (mTOR) for health and diseases
    Chi Kwan Tsang, Haiyan Qi, Leroy F. Liu, Xi Zheng · 2006 · Drug Discovery Today
  54. Rapamycin pre-treatment protects against apoptosis
    Brinda Ravikumar, Zdenek Berger, Coralie Vacher, Cahir J. O’Kane, David Chaim Rubinsztein · 2006 · Human Molecular Genetics
  55. Autophagy in lysosomal storage disorders
    Lieberman, Andrew P., Puertollano, Rosa, Raben, Nina, Slaugenhaupt, Susan, Walkley, Steven U., Ballabio, Andrea · 2012 · Autophagy
  56. SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
    Ghosh, Hiyaa Singhee, McBurney, Michael, Robbins, Paul D. · 2010 · PLoS ONE
  57. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
    Waza, Masahiro, Adachi, Hiroaki, Katsuno, Masahisa, Minamiyama, Makoto, Sang, Chen, Tanaka, Fumiaki, Inukai, Akira, Doyu, Manabu, Sobue, Gen · 2005 · Nature Medicine
  58. The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation
    Y. Wong, E. Holzbaur · 2014 · Journal of Neuroscience
  59. Autophagy in Ischemic Heart Disease
    Åsa B. Gustafsson, Roberta A. Gottlieb · 2009 · Circulation Research
  60. Effects of aging on articular cartilage homeostasis
    Martin Lotz, Richard F. Loeser · 2012 · Bone
  61. Molecular neurobiology of mTOR
    Katarzyna Switon, Katarzyna Kotulska, Aleksandra Janusz, Justyna Zmorzyńska, Jacek Jaworski · 2016 · Neuroscience
  62. Nuclear DNA damage signalling to mitochondria in ageing
    Fang, Evandro Fei, Scheibye-Knudsen, Morten, Chua, Katrin F., Mattson, Mark P., Croteau, Deborah L., Bohr, Vilhelm A. · 2016 · Nature Reviews Molecular Cell Biology
  63. Rapamycin Markedly Slows Disease Progression in a Rat Model of Polycystic Kidney Disease
    Yunxia Tao, Jun Kim, Robert W. Schrier, Charles L. Edelstein · 2004 · Journal of the American Society of Nephrology
  64. Autophagy in Atherosclerosis
    Wim Martinet, Guido R.Y. De Meyer · 2009 · Circulation Research
  65. Autophagy: A Critical Regulator of Cellular Metabolism and Homeostasis
    Stefan W. Ryter, Suzanne M. Cloonan, Augustine M.K. Choi · 2013 · Molecules and Cells
  66. Complex Inhibitory Effects of Nitric Oxide on Autophagy
    Sovan Sarkar, Viktor I. Korolchuk, Maurizio Renna, Sara Imarisio, Angeleen Fleming, Andrea J. Williams, Moisés Garcı́a-Arencibia, Claudia Rose, Shouqing Luo, Benjamin R. Underwood et al. · 2011 · Molecular Cell
  67. Protein aggregates in Huntington's disease
    Montserrat Arrasate, Steven M. Finkbeiner · 2011 · Experimental Neurology
  68. Distinct RolesIn Vivofor the Ubiquitin–Proteasome System and the Autophagy–Lysosomal Pathway in the Degradation of α-Synuclein
    Darius Ebrahimi‐Fakhari, Ippolita Cantuti‐Castelvetri, Zhanyun Fan, Edward M. Rockenstein, Eliezer Masliah, Bradley T. Hyman, Pamela J. McLean, Vivek K. Unni · 2011 · Journal of Neuroscience
  69. Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
    Wang, I-Fang, Guo, Bo-Shen, Liu, Yu-Chih, Wu, Cheng-Chun, Yang, Chun-Hung, Tsai, Kuen-Jer, Shen, Che-Kun James · 2012 · Proceedings of the National Academy of Sciences
  70. Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy
    Adhami, Faisal, Liao, Guanghong, Morozov, Yury M., Schloemer, Aryn, Schmithorst, Vincent J., Lorenz, John N., Dunn, R. Scott, Vorhees, Charles V., Wills-Karp, Marsha, Degen, Jay L. et al. · 2006 · The American Journal of Pathology
  71. Mechanisms of cell death in rhodopsin retinitis pigmentosa: implications for therapy
    Hugo F. Mendes, Jacqueline van der Spuy, J. Paul Chapple, Michael E. Cheetham · 2005 · Trends in Molecular Medicine
  72. Protein homeostasis and aging in neurodegeneration
    Peter M. Douglas, Andrew G. Dillin · 2010 · The Journal of Cell Biology
  73. Application and interpretation of current autophagy inhibitors and activators
    Yaping Yang, Li‐Fang Hu, Hui-fen Zheng, Chengjie Mao, Weidong Hu, Kangping Xiong, Fen Wang, Chun‐Feng Liu · 2013 · Acta Pharmacologica Sinica
  74. Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
    Leslie A. Crews, Brian J. Spencer, Paula Desplats, Christina Patrick, Amy Paulino, Edward M. Rockenstein, Lawrence A. Hansen, Anthony Adame, Douglas R Galasko, Eliezer Masliah · 2010 · PLoS ONE · Retracted
  75. Autophagy and disease: unanswered questions
    Ying Yang, Daniel J. Klionsky · 2020 · Cell Death and Differentiation
  76. The mTOR signalling cascade: paving new roads to cure neurological disease
    Crino, Peter B. · 2016 · Nature Reviews Neurology
  77. Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
    Sovan Sarkar · 2013 · Biochemical Society Transactions
  78. Role of lysosomes in physiological activities, diseases, and therapy
    Ziqi Zhang, Pengfei Yue, Tianqi Lu, Yang Wang, Yuquan Wei, Xiawei Wei · 2021 · Journal of Hematology & Oncology
  79. Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
    Gorman, Adrienne M. · 2008 · Journal of Cellular and Molecular Medicine
  80. mTOR in Brain Physiology and Pathologies
    Joël Bockaert, Philippe Marin · 2015 · Physiological Reviews
  81. Polyglutamine tracts regulate beclin 1-dependent autophagy
    Ashkenazi, Avraham, Bento, Carla F., Ricketts, Thomas, Vicinanza, Mariella, Siddiqi, Farah, Pavel, Mariana, Squitieri, Ferdinando, Hardenberg, Maarten C., Imarisio, Sara, Menzies, Fiona M. et al. · 2017 · Nature
  82. Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
    Ai Yamamoto, María Laura Cremona, James E. Rothman · 2006 · The Journal of Cell Biology
  83. The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses
    Ewan M. Smith, Stephen G. FINN, Andrew R. Tee, Gareth J. Browne, Christopher G. Proud · 2005 · Journal of Biological Chemistry
  84. Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection
    Nedelsky, Natalia B., Todd, Peter K., Taylor, J. Paul · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  85. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
    Sovan Sarkar, Gauri Krishna, Sara Imarisio, Shinji Saiki, Cahir J. O’Kane, David Chaim Rubinsztein · 2007 · Human Molecular Genetics
  86. The independence of and associations among apoptosis, autophagy, and necrosis
    Qi Chen, Jian Kang, Caiyun Fu · 2018 · Signal Transduction and Targeted Therapy
  87. HspB8 Chaperone Activity toward Poly(Q)-containing Proteins Depends on Its Association with Bag3, a Stimulator of Macroautophagy
    Serena Carra, Samuel J. Seguin, Herman Lambert, Jacques Landry · 2007 · Journal of Biological Chemistry
  88. Chemical modulators of autophagy as biological probes and potential therapeutics
    Angeleen Fleming, Takeshi Noda, Tamotsu Yoshimori, David Chaim Rubinsztein · 2010 · Nature Chemical Biology
  89. Development of autophagy inducers in clinical medicine
    Beth Levine, Milton Packer, Patrice Codogno · 2015 · Journal of Clinical Investigation
  90. Autophagy in Huntington disease and huntingtin in autophagy
    Dale D. O. Martin, Safia Ladha, Dagmar E. Ehrnhoefer, Michael R. Hayden · 2014 · Trends in Neurosciences
  91. Neuronal autophagy and neurodegenerative diseases
    Jin H. Son, Jung Hee Shim, Kyung‐Hee Kim, Ji‐Young Ha, Ji‐Young Han · 2012 · Experimental & Molecular Medicine
  92. Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II)
    Fujita, Eriko, Kouroku, Yoriko, Isoai, Atsushi, Kumagai, Hiromichi, Misutani, Akifumi, Matsuda, Chie, Hayashi, Yukiko K., Momoi, Takashi · 2007 · Human Molecular Genetics
  93. Autophagy is a therapeutic target in anticancer drug resistance
    Suning Chen, Sumaiyah K. Rehman, Wei Zhang, Aidong Wen, Libo Yao, Jian Zhang · 2010 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  94. The TOR pathway comes of age
    Monique N. Stanfel, Lara S. Shamieh, Matt R. Kaeberlein, Brian Keith Kennedy · 2009 · Biochimica et Biophysica Acta (BBA) - General Subjects
  95. Role of mTOR in physiology and pathology of the nervous system
    Swiech, Lukasz, Perycz, Malgorzata, Malik, Anna, Jaworski, Jacek · 2008 · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  96. Autophagy and Lipid Droplets in the Liver
    Nuria Martínez-López, Rajat Singh · 2015 · Annual Review of Nutrition
  97. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
    Karen Castillo, Melissa Nassif, Vicente Valenzuela, Fabiola Rojas, Soledad Matus, Gabriela Mercado, Felipe A. Court, Brigitte van Zundert, Claudio A. Hetz · 2013 · Autophagy
  98. The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution
    Nico P. Dantuma, Laura C. Bott · 2014 · Frontiers in Molecular Neuroscience
  99. Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
    Dai, Dao-Fu, Chen, Tony, Johnson, Simon C., Szeto, Hazel, Rabinovitch, Peter S. · 2012 · Antioxidants & Redox Signaling
  100. Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy
    Christina H. Eng, Ker Yu, Judy Lucas, Eileen White, Robert T. Abraham · 2010 · Science Signaling