Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
Ravikumar, Brinda, Vacher, Coralie, Berger, Zdenek, Davies, Janet E, Luo, Shouqing, Oroz, Lourdes G, Scaravilli, Francesco, Easton, Douglas F, Duden, Rainer, O'Kane, Cahir J, Rubinsztein, David C·2004·Nature Genetics
DOI 10.1038/ng1362
Cited by (1,011)
Items 1,001–1,011 of 1,011
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- Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human DiseasesPanda, Prashanta Kumar, Fahrner, Alexandra, Vats, Somya, Seranova, Elena, Sharma, Vartika, Chipara, Miruna, Desai, Priyal, Torresi, Jorge, Rosenstock, Tatiana, Kumar, Dhiraj et al. · 2019 · Frontiers in Cell and Developmental Biology
- Regulation of mRNA Translation as a Conserved Mechanism of Longevity ControlMehta, Ranjana, Chandler-Brown, Devon, Ramos, Fresnida J., Shamieh, Lara S., Kaeberlein, Matt · 2010 · Advances in Experimental Medicine and Biology
- Protective roles for induction of autophagy in multiple proteinopathiesMenzies, Fiona M., Ravikumar, Brinda, Rubinsztein, David C. · 2006 · Autophagy
- The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?Austad, Steven N. · 2016 · Advances in Geroscience
- A new method to measure autophagy flux in the nervous systemMatus, Soledad, Valenzuela, Vicente, Hetz, Claudio · 2014 · Autophagy
- Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytesChen, Lei-lei, Wu, Jun-chao, Wang, Lin-hui, Wang, Jin, Qin, Zheng-hong, Difiglia, Marian, Lin, Fang · 2012 · Acta Pharmacologica Sinica
- Transcription factors and cognate signalling cascades in the regulation of autophagyChandra, Vemika, Bhagyaraj, Ella, Parkesh, Raman, Gupta, Pawan · 2016 · Biological Reviews
- Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington’s DiseaseMustafa, Rasem, Kreiner, Grzegorz, Kamińska, Katarzyna, Wood, Amelia-Elise J., Kirsch, Joachim, Tucker, Kerry L., Parlato, Rosanna · 2019 · Frontiers in Cellular Neuroscience
- Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in DrosophilaRoth, Jonathan R., Moraes, Ruan Carlos Macedo de, Xu, Brittney P., Crawley, Savannah R., Khan, Malghalara A., Melkani, Girish C. · 2023 · Frontiers in Aging Neuroscience