Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, Brinda, Vacher, Coralie, Berger, Zdenek, Davies, Janet E, Luo, Shouqing, Oroz, Lourdes G, Scaravilli, Francesco, Easton, Douglas F, Duden, Rainer, O'Kane, Cahir J, Rubinsztein, David C·2004·Nature Genetics

Cited by (1,011)

Items 1,001–1,011 of 1,011

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    Laura Rué, Graciela López-Soop, Ellen Gelpí, Marta Martínez‐Vicente, Jordi Alberch, Esther Pérez‐Navarro · 2013 · Neurobiology of Disease
  2. Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders
    Evangelisti, Camilla, Cenni, Vittoria, Lattanzi, Giovanna · 2016 · British Journal of Clinical Pharmacology
  3. Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases
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  4. Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control
    Mehta, Ranjana, Chandler-Brown, Devon, Ramos, Fresnida J., Shamieh, Lara S., Kaeberlein, Matt · 2010 · Advances in Experimental Medicine and Biology
  5. Protective roles for induction of autophagy in multiple proteinopathies
    Menzies, Fiona M., Ravikumar, Brinda, Rubinsztein, David C. · 2006 · Autophagy
  6. The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?
    Austad, Steven N. · 2016 · Advances in Geroscience
  7. A new method to measure autophagy flux in the nervous system
    Matus, Soledad, Valenzuela, Vicente, Hetz, Claudio · 2014 · Autophagy
  8. Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes
    Chen, Lei-lei, Wu, Jun-chao, Wang, Lin-hui, Wang, Jin, Qin, Zheng-hong, Difiglia, Marian, Lin, Fang · 2012 · Acta Pharmacologica Sinica
  9. Transcription factors and cognate signalling cascades in the regulation of autophagy
    Chandra, Vemika, Bhagyaraj, Ella, Parkesh, Raman, Gupta, Pawan · 2016 · Biological Reviews
  10. Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington’s Disease
    Mustafa, Rasem, Kreiner, Grzegorz, Kamińska, Katarzyna, Wood, Amelia-Elise J., Kirsch, Joachim, Tucker, Kerry L., Parlato, Rosanna · 2019 · Frontiers in Cellular Neuroscience
  11. Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila
    Roth, Jonathan R., Moraes, Ruan Carlos Macedo de, Xu, Brittney P., Crawley, Savannah R., Khan, Malghalara A., Melkani, Girish C. · 2023 · Frontiers in Aging Neuroscience