Cited by 744Genetic diversity and population structureEvolution and Genetic DynamicsChromosomal and Genetic Variations

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Variation in gene expression within and among natural populations

Oleksiak, Marjorie F., Churchill, Gary A., Crawford, Douglas L.·2002·Nature Genetics

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Abstract

Evolution may depend more strongly on variation in gene expression than on differences between variant forms of proteins. Regions of DNA that affect gene expression are highly variable, containing 0.6% polymorphic sites. These naturally occurring polymorphic nucleotides can alter in vivo transcription rates. Thus, one might expect substantial variation in gene expression between individuals. But the natural variation in mRNA expression for a large number of genes has not been measured. Here we report microarray studies addressing the variation in gene expression within and between natural populations of teleost fish of the genus Fundulus. We observed statistically significant differences in expression between individuals within the same population for approximately 18% of 907 genes. Expression typically differed by a factor of 1.5, and often more than 2.0. Differences between populations increased the variation. Much of the variation between populations was a positive function of the variation within populations and thus is most parsimoniously described as random. Some genes showed unexpected patterns of expression--changes unrelated to evolutionary distance. These data suggest that substantial natural variation exists in gene expression and that this quantitative variation is important in evolution.

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Authors: Oleksiak, M. F., Churchill, G. A., & Crawford, D. L.
Affiliations: University of Missouri–Kansas City (US)
Jackson Laboratory (US)
Corresponding author: Crawford, Douglas L.
ORCID: Oleksiak, Marjorie F.
Churchill, Gary A.
Crawford, Douglas L.
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2002-09-03
Volume: 32
Issue: 2
Pages: 261-266
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng983
OpenAlex: W2111696544
Cited by: 736
References: 29
Citations by year: 2026: 4 · 2025: 7 · 2024: 15 · 2023: 8 · 2022: 7 · 2021: 59 · 2020: 20 · 2019: 12 · 2018: 17 · 2017: 24 · 2016: 13 · 2015: 25 · 2014: 31 · 2013: 29 · 2012: 29
FWCI: 26.28
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: gene expression variation, natural genetic variation, Fundulus, teleosts, genetic differentiation, mRNA expression, quantitative genetic variation, gene expression evolution
MeSH terms: Analysis of Variance, Phylogeny, RNA, Messenger, Genetic Variation, Gene Expression, Fundulidae

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Variation in gene expression within and among natural populations

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