The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Variation in gene expression within and among natural populations
Abstract
Evolution may depend more strongly on variation in gene expression than on differences between variant forms of proteins. Regions of DNA that affect gene expression are highly variable, containing 0.6% polymorphic sites. These naturally occurring polymorphic nucleotides can alter in vivo transcription rates. Thus, one might expect substantial variation in gene expression between individuals. But the natural variation in mRNA expression for a large number of genes has not been measured. Here we report microarray studies addressing the variation in gene expression within and between natural populations of teleost fish of the genus Fundulus. We observed statistically significant differences in expression between individuals within the same population for approximately 18% of 907 genes. Expression typically differed by a factor of 1.5, and often more than 2.0. Differences between populations increased the variation. Much of the variation between populations was a positive function of the variation within populations and thus is most parsimoniously described as random. Some genes showed unexpected patterns of expression--changes unrelated to evolutionary distance. These data suggest that substantial natural variation exists in gene expression and that this quantitative variation is important in evolution.
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“Variation in gene expression mediated by cis-REs plays an important role in evolutionary phenotypic change (32, 42–46).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [44]
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Cites
Molecular Evolutionary Genetics
Nei, M. (1987) · Columbia University Press eBooks · doi:10.7312/nei-92038 · Cited by 16,583
Cluster analysis and display of genome-wide expression patterns
Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184
Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., et al. (1999) · Science · doi:10.1126/science.286.5439.531 · Cited by 11,516
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Alizadeh, A. A., Eisen, M. B., Davis, R. E., Ma, C., Lossos, I. S., Rosenwald, A., Boldrick, J. C., Sabet, H., Tran, T., Yu, X., et al. (2000) · Nature · doi:10.1038/35000501 · Cited by 9,925
King, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815
Use of a cDNA microarray to analyse gene expression patterns in human cancer
DeRisi, J. L., Penland, L., Brown, P. O., Bittner, M. L., Meltzer, P. S., Ray, M., Chen, Y.-W., Su, Y. A., & Trent, J. M. (1996) · Nature Genetics · doi:10.1038/ng1296-457 · Cited by 1,952
Resampling-Based Multiple Testing: Examples and Methods for p-Value Adjustment.
Martin, M. A., Westfall, P. H., & Young, S. S. (1994) · Biometrics · doi:10.2307/2533464 · Cited by 1,713
Genetic Dissection of Transcriptional Regulation in Budding Yeast
Brem, R. B., Yvert, G., Clinton, R., & Kruglyak, L. (2002) · Science · doi:10.1126/science.1069516 · Cited by 1,392
Analysis of Variance for Gene Expression Microarray Data
Kerr, K. F., Martin, M., & Churchill, G. A. (2000) · Journal of Computational Biology · doi:10.1089/10665270050514954 · Cited by 1,310
Haplotype Variation and Linkage Disequilibrium in 313 Human Genes
Stephens, J. C., Schneider, J. A., Tanguay, D. A., Choi, J. Y., Acharya, T., Stanley, S. E., Jiang, R., Messer, C. J., Chew, A., Han, J.-H., et al. (2001) · Science · doi:10.1126/science.1059431 · Cited by 867
Research works printed but not linked: 1
- Cashner, R.C., Rogers, J.S. & Grady, J.M. Phylogenetic studies of the genus Fundulus. in Systematic, Historical Ecology and North American Freshwater Fishes (ed. Mayden, R.L.) 421–437 (Stanford Univ. Press, Stanford, California, 1992).
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Genomic insights that advance the species definition for prokaryotes
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The Evolution of Transcriptional Regulation in Eukaryotes
Wray, G. A. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msg140 · Cited by 1,229
Genetic analysis of genome-wide variation in human gene expression
Morley, M. P., Molony, C. M., Weber, T. M., Devlin, J. L., Ewens, K. G., Spielman, R. S., & Cheung, V. G. (2004) · Nature · doi:10.1038/nature02797 · Cited by 1,212
Fundamentals of experimental design for cDNA microarrays
Churchill, G. A. (2002) · Nature Genetics · doi:10.1038/ng1031 · Cited by 1,049
Evolution, the Extended Synthesis
Pigliucci, M., & Müller, G. (2010) · The MIT Press eBooks · doi:10.7551/mitpress/9780262513678.001.0001 · Cited by 976
Metadata
- Authors
- Oleksiak, M. F., Churchill, G. A., & Crawford, D. L.
- Affiliations
- University of Missouri–Kansas City (US)
- Jackson Laboratory (US)
- Corresponding author
- Crawford, Douglas L.
- Venue
- Nature Genetics
- Published
- 2002-09-03
- Volume
- 32
- Issue
- 2
- Pages
- 261-266
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W2111696544
- Cited by
- 736
- References
- 29
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 15 · 2023: 8 · 2022: 7 · 2021: 59 · 2020: 20 · 2019: 12 · 2018: 17 · 2017: 24 · 2016: 13 · 2015: 25 · 2014: 31 · 2013: 29 · 2012: 29
- FWCI
- 26.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- gene expression variation, natural genetic variation, Fundulus, teleosts, genetic differentiation, mRNA expression, quantitative genetic variation, gene expression evolution
- MeSH terms
- Analysis of Variance, Phylogeny, RNA, Messenger, Genetic Variation, Gene Expression, Fundulidae
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