The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity
Open accessAbstract
Dendritic cells can prime naive CD4+ T cells; however, here we demonstrate that dendritic cell–mediated priming was insufficient for the development of T helper type 2 cell–dependent immunity. We identify basophils as a dominant cell population that coexpressed major histocompatibility complex class II and interleukin 4 message after helminth infection. Basophilia was promoted by thymic stromal lymphopoietin, and depletion of basophils impaired immunity to helminth infection. Basophils promoted antigen-specific CD4+ T cell proliferation and interleukin 4 production in vitro, and transfer of basophils augmented the population expansion of helminth-responsive CD4+ T cells in vivo. Collectively, our studies suggest that major histocompatibility complex class II–dependent interactions between basophils and CD4+ T cells promote T helper type 2 cytokine responses and immunity to helminth infection.
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Allen, J. E., & Maizels, R. M. (2011) · Nature reviews. Immunology · doi:10.1038/nri2992 · Cited by 831
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Hubbell, J. A., Thomas, S. N., & Swartz, M. A. (2009) · Nature · doi:10.1038/nature08604 · Cited by 561
Bartemes, K. R., Iijima, K., Kobayashi, T., Kephart, G. M., McKenzie, A. N., & Kita, H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102832 · Cited by 549
Metadata
- Authors
- Perrigoue, J. G., Saenz, S. A., Siracusa, M. C., Allenspach, E. J., Taylor, B. C., Giacomin, P. R., Nair, M. G., Du, Y., Zaph, C., van Rooijen, N., Comeau, M. R., Pearce, E. J., Laufer, T. M., & Artis, D.
- Venue
- Nature Immunology
- Published
- 2009-05-24
- Volume
- 10
- Issue
- 7
- Pages
- 697-705
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2129115323
- Cited by
- 601
- References
- 58
- FWCI
- 35.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Perrigoue, J. G., Saenz, S. A., Siracusa, M. C., Allenspach, E. J., Taylor, B. C., Giacomin, P. R., Nair, M. G., Du, Y., Zaph, C., van Rooijen, N., Comeau, M. R., Pearce, E. J., Laufer, T. M., & Artis, D. (2009). MHC class II–dependent basophil–CD4+ T cell interactions promote TH2 cytokine–dependent immunity. Nature Immunology. https://doi.org/10.1038/ni.1740
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