The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation
Open accessAbstract
Interleukin 9 (IL-9) is a cytokine linked to lung inflammation, but its cellular origin and function remain unclear. Here we describe a reporter mouse strain designed to map the fate of cells that have activated IL-9. We found that during papain-induced lung inflammation, IL-9 production was largely restricted to innate lymphoid cells (ILCs). IL-9 production by ILCs depended on IL-2 from adaptive immune cells and was rapidly lost in favor of other cytokines, such as IL-13 and IL-5. Blockade of IL-9 production via neutralizing antibodies resulted in much lower expression of IL-13 and IL-5, which suggested that ILCs provide the missing link between the well-established functions of IL-9 in the regulation of type 2 helper T cell cytokines and responses.
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Fate mapping of IL-17-producing T cells in inflammatory responses
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IL-9 and its receptor in allergic and nonallergic lung disease: Increased expression in asthma
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Pulmonary overexpression of IL-9 induces Th2 cytokine expression, leading to immune pathology
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IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells
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Cited by
Innate lymphoid cells — a proposal for uniform nomenclature
Spits, H., Artis, D., Colonna, M., Diefenbach, A., Di Santo, J. P., Eberl, G., Koyasu, S., Locksley, R. M., McKenzie, A. N. J., Mebius, R. E., et al. (2013) · Nature Reviews Immunology · doi:10.1038/nri3365 · Cited by 2,389
Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673
TGF-β Activation and Function in Immunity
Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
DuPage, M., & Bluestone, J. A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.18 · Cited by 513
Metadata
- Authors
- Wilhelm, C., Hirota, K., Stieglitz, B., Van Snick, J., Tolaini, M., Lahl, K., Sparwasser, T., Helmby, H., & Stockinger, B.
- Venue
- Nature Immunology
- Published
- 2011-10-09
- Volume
- 12
- Issue
- 11
- Pages
- 1071-1077
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2089685608
- Cited by
- 481
- References
- 10
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Wilhelm, C., Hirota, K., Stieglitz, B., Van Snick, J., Tolaini, M., Lahl, K., Sparwasser, T., Helmby, H., & Stockinger, B. (2011). An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nature Immunology. https://doi.org/10.1038/ni.2133
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