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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Open accessAbstract
We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively expressed by macrophages rather than dendritic cells, and many of these were not present in all macrophages. Nonetheless, well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages. TCEF3, C/EBP-α, Bach1 and CREG-1 were among the transcriptional regulators predicted to regulate these core macrophage-associated genes. The mRNA encoding other transcription factors, such as Gata6, was associated with single macrophage populations. We further identified how these transcripts and the proteins they encode facilitated distinguishing macrophages from dendritic cells.
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“Microglia also express hundreds of genes at higher levels than other macrophage subsets (24–26) that may be influenced by factors present in the CNS microenvironment (25, 27), suggesting mechanisms by which the brain environment influences the activity and functions of one of its primary support cells.”
From An environment-dependent transcriptional network specifies human microglia identity (2017) · cites this paper as [24]
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“Recent work demonstrated that all tissue resident macrophages are different to an extent yet cluster together when compared to monocytes and DCs and that spleen red pulp macrophages were closely associated with microglia14.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [14]
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“We also found that organ-resident macrophages in the gut and liver are “microglia-like” as they express Gas6 and Mertk and these genes may have a role in maintaining tissue homeostasis which is consistent with a recent transcriptional profiling of murine tissue macrophages14.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [14]
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“FFAR2-deficient mice displayed microglia reminiscent of those found in GF mice (103).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [103]
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“we found increased microglial expression of C1q, Csfr1 and Cd34 genes, which are known to be expressed on tissue resident macrophages14.”
From Identification of a unique TGF-β–dependent molecular and functional signature in microglia (2014) · cites this paper as [14]
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“Because macrophages and dendritic cells have similar transcriptomic profiles23–25, we repeated SingleR analysis using published RNA-seq datasets of mouse lung macrophages and dendritic cells26,27 to isolate the macrophages”
From Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage (2019) · cites this paper as [25]
In the citing paper
“microglia — but not peripheral myeloid cells — were shown to express P2Y purinoceptor 12 (P2ry12), transmembrane protein 119 (Tmem119), sialic acid binding Ig-like lectin H (Siglech), probable G protein coupled receptor 34 (Gpr34), suppressor of cytokine signalling 3 (Socs3), β-hexosaminidase subunit β (Hexb), olfactomedin-like protein 3 (Olfml3) and Fc receptor-like S, scavenger receptor (Fcrls).”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [29]
In the citing paper
“In the healthy brain, they exhibit a unique molecular homeostatic ‘signature’, consisting of a specific transcriptional profile and surface protein expression pattern, which differs from that of tissue macrophages.”
From Microglial signatures and their role in health and disease (2018) · cites this paper as [29]
In the citing paper
“Tissue micro-environmental factors activate cascades resulting in co-operative binding of certain transcription factors with PU.1, leading to a unique enhancer profile enabling microglial dynamic response to its surrounding micro-environment [24, 72].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [72]
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Citations
Cites
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Self-citationA Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Batf3 Deficiency Reveals a Critical Role for CD8α + Dendritic Cells in Cytotoxic T Cell Immunity
Hildner, K., Edelson, B. T., Purtha, W. E., Diamond, M., Matsushita, H., Kohyama, M., Calderon, B., Schraml, B. U., Unanue, E. R., Diamond, M. S., et al. (2008) · Science · doi:10.1126/science.1164206 · Cited by 2,081
The Immunological Genome Project: networks of gene expression in immune cells
The Immunological Genome Project Consortium, Heng, T. S. P., Painter, M. W., Elpek, K., Lukacs-Kornek, V., Mauermann, N., Turley, S. J., Koller, D., Kim, F. S., Wagers, A. J., et al. (2008) · Nature Immunology · doi:10.1038/ni1008-1091 · Cited by 1,864
Self-citationGenetic regulation of osteoclast development and function
Teitelbaum, S. L., & Ross, F. P. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1122 · Cited by 1,720
CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions
Ohl, L., Mohaupt, M., Czeloth, N., Hintzen, G., Kiafard, Z., Zwirner, J., Blankenstein, T., Henning, G., & Förster, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.014 · Cited by 1,086
A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells
Fogg, D. K., Sibon, C., Miled, C., Jung, S., Aucouturier, P., Littman, D. R., Cumano, A., & Geissmann, F. (2005) · Science · doi:10.1126/science.1117729 · Cited by 1,050
Cited by
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Items 901–1,000 of 1,008
Han, L.-R., Lei, H.-Z., Tian, Z., Wang, X., Cheng, D., & Wang, C.-L. (2018) · Food & Function · doi:10.1039/c8fo00269j · Cited by 38
The E3 ligase VHL controls alveolar macrophage function via metabolic–epigenetic regulation
Zhang, W., Li, Q., Li, D., Li, J., Aki, D., & Liu, Y. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20181211 · Cited by 44
Li, F., Okreglicka, K. M., Pohlmeier, L. M., Schneider, C., & Köpf, M. (2020) · The EMBO Journal · doi:10.15252/embj.2019103205 · Cited by 43
Therapeutic validation of an orphan G protein‐coupled receptor: The case of GPR84
Marsango, S., Barki, N., Jenkins, L., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15248 · Cited by 45
“There is certainly potential for inflammation‐induced up‐regulation of GPR84 mRNA to provide a sensitive and valuable preclinical biomarker, and as well as peripheral disorders, blockade of GPR84 may be of value in the treatment of neuroinflammatory conditions in the CNS.”
BackgroundInfluentialMacrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance
Pinney, J. J., Rivera‐Escalera, F., Chu, C. C., Whitehead, H. E., VanDerMeid, K. R., Nelson, A. M., Barbeau, M. C., Zent, C. S., & Elliott, M. R. (2020) · Blood · doi:10.1182/blood.2020005571 · Cited by 44
Recruitment and training of alveolar macrophages after pneumococcal pneumonia
Arafa, E. I., Shenoy, A. T., Barker, K. A., Etesami, N. S., Martin, I. M. C., Ana, C. L. D., Na, E., Odom, C. V., Goltry, W. N., Korkmaz, F. T., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.150239 · Cited by 47
“Unlike after adenovirus or influenza infections (35, 39), AM from lungs that have recovered from pneumococcal pneumonia do not demonstrate elevated Cxcl2 or Il6 expression, whether of embryonic or adult HSC origin (Figure 10, B and C).”
Yadav, H., Jaldhi, Bhardwaj, R., Anamika, A., Bakshi, A., Gupta, S., & Maurya, S. K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122022 · Cited by 47
Han, J., Gallerand, A., Erlich, E. C., Helmink, B. A., Mair, I., Li, X., Eckhouse, S. R., Dimou, F. M., Shakhsheer, B. A., Phelps, H. M., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01688-7 · Cited by 45
“Our data linked human CD1c + mononuclear phagocytes that bear monocytic markers CD14 and CD64 with mouse F4/80 lo MHCII + SCM. Mouse SCM simultaneously express features of macrophages and DCs 1,20,22,23,34 .”
InfluentialSelf-citationCam, A., Sivaguru, M., & de Mejı́a, E. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072115 · Cited by 44
Microglia – the brain’s busy bees
Cronk, J. C., & Kipnis, J. (2013) · F1000Prime Reports · doi:10.12703/p5-53 · Cited by 49
Bhatia, H. S., Roelofs, N., Muñóz, E., & Fiebich, B. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-00225-5 · Cited by 46
Koker, S. D., Hoecke, L. V., Beuckelaer, A. D., Roose, K., Deswarte, K., Willart, M. A. M., Bogaert, P., Naessens, T., Geest, B. G. D., Saelens, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06236-6 · Cited by 44
Small Molecules for Early Endosome-Specific Patch Clamping
Chen, C., Butz, E. S., Chao, Y., Grishchuk, Y., Becker, L., Heller, S., Slaugenhaupt, S. A., Biel, M., Wahl‐Schott, C., & Grimm, C. M. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.05.025 · Cited by 44
Cardiomyocytes and Macrophages Discourse on the Method to Govern Cardiac Repair
Gomez, I., Duval, V., & Silvestre, J. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00134 · Cited by 49
Characterization of Subpopulations of Chicken Mononuclear Phagocytes That Express TIM4 and CSF1R
Hu, T., Wu, Z., Bush, S. J., Freem, L. J., Vervelde, L., SUMMERS, K. M., Balic, A., Hume, D. A., & Kaiser, P. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800504 · Cited by 49
Pathology of inflammatory diseases of the nervous system: Human disease versus animal models
Lassmann, H. (2019) · Glia · doi:10.1002/glia.23726 · Cited by 44
“Within the normal CNS microglia assumes a resting or homeostatic phenotype, which is characterized by a cell type specific pattern of gene and protein expression (Butovsky et al., 2014; Gautier et al., 2012; Hickman et al., 2013).”
BackgroundVerheijden, S., Beckers, L., Casazza, A., Butovsky, O., Mazzone, M., & Baes, M. (2015) · Glia · doi:10.1002/glia.22831 · Cited by 40
“…important progress was made in the molecular characterization of homeostatic microglia, by differentiating their transcriptome signature from that of neural cells and other myeloid cells (Butovsky et al., 2012; Butovsky et al., 2014; Chiu et al., 2013; Gautier et al., 2012; Hickman et al., 2013,).”
BackgroundRamsingh, A. I., MANLEY, K. M., Rong, Y., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv335 · Cited by 43
The intestinal microenvironment shapes macrophage and dendritic cell identity and function
Filardy, A. A., Ferreira, J. R. M., Rezende, R. M., Kelsall, B. L., & de Oliveira, R. P. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.01.003 · Cited by 50
Atherosclerosis—Multiple Pathways to Lesional Macrophages
Schulz, C., & Maßberg, S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008922 · Cited by 43
Monocyte, Macrophage, and Dendritic Cell Development: the Human Perspective
Collin, M. P., & Bigley, V. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0015-2015 · Cited by 45
Huang, F., Chen, Z., Chen, H., Lu, W., Xie, S., Meng, Q. H., Wu, Y., & Xia, D. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy039 · Cited by 43
The multifaceted role of the renal mononuclear phagocyte system
Viehmann, S. F., Böhner, A. M. C., Kurts, C., & Brähler, S. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.04.009 · Cited by 43
Arai, S., & Miyazaki, T. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0717-6 · Cited by 44
The Multifarious Role of Microglia in Brain Metastasis
Soto, M. S., & Sibson, N. R. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00414 · Cited by 42
The Formation and Therapeutic Update of Tumor-Associated Macrophages in Cervical Cancer
Wang, Q., Steger, A., Mahner, S., Jeschke, U., & Heidegger, H. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133310 · Cited by 43
“They generally show specialized properties and functions that are related to their respective tissue locations, such as Kupffer cells in the liver, alveolar macrophages in the lungs, red pulp macrophages in the spleen and microglia in the brain [12,13].”
BackgroundMonaghan, K. L., Zheng, W., Hu, G., & Wan, E. C. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02779 · Cited by 44
Nanomedicine enables spatiotemporally regulating macrophage-based cancer immunotherapy
Zhao, Y., Mamuti, M., An, H., Fang, X., Zhao, Y., & Wang, H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120552 · Cited by 44
Functional genomics of inflamm-aging and immunosenescence
Lu, R. J., Wang, E. K., & Benayoun, B. A. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab009 · Cited by 43
“expressed genes are important for specialized functions [40,41].”
BackgroundBonnardel, J., Silva, C. D., Wagner, C., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.30 · Cited by 43
Wang, C., Cui, A., Bukenya, M., Aung, A., Pradhan, D., Whittaker, C. A., Agarwal, Y., Thomas, A., Liang, S., Amlashi, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110021 · Cited by 43
“3, Biolegend) and anti-NG2-AF488 (polyclonal, Sigma-Aldrich).”
Pisu, D., Johnston, L., Mattila, J. T., & Russell, D. G. (2024) · Nature Communications · doi:10.1038/s41467-024-52846-w · Cited by 42
Ji, W., Ma, Y., Zhou, X., Zhang, Y., Lu, R., Guo, Z.-Z., Sun, H.-Y., Hu, D.-C., Yang, G.-H., Li, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081090 · Cited by 42
Meliopoulos, V., de Velde, L.-A. V., van de Velde, N. C., Karlsson, E. A., Neale, G. A. M., Vogel, P., Guy, C. S., Sharma, S., Duan, S., Surman, S. L., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005804 · Cited by 43
“AMs have characteristic flow cytometry properties as compared to dendritic cells (DCs) or incoming activated bone marrow-derived inflammatory monocytes including autofluoresence in the FITC channel, high constitutive expression of CD11c, F4/80 and SiglecF and low expression of CD11b [4,41,42].”
BackgroundSurdziel, E., Clay, I., Nigsch, F., Thiemeyer, A., Allard, C., Hoffman, G. R., Reece-Hoyes, J. S., Phadke, T., Gambert, R., Keller, C. G., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183679 · Cited by 42
Leuschner, F., & Nahrendorf, M. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz159 · Cited by 43
Schroder, W. A., Hirata, T. D. C., Le, T. T., Gardner, J., Boyle, G. M., Ellis, J. J., Nakayama, E., Pathirana, D., Nakaya, H. I., & Suhrbier, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-48741-w · Cited by 43
Immunological memory in rheumatic inflammation - a roadblock to tolerance induction
Maschmeyer, P., Chang, H.-D., Cheng, Q., Mashreghi, M.-F., Hiepe, F., Alexander, T., & Radbruch, A. (2021) · Nature Reviews Rheumatology · doi:10.1038/s41584-021-00601-6 · Cited by 40
Bosteels, C., Damme, K. F. A. V., Leeuw, E. D., Declercq, J., Maes, B., Bosteels, V., Hoste, L., Naesens, L., Debeuf, N., Deckers, J., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100833 · Cited by 43
Backer, R. A., Probst, H. C., & Clausen, B. E. (2023) · European Journal of Immunology · doi:10.1002/eji.202149548 · Cited by 42
Metabolic Reprograming of Mononuclear Phagocytes in Progressive Multiple Sclerosis
Tannahill, G. M., Iraci, N., Gaude, E., Frezza, C., & Pluchino, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00106 · Cited by 43
Fiala, M., Terrando, N., & Dalli, J. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150367 · Cited by 43
Microglia Transcriptome Changes in a Model of Depressive Behavior after Immune Challenge
González-Peña, D., Nixon, S. E., O’Connor, J. C., Southey, B. R., Lawson, M. A., McCusker, R. H., Borras, T., Machuca, D., Hernández, Á. G., Dantzer, R., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150858 · Cited by 43
“The prevalent differential expression between cell types is consistent with prior transcriptomic comparisons and has been linked to differences in cell type origin and local environment [7,34,35].”
BackgroundCarretero-Iglesia, L., Bouchet‐Delbos, L., Louvet, C., Drujont, L., Segovia, M., Mérieau, E., Chiffoleau, E., Josien, R., Hill, M., Cuturi, M. C., et al. (2016) · Transplantation · doi:10.1097/tp.0000000000001315 · Cited by 41
Microglia in the CNS and Neuropathic Pain
Tsuda, M. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1756-9_7 · Cited by 39
Synovial macrophages: from ordinary eaters to extraordinary multitaskers
Hannemann, N., Apparailly, F., & Courties, G. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.03.002 · Cited by 41
Microglia as therapeutic targets after neurological injury: strategy for cell therapy
Scott, M. C., Bedi, S. S., Olson, S. D., Sears, C. M., & Cox, C. S. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1934447 · Cited by 43
VEGF receptor 2 (KDR) protects airways from mucus metaplasia through a Sox9-dependent pathway
Jiang, M. Z., Fang, Y., Li, Y., Huang, H., Wei, Z., Gao, X., Sung, H., Hu, J., Qiang, L., Ruan, J., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.04.027 · Cited by 42
Beyond Immunity: Underappreciated Functions of Intestinal Macrophages
Chiaranunt, P., Tai, S. L., Ngai, L., & Mortha, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.749708 · Cited by 38
Tissue Immunity in the Bladder
Bowyer, G., Loudon, K. W., Suchánek, O., & Clatworthy, M. R. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101220-032117 · Cited by 43
McKendrick, J. G., Jones, G., Elder, S. S., Watson, E. E., T’Jonck, W., Mercer, E., Pinto, M. M., Rocchi, C., Hegarty, L. M., Johnson, A. L., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.add4374 · Cited by 45
“Application of single cell technologies, such as single cell RNA sequencing (scRNA-seq), have revealed the diversity of macrophages across and within tissues in both mouse and human (6–8).”
Inflammatory microenvironment in gastric premalignant lesions: implication and application
Zhang, S., Shen, Y., Liu, H., Zhu, D., Fang, J., Pan, H., & Liu, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1297101 · Cited by 45
CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland
Dwyer, A. R., & Pixley, F. J. (2014) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-014-9320-1 · Cited by 40
“However, recent transcriptional analyses of macrophages activated in vitro by a diverse range of stimuli or in vivo in different tissue microenvironments have revealed distinct and often unique variations in gene expression between each macrophage population [28,121].”
BackgroundMicrobiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state
Swiecki, M. K., Miller, H. L., Sesti‐Costa, R., Cella, M., Gilfillan, S., & Colonna, M. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.99 · Cited by 38
“In contrast, serum CCL3 and CCL5 were increased in Clod-treated mice (Figure 4d) perhaps because of reduced consumption by pDCs and mononuclear phagocytes, which express CCR5.”
BackgroundChang, Y.-H., Wang, K. C., Chu, K.-L., Clouthier, D., Tran, A., Perez, M. S. T., Zhou, A. C., Sater, A. A. A., & Watts, T. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.10.014 · Cited by 40
“…populations weredistinct fromcDCs in lacking the signature transcription factor Zbtb46 (Figure S1B; Murphy et al., 2016; Satpathy et al., 2012), whereas inflammatory macrophages were distinguished from inflammatory DCs by expression of themacrophagemarker MerTK (Figure S1B; Gautier et al., 2012).”
BackgroundNeidert, N. N., von Ehr, A., Zöller, T., & Spittau, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01728 · Cited by 39
“Olfml3 is expressed in Microglia In Vivo It has been described that Olfml3 belongs to a set of genes, which have been demonstrated to be microglia-specific and, which are not expressed by other macrophage populations (5, 6, 8, 9).”
BackgroundOrigin and development of classical dendritic cells
Guermonprez, P., Gerber-Ferder, Y., Vaivode, K., Bourdely, P., & Helft, J. (2019) · International review of cytology · doi:10.1016/bs.ircmb.2019.08.002 · Cited by 39
Self-citationHuang, L., Chen, H., Xu, Y., Chen, J., Liu, Z., & Xu, Q. (2020) · Cancer Medicine · doi:10.1002/cam4.3466 · Cited by 40
Dissecting heterogeneous cell populations across drug and disease conditions with PopAlign
Chen, S., Rivaud, P., Park, J., Tsou, T., Charles, E. J., Haliburton, J. R., Pichiorri, F., & Thomson, M. W. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005990117 · Cited by 36
“4G), consistent with previous reports of functional diversity among macrophages (26).”
ResultUnified nexus of macrophages and maresins in cardiac reparative mechanisms
Jadapalli, J. K., & Halade, G. V. (2018) · The FASEB Journal · doi:10.1096/fj.201800254r · Cited by 39
Zheng, W., Chang, I.-C., Limberis, J. D., Budzik, J. M., Zha, B. S., Howard, Z. P., Chen, L., & Ernst, J. D. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012205 · Cited by 36
Miyazaki, Y., Vieira‐de‐Abreu, A., Harris, E. S., Shah, A. M., Weyrich, A. S., Castro-Faria-Neto, H. C., & Zimmerman, G. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112770 · Cited by 39
“It is highly expressed by macrophages in the splenic red pulp in humans, dogs, rats, and mice [12, 14, 17, 43], suggesting important recognition and clearance activities in defense against blood-borne pathogens and in surveillance of antigens and microparticulates [14].”
BackgroundSoria, I., López-Relaño, J., Viñuela, M., et al. (2018) · Allergy · doi:10.1111/all.13396 · Cited by 39
Davis, F. M., Kimball, A., denDekker, A. D., Joshi, A., Boniakowski, A. E., Nysz, D., Allen, R., Andrea, T., Singer, K., Henke, P. K., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801258 · Cited by 38
Bush, S. J., Freem, L. J., MacCallum, A. J., O’Dell, J., Wu, C., Afrasiabi, C., Psifidi, A., Stevens, M. P., Smith, J., SUMMERS, K. M., et al. (2018) · BMC Genomics · doi:10.1186/s12864-018-4972-7 · Cited by 40
Hu, G., Dong, T., Wang, S., Jing, H., & Chen, J. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.039 · Cited by 39
“The signature gene sets of different tissue macrophages (Tables S2) were extracted based on a previous study [31].”
BackgroundMethodPatsalos, A., Tzerpos, P., Halász, L., Nagy, G., Pap, A., Giannakis, N., Lyroni, K., Koliaraki, V., Pintye, É., Dezsö, B., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900553 · Cited by 40
Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer
Zagórska, A., Través, P. G., Jiménez-García, L., Strickland, J. D., Oh, J., Tapia, F. J., Mayoral, R., Burrola, P., Copple, B. L., & Lemke, G. (2020) · Life Science Alliance · doi:10.26508/lsa.202000694 · Cited by 38
“…with the fact that relatively high steady-state expression of Mer is a de fi ning feature of phagocytic tissue macrophages throughout the body (Gautier et al, 2012; Lemke, 2019) and with the demonstration that Mer is absolutely required for the ef fi cient clearance of ACs by these cells…”
Nielsen, J. E., Pedersen, K. S., Vestergård, K., Maltesen, R. G., Christiansen, G., Lundbye‐Christensen, S., Moos, T., Kristensen, S. R., & Pedersen, S. (2020) · Biomedicines · doi:10.3390/biomedicines8070199 · Cited by 39
Oral Pathogen Porphyromonas gingivalis Can Escape Phagocytosis of Mammalian Macrophages
Werheim, E., Senior, K. G., Shaffer, C. A., & Cuadra, G. A. (2020) · Microorganisms · doi:10.3390/microorganisms8091432 · Cited by 41
Toward a Consensus in the Repertoire of Hemocytes Identified in Drosophila
Cattenoz, P. B., Monticelli, S., Pavlidaki, A., & Giangrande, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.643712 · Cited by 39
“The markers involved in mitosis, including Cyclin B (CycB) (Gavet and Pines, 2010), the phosphatase String (Stg) (Edgar and O’Farrell, 1990), the importin Pendulin (Pen) (Kussel and Frasch, 1995) and the kinase Polo (Sunkel and Glover, 1988) are enriched in clusters PM2 as well as PM9 in Tattikota…”
BackgroundGainullina, A., Mogilenko, D. A., Huang, L., Todorov, H., Narang, V., Kim, K.-W., Lim, S. Y., Kent, A., Jia, B., Seddu, K., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112046 · Cited by 36
“Gainullina et al. describe metabolic variability of the mononuclear phagocytes across 38 mouse tissues using GAM-clustering, a metabolic network analysis approach.”
Self-citationSung, S. J., Ge, Y., Dai, C., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601565 · Cited by 39
Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis
Zhang, S., Yeap, X., Grigoryeva, L. S., Dehn, S., DeBerge, M., Tye, M. Y., Rostlund, E., Schrijvers, D. M., Zhang, Z. J., Sumagin, R., et al. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.08.009 · Cited by 40
A transcriptional perspective on human macrophage biology
Schultze, J. L., Freeman, T. C., Hume, D. A., & Latz, E. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.02.001 · Cited by 39
Wilhelmsson, U., Andersson, D., de Pablo, Y., Pekny, R., Ståhlberg, A., Mulder, J., Mitsios, N., Hortobágyi, T., Pekny, M., & Pekna, M. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx069 · Cited by 38
“The chemokine receptor CX3CR1 is selectively expressed by resident microglia (Gautier et al. 2012, Wolf et al. 2013) and infiltrating monocytes (Saederup et al. 2010; Mizutani et al. 2012).”
BackgroundT he microglial reaction signature revealed by RNA seq from individual mice
Hirbec, H., Marmai, C., Duroux-Richard, I., Roubert, C., Esclangon, A., Croze, S., Lachuer, J., Peyroutou, R., & Rassendren, F. (2018) · Glia · doi:10.1002/glia.23295 · Cited by 39
“Non-reactive microglia are an apparent homogenous cell population for which cell surface markers are available and have been used for purification and genome-wide transcriptome profiling (Bennett et al., 2016; Beutner et al., 2013; Butovsky et al., 2014; Chiu et al., 2013; Gautier et al., 2012; Hickman et al., 2013; S…”
BackgroundMethodMicroglia have a more extensive and divergent response to interferon‐α compared with astrocytes
Li, W., Viengkhou, B., Denyer, G. S., West, P. K., Campbell, I. L., & Hofer, M. J. (2018) · Glia · doi:10.1002/glia.23460 · Cited by 39
“Similarly, almost 95% of the unique microglia-expressed genes had previously been characterized as a core signature for yolk-sac derived tissue macrophages (Gautier et al., 2012) that includes microglia.”
BackgroundMicroglia support neural stem cell maintenance and growth
Matsui, T. K., & Mori, E. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.130 · Cited by 38
Mesothelial cell CSF1 sustains peritoneal macrophage proliferation
Ivanov, S., Gallerand, A., Gros, M., Stunault, M. I., Merlin, J., Vaillant, N., Yvan‐Charvet, L., & Guinamard, R. (2019) · European Journal of Immunology · doi:10.1002/eji.201948164 · Cited by 38
Self-citationThe role of ApoE-mediated microglial lipid metabolism in brain aging and disease
Yen, J.-H. J., & Yu, I.-C. I. (2023) · Immunometabolism · doi:10.1097/in9.0000000000000018 · Cited by 38
Li, X., Liu, Y., Tang, Y., & Xia, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1474688 · Cited by 46
Immunoproteasomes Shape the Transcriptome and Regulate the Function of Dendritic Cells
de Verteuil, D. A., Rouette, A., Hardy, M., Lavallée, S., Trofimov, A., Gaucher, É., & Perreault, C. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400871 · Cited by 38
Human IgG1 antibodies suppress angiogenesis in a target-independent manner
Bogdanovich, S., Kim, Y., Mizutani, T., Yasuma, R., Tudisco, L., Cicatiello, V., Bastos-Carvalho, A., Kerur, N., Hirano, Y., Baffi, J., et al. (2016) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2015.1 · Cited by 37
Metabolic Reprogramming during Microglia Activation
Geric, I., Schoors, S., Claes, C., Gressèns, P., Verderio, C., Verfaillie, C. M., Veldhoven, P. P. V., Carmeliet, P., & Baes, M. I. (2019) · Immunometabolism · doi:10.20900/immunometab20190002 · Cited by 38
“, neurons, astrocytes and oligodendrocytes [4,5].”
Jeong, J. Y., Chung, Y. C., & Jin, B. K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081927 · Cited by 37
“Due to microglia and macrophages sharing very similar gene expression pattern, cell surface markers, and activation states [13], this similarity limits the understanding of their pathological”
BackgroundATP-Binding Cassette Transporter 1 Attenuates Ovalbumin-Induced Neutrophilic Airway Inflammation
Dai, C., Yao, X., Vaisman, B. L., Brenner, T. A., Meyer, K. S., Gao, M., Keeran, K. J., Nugent, G. Z., Qu, X., Yu, Z., et al. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0264oc · Cited by 38
Blanchet, C., Jouvion, G., Fitting, C., Cavaillon, J., & Adib‐Conquy, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087927 · Cited by 37
Arlt, O., Schwiebs, A., Japtok, L., Rüger, K., Katzy, E., Kleuser, B., & Radeke, H. H. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362982 · Cited by 39
Allergic ocular disorders: a spectrum of diseases.
Ehlers, W. H., & Donshik, P. C. (1992) · PubMed · Cited by 37
Resident macrophages of the lung and liver: The guardians of our tissues
Kulle, A., Thanabalasuriar, A., Cohen, T. S., & Szydlowska, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1029085 · Cited by 43
Cytomegalovirus immune evasion of myeloid lineage cells
Brinkmann, M. M., Dağ, F., Hengel, H., Messerle, M., Kalinke, U., & Čičin‐Šain, L. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0403-4 · Cited by 38
African trypanosome control in the insect vector and mammalian host
Beschin, A., Abbeele, J. V. D., BAETSELIER, P. D., & Pays, É. (2014) · Trends in Parasitology · doi:10.1016/j.pt.2014.08.006 · Cited by 36
Raine, T., Liu, J. Z., Anderson, C. A., Parkes, M., & Kaser, A. (2014) · Gut · doi:10.1136/gutjnl-2013-306657 · Cited by 36
Central Nervous System: (Immunological) Ivory Tower or Not?
Marin, I. A., & Kipnis, J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.122 · Cited by 36
“Modern RNA-seq analyses show that the microglial transcriptome shares homology with tissue-resident macrophages (Gautier et al, 2012) while also exhibiting their unique genetic signature.”
BackgroundImpact of Local Alloimmunity and Recipient Cells in Transplant Arteriosclerosis
Cai, J., Deng, J., Gu, W., Ni, Z., Liu, Y., Kamra, Y., Saxena, A., Hu, Y., Yuan, H., Xiao, Q., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316470 · Cited by 36
Organ-Chip Models: Opportunities for Precision Medicine in Pancreatic Cancer
Haque, M. R., Rempert, T. H., Al-Hilal, T. A., Wang, C., Bhushan, A., & Bishehsari, F. (2021) · Cancers · doi:10.3390/cancers13174487 · Cited by 39
Bringing Macrophages to the Frontline against Cancer: Current Immunotherapies Targeting Macrophages
Reis-Sobreiro, M., da Mota, A. T., Jardim, C., & Serre, K. (2021) · Cells · doi:10.3390/cells10092364 · Cited by 44
“Representing indispensable components of the innate immune system, macrophages possess remarkable strategic anatomical, and functional diversities [1,2], performing a plethora of activities to protect tissues when homeostasis is disrupted [3,4].”
BackgroundTumor-associated macrophages: Prognostic and therapeutic targets for cancer in humans and dogs
Brady, R. V., & Thamm, D. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1176807 · Cited by 35
“Regardless of their remarkable diversity, a few core genetic programs establish macrophages’ key role as phagocytes (3, 4).”
BackgroundMacrophages as a Cell-Based Therapy for Liver Disease
Starkey Lewis, P. J., Moroni, F., & Forbes, S. J. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1688502 · Cited by 36
Metadata
- Authors
- the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., Gordonov, S., Mazloom, A. R., Ma'ayan, A., Chua, W.-J., Hansen, T. H., Turley, S. J., Merad, M., & Randolph, G. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Broad Institute (US)
- Mount Sinai Hospital (US)
- Washington University in St. Louis (US)
- Harvard University (US)
- Corresponding author
- Randolph, Gwendalyn J
- ORCID
- Venue
- Nature Immunology
- Published
- 2012-09-30
- Volume
- 13
- Issue
- 11
- Pages
- 1118-1128
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC3558276
- OpenAlex
- W2136188258
- Cited by
- 1,972
- References
- 41
- Citations by year
- 2026: 71 · 2025: 88 · 2024: 104 · 2023: 113 · 2022: 152 · 2021: 174 · 2020: 177 · 2019: 155 · 2018: 183 · 2017: 190 · 2016: 159 · 2015: 170 · 2014: 140 · 2013: 90 · 2012: 4
- FWCI
- 56.29
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Drug Abuse (T32DA007135)
- National Cancer Institute (R01CA154947)
- National Institute of General Medical Sciences (P50GM071558, R01GM098316)
- National Institute of Allergy and Infectious Diseases (R01AI049653, R01AI046553, R01AI061741, R24AI072073)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK08854, P30DK020579)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- tissue macrophages, macrophage heterogeneity, gene expression profiling, macrophage identity, dendritic cells, MERTK, C/EBPα, BACH1, GATA6, mouse organs
- MeSH terms
- Animals, Cell Differentiation, Dendritic Cells, Gene Expression Regulation, Liver, Lung, Macrophages, Organ Specificity, RNA, Messenger, Spleen, Transcription Factors, Transcription, Genetic, Genetic Variation, Antigens, CD, Microglia, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Mice
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