Cited by 571Inflammasome and immune disordersTuberculosis Research and EpidemiologyImmune Response and Inflammation

The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

Open access

Mishra, Bibhuti B, Rathinam, Vijay A K, Martens, Gregory W, Martinot, Amanda J, Kornfeld, Hardy, Fitzgerald, Katherine A, Sassetti, Christopher M·2013·Nature Immunology

DOI 10.1038/ni.2474PMC PMC3721324

Open this paper in CoChat — free account

Abstract

Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote inflammatory tissue damage. During chronic infections such as tuberculosis, the beneficial antimicrobial role of IL-1 must be balanced with the need to prevent immunopathology. By exogenously controlling the replication of Mycobacterium tuberculosis in vivo, we obviated the requirement for antimicrobial immunity and discovered that both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived interferon-γ (IFN-γ). This effect was mediated by nitric oxide (NO), which we found specifically inhibited assembly of the NLRP3 inflammasome via thiol nitrosylation. Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/ni.2474

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Self-citation
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627
Self-citation
Nonresolving Inflammation
Nathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
Untitled work
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261
Identification of nitric oxide synthase as a protective locus against tuberculosis
MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., & Nathan, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5243 · Cited by 1,180
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages
Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131
The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026
Regulation of inflammasome signaling
Rathinam, V. A. K., Vanaja, S. K., & Fitzgerald, K. A. (2012) · Nature Immunology · doi:10.1038/ni.2237 · Cited by 960
Self-citation
The Biotin Switch Method for the Detection of S -Nitrosylated Proteins
Jaffrey, S. R., & Snyder, S. H. (2001) · Science Signaling · doi:10.1126/stke.2001.86.pl1 · Cited by 855

Show all 49 references

Research works printed but not linked: 1

Nandi, B. & Behar, S.M. Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection. J. Exp. Med. 208, 2251–2262 (2011). · DOI

Sorted by citations

Items 101–200 of 571

Myeloid Ikaros–SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver
Kadono, K., Kageyama, S., Nakamura, K., Hirao, H., Ito, T., Kojima, H., Dery, K. J., Li, X., & Kupiec‐Weglinski, J. W. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.11.026 · Cited by 109
Role of Caspase-1 in the Pathogenesis of Inflammatory-Associated Chronic Noncommunicable Diseases
Molla, M. D., Akalu, Y., Geto, Z., Dagnew, B., Ayelign, B., & Shibabaw, T. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s277457 · Cited by 119
The Intracellular Environment of Human Macrophages That Produce Nitric Oxide Promotes Growth of Mycobacteria
Jung, J., Madan-Lala, R., Georgieva, M., Rengarajan, J., Sohaskey, C. D., Bange, F., & Robinson, C. M. (2013) · Infection and Immunity · doi:10.1128/iai.00611-13 · Cited by 110
Autophagy as an immune effector against tuberculosis
Bradfute, S. B., Castillo, E. F., Arko‐Mensah, J., Chauhan, S., Jiang, S., Mandell, M. A., & Deretic, V. P. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.05.003 · Cited by 104
The Immune Mechanisms of Lung Parenchymal Damage in Tuberculosis and the Role of Host-Directed Therapy
Stek, C. J., Allwood, B., Walker, N. F., Wilkinson, R. J., Lynen, L., & Meintjes, G. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02603 · Cited by 105
Autophagy in TuberculosisPreprint
Deretic, V. P. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018481 · Cited by 100
The NLRP3 inflammasome - interleukin 1 pathway as a therapeutic target in gout
Szekanecz, Z., Szamosi, S., Kovács, G. E., Kocsis, E., & Benkő, S. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.01.031 · Cited by 101
Advances in Nod-like receptors (NLR) biology
Barbé, F., Douglas, T., & Saleh, M. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.07.001 · Cited by 106
Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression
Cunningham‐Bussel, A., Zhang, T., & Nathan, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316894110 · Cited by 98
Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation
Ka, S., Lin, J., Lin, T.-J., Liu, F., Chao, L. K., Ho, C., Yeh, L., Sytwu, H., Hua, K., & Chen, A. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0844-6 · Cited by 100
Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
Moreira-Teixeira, L., Sousa, J., McNab, F. W., Torrado, E., Cardoso, F., Machado, H., Castro, F., Cardoso, V., Gaifem, J., Wu, X., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600584 · Cited by 99
Tuberculosis Infectiousness and Host Susceptibility
Turner, R. D., Chiu, C., Churchyard, G., Esmail, H., Lewinsohn, D. M., Gandhi, N. R., & Fennelly, K. P. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix361 · Cited by 111
Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma
Inserra, A., Mastronardi, C. A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1359-3 · Cited by 99
The Interplay Between Systemic Inflammation, Oxidative Stress, and Tissue Remodeling in Tuberculosis
Amaral, E. P., Vinhaes, C. L., Oliveira-de-Souza, D., Nogueira, B. M. F., Akrami, K., & Andrade, B. B. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8124 · Cited by 101
Redox regulation of macrophages
Tran, N., & Mills, E. L. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103123 · Cited by 101
The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways
Jiang, D., Chen, S., Sun, R., Zhang, X., & Wang, D. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.034 · Cited by 95
Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship
Briken, V., Ahlbrand, S. E., & Shah, S. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00062 · Cited by 92
In Vivo Expansion of Melanoma-Specific T Cells Using Microneedle Arrays Coated with Immune-Polyelectrolyte Multilayers
Zeng, Q., Gammon, J. M., Tostanoski, L. H., Chiu, Y.-C., & Jewell, C. M. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00414 · Cited by 91
Mycobacterium tuberculosis inhibits the NLRP3 inflammasome activation via its phosphokinase PknF
Rastogi, S., Ellinwood, S., Augenstreich, J., Mayer-Barber, K. D., & Briken, V. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009712 · Cited by 92
Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity
Yang, S., Xia, C., Li, S., Du, L., Zhang, L., & Zhou, R. (2014) · Redox Biology · doi:10.1016/j.redox.2014.04.001 · Cited by 88
The thioredoxin system: Balancing redox responses in immune cells and tumors
Muri, J., & Köpf, M. (2022) · European Journal of Immunology · doi:10.1002/eji.202249948 · Cited by 91
Perspectives on host adaptation in response to Mycobacterium tuberculosis: Modulation of inflammation
Dorhoi, A., & Kaufmann, S. H. E. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.10.002 · Cited by 90
HIV–tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling
Lai, R., Meintjes, G., Wilkinson, K. A., Graham, C. M., Marais, S., van der Plas, H., Deffur, A., Schutz, C., Bloom, C. I., Munagala, I. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms9451 · Cited by 88
HIF-1α as a central mediator of cellular resistance to intracellular pathogens
Knight, M., & Stanley, S. A. (2019) · Current Opinion in Immunology · doi:10.1016/j.coi.2019.05.005 · Cited by 86
Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
Rohlwink, U. K., Figaji, A. A., Wilkinson, K. A., Horswell, S. D., Sesay, A. K., Deffur, A., Enslin, N., Solomons, R., van Toorn, R., Eley, B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11783-9 · Cited by 87
Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators
Liu, D., Zeng, X., Li, X., Cui, C., Hou, R., Guo, Z., Mehta, J. L., & Wang, X. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113863 · Cited by 88
Relative contribution of IL‐1α, IL‐1β and TNF to the host response to Mycobacterium tuberculosis and attenuated M. bovis BCG
Bourigault, M.-L., Segueni, N., Rose, S., Court, N., Vacher, R., Vasseur, V., Erard, F., Bert, M. L., Garcia, I., Iwakura, Y., et al. (2013) · Immunity Inflammation and Disease · doi:10.1002/iid3.9 · Cited by 90
Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS
Yoon, S., Park, J.-Y., Choi, S. H., Lee, J.-B., Jung, H., Kim, T., Yoon, S. R., Choi, I., Shim, S., & Park, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.06.080 · Cited by 86
Genetic modification of inflammation- and clonal hematopoiesis–associated cardiovascular risk
Yu, Z., Fidler, T. P., Ruan, Y., Vlasschaert, C., Nakao, T., Uddin, M. M., Mack, T., Niroula, A., Heimlich, J. B., Zekavat, S. M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168597 · Cited by 91
Inflammasomes in Respiratory Disease
Brusselle, G., Provoost, S., Bracke, K. R., Kuchmiy, A. A., & Lamkanfi, M. (2014) · CHEST Journal · doi:10.1378/chest.13-1885 · Cited by 87
Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation
Yin, Z., Deng, T., Peterson, L. E., Yu, R., Lin, J., Hamilton, D. J., Reardon, P. R., Sherman, V., Winnier, G. E., Zhan, M., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.06.018 · Cited by 88
Thioredoxin-1 distinctly promotes NF-κB target DNA binding and NLRP3 inflammasome activation independently of Txnip
Muri, J., Thut, H., Feng, Q., & Köpf, M. (2020) · eLife · doi:10.7554/elife.53627 · Cited by 83
Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production
Sousa, J., Cá, B., Maceiras, A. R., Costa, A. L., Fonseca, K. L., Fernandes, A. I., Ramos, A., Carvalho, T., Barros, L., Magalhães, C., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15832-6 · Cited by 83
Negative regulation of NLRP3 inflammasome signaling
Chen, S., & Sun, B. (2013) · Protein & Cell · doi:10.1007/s13238-013-2128-8 · Cited by 84
Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis
Palma, C., Rocca, C. L., Gigantino, V., Aquino, G., Piccaro, G., Silvestre, D. D., Brambilla, F., Rossi, R., Bonacina, F., Lepore, M. T., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.016 · Cited by 82
Arginine metabolism in myeloid cells in health and disease
Karadima, E., Chavakis, T., & Alexaki, V. I. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-025-01038-9 · Cited by 86
Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome
Shim, D.-W., & Lee, K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01054 · Cited by 80
Interferons and inflammasomes: Cooperation and counterregulation in disease
Labzin, L. I., Lauterbach, M., & Latz, E. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.05.010 · Cited by 77
Vascular dysfunction in aged mice contributes to persistent lung fibrosis
Caporarello, N., Meridew, J. A., Aravamudhan, A., Jones, D. L., Austin, S. A., Pham, T. X., Haak, A. J., Choi, K. M., Tan, Q., Haresi, A. J., et al. (2020) · Aging Cell · doi:10.1111/acel.13196 · Cited by 79
Induction, Propagation, and Activity of Host Nitric Oxide: Lessons from Leishmania Infection
Olekhnovitch, R., & Bousso, P. (2015) · Trends in Parasitology · doi:10.1016/j.pt.2015.08.001 · Cited by 79
Aberrant Inflammasome Activation Characterizes Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
Tan, H. Y., Yong, Y. K., Shankar, E. M., Paukovics, G., Ellegård, R., Larsson, M., Kamarulzaman, A., French, M. A., & Crowe, S. M. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502203 · Cited by 77
MiR-20b inhibits mycobacterium tuberculosis induced inflammation in the lung of mice through targeting NLRP3
Lou, J., Wang, Y., Zhang, Z., & Qiu, W. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.06.007 · Cited by 78
Immune Vulnerability of Infants to Tuberculosis
Driessche, K. V., Persson, A., Marais, B. J., Fink, P. J., & Urdahl, K. B. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/781320 · Cited by 83
NLRP3 Activation Was Regulated by DNA Methylation Modification during Mycobacterium tuberculosis Infection
Wei, M., Wang, L., Wu, T., Xi, J., Han, Y.-Z., Yang, X., Zhang, D., Fang, Q., & Tang, B. (2016) · BioMed Research International · doi:10.1155/2016/4323281 · Cited by 76
Sex differences in the C57BL/6 model of Mycobacterium tuberculosis infection
Dibbern, J., Eggers, L. F., & Schneider, B. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-11438-z · Cited by 80
Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition
Baker, P. J., Nardo, D. D., Moghaddas, F., Tran, L. S., Bachem, A., Nguyen, T. A., Hayman, T. J., Tye, H., Vince, J. E., Bedoui, S., et al. (2017) · Physiological Reviews · doi:10.1152/physrev.00026.2016 · Cited by 75
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis
Burke, T., Engström, P., Chavez, R. A., Fonbuena, J. A., Vance, R. E., & Welch, M. D. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0673-5 · Cited by 75
CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis
Lee, J., Boyce, S., Powers, J., Baer, C. E., Sassetti, C. M., & Behar, S. M. (2020) · PLoS Pathogens · doi:10.1371/journal.ppat.1008621 · Cited by 70
Self-citation
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
Lovey, A., Verma, S., Kaipilyawar, V., Ribeiro‐Rodrigues, R., Husain, S., Palaci, M., Dietze, R., Ma, S., Morrison, R. D., Sherman, D. R., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28506-2 · Cited by 79
Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis
Sankar, P., & Mishra, B. B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1260859 · Cited by 83
Self-citation
Heme as a danger molecule in pathogen recognition
Wegiel, B., Hauser, C. J., & Otterbein, L. E. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.020 · Cited by 72
Mouse Model of TuberculosisPreprint
Cooper, A. M. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a018556 · Cited by 77
The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases
Jiang, H., Gong, T., & Zhou, R. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.11.003 · Cited by 71
RETRACTED: NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization
Ji, J., Xiang, P., Li, T., Lan, L., Xu, X., Guo, L., Ji, H., Zhang, Y., & Li, Y. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00154 · Cited by 70
Retracted
Neutrophils: Innate Effectors of TB Resistance?
Kroon, E. E., Coussens, A. K., Kinnear, C. J., Orlova, M., Möller, M., Seeger, A., Wilkinson, R. J., Hoal, E. G., & Schurr, E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02637 · Cited by 73
The Role of Post-Translational Modifications in Regulation of NLRP3 Inflammasome Activation
Xia, J., Jiang, S., Dong, S., Liao, Y., & Zhou, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076126 · Cited by 74
Versatile myeloid cell subsets contribute to tuberculosis‐associated inflammation
Dorhoi, A., & Kaufmann, S. H. E. (2015) · European Journal of Immunology · doi:10.1002/eji.201545493 · Cited by 71
Pyroptosis: The missing puzzle among innate and adaptive immunity crosstalk
Hachim, M. Y., Khalil, B. A., Elemam, N. M., & Maghazachi, A. A. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mir0120-625r · Cited by 71
Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution
Lee, W., Kang, J.-S., Choi, W. Y., Zhang, Q., Kim, C. H., Choi, U. Y., Kim‐Ha, J., & Kim, Y. (2016) · Nature Communications · doi:10.1038/ncomms11322 · Cited by 69
ESAT-6–dependent cytosolic pattern recognition drives noncognate tuberculosis control in vivo
Kupz, A., Zedler, U., Stäber, M., Perdomo, C., Dorhoi, A., Brosch, R., & Kaufmann, S. H. E. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84978 · Cited by 67
Redox signaling in innate immunity and inflammation: focus on macrophages and neutrophils
Braunstein, I., Motohashi, H., Dallenga, T. K., Schaible, U. E., & Benhar, M. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.06.006 · Cited by 75
Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases
Mourik, B. C., Lubberts, E., de Steenwinkel, J. E. M., Ottenhoff, T. H. M., & Leenen, P. J. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00294 · Cited by 68
Copper Regulates the Canonical NLRP3 Inflammasome
Deigendesch, N., Zychlinsky, A., & Meissner, F. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700712 · Cited by 68
Persistent inflammation during anti-tuberculosis treatment with diabetes comorbidity
Kumar, N. P., Fukutani, K. F., Shruthi, B. S., Alves, T., Silveira-Mattos, P. S., Rocha, M. S., West, K., Natarajan, M., Viswanathan, V., Babu, S., et al. (2019) · eLife · doi:10.7554/elife.46477 · Cited by 66
Self-citation
Post-translational control of NLRP3 inflammasome signaling
O'Keefe, M. E., Dubyak, G., & Abbott, D. W. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107386 · Cited by 68
Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease
Paramel, G. V., Sirsjö, A., & Fransén, K. (2015) · Mediators of Inflammation · doi:10.1155/2015/846782 · Cited by 66
Sensing the enemy, containing the threat: cell-autonomous immunity toChlamydia trachomatis
Finethy, R., & Coers, J. (2016) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuw027 · Cited by 68
Macrophage Heterogeneity in the Immunopathogenesis of Tuberculosis
Marakalala, M. J., Martínez, F. O., Plüddemann, A., & Gordon, S. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01028 · Cited by 68
Inflammasome activation underlies central nervous system deterioration in HIV-associated tuberculosis
Marais, S., Lai, R., Wilkinson, K. A., Meintjes, G., O’Garra, A., & Wilkinson, R. J. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw561 · Cited by 64
Regulation of the NLRP3 Inflammasome by Posttranslational Modifications
Zangiabadi, S., & Sater, A. A. A. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100734 · Cited by 63
The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription
Simon, P. S., Sharman, S. K., Lu, C., Yang, D., Paschall, A. V., Tulachan, S., & Liu, K. (2015) · BMC Cancer · doi:10.1186/s12885-015-1808-6 · Cited by 63
Orchestration of pulmonary T cell immunity during Mycobacterium tuberculosis infection: Immunity interruptus
Behar, S. M., Carpenter, S. M., Booty, M. G., Barber, D. L., & Jayaraman, P. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.003 · Cited by 65
The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-κB and MAPK signaling pathways
Sun, J., Zhang, Q., Yang, G., Li, Y., Fu, Y., Zheng, Y., & Jiang, X. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115368 · Cited by 66
Recent advances on endogenous gasotransmitters in inflammatory dermatological disorders
Wang, L., Xie, X., Ke, B., Huang, W., Jiang, X. L., & He, G. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.08.012 · Cited by 63
NIR‐Triggered Multifunctional NO Nanoplatform for Conquering Thermal Resistance in Biofilms
Zhou, B., Dong, B., Hu, S., Liu, W., Sun, L., Xu, L. H., Bai, X., Wang, L., Qi, M., & Song, H. (2024) · Small · doi:10.1002/smll.202310706 · Cited by 62
TXNIP Deficiency Exacerbates Endotoxic Shock via the Induction of Excessive Nitric Oxide Synthesis
Park, Y., Yoon, S., Suh, H., Kim, D. O., Park, J.-R., Jung, H., Kim, T., Yoon, S. R., Min, J., Na, H.-J., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003646 · Cited by 61
Interaction of Mycobacteria With Host Cell Inflammasomes
Rastogi, S., & Briken, V. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.791136 · Cited by 64
Redox-signals and macrophage biology
Weigert, A., von Knethen, A., Fuhrmann, D. C., Dehne, N., & Brüne, B. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.01.003 · Cited by 60
Pyroptotic death storms and cytopenia
Croker, B. A., O’Donnell, J. A., & Gerlic, M. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.12.002 · Cited by 60
A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling
Cheallaigh, C. N., Sheedy, F. J., Harris, J., Muñoz‐Wolf, N., Lee, J., West, K., Pålsson‐McDermott, E. M., Smyth, A., Gleeson, L. E., Coleman, M. M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.019 · Cited by 58
Self-citation
Advances on the Role and Applications of Interleukin-1 in Tuberculosis
Silvério, D., Gonçalves, R., Appelberg, R., & Saraiva, M. (2021) · mBio · doi:10.1128/mbio.03134-21 · Cited by 59
Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection
Matty, M. A., Knudsen-Palmer, D. R., Walton, E. M., Beerman, R. W., Cronan, M. R., Pyle, C. J., Hernandez, R. E., & Tobin, D. M. (2019) · eLife · doi:10.7554/elife.39123 · Cited by 59
From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading
Yang, T., Du, Z., Qiu, H., Gao, P., Zhao, X., Wang, H., Tu, Q., Xiong, K., Huang, N., & Yang, Z. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2019.12.006 · Cited by 59
The E3 Ubiquitin Ligase TRIM65 Negatively Regulates Inflammasome Activation Through Promoting Ubiquitination of NLRP3
Tang, T., Li, P., Zhou, X., Wang, R., Fan, X., Yang, M., & Qi, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.741839 · Cited by 61
Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop
Takeda, H., Murakami, S., Liu, Z., Sawa, T., Takahashi, M., Izumi, Y., Bamba, T., Sato, H., Akaike, T., Sekine, H., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102834 · Cited by 59
Macrophage Takeover and the Host–bacilli interplay During Tuberculosis
Bhat, K. H., & Mukhopadhyay, S. (2015) · Future Microbiology · doi:10.2217/fmb.15.11 · Cited by 62
Targeting immunometabolism in host defence against Mycobacterium tuberculosis
Sheedy, F. J., & Divangahi, M. (2020) · Immunology · doi:10.1111/imm.13276 · Cited by 62
S-Nitrosylation in Tumor Microenvironment
Sharma, V., Fernando, V., Letson, J., Walia, Y., Zheng, X., Fackelman, D., & Furuta, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094600 · Cited by 59
IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
Dis, E. S. V., Fox, D., Morrison, H. M., Fines, D. M., Babirye, J. P., McCann, L. H., Rawal, S. L., Cox, J. S., & Stanley, S. A. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010721 · Cited by 54
A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses
Postat, J., Olekhnovitch, R., Lemaı̂tre, F., & Bousso, P. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.014 · Cited by 57
Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells
Kiritsy, M. C., McCann, K. J., Mott, D., Holland, S. M., Behar, S. M., Sassetti, C. M., & Olive, A. J. (2021) · eLife · doi:10.7554/elife.65109 · Cited by 58
Self-citation
Activation and Pharmacological Regulation of Inflammasomes
Chen, C., & Xu, P. (2022) · Biomolecules · doi:10.3390/biom12071005 · Cited by 59
ESAT-6 a Major Virulence Factor of Mycobacterium tuberculosis
Anes, E., Pires, D., Mandal, M., & Azevedo‐Pereira, J. M. (2023) · Biomolecules · doi:10.3390/biom13060968 · Cited by 67
Host Defense and Recruitment of Foxp3+ T Regulatory Cells to the Lungs in Chronic Mycobacterium tuberculosis Infection Requires Toll-like Receptor 2
McBride, A., Konowich, J., & Salgame, P. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003397 · Cited by 58
Influenza Vaccination Induces NK-Cell-Mediated Type-II IFN Response that Regulates Humoral Immunity in an IL-6-Dependent Manner
Farsakoglu, Y., Palomino‐Segura, M., Latino, I., Zanaga, S., Chatziandreou, N., Pizzagalli, D. U., Rinaldi, A., Bolis, M., Sallusto, F., Stein, J. V., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.104 · Cited by 53
Tanshinone IIA alleviates NLRP3 inflammasome-mediated pyroptosis in Mycobacterium tuberculosis-(H37Ra-) infected macrophages by inhibiting endoplasmic reticulum stress
Li, Y., Fu, Y., Sun, J., Shen, J., Liu, F., Ning, B., Lu, Z., Wei, L., & Jiang, X. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114595 · Cited by 55
Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques
Winchell, C. G., Mishra, B. B., Phuah, J. Y., Saqib, M., Nelson, S. J., Maiello, P. A., Causgrove, C. M., Ameel, C. L., Stein, B., Borish, H. J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00891 · Cited by 53
Self-citation
Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch
Meng, Q., Cai, C., Sun, T., Wang, Q., Xie, W., Wang, R., & Cui, J. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201505091 · Cited by 56
Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling
Kim, J. K., Jin, H. S., Suh, H., & Jo, E. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2017.23 · Cited by 54
NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium
Ma, P., Zha, S., Shen, X., Zhao, Y., Li, L., Yang, L., Lei, M., & Liu, W. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0406-7 · Cited by 54

Authors: Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M.
Affiliations: University of Massachusetts Chan Medical School (US)
Harvard University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Sassetti, Christopher M
ORCID: Mishra, Bibhuti B
Rathinam, Vijay A K
Martinot, Amanda J
Kornfeld, Hardy
Fitzgerald, Katherine A
Sassetti, Christopher M
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2012-11-18
Volume: 14
Issue: 1
Pages: 52-60
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.2474
PMC: PMC3721324
OpenAlex: W2048884877
Cited by: 571
References: 49
Citations by year: 2026: 24 · 2025: 27 · 2024: 29 · 2023: 39 · 2022: 47 · 2021: 53 · 2020: 46 · 2019: 43 · 2018: 51 · 2017: 46 · 2016: 46 · 2015: 40 · 2014: 40 · 2013: 37 · 2012: 3
FWCI: 15.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Heart, Lung, and Blood Institute (R01HL064884, R01HL081149, HL064884)
National Institute of Allergy and Infectious Diseases (AI064282, R01AI064282, AI083713, U54AI057159, R01AI083713, T32AI007638)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: nitric oxide, NLRP3 inflammasome, interleukin-1β processing, tuberculosis, immunopathology, Mycobacterium tuberculosis, nitrosylation, interferon-gamma, innate immunity, chronic infection, adaptive immunity
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Cells, Cultured, Humans, Immunity, Innate, Interferon-gamma, Mice, Inbred C57BL, Mycobacterium tuberculosis, Nitric Oxide, Tuberculosis, Signal Transduction, Mice, Knockout, Protein Modification, Translational, Mice, Interleukin-1beta, Protein Multimerization, Inflammasomes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks