The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome–dependent processing of IL-1β
Open accessAbstract
Interleukin 1 (IL-1) is an important mediator of innate immunity but can also promote inflammatory tissue damage. During chronic infections such as tuberculosis, the beneficial antimicrobial role of IL-1 must be balanced with the need to prevent immunopathology. By exogenously controlling the replication of Mycobacterium tuberculosis in vivo, we obviated the requirement for antimicrobial immunity and discovered that both IL-1 production and infection-induced immunopathology were suppressed by lymphocyte-derived interferon-γ (IFN-γ). This effect was mediated by nitric oxide (NO), which we found specifically inhibited assembly of the NLRP3 inflammasome via thiol nitrosylation. Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, NO directly blocks inflammasome activation via nitrosylation of NLRP3, thereby preventing excessive tissue damage in the course of M. tuberculosis infection (102, 103).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [103]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026
Self-citationImmunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627
Self-citationNathan, C., & Ding, A. (2010) · Cell · doi:10.1016/j.cell.2010.02.029 · Cited by 2,183
Stamler (2001) · doi:10.1016/s0092-8674(01)00495-0 · Cited by 1,261
Identification of nitric oxide synthase as a protective locus against tuberculosis
MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K., & Nathan, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5243 · Cited by 1,180
Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131
Fernandes-Alnemri, T., Wu, J., Yu, J.-W., Datta, P., Miller, B., Jankowski, W., Rosenberg, S., Zhang, J., & Alnemri, E. S. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402194 · Cited by 1,026
Regulation of inflammasome signaling
Rathinam, V. A. K., Vanaja, S. K., & Fitzgerald, K. A. (2012) · Nature Immunology · doi:10.1038/ni.2237 · Cited by 960
Self-citationThe Biotin Switch Method for the Detection of S -Nitrosylated Proteins
Jaffrey, S. R., & Snyder, S. H. (2001) · Science Signaling · doi:10.1126/stke.2001.86.pl1 · Cited by 855
Active Caspase-1 Is a Regulator of Unconventional Protein Secretion
Keller, M., Rüegg, A., Werner, S., & Beer, H. (2008) · Cell · doi:10.1016/j.cell.2007.12.040 · Cited by 851
Dimmeler, S., Haendeler, J., Nehls, M. C., & Zeiher, A. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.4.601 · Cited by 806
North, R. J., & Jung, Y. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104635 · Cited by 677
Brož, P., von Moltke, J., Jones, J. W. M., Vance, R. E., & Monack, D. M. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.11.007 · Cited by 636
Hise, A. G., Tomalka, J. A., Ganesan, S., Patel, K., Hall, B. A., Brown, G. D., & Fitzgerald, K. A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.002 · Cited by 582
Self-citationMogues, T., Goodrich, M. E., Ryan, L., LaCourse, R., & North, R. J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.3.271 · Cited by 559
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
Broz, P., Newton, K., Lamkanfi, M., Mariathasan, S., Dixit, V. M., & Monack, D. M. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100257 · Cited by 549
Eum, S.-Y., Kong, J.-H., Hong, M.-S., Lee, Y.-J., Kim, J.-H., Hwang, S.-H., Cho, S.-N., Via, L. E., & Barry, C. E. (2010) · Chest · doi:10.1378/chest.09-0903 · Cited by 548
Vance, R. E., Isberg, R. R., & Portnoy, D. A. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.06.007 · Cited by 540
The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans
Tobin, D. M., Vary, J. C., Ray, J. P., Walsh, G. S., Dunstan, S. J., Bang, N. D., Hagge, D. A., Khadge, S., King, M., Hawn, T. R., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.013 · Cited by 520
Capuano, S., Croix, D. A., Pawar, S., Zinovik, A., Myers, A. J., Lin, P. L., Bissel, S. J., Fuhrman, C. R., Klein, E. C., & Flynn, J. L. (2003) · Infection and Immunity · doi:10.1128/iai.71.10.5831-5844.2003 · Cited by 479
Mayer-Barber, K. D., Barber, D. L., Shenderov, K., White, S., Wilson, M. S., Cheever, A. W., Kugler, D. G., Hieny, S. E., Caspar, P., Núñez, G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904189 · Cited by 472
Mayer-Barber, K. D., Andrade, B. B., Barber, D. L., Hieny, S., Feng, C. G., Caspar, P., Oland, S., Gordon, S., & Sher, A. (2011) · Immunity · doi:10.1016/j.immuni.2011.12.002 · Cited by 418
Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis
Chan, J., Tanaka, K. E., Carroll, D., Flynn, J. L., & Bloom, B. R. (1995) · Infection and Immunity · doi:10.1128/iai.63.2.736-740.1995 · Cited by 408
Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection
Nandi, B., & Behar, S. M. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20110919 · Cited by 385
Inflammasomes: guardians of cytosolic sanctity
Lamkanfi, M., & Dixit, V. M. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00730.x · Cited by 372
Mycobacterium tuberculosis protein ESAT-6 is a potent activator of the NLRP3/ASC inflammasome
Mishra, B. B., Moura‐Alves, P., Sonawane, A., Hacohen, N., Griffiths, G. W., Moita, L. F., & Anes, E. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01450.x · Cited by 353
Self-citationFremond, C., Togbe, D., Doz, E., Rose, S., Vasseur, V., Maillet, I., Jacobs, M., Ryffel, B., & Quesniaux, V. F. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1178 · Cited by 339
Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
Meissner, F., Molawi, K., & Zychlinsky, A. (2008) · Nature Immunology · doi:10.1038/ni.1633 · Cited by 308
Pelegrı́n, P., & Surprenant, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610351200 · Cited by 301
Eruslanov, E. B., Lyadova, I. V., Kondratieva, T. K., Majorov, K. B., Scheglov, I. V., Orlova, M. O., & Apt, A. S. (2005) · Infection and Immunity · doi:10.1128/iai.73.3.1744-1753.2005 · Cited by 295
Pandey, A. K., Yang, Y., Jiang, Z., Fortune, S. M., Coulombe, F., Behr, M. A., Fitzgerald, K. A., Sassetti, C. M., & Kelliher, M. A. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000500 · Cited by 292
Self-citationSeiler, P. J., Aichele, P., Bandermann, S., Hauser, A. E., Lu, B., Gerard, N. P., Gerard, C. J., Ehlers, S., Mollenkopf, H., & Kaufmann, S. H. E. (2003) · European Journal of Immunology · doi:10.1002/eji.200323956 · Cited by 237
Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide
Coulombe, F., Divangahi, M., Veyrier, F. J., de Léséleuc, L., Gleason, J. L., Yang, Y., Kelliher, M. A., Pandey, A. K., Sassetti, C. M., Reed, M. B., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081779 · Cited by 230
Self-citationForrester, M. T., Foster, M. W., & Stamler, J. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609684200 · Cited by 221
Koo, I. C., Wang, C., Raghavan, S., Morisaki, J. H., Cox, J. S., & Brown, E. J. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01177.x · Cited by 198
[13] Nitric oxide-cyclic GMP signal transduction system
Hobbs, A. J., & Ignarro, L. J. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69016-8 · Cited by 181
Tuberculosis Susceptibility of Diabetic Mice
Martens, G. W., Arıkan, M., Lee, J., Ren, F., Greiner, D. L., & Kornfeld, H. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0478oc · Cited by 178
Self-citationRole of Interleukin‐l in Infectious Diseases
Dinarello, C. A. (1992) · Immunological Reviews · doi:10.1111/j.1600-065x.1992.tb01411.x · Cited by 175
Chackerian, A. A., Perera, T. V., & Behar, S. M. (2001) · Infection and Immunity · doi:10.1128/iai.69.4.2666-2674.2001 · Cited by 171
Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection
Carlsson, F., Kim, J., Dumitru, C. D., Barck, K. H., Carano, R. A. D., Sun, M., Diehl, L. J., & Brown, E. J. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000895 · Cited by 161
McElvania, E., Allen, I. C., Hulseberg, P. D., Sullivan, J. T., McCann, J. R., Sándor, M., Braunstein, M., & Ting, J. P. ‐. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012320 · Cited by 159
Profiling Early Lung Immune Responses in the Mouse Model of Tuberculosis
Kang, D., Lin, Y., Rangel‐Moreno, J., Randall, T. D., & Khader, S. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016161 · Cited by 138
Arginine as an adjuvant to chemotherapy improves clinical outcome in active tuberculosis
Schön, T., Elias, D., Moges, F., Melese, E. B., Tessema, T. S., Stendahl, O. I., Britton, S., & Sundqvist, T. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00090702 · Cited by 97
Roberson, S. M., & Walker, W. S. (1988) · Cellular Immunology · doi:10.1016/0008-8749(88)90236-5 · Cited by 81
Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis
Honoré, N., Marchal, G., & Cole, S. T. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.3.769 · Cited by 77
Anti‐inflammatory effect of augmented nitric oxide production in chronic lung infection
Hopkins, N. O., Gunning, Y., O’Croinin, D. F., Laffey, J. G., & McLoughlin, P. (2006) · The Journal of Pathology · doi:10.1002/path.1963 · Cited by 32
Unique Model of Dormant Infection for Tuberculosis Vaccine Development
Kashino, S. S., Ovendale, P. J., Izzo, A. A., & Campos‐Neto, A. (2006) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00120-06 · Cited by 28
Feedback Regulation of Murine Autoimmunity via Dominant Anti-Inflammatory Effects of Interferon γ
Minguela, A., Pastor, S., Mi, W., Richardson, J. A., & Ward, E. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.134 · Cited by 24
Flagged first, then by citations
Research works printed but not linked: 1
- Nandi, B. & Behar, S.M. Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection. J. Exp. Med. 208, 2251–2262 (2011). · DOI
Cited by
Sorted by citations
The NLRP3 Inflammasome: an overview of mechanisms of activation and regulation
Kelley, N., Jeltema, D., Duan, Y., & He, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133328 · Cited by 3,539
Inflammasomes: mechanism of assembly, regulation and signalling
Broz, P., & Dixit, V. M. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.58 · Cited by 3,500
Activation and regulation of the inflammasomes
Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884
Reactive oxygen species and mitochondria: A nexus of cellular homeostasis
Dunn, J. D., Álvarez, L., Zhang, X., & Soldati, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.09.005 · Cited by 1,233
Regulation of inflammasome activation
Man, S. M., & Kanneganti, T. (2015) · Immunological Reviews · doi:10.1111/imr.12296 · Cited by 1,088
Metadata
- Authors
- Mishra, B. B., Rathinam, V. A. K., Martens, G. W., Martinot, A. J., Kornfeld, H., Fitzgerald, K. A., & Sassetti, C. M.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Harvard University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Sassetti, Christopher M
- ORCID
- Venue
- Nature Immunology
- Published
- 2012-11-18
- Volume
- 14
- Issue
- 1
- Pages
- 52-60
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC3721324
- OpenAlex
- W2048884877
- Cited by
- 571
- References
- 49
- Citations by year
- 2026: 24 · 2025: 27 · 2024: 29 · 2023: 39 · 2022: 47 · 2021: 53 · 2020: 46 · 2019: 43 · 2018: 51 · 2017: 46 · 2016: 46 · 2015: 40 · 2014: 40 · 2013: 37 · 2012: 3
- FWCI
- 15.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (R01HL064884, R01HL081149, HL064884)
- National Institute of Allergy and Infectious Diseases (AI064282, R01AI064282, AI083713, U54AI057159, R01AI083713, T32AI007638)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- nitric oxide, NLRP3 inflammasome, interleukin-1β processing, tuberculosis, immunopathology, Mycobacterium tuberculosis, nitrosylation, interferon-gamma, innate immunity, chronic infection, adaptive immunity
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Cells, Cultured, Humans, Immunity, Innate, Interferon-gamma, Mice, Inbred C57BL, Mycobacterium tuberculosis, Nitric Oxide, Tuberculosis, Signal Transduction, Mice, Knockout, Protein Modification, Translational, Mice, Interleukin-1beta, Protein Multimerization, Inflammasomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
