Cited by 790Inflammasome and immune disordersImmune Response and InflammationAutoimmune and Inflammatory Disorders Research

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

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Baroja-Mazo, Alberto, Martín-Sánchez, Fatima, Gomez, Ana I, Martínez, Carlos M, Amores-Iniesta, Joaquín, Compan, Vincent, Barberà-Cremades, Maria, Yagüe, Jordi, Ruiz-Ortiz, Estibaliz, Antón, Jordi, Buján, Segundo, Couillin, Isabelle, Brough, David, Arostegui, Juan I, Pelegrín, Pablo·2014·Nature Immunology

DOI 10.1038/ni.2919

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Abstract

Assembly of the NLRP3 inflammasome activates caspase-1 and mediates the processing and release of the leaderless cytokine IL-1β and thereby serves a central role in the inflammatory response and in diverse human diseases. Here we found that upon activation of caspase-1, oligomeric NLRP3 inflammasome particles were released from macrophages. Recombinant oligomeric protein particles composed of the adaptor ASC or the p.D303N mutant form of NLRP3 associated with cryopyrin-associated periodic syndromes (CAPS) stimulated further activation of caspase-1 extracellularly, as well as intracellularly after phagocytosis by surrounding macrophages. We found oligomeric ASC particles in the serum of patients with active CAPS but not in that of patients with other inherited autoinflammatory diseases. Our findings support a model whereby the NLRP3 inflammasome, acting as an extracellular oligomeric complex, amplifies the inflammatory response.

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Background
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Background
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Background
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Authors: Baroja-Mazo, A., Martín-Sánchez, F., Gomez, A. I., Martínez, C. M., Amores-Iniesta, J., Compan, V., Barberà-Cremades, M., Yagüe, J., Ruiz-Ortiz, E., Antón, J., Buján, S., Couillin, I., Brough, D., Arostegui, J. I., & Pelegrín, P.
Affiliations: Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
University of Manchester (GB)
Hospital Clínic de Barcelona (ES)
Hospital Sant Joan de Déu Barcelona (ES)
Vall d'Hebron Hospital Universitari (ES)
Université d'Orléans (FR)
ORCID: Martínez, Carlos M
Compan, Vincent
Yagüe, Jordi
Antón, Jordi
Couillin, Isabelle
Brough, David
Pelegrín, Pablo
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2014-06-22
Volume: 15
Issue: 8
Pages: 738-748
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni.2919
OpenAlex: W2143119237
Cited by: 790
References: 50
Citations by year: 2026: 28 · 2025: 39 · 2024: 41 · 2023: 63 · 2022: 81 · 2021: 84 · 2020: 86 · 2019: 68 · 2018: 74 · 2017: 88 · 2016: 60 · 2015: 57 · 2014: 20
FWCI: 30.77
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Hispana (publishedVersion, cc-by-nc-nd)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords: NLRP3 inflammasome, caspase-1, IL-1β processing, cryopyrin-associated periodic syndromes, macrophages, autoinflammatory disease, phagocytosis
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Cells, Cultured, Cytoskeletal Proteins, Humans, Inflammation, Macrophages, Mice, Inbred C57BL, Phagocytosis, Signal Transduction, Mice, Knockout, Caspases, Caspase 1, Apoptosis Regulatory Proteins, Mice, CARD Signaling Adaptor Proteins, Caspases, Initiator, Interleukin-1beta, Cryopyrin-Associated Periodic Syndromes, HEK293 Cells, Inflammasomes

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The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

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