The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

Baroja-Mazo, Alberto, Martín-Sánchez, Fatima, Gomez, Ana I, Martínez, Carlos M, Amores-Iniesta, Joaquín, Compan, Vincent, Barberà-Cremades, Maria, Yagüe, Jordi, Ruiz-Ortiz, Estibaliz, Antón, Jordi, Buján, Segundo, Couillin, Isabelle, Brough, David, Arostegui, Juan I, Pelegrín, Pablo·2014·Nature Immunology

DOI 10.1038/ni.2919

Cited by (789)

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Shanshan Wei, Wanjun Ma, Xiaohui Li, Chuanhao Jiang, Taoli Sun, Yuan‐Jian Li, Bikui Zhang, Wenqun Li · 2020 · Cardiovascular Toxicology
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Jack Barrington, Eloïse Lemarchand, Stuart McRae Allan · 2016 · Brain Pathology
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Simon J. Freeley, Claudia Kemper, Gaëlle Le Friec · 2016 · Immunological Reviews
Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells
Xuting Liu, Bin Lu, Juanli Fu, Xiaokang Zhu, Erqun Song, Yang Song · 2020 · Journal of Hazardous Materials
Caspase crosstalk: integration of apoptotic and innate immune signalling pathways
Emma M. Creagh · 2014 · Trends in Immunology
Colchicine therapy in acute coronary syndrome patients acts on caspase-1 to suppress NLRP3 inflammasome monocyte activation
S. E. J. Robertson, Gonzalo J. Martínez, Cloé A. Payet, Jennifer Barraclough, David Stephen Celermajer, Christina A. Bursill, Sanjay Patel · 2016 · Clinical Science
Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro
Dongping Zhang, Jinhong Qian, Peng Zhang, Haiying Li, Haitao Shen, Xiang Li, Gang Chen · 2019 · Journal of Neuroscience Research
Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro
Anna Gritsenko, Shi Yu, Fatima Martín‐Sánchez, Ines Diaz-del-Olmo, Eva-Maria Nichols, Daniel M. Davis, David Brough, Gloria López‐Castejón · 2020 · Frontiers in Immunology
Lymph node – an organ for T‐cell activation and pathogen defense
Georg Gasteiger, Marco A. Ataide, Wolfgang Kastenmüller · 2016 · Immunological Reviews
Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism—UK Single Center Experience
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ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination
Guangming Ren, Xuanyi Zhang, Yang Xiao, Wen Zhang, Yu Wang, Wenbing Ma, Xiaohan Wang, Pan Song, Lili Lai, Hui Chen et al. · 2019 · The EMBO Journal
Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation
Ana Tapia‐Abellán, Diego Angosto-Bazarra, Cristina Alarcón‐Vila, María C. Baños, Iva Hafner‐Bratkovič, Baldomero Oliva, Pablo Pelegrín · 2021 · Science Advances
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Florian Hoß, Juan F. Rodríguez-Alcázar, Eicke Latz · 2016 · Cellular and Molecular Life Sciences
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Charles Lee Evavold, Jonathan C. Kagan · 2017 · Journal of Molecular Biology
Update on the role of alternatively activated macrophages in asthma
Zhilong Jiang, Lei Zhu · 2016 · Journal of Asthma and Allergy
Activation of the NLRP 3 inflammasome in microglia: the role of ceramide
Scheiblich, Hannah, Schlütter, Anna, Golenbock, Douglas T., Latz, Eicke, Martinez‐Martinez, Pilar, Heneka, Michael T. · 2017 · Journal of Neurochemistry
Crystallopathies
Shrikant R. Mulay, Hans‐Joachim Anders · 2016 · New England Journal of Medicine
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Minghui Wang, Hu Zhang, Jiling Liang, Jielun Huang, Ning Chen · 2023 · Journal of Neuroinflammation
The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury
Xintong Ge, Wenzhu Li, SHAN HU HUANG, Zhenyu Yin, Xin Juan Xu, Fanglian Chen, Xiaodong Kong, Haichen Wang, Jianning Zhang, Ping Lei · 2018 · Brain Research
Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome
Laura R. Hoyt, Matthew J. Randall, Jennifer L. Ather, Daniel P. DePuccio, Christopher C. Landry, Xi Qian, Yvonne M. W. Janssen-Heininger, Albert van der Vliet, Anne E. Dixon, Eyal Amiel et al. · 2017 · Redox Biology
NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway
Iva Hafner‐Bratkovič, Petra Sušjan, Duško Lainšček, Ana Tapia‐Abellán, Kosta Cerović, Lucija Kadunc, Diego Angosto-Bazarra, Pablo Pelegrı́n, Roman Jerala · 2018 · Nature Communications
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology
Xiaolong He, Weijun Yang, Zhijie Zeng, Yi Wei, Jie Gao, Bao Zhang, Li Li, Liqun Liu, Yu Wan, Qing Zeng et al. · 2019 · Cellular and Molecular Immunology
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Ting‐Yu Shih, Serena O. Blacklow, Aileen W. Li, Benjamin R. Freedman, Sidi A. Bencherif, Sandeep T. Koshy, Max Darnell, David J. Mooney · 2018 · Advanced Healthcare Materials
NLRP3 inflammasome in neurodegenerative disease
Faith L. Anderson, Karl E. Biggs, Brynn E. Rankin, Matthew C. Havrda · 2022 · Translational research
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Fawaz Awad, Eman Assrawi, Camille Louvrier, Claire Jumeau, Sophie Georgin‐Lavialle, Gilles Grateau, Serge Amselem, Irina Giurgea, Sonia‐Athina Karabina · 2018 · Pharmacology & Therapeutics
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Aigli G. Vakrakou, Sorina Boiu, Panayiotis D. Ziakas, Evangelia Xingi, Haralabia Boleti, Menelaos N. Manoussakis · 2018 · Journal of Autoimmunity
The inflammasome in host response to biomaterials: Bridging inflammation and tissue regeneration
Daniela P. Vasconcelos, Artur P. Águas, Mário Adolfo Barbosa, Pablo Pelegrı́n, Judite Novais Barbosa · 2018 · Acta Biomaterialia
L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation
Ruohang He, Ying Li, Chaoqun Han, Rong Lin, Wei Qian, Xiaohua Hou · 2019 · International Immunopharmacology
Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype
Pinto, Sara, Cunha, Carolina, Barbosa, Marta, Vaz, Ana R., Brites, Dora · 2017 · Frontiers in Neuroscience
Grape seed proanthocyanidin extract ameliorates dextran sulfate sodium-induced colitis through intestinal barrier improvement, oxidative stress reduction, and inflammatory cytokines and gut microbiota modulation
Kangliang Sheng, Guanghui Zhang, Ming Sun, Shiman He, Xiaowei Kong, Jingmin Wang, Fenfang Zhu, Xiangdong Zha, Yongzhong Wang · 2020 · Food & Function
Structural Biology of Innate Immunity
Qian Yin, Tian‐Min Fu, Jixi Li, Hao Wu · 2015 · Annual Review of Immunology
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Carlos de Torre‐Minguela, María Barberà-Cremades, Ana I. Gómez, Fatima Martín‐Sánchez, Pablo Pelegrı́n · 2016 · Scientific Reports
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Koustav Chatterjee, Akash Roy, Rebecca Banerjee, Supriyo Choudhury, Banashree Mondal, Saptak Halder, Purba Basu, Shantanu Shubham, Sanjit Dey, Hrishikesh Kumar · 2019 · Journal of Neuroimmunology
Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome
Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li, Ming Niu, Jiabo Wang, Youping Liu et al. · 2019 · Acta Pharmaceutica Sinica B
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Pathogenesis of Mycoplasma pneumoniae: An update
Rama Chaudhry, A Ghosh, Amita Chandolia · 2016 · Indian Journal of Medical Microbiology
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Pedro Bullón, Elísabet Alcocer‐Gómez, Ángel Manuel Carrión, Fabiola Marín‐Aguilar, Juan Garrido‐Maraver, Lourdes Román-Malo, Jesús Ruı́z-Cabello, Ognjen Čulić, Bernhard Ryffel, Lionel Apétoh et al. · 2015 · Antioxidants and Redox Signaling
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Lavanya Bellumkonda, Daniel J. Tyrrell, Scott L. Hummel, Daniel R. Goldstein · 2017 · Aging Cell
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Héctor Cordero, Monica Fengsrud Brinchmann, Alberto Cuesta, José Meseguer, María Ángeles Esteban · 2015 · PROTEOMICS
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Bradford S. Powell, Alexander K. Andrianov, Peter C. Fusco · 2015 · Clinical and Experimental Vaccine Research
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Activation of NLRP3 inflammasome by crystalline structures via cell surface contact
Aswin Hari, Yifei Zhang, Zhongyuan Tu, Pascal Detampel, Melanie D. Stenner, Anutosh Ganguly, Yan Shi · 2014 · Scientific Reports
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