The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
Open accessAbstract
Foxp3+ regulatory T cells (Treg cells) are required for immunological homeostasis. One notable distinction between conventional T cells (Tconv cells) and Treg cells is differences in the activity of phosphatidylinositol-3-OH kinase (PI(3)K); only Tconv cells downregulate PTEN, the main negative regulator of PI(3)K, upon activation. Here we found that control of PI(3)K in Treg cells was essential for lineage homeostasis and stability. Mice lacking Pten in Treg cells developed an autoimmune-lymphoproliferative disease characterized by excessive T helper type 1 (TH1) responses and B cell activation. Diminished control of PI(3)K activity in Treg cells led to reduced expression of the interleukin-2 (IL-2) receptor α subunit CD25, accumulation of Foxp3+CD25− cells and, ultimately, loss of expression of the transcription factor Foxp3 in these cells. Collectively, our data demonstrate that control of PI(3)K signaling by PTEN in Treg cells is critical for maintaining their homeostasis, function and stability.
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Citations
Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
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Self-citationControl of TH17/Treg Balance by Hypoxia-Inducible Factor 1
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The CD28 Signaling Pathway Regulates Glucose Metabolism
Frauwirth, K. A., Riley, J. L., Harris, M. H., Parry, R. V., Rathmell, J. C., Plas, D. R., Elstrom, R. L., June, C. H., & Thompson, C. B. (2002) · Immunity · doi:10.1016/s1074-7613(02)00323-0 · Cited by 1,475
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Regulatory T (Treg) cells in cancer: Can Treg cells be a new therapeutic target?
Ohue, Y., & Nishikawa, H. (2019) · Cancer Science · doi:10.1111/cas.14069 · Cited by 1,041
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Metadata
- Authors
- Huynh, A., DuPage, M., Priyadharshini, B., Sage, P. T., Quiros, J., Borges, C. M., Townamchai, N., Gerriets, V. A., Rathmell, J. C., Sharpe, A. H., Bluestone, J. A., & Turka, L. A.
- Venue
- Nature Immunology
- Published
- 2015-01-05
- Volume
- 16
- Issue
- 2
- Pages
- 188-196
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2063241227
- Cited by
- 411
- References
- 50
- FWCI
- 22.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Huynh, A., DuPage, M., Priyadharshini, B., Sage, P. T., Quiros, J., Borges, C. M., Townamchai, N., Gerriets, V. A., Rathmell, J. C., Sharpe, A. H., Bluestone, J. A., & Turka, L. A. (2015). Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nature Immunology. https://doi.org/10.1038/ni.3077
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