CoChat
Sign Up
Cited by 190

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

Li, Xia, Zhang, Qian, Ding, Yuanyuan, Liu, Yiqi, Zhao, Dezhi, Zhao, Kai, Shen, Qicong, Liu, Xingguang, Zhu, Xuhui, Li, Nan, Cheng, Zhongyi, Fan, Guoping, Wang, Qingqing, Cao, Xuetao·2016·Nature Immunology
DOI 10.1038/ni.3464
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ni.3464

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 9 references

Research works printed but not linked: 44

  1. Smale, S.T., Tarakhovsky, A. & Natoli, G. Chromatin contributions to the regulation of innate immunity. Annu. Rev. Immunol. 32, 489–511 (2014). · DOI
  2. Álvarez-Errico, D., Vento-Tormo, R., Sieweke, M. & Ballestar, E. Epigenetic control of myeloid cell differentiation, identity and function. Nat. Rev. Immunol. 15, 7–17 (2015). · DOI
  3. Ramirez-Carrozzi, V.R. et al. Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response. Genes Dev. 20, 282–296 (2006). · DOI
  4. Jones, P.A. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat. Rev. Genet. 13, 484–492 (2012). · DOI · Paper page
  5. Anderson, P. Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat. Rev. Immunol. 10, 24–35 (2010). · DOI · Paper page
  6. Mowen, K.A. & David, M. Unconventional post-translational modifications in immunological signaling. Nat. Immunol. 15, 512–520 (2014). · DOI
  7. Piccirillo, C.A., Bjur, E., Topisirovic, I., Sonenberg, N. & Larsson, O. Translational control of immune responses: from transcripts to translatomes. Nat. Immunol. 15, 503–511 (2014). · DOI
  8. Verdin, E. & Ott, M. 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond. Nat. Rev. Mol. Cell Biol. 16, 258–264 (2015). · DOI
  9. Cao, W., Bao, C., Padalko, E. & Lowenstein, C.J. Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J. Exp. Med. 205, 1491–1503 (2008). · DOI
  10. Munshi, N. et al. Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome. Mol. Cell 2, 457–467 (1998). · DOI
  11. Nusinzon, I. & Horvath, C.M. Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Natl. Acad. Sci. USA 100, 14742–14747 (2003). · DOI
  12. Fitzgerald, K.A. et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat. Immunol. 4, 491–496 (2003). · DOI
  13. Cao, X. Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease. Nat. Rev. Immunol. 16, 35–50 (2016). · DOI
  14. Li, S., Wang, L., Berman, M., Kong, Y.Y. & Dorf, M.E. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity 35, 426–440 (2011). · DOI
  15. Cui, J. et al. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat. Immunol. 13, 387–395 (2012). · DOI
  16. Wu, C., Macleod, I. & Su, A.I. BioGPS and MyGene.info: organizing online, gene-centric information. Nucleic Acids Res. 41, D561–D565 (2013). · DOI
  17. Chen, W. et al. Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell 152, 467–478 (2013). · DOI
  18. Servant, M.J. et al. Identification of the minimal phosphoacceptor site required for in vivo activation of interferon regulatory factor 3 in response to virus and double-stranded RNA. J. Biol. Chem. 278, 9441–9447 (2003). · DOI
  19. Chau, T.L. et al. Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated? Trends Biochem. Sci. 33, 171–180 (2008). · DOI
  20. Ma, X. et al. Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation. Proc. Natl. Acad. Sci. USA 109, 9378–9383 (2012). · DOI
  21. Kanehisa, M., Goto, S., Sato, Y., Furumichi, M. & Tanabe, M. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res. 40, D109–D114 (2012). · DOI · Paper page
  22. Jones, P.L. et al. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 19, 187–191 (1998). · DOI
  23. Nan, X. et al. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393, 386–389 (1998). · DOI · Paper page
  24. Viré, E. et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439, 871–874 (2006). · DOI · Paper page
  25. Clément, J.F., Meloche, S. & Servant, M.J. The IKK-related kinases: from innate immunity to oncogenesis. Cell Res. 18, 889–899 (2008). · DOI
  26. Tu, D. et al. Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep. 3, 747–758 (2013). · DOI
  27. Wang, L., Li, S. & Dorf, M.E. NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses. PLoS One 7, e43756 (2012). · DOI
  28. Ramirez-Carrozzi, V.R. et al. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell 138, 114–128 (2009). · DOI
  29. Marr, A.K. et al. Leishmania donovani infection causes distinct epigenetic DNA methylation changes in host macrophages. PLoS Pathog. 10, e1004419 (2014). · DOI
  30. Rowles, D.L. et al. DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection. Proteomics 15, 1968–1982 (2015). · DOI
  31. Chen, C. et al. DNA methyltransferases 1 and 3B are required for hepatitis C virus infection in cell culture. Virology 441, 57–65 (2013). · DOI
  32. Vivekanandan, P., Daniel, H.D., Kannangai, R., Martinez-Murillo, F. & Torbenson, M. Hepatitis B virus replication induces methylation of both host and viral DNA. J. Virol. 84, 4321–4329 (2010). · DOI
  33. Northrup, D.L. & Zhao, K. Application of ChIP-Seq and related techniques to the study of immune function. Immunity 34, 830–842 (2011). · DOI
  34. Shakespear, M.R., Halili, M.A., Irvine, K.M., Fairlie, D.P. & Sweet, M.J. Histone deacetylases as regulators of inflammation and immunity. Trends Immunol. 32, 335–343 (2011). · DOI · Paper page
  35. Aung, H.T. et al. LPS regulates proinflammatory gene expression in macrophages by altering histone deacetylase expression. FASEB J. 20, 1315–1327 (2006). · DOI
  36. Halili, M.A. et al. Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. J. Leukoc. Biol. 87, 1103–1114 (2010). · DOI · Paper page
  37. Nusinzon, I. & Horvath, C.M. Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Mol. Cell. Biol. 26, 3106–3113 (2006). · DOI
  38. Zhu, J., Coyne, C.B. & Sarkar, S.N. PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin. EMBO J. 30, 4838–4849 (2011). · DOI
  39. Saul, V.V., Niedenthal, R., Pich, A., Weber, F. & Schmitz, M.L. SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity. Biochim. Biophys. Acta 1853, 136–143 (2015). · DOI
  40. Zhao, W. Negative regulation of TBK1-mediated antiviral immunity. FEBS Lett. 587, 542–548 (2013). · DOI
  41. Han, C. et al. Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b. Nat. Immunol. 11, 734–742 (2010). · DOI
  42. Xu, S. et al. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat. Immunol. 13, 551–559 (2012). · DOI
  43. Zhao, T. et al. The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways. Nat. Immunol. 8, 592–600 (2007). · DOI
  44. Li, Y. et al. The DNA methylome of human peripheral blood mononuclear cells. PLoS Biol. 8, e1000533 (2010). · DOI

Cited by

Metadata

Authors
Li, X., Zhang, Q., Ding, Y., Liu, Y., Zhao, D., Zhao, K., Shen, Q., Liu, X., Zhu, X., Li, N., Cheng, Z., Fan, G., Wang, Q., & Cao, X.
ORCID
Fan, Guoping
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2016-05-30
Volume
17
Issue
7
Pages
806-815
ISSN
  • 1529-2908
  • 1529-2916
DOI
10.1038/ni.3464
Cited by
190
References
9
Language
en
Update notices
erratum (2016-07-19)
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review