Epigenetic regulation of the innate immune response to infection

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382 · see citing works

The language of covalent histone modifications

Strahl, B. D., & Allis, C. D. (2000) · Nature · doi:10.1038/47412 · Cited by 8,679 · see citing works

Functions of DNA methylation: islands, start sites, gene bodies and beyond

Jones, P. A. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3230 · Cited by 6,061 · see citing works

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836 · see citing works

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722 · see citing works

Toll-like receptors and innate immunity

Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308 · see citing works

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176 · see citing works

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106 · see citing works

Unique features of long non-coding RNA biogenesis and function

Quinn, J. J., & Chang, H. Y. (2015) · Nature Reviews Genetics · doi:10.1038/nrg.2015.10 · Cited by 3,653 · see citing works

Dynamic RNA Modifications in Gene Expression Regulation

Roundtree, I. A., Evans, M., Pan, T., & He, C. (2017) · Cell · doi:10.1016/j.cell.2017.05.045 · Cited by 3,459 · see citing works

Perceptions of epigenetics

Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011 · see citing works

Exon-intron circular RNAs regulate transcription in the nucleus

Li, Z., Huang, C., Bao, C., Chen, L., Lin, M., Wang, X., Zhong, G., Yu, B., Hu, W., Dai, L., et al. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2959 · Cited by 2,905 · see citing works

The molecular hallmarks of epigenetic control

Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809 · see citing works

Trained immunity: A program of innate immune memory in health and– disease

Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., O’Neill, L. A. J., & Xavier, R. J. (2016) · Science · doi:10.1126/science.aaf1098 · Cited by 2,768 · see citing works

Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750 · see citing works

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Franke, A., McGovern, D. P. B., Barrett, J. C., Wang, K., Radford-Smith, G. L., Ahmad, T., Lees, C. W., Balschun, T., Lee, J., Roberts, R., et al. (2010) · Nature Genetics · doi:10.1038/ng.717 · Cited by 2,520 · see citing works

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224 · see citing works

Metabolic control through the PGC-1 family of transcription coactivators

Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · see citing works

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature · doi:10.1038/nature25986 · Cited by 1,885 · see citing works

The Immunological Genome Project: networks of gene expression in immune cells

The Immunological Genome Project Consortium, Heng, T. S. P., Painter, M. W., Elpek, K., Lukacs-Kornek, V., Mauermann, N., Turley, S. J., Koller, D., Kim, F. S., Wagers, A. J., et al. (2008) · Nature Immunology · doi:10.1038/ni1008-1091 · Cited by 1,864 · see citing works

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Saeed, S., Quintin, J., Kerstens, H. H. D., Rao, N. A., Aghajanirefah, A., Matarese, F., Cheng, S.-C., Ratter, J., Berentsen, K., van der Ent, M. A., et al. (2014) · Science · doi:10.1126/science.1251086 · Cited by 1,761 · see citing works

TET-mediated active DNA demethylation: mechanism, function and beyond

Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661 · see citing works

Tetrahymena Histone Acetyltransferase A: A Homolog to Yeast Gcn5p Linking Histone Acetylation to Gene Activation

Brownell, J. E., Zhou, J., Ranalli, T. A., Kobayashi, R., Edmondson, D. G., Dent, S., & Allis, C. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81063-6 · Cited by 1,636 · see citing works

Suppression of inflammation by a synthetic histone mimic

Nicodeme, E., Jeffrey, K. L., Schaefer, U., Beinke, S., Dewell, S., Chung, C.-W., Chandwani, R., Marazzi, I., Wilson, P., Coste, H., et al. (2010) · Nature · doi:10.1038/nature09589 · Cited by 1,563 · see citing works

Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the Warburg effect in LPS-activated macrophages

Palsson-McDermott, E. M., Curtis, A. M., Goel, G., Lauterbach, M. A. R., Sheedy, F. J., Gleeson, L. E., van den Bosch, M. W. M., Quinn, S. R., Domingo-Fernandez, R., Johnston, D. G. W., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.005 · Cited by 1,397 · see citing works

Gene-specific control of inflammation by TLR-induced chromatin modifications

Foster, S. L., Hargreaves, D. C., & Medzhitov, R. (2007) · Nature · doi:10.1038/nature05836 · Cited by 1,344 · see citing works

Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

Clapier, C. R., Iwasa, J., Cairns, B. R., & Peterson, C. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.26 · Cited by 1,305 · see citing works

Candida albicans Infection Affords Protection against Reinfection via Functional Reprogramming of Monocytes

Quintin, J., Saeed, S., Martens, J. H. A., Giamarellos-Bourboulis, E. J., Ifrim, D. C., Logie, C., Jacobs, L., Jansen, T., Kullberg, B.-J., Wijmenga, C., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.06.006 · Cited by 1,289 · see citing works

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Liu, P.-S., Wang, H., Li, X., Chao, T., Teav, T., Christen, S., Di Conza, G., Cheng, W.-C., Chou, C.-H., Vavakova, M., et al. (2017) · Nature Immunology · doi:10.1038/ni.3796 · Cited by 1,264 · see citing works

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

Chen, L., Fischle, W., Verdin, E. M., & Greene, W. C. (2001) · Science · doi:10.1126/science.1062374 · Cited by 1,231 · see citing works

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

Kaufmann, E., Sanz, J., Dunn, J. L., Khan, N., Mendonça, L. E., Pacis, A., Tzelepis, F., Pernet, E., Dumaine, A., Grenier, J.-C., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.031 · Cited by 1,191 · see citing works

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., et al. (2010) · Nature Immunology · doi:10.1038/ni.1920 · Cited by 1,156 · see citing works

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Mitroulis, I., Ruppova, K., Wang, B., Chen, L.-S., Grzybek, M., Grinenko, T., Eugster, A., Troullinaki, M., Palladini, A., Kourtzelis, I., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.034 · Cited by 1,100 · see citing works

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

Kawahara, T. L. A., Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., et al. (2009) · Cell · doi:10.1016/j.cell.2008.10.052 · Cited by 1,090 · see citing works

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Liddicoat, B., Piskol, R., Chalk, A. M., Ramaswami, G., Higuchi, M., Hartner, J. C., Li, J. B., Seeburg, P. H., & Walkley, C. R. (2015) · Science · doi:10.1126/science.aac7049 · Cited by 955 · see citing works

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Kruidenier, L., Chung, C.-W., Cheng, Z., Liddle, J., Che, K., Joberty, G., Bantscheff, M., Bountra, C., Bridges, A., Diallo, H., et al. (2012) · Nature · doi:10.1038/nature11262 · Cited by 950 · see citing works

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

Carpenter, S. B., Aiello, D. A., Atianand, M., Ricci, E. P., Gandhi, P., Hall, L. L., Byron, M., Monks, B. G., Henry-Bezy, M., Lawrence, J. B., et al. (2013) · Science · doi:10.1126/science.1240925 · Cited by 946 · see citing works

The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1

Zhong, H., May, M. J., Jimi, E., & Ghosh, S. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00477-x · Cited by 930 · see citing works

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

Arts, R. J. W., Novakovic, B., ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S.-C., Wang, S.-Y., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.008 · Cited by 930 · see citing works

Metabolic regulation of immune responses

Ganeshan, K., & Chawla, A. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120236 · Cited by 926 · see citing works

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 863 · see citing works

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807 · see citing works

Metabolic Induction of Trained Immunity through the Mevalonate Pathway

Bekkering, S., Arts, R. J. W., Novakovic, B., Kourtzelis, I., van der Heijden, C. D. C. C., Li, Y., Popa, C. D., ter Horst, R., van Tuijl, J., Netea-Maier, R. T., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.025 · Cited by 794 · see citing works

C-type lectins in immunity and homeostasis

Brown, G. D., Willment, J. A., & Whitehead, L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0004-8 · Cited by 747 · see citing works

Type VI secretion system effectors: poisons with a purpose

Russell, A. B., Peterson, S. B., & Mougous, J. D. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3185 · Cited by 718 · see citing works

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Bambouskova, M., Gorvel, L., Lampropoulou, V., Sergushichev, A., Loginicheva, E., Johnson, K., Korenfeld, D., Mathyer, M. E., Kim, H., Huang, L.-H., et al. (2018) · Nature · doi:10.1038/s41586-018-0052-z · Cited by 713 · see citing works

p38-dependent marking of inflammatory genes for increased NF-κB recruitment

Saccani, S., Pantano, S., & Natoli, G. (2001) · Nature Immunology · doi:10.1038/ni748 · Cited by 694 · see citing works

β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance

Novakovic, B., Habibi, E., Wang, S.-Y., Arts, R. J. W., Davar, R., Megchelenbrink, W., Kim, B., Kuznetsova, T., Kox, M., Zwaag, J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.09.034 · Cited by 689 · see citing works

Gene regulation in the immune system by long noncoding RNAs

Chen, Y. G., Satpathy, A. T., & Chang, H. Y. (2017) · Nature Immunology · doi:10.1038/ni.3771 · Cited by 686 · see citing works

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription

Kaikkonen, M. U., Spann, N. J., Heinz, S., Romanoski, C. E., Allison, K. A., Stender, J. D., Chun, H. B., Tough, D. F., Prinjha, R. K., Benner, C., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.07.010 · Cited by 672 · see citing works

Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease

Cao, X. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.8 · Cited by 661 · see citing works

Intracellular Crotonyl-CoA Stimulates Transcription through p300-Catalyzed Histone Crotonylation

Sabari, B. R., Tang, Z., Huang, H., Yong-Gonzalez, V., Molina, H., Kong, H. E., Dai, L., Shimada, M., Cross, J. R., Zhao, Y., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.02.029 · Cited by 659 · see citing works

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

Hargreaves, D. C., Horng, T., & Medzhitov, R. M. (2009) · Cell · doi:10.1016/j.cell.2009.05.047 · Cited by 649 · see citing works

DNA methylation on N6-adenine in mammalian embryonic stem cells

Wu, T. P., Wang, T., Seetin, M. G., Lai, Y., Zhu, S., Lin, K., Liu, Y., Byrum, S. D., Mackintosh, S. G., Zhong, M., et al. (2016) · Nature · doi:10.1038/nature17640 · Cited by 648 · see citing works

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

Ramirez-Carrozzi, V. R., Braas, D., Bhatt, D. M., Cheng, C. S., Hong, C., Doty, K. R., Black, J. C., Hoffmann, A., Carey, M., & Smale, S. T. (2009) · Cell · doi:10.1016/j.cell.2009.04.020 · Cited by 581 · see citing works

Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

Yamamoto, Y., Verma, U. N., Prajapati, S., Kwak, Y.-T., & Gaynor, R. B. (2003) · Nature · doi:10.1038/nature01576 · Cited by 577 · see citing works

Histone deacetylases as regulators of inflammation and immunity

Shakespear, M. R., Halili, M. A., Irvine, K. M., Fairlie, D. P., & Sweet, M. J. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.001 · Cited by 546 · see citing works

Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

Chung, H., Calis, J. J. A., Wu, X., Sun, T., Yu, Y., Sarbanes, S. L., Dao Thi, V. L., Shilvock, A. R., Hoffmann, H.-H., Rosenberg, B. R., et al. (2018) · Cell · doi:10.1016/j.cell.2017.12.038 · Cited by 538 · see citing works

Post-activation Turn-off of NF-κB-dependent Transcription Is Regulated by Acetylation of p65

Kiernan, R. E., Brès, V., Ng, R. W. M., Coudart, M.-P., Messaoudi, S. E., Sardet, C., Jin, D., Emiliani, S., & Benkirane, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209572200 · Cited by 536 · see citing works

A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

Anest, V., Ostrander, J. H., Cogswell, P. C., Steinbrecher, K. A., Strahl, B. D., & Baldwin, A. S. (2003) · Nature · doi:10.1038/nature01648 · Cited by 522 · see citing works

Epigenetic control of CD8+ T cell differentiation

Henning, A. N., Roychoudhuri, R., & Restifo, N. P. (2018) · Nature reviews. Immunology · doi:10.1038/nri.2017.146 · Cited by 501 · see citing works

Sensing Self and Foreign Circular RNAs by Intron Identity

Chen, Y. G., Kim, M. V., Chen, X., Batista, P. J., Aoyama, S., Wilusz, J. E., Iwasaki, A., & Chang, H. Y. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.022 · Cited by 475 · see citing works

Immunobiology of Long Noncoding RNAs

Atianand, M., Caffrey, D. R., & Fitzgerald, K. A. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055459 · Cited by 459 · see citing works

Selective and antagonistic functions of SWI/SNF and Mi-2beta nucleosome remodeling complexes during an inflammatory response.Preprint

Ramirez-Carrozzi, V., Nazarian, A. A., Li, C.-Y. C., Gore, S., Sridharan, R., Imbalzano, A., & Smale, S. (2006) · Genes & Development · doi:10.1101/gad.1383206 · Cited by 456 · see citing works

A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation

Atianand, M., Hu, W., Satpathy, A. T., Shen, Y., Ricci, E. P., Alvarez‐Dominguez, J. R., Bhatta, A., Schattgen, S., McGowan, J. D., Blin, J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.075 · Cited by 446 · see citing works

Long Noncoding RNAs with snoRNA Ends

Yin, Q.-F., Yang, L. C., Zhang, Y., Xiang, J., Wu, Y., Carmichael, G., & Chen, L. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.033 · Cited by 444 · see citing works

Histone H2A Monoubiquitination Represses Transcription by Inhibiting RNA Polymerase II Transcriptional Elongation

Zhou, W., Zhu, P., Wang, J., Pascual, G., Ohgi, K. A., Lozach, J., Glass, C. K., & Rosenfeld, M. G. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.002 · Cited by 407 · see citing works

Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host

Meisel, M., Hinterleitner, R., Pacis, A., Chen, L., Earley, Z. M., Mayassi, T., Pierre, J. F., Ernest, J. D., Galipeau, H. J., Thuille, N., et al. (2018) · Nature · doi:10.1038/s41586-018-0125-z · Cited by 406 · see citing works

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity

Domínguez‐Andrés, J., Novakovic, B., Li, Y., Scicluna, B. P., Gresnigt, M. S., Arts, R. J. W., Oosting, M., Moorlag, S. J. C. F. M., Groh, L. A., Zwaag, J., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.003 · Cited by 394 · see citing works

The RNA helicase DDX46 inhibits innate immunity by entrapping m6A-demethylated antiviral transcripts in the nucleus

Zheng, Q., Hou, J., Zhou, Y., Li, Z., & Cao, X. (2017) · Nature Immunology · doi:10.1038/ni.3830 · Cited by 369 · see citing works

Epigenetics and Bacterial InfectionsPreprint

Bierne, H., Hamon, M. A., & Cossart, P. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a010272 · Cited by 363 · see citing works

Activation of DNA Methyltransferase 1 by EBV Latent Membrane Protein 2A Leads to Promoter Hypermethylation of PTEN Gene in Gastric Carcinoma

Hino, R., Uozaki, H., Murakami, N., Ushiku, T., Shinozaki‐Ushiku, A., Ishikawa, S., Morikawa, T., Nakaya, T., Sakatani, T., Takada, K., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3070 · Cited by 344 · see citing works

Synergistic Activation of Inflammatory Cytokine Genes by Interferon-γ-Induced Chromatin Remodeling and Toll-like Receptor Signaling

Qiao, Y., Giannopoulou, E. G., Chan, C. H., Park, S.-H., Gong, S., Chen, J., Hu, X., Elemento, O., & Ivashkiv, L. B. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.009 · Cited by 330 · see citing works

An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism

Wang, P., Xu, J., Wang, Y., & Cao, X. (2017) · Science · doi:10.1126/science.aao0409 · Cited by 316 · see citing works

Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation

Mullican, S. E., Gaddis, C. A., Alenghat, T., Nair, M. G., Giacomin, P. R., Everett, L. J., Feng, D., Steger, D. J., Schug, J., Artis, D., et al. (2011) · Genes & Development · doi:10.1101/gad.175950.111 · Cited by 314 · see citing works

Self-Recognition of an Inducible Host lncRNA by RIG-I Feedback Restricts Innate Immune Response

Jiang, M., Zhang, S., Yang, Z., Lin, H., Zhu, J., Liu, L., Wang, W., Liu, S., Liu, W., Ma, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.064 · Cited by 301 · see citing works

Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16

Li, T., Diner, B. A., Chen, J., & Cristea, I. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203447109 · Cited by 297 · see citing works

Statistical and integrative system-level analysis of DNA methylation data

Teschendorff, A. E., & Relton, C. L. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.86 · Cited by 292 · see citing works

From profiles to function in epigenomics

Stricker, S. H., Köferle, A., & Beck, S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.138 · Cited by 290 · see citing works

Noncoding RNA and Polycomb recruitment

Brockdorff, N. (2013) · RNA · doi:10.1261/rna.037598.112 · Cited by 284 · see citing works

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

Chen, K., Liu, J., Liu, S., Meng, X., Zhang, X., Han, D., Jiang, Y., Wang, C., & Cao, X. (2017) · Cell · doi:10.1016/j.cell.2017.06.042 · Cited by 283 · see citing works

Single-cell epigenomics: techniques and emerging applications

Schwartzman, O., & Tanay, A. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3980 · Cited by 282 · see citing works

Regulation of NF-κB by NSD1/FBXL11-dependent reversible lysine methylation of p65

Lu, T., Jackson, M. W., Wang, B., Yang, M., Chance, M. R., Miyagi, M., Gudkov, A. V., & Stark, G. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912493107 · Cited by 281 · see citing works

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

Eskandarian, H. A., Impens, F., Nahori, M., Soubigou, G., Coppée, J., Cossart, P., & Hamon, M. A. (2013) · Science · doi:10.1126/science.1238858 · Cited by 268 · see citing works

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity

Chiang, J. J., Sparrer, K. M. J., van Gent, M., Lässig, C., Huang, T., Osterrieder, N., Hopfner, K., & Gack, M. U. (2017) · Nature Immunology · doi:10.1038/s41590-017-0005-y · Cited by 260 · see citing works

Advances in the profiling of DNA modifications: cytosine methylation and beyond

Plongthongkum, N., Diep, D. H., & Zhang, K. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3772 · Cited by 259 · see citing works

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

Bougdour, A., Durandau, E., Brenier‐Pinchart, M., Ortet, P., Barakat, M., Kieffer‐Jaquinod, S., Curt, A., Bertini, R., Bastien, O., Couté, Y., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.03.002 · Cited by 258 · see citing works

The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages

Czimmerer, Z., Dániel, B., Horváth, A., Rückerl, D., Nagy, G., Kiss, M., Peloquin, M., Budai, M. M., Cuaranta‐Monroy, I., Simándi, Z., et al. (2018) · Immunity · doi:10.1016/j.immuni.2017.12.010 · Cited by 253 · see citing works

Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20

Stender, J. D., Pascual, G., Liu, W., Kaikkonen, M. U., Do, K. J., Spann, N. J., Boutros, M., Perrimon, N., Rosenfeld, M. G., & Glass, C. K. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.020 · Cited by 248 · see citing works

Activation of DNA Methyltransferase 1 by EBV LMP1 Involves c-Jun NH2-Terminal Kinase Signaling

Tsai, C.-L., Li, H.-P., Lu, Y.-J., Hsueh, C., Liang, Y. J., Chen, C., Tsao, S. W., Tse, K., Yu, J., & Chang, Y. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2194 · Cited by 246 · see citing works

Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation

Shen, Q., Zhang, Q., Shi, Y., Shi, Q., Jiang, Y., Gu, Y. H., Li, Z., Li, X., Zhao, K., Wang, C., et al. (2018) · Nature · doi:10.1038/nature25434 · Cited by 246 · see citing works

PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB

Han, W., Wang, B., Miyagi, M., She, Y., Gopalan, B., Huang, D.-B., Ghosh, G., Stark, G. R., & Lu, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311784110 · Cited by 237 · see citing works

Epigenetic Reprogramming by Adenovirus e1a

Ferrari, R., Pellegrini, M. A., Horwitz, G. A., Xie, W., Berk, A. J., & Kurdistani, S. K. (2008) · Science · doi:10.1126/science.1155546 · Cited by 230 · see citing works

Epigenetic reprogramming of host genes in viral and microbial pathogenesis

Paschos, K., & Allday, M. J. (2010) · Trends in Microbiology · doi:10.1016/j.tim.2010.07.003 · Cited by 229 · see citing works

Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

Xia, P., Ye, B., Wang, S., Zhu, X., Du, Y., Xiong, Z., Tian, Y., & Fan, Z. (2016) · Nature Immunology · doi:10.1038/ni.3356 · Cited by 220 · see citing works

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

Hardbower, D. M., Asim, M., Luis, P. B., Singh, K., Barry, D. P., Yang, C., Steeves, M. A., Cleveland, J. L., Schneider, C. G., Piazuelo, M. B., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614958114 · Cited by 219 · see citing works

Acetylation-Dependent Signal Transduction for Type I Interferon Receptor

Tang, X., Gao, J., Guan, Y. A., McLane, K. E., Yuan, Z., Ramratnam, B., & Chin, Y. E. (2007) · Cell · doi:10.1016/j.cell.2007.07.034 · Cited by 211 · see citing works

Chromatin Contributions to the Regulation of Innate Immunity

Smale, S. T., Tarakhovsky, A., & Natoli, G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101303 · Cited by 209 · see citing works

Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

Li, X., Zhang, Q., Ding, Y., Liu, Y., Zhao, D., Zhao, K., Shen, Q., Liu, X., Zhu, X., Li, N., et al. (2016) · Nature Immunology · doi:10.1038/ni.3464 · Cited by 202 · see citing works

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Pålsson‐McDermott, E. M., Curtis, A. M., Goel, G., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.017 · Cited by 201 · see citing works

Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A

Zheng, D., Zhang, L., Cheng, N., Xu, X., Deng, Q., Teng, X.-M., Wang, K.-S., Zhang, X., Huang, J., & Han, Z. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.10.019 · Cited by 199 · see citing works

Inflammation-sensitive super enhancers form domains of coordinately regulated enhancer RNAs

Hah, N., Benner, C. W., Chong, L.-W., Yu, R. T., Downes, M., & Evans, R. M. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1424028112 · Cited by 189 · see citing works

Roadmap for regulation

Romanoski, C. E., Glass, C. K., Stunnenberg, H. G., Wilson, L., & Almouzni, G. (2015) · Nature · doi:10.1038/518314a · Cited by 182 · see citing works

Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3

Yaseen, I., Kaur, P., Nandicoori, V. K., & Khosla, S. (2015) · Nature Communications · doi:10.1038/ncomms9922 · Cited by 182 · see citing works

IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300

Hoberg, J. E., Popko, A. E., Ramsey, C. S., & Mayo, M. W. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.2.457-471.2006 · Cited by 181 · see citing works

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation

Rialdi, A., Campisi, L., Zhao, N., Lagda, A. C., Pietzsch, C. A., Ho, J., Martínez‐Gil, L., Fenouil, R., Chen, X., Edwards, M. R., et al. (2016) · Science · doi:10.1126/science.aad7993 · Cited by 174 · see citing works

Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells

Youngblood, B., Noto, A., Porichis, F., Akondy, R. S., Ndhlovu, Z. M., Austin, J. W., Bordi, R., Procopio, F. A., Miura, T., Allen, T. M., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203161 · Cited by 169 · see citing works

Epigenetics in rheumatoid arthritis

Klein, K., & Gay, S. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000128 · Cited by 167 · see citing works

Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20

Meng, X., Liu, J., Wu, X., Liu, S., Li, G., Han, C., Song, L., Li, Z., Wang, Q., Wang, J., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.016 · Cited by 165 · see citing works

Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response

Fang, T., Schaefer, U., Mecklenbräuker, I., Stienen, A., Dewell, S. B., Chen, M. S., Rioja, I., Parravicini, V., Prinjha, R. K., Chandwani, R., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112343 · Cited by 162 · see citing works

An Adenine Code for DNA: A Second Life for N6-Methyladenine

Heyn, H., & Esteller, M. (2015) · Cell · doi:10.1016/j.cell.2015.04.021 · Cited by 162 · see citing works

Long noncoding RNAs in innate immunity

Zhang, Y., & Cao, X. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.68 · Cited by 161 · see citing works

Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy

Escoll, P., Mondino, S., Rolando, M., & Buchrieser, C. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.1 · Cited by 160 · see citing works

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

Decque, A., Joffre, O. P., Magalhaes, J. G., Cossec, J., Blecher‐Gonen, R., Lapaquette, P., Silvin, A., Manel, N., Joubert, P.-E., Seeler, J.-S., et al. (2015) · Nature Immunology · doi:10.1038/ni.3342 · Cited by 157 · see citing works

IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling

Chen, J., & Ivashkiv, L. B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007816107 · Cited by 154 · see citing works

Insights into newly discovered marks and readers of epigenetic information

Andrews, F. H., Strahl, B. D., & Kutateladze, T. G. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2149 · Cited by 153 · see citing works

O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

Li, T., Li, X., Attri, K. S., Liu, C., Li, L., Herring, L. E., Asara, J. M., Lei, Y. L., Singh, P. K., Gao, C., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.11.001 · Cited by 146 · see citing works

The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection

Schliehe, C., Flynn, E. K., Vilagos, B., Richson, U., Swaminathan, S., Bošnjak, B., Bauer, L., Kandasamy, R. K., Griesshammer, I. M., Kosack, L., et al. (2014) · Nature Immunology · doi:10.1038/ni.3046 · Cited by 144 · see citing works

Noncanonical NF-κB Pathway Controls the Production of Type I Interferons in Antiviral Innate Immunity

Jin, J., Hu, H., Li, H. S., Yu, J., Xiao, Y., Brittain, G. C., Zou, Q., Cheng, X., Mallette, F. A., Watowich, S. S., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.006 · Cited by 139 · see citing works

Single-molecule decoding of combinatorially modified nucleosomes

Shema, E., Jones, D. R., Noam Shoresh, F., Donohue, L., Ram, O., & Bernstein, B. (2016) · Science · doi:10.1126/science.aad7701 · Cited by 138 · see citing works

RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer

Tarcic, O., Pateras, I. S., Cooks, T., Shema, E., Kanterman, J., Ashkenazi, H., Boocholez, H., Hubert, A., Rotkopf, R., Baniyash, M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.020 · Cited by 135 · see citing works

Bioenergetic state regulates innate inflammatory responses through the transcriptional co-repressor CtBP

Shen, Y., Kapfhamer, D., Minnella, A. M., Kim, J.-E., Won, S. J., Chen, Y., Huang, Y., Low, L. H., Massa, S. M., & Swanson, R. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00707-0 · Cited by 133 · see citing works

Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages

Marr, A. K., MacIsaac, J. L., Jiang, R., Airo, A. M., Kobor, M. S., & McMaster, W. R. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004419 · Cited by 126 · see citing works

Adenovirus Evasion of Interferon-Mediated Innate Immunity by Direct Antagonism of a Cellular Histone Posttranslational Modification

Fonseca, G. J., Thillainadesan, G., Yousef, A. F., Ablack, J., Mossman, K. L., Torchia, J., & Mymryk, J. S. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.05.005 · Cited by 124 · see citing works

Regulation of Viral and Cellular Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus Polyadenylated Nuclear RNA

Rossetto, C. C., Tarrant-Elorza, M., Verma, S. C., Purushothaman, P., & Pari, G. S. (2013) · Journal of Virology · doi:10.1128/jvi.03111-12 · Cited by 122 · see citing works

Cell-Type-Specific Control of Enhancer Activity by H3K9 Trimethylation

Zhu, Y., van Essen, D., & Saccani, S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.011 · Cited by 117 · see citing works

Epigenetics in autoimmune diseases: Pathogenesis and prospects for therapy.

Zhang, Z., & Zhang, R. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.05.008 · Cited by 116 · see citing works

Adenovirus Small E1A Employs the Lysine Acetylases p300/CBP and Tumor Suppressor Rb to Repress Select Host Genes and Promote Productive Virus Infection

Ferrari, R., Gou, D., Jawdekar, G. W., Johnson, S., Nava, M., Su, T., Yousef, A. F., Zemke, N. R., Pellegrini, M. A., Kurdistani, S. K., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.10.004 · Cited by 113 · see citing works

Direct Involvement of CREB-binding Protein/p300 in Sequence-specific DNA Binding of Virus-activated Interferon Regulatory Factor-3 Holocomplex

Suhara, W., Yoneyama, M., Kitabayashi, I., & Fujita, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200192200 · Cited by 108 · see citing works

Kaposi's Sarcoma-Associated Herpesvirus Noncoding Polyadenylated Nuclear RNA Interacts with Virus- and Host Cell-Encoded Proteins and Suppresses Expression of Genes Involved in Immune Modulation

Rossetto, C. C., & Pari, G. S. (2011) · Journal of Virology · doi:10.1128/jvi.05886-11 · Cited by 108 · see citing works

The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation

Wang, J., Ge, P., Qiang, L., Tian, F., Zhao, D., Chai, Q., Zhu, M., Zhou, R., Meng, G., Iwakura, Y., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00279-z · Cited by 108 · see citing works

Class-specific Regulation of Pro-inflammatory Genes by MyD88 Pathways and IκBζ

Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T., & Takeda, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709965200 · Cited by 104 · see citing works

A Feed-Forward Circuit Controlling Inducible NF-κB Target Gene Activation by Promoter Histone Demethylation

van Essen, D., Zhu, Y., & Saccani, S. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.010 · Cited by 103 · see citing works

Akirin2 is critical for inducing inflammatory genes by bridging IκB‐ζ and the SWI/SNF complex

Tartey, S., Matsushita, K., Vandenbon, A., Ori, D., Imamura, T., Mino, T., Standley, D. M., Hoffmann, J. A., Reichhart, J., Akira, S., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201488447 · Cited by 102 · see citing works

NF-κB: Regulation by Methylation

Lu, T., & Stark, G. R. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1022 · Cited by 100 · see citing works

PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

Kim, D., Nam, H. J., Lee, W., Yim, H. Y., Ahn, J.-Y., Park, S. W., Shin, H. R., Yu, R., Won, K., Bae, J., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.002 · Cited by 99 · see citing works

Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response

Reintjes, A., Fuchs, J. E., Kremser, L., Lindner, H. H., Liedl, K. R., Huber, L. A., & Valovka, T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522372113 · Cited by 91 · see citing works

Demethylase Kdm6a epigenetically promotes IL-6 and IFN-β production in macrophages

Li, X., Zhang, Q., Shi, Q., Liu, Y., Zhao, K., Shen, Q., Shi, Y., Liu, X., Wang, C., Li, N., et al. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.02.007 · Cited by 90 · see citing works

The Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis

Austenaa, L. M. I., Barozzi, I., D’Antonio‐Chronowska, A., Termanini, A., Ostuni, R., Prosperini, E., Stewart, A. F., Testa, G., & Natoli, G. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.016 · Cited by 86 · see citing works

RNA modifications go viral

Gokhale, N. S., & Horner, S. M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006188 · Cited by 85 · see citing works

RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo

Ptaschinski, C., Mukherjee, S., Moore, M. L., Albert, M., Helin, K., Kunkel, S. L., & Lukacs, N. W. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004978 · Cited by 84 · see citing works

The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF

Sadler, A. J., Suliman, B. A., Yu, L., Yuan, X., Wang, D., Irving, A. T., Sarvestani, S. T., Banerjee, A., Mansell, A. S., Liu, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms7795 · Cited by 82 · see citing works

MRTF-A mediates LPS-induced pro-inflammatory transcription by interacting with the COMPASS complex

Yu, L., Weng, X., Liang, P., Dai, X., Wu, X.-Y., Xu, H., Fang, M., Fang, F., & Xu, Y. (2014) · Journal of Cell Science · doi:10.1242/jcs.152314 · Cited by 81 · see citing works

Nuclear factor-κB binding motifs specify Toll-like receptor-induced gene repression through an inducible repressosome

Yan, Q., Carmody, R. J., Qu, Z., Ruan, Q., Jager, J., Mullican, S. E., Lazar, M. A., & Chen, Y. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119842109 · Cited by 78 · see citing works

Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA

Lu, F. Y., Tsai, K., Chen, H.-S., et al. (2012) · Journal of Virology · doi:10.1128/jvi.07216-11 · Cited by 78 · see citing works

H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1

Zhao, D., Zhang, Q., Liu, Y., Li, X., Zhao, K., Ding, Y., Li, Z., Shen, Q., Wang, C., Li, N., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.035 · Cited by 78 · see citing works

TET2 functions as a resistance factor against DNA methylation acquisition during Epstein-Barr virus infection

Namba-Fukuyo, H., Funata, S., Matsusaka, K., Fukuyo, M., Rahmutulla, B., Mano, Y., Fukayama, M., Aburatani, H., & Kaneda, A. (2016) · Oncotarget · doi:10.18632/oncotarget.13130 · Cited by 74 · see citing works

HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene

Pion, M., Jaramillo-Ruiz, D., Martínez, A., Muñoz‐Fernández, M. Á., & Correa‐Rocha, R. (2013) · AIDS · doi:10.1097/qad.0b013e32836253fd · Cited by 71 · see citing works

MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response

Yu, L., Fang, F., Dai, X. J., Xu, H., Qi, X., Fang, M., & Xu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-00301-w · Cited by 71 · see citing works

Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis

Periyasamy, P., Thangaraj, A., Guo, M., Hu, G., Callen, S. E., & Buch, S. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3474-17.2018 · Cited by 65 · see citing works

Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition

Yang, J., Tian, B., Sun, H., Garofalo, R., & Brasier, A. R. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.86 · Cited by 63 · see citing works

Epigenetics: A New Model for Intracellular Parasite–Host Cell Regulation

McMaster, W. R., Morrison, C., & Kobor, M. S. (2016) · Trends in Parasitology · doi:10.1016/j.pt.2016.04.002 · Cited by 61 · see citing works

The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3

Wang, C., Wang, Q., Xu, X., Xie, B., Zhao, Y. B., Li, N., & Cao, X. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170856 · Cited by 61 · see citing works

Histone Lysine Methyltransferase Ezh1 Promotes TLR-Triggered Inflammatory Cytokine Production by Suppressing Tollip

Liu, Y., Zhang, Q., Ding, Y., Li, X., Zhao, D., Zhao, K., Guo, Z., & Cao, X. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402087 · Cited by 56 · see citing works

TET3 Inhibits Type I IFN Production Independent of DNA Demethylation

Xue, S., Liu, C., Sun, X., Li, W., Zhang, C., Zhou, X., Lu, Y., Xiao, J., Li, C., Xu, X., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.068 · Cited by 55 · see citing works

Epigenetic editing: How cutting-edge targeted epigenetic modification might provide novel avenues for autoimmune disease therapy

Jeffries, M. A. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.02.001 · Cited by 49 · see citing works

Histone Methyltransferase SET8 Epigenetically Reprograms Host Immune Responses to Assist Mycobacterial Survival

Singh, V., Prakhar, P., Rajmani, R. S., Mahadik, K., Borbora, S. M., & Balaji, K. N. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix322 · Cited by 47 · see citing works

Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling

Lai, D., Wan, M., Wu, J., Preston‐Hurlburt, P., Kushwaha, R., Grundström, T., Imbalzano, A. N., & Chi, T. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811274106 · Cited by 46 · see citing works

Rb selectively inhibits innate IFN-β production by enhancing deacetylation of IFN-β promoter through HDAC1 and HDAC8

Meng, J., Liu, X., Zhang, P., Li, D., Xu, S., Zhou, Q., Guo, M., Huai, W., Chen, X., Wang, Q., et al. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.05.012 · Cited by 40 · see citing works

Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells

Álvarez, Y., Rodríguez, M. R., Municio, C., Hugo, E., Alonso, S., Ibarrola, N., Fernández, N., & Crespo, M. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.391839 · Cited by 36 · see citing works

CARM1 but not Its Enzymatic Activity Is Required for Transcriptional Coactivation of NF-κB-Dependent Gene Expression

Jayne, S., Rothgiesser, K., & Hottiger, M. O. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.09.032 · Cited by 35 · see citing works

Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response

Xu, J. M., Xu, X., Wang, B., Ma, Y., Zhang, L., Xu, H., Hu, Y., Wu, J., & Cao, X. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700917114 · Cited by 35 · see citing works

The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages

Carson, W. F., Cavassani, K. A., Soares, E. M., Hirai, S., Kittan, N. A., Schaller, M. A., Scola, M. M., Joshi, A., Matsukawa, A., Aronoff, D. M., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601272 · Cited by 33 · see citing works

Death Domain-associated Protein 6 (Daxx) Selectively Represses IL-6 Transcription through Histone Deacetylase 1 (HDAC1)-mediated Histone Deacetylation in Macrophages

Yao, Z., Zhang, Q., Li, X., Zhao, D., Liu, Y., Zhao, K., Liu, Y., Wang, C., Jiang, M., Li, N., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.533992 · Cited by 31 · see citing works

Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ.

Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., Mizutani, T., Kuwata, H., Iba, H., Matsumoto, M., Honda, K., Smale, S. T., & Takeda, K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.a114.709965 · Cited by 30 · see citing works

Epigenetic modulation of metabolic decisions

Öst, A., & Pospisilik, J. A. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.12.005 · Cited by 28 · see citing works

Systems Approaches towards Molecular Profiling of Human Immunity

Burel, J. G., Apte, S. H., & Doolan, D. L. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.11.006 · Cited by 25 · see citing works

MKL 1 is an epigenetic mediator of TNF ‐α‐induced proinflammatory transcription in macrophages by interacting with ASH 2

Song, M., Fang, F., Dai, X. J., Yu, L., Fang, M., & Xu, Y. (2017) · FEBS Letters · doi:10.1002/1873-3468.12601 · Cited by 19 · see citing works

Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IκBζ.

Kayama, H., Ramirez-Carrozzi, V. R., Yamamoto, M., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.a115.709965 · Cited by 9 · see citing works

Exogenous thymine DNA glycosylase regulates epigenetic modifications and meiotic cell cycle progression of mouse oocytes

Ma, J., Zhao, K., Ouyang, Y., Wang, Z., Luo, Y., Hou, Y., Schatten, H., Shen, W., & Sun, Q. (2014) · Molecular Human Reproduction · doi:10.1093/molehr/gau094 · Cited by 6 · see citing works

Targeting chromatin kinases reveals their role in inducible transcription of inflammatory genes

Josefowicz, S. Z., Shimada, M., Armache, A., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.202.13 · Cited by 1 · see citing works

The BET family in immunity and disease

Wang, N., Wu, R., Tang, D., & Kang, R. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00384-4 · Cited by 295 · see citing works

A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?

Bektas, A., Schurman, S. H., Franceschi, C., & Ferrucci, L. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00196-8 · Cited by 102 · see citing works

The role of exercise-induced myokines in promoting angiogenesis

Qi, C., Song, X., Wang, H., Yan, Y., & Liu, B. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.981577 · Cited by 63 · see citing works

Race and ethnicity: Risk factors for fungal infections?

Jenks, J. D., Aneke, C. I., Al-Obaidi, M. M., Egger, M., Garcia, L., Gaines, T., Hoenigl, M., & Thompson, G. R. (2023) · PLOS Pathogens · doi:10.1371/journal.ppat.1011025 · Cited by 55 · see citing works

Analog epigenetic memory revealed by targeted chromatin editing

Palacios, S., Bruno, S., Weiss, R., Salibi, E., Kane, A., Ilia, K., & Del Vecchio, D. (2024) · doi:10.1101/2024.02.13.580200 · Cited by 13 · see citing works

Epigenetic Modifiers as Game Changers for Healthy Aging

Sharma, S., & Bhonde, R. R. (2023) · Rejuvenation Research · doi:10.1089/rej.2022.0059 · Cited by 10 · see citing works

Mouse Models of Epigenetic Inheritance

Bernal, A. J., Murphy, S. K., & Jirtle, R. L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375709-8.00015-0 · Cited by 32 · see citing works

Salt-Dependent Structural Changes of Chromatin in Isolated Chicken Liver Nuclei as Visualized by Scanning Electron Microscopy

Soichiro, A. R. A. I., Hayashi, M., & Nakanishi, Y. H. (1995) · Journal of Electron Microscopy · doi:10.1093/oxfordjournals.jmicro.a051169 · Cited by 2 · see citing works

Signaling crosstalk between ethylene and other molecules

Konishi, M., & Yanagisawa, S. (2005) · Plant Biotechnology · doi:10.5511/plantbiotechnology.22.401 · Cited by 3 · see citing works

Epigenetic Responses to Diet in Aging

Ford, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00016-9 · Cited by 3 · see citing works