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Post-transcriptional regulons coordinate the initiation and resolution of inflammation

Anderson, Paul·2010·Nature Reviews Immunology
DOI 10.1038/nri2685
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Abstract

Transcriptional control mechanisms chart the course of the inflammatory response by synthesizing mRNAs encoding proteins that promote or inhibit inflammation. Because these mRNAs can be long-lived, turning off their synthesis does not rapidly stop or change the direction of inflammation. Post-transcriptional mechanisms that modify mRNA stability and/or translation provide more rapid and flexible control of this process and are particularly important in coordinating the initiation and resolution of inflammation. Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process.

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Metadata

Authors
Anderson, P.
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2010-01
Volume
10
Issue
1
Pages
24-35
ISSN
  • 1474-1733
  • 1474-1741
DOI
10.1038/nri2685
Cited by
257
References
7
Language
en
Licence
www.springer.com/tdm (tdm)

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