The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Calcium signaling in immune cells
Open accessAbstract
Calcium acts as a second messenger in many cell types, including lymphocytes. Resting lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen receptors induces calcium influx from the extracellular space by several routes. A chief mechanism of Ca2+ entry in lymphocytes is through store-operated calcium (SOC) channels. The identification of two important molecular components of SOC channels, CRACM1 (the pore-forming subunit) and STIM1 (the sensor of stored calcium), has allowed genetic and molecular manipulation of the SOC entry pathway. In this review, we highlight advances in the understanding of Ca2+ signaling in lymphocytes with special emphasis on SOC entry. We also discuss outstanding questions and probable future directions of the field.
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Cites
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S.-H., Tanasa, B., Hogan, P. G., Lewis, R. S., Daly, M., & Rao, A. (2006) · Nature · doi:10.1038/nature04702 · Cited by 2,288
STIM Is a Ca2+ Sensor Essential for Ca2+-Store-Depletion-Triggered Ca2+ Influx
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Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/386855a0 · Cited by 1,752
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/40912 · Cited by 1,521
Zhang, S. L., Yu, Y., Roos, J., Kozak, J. A., Deerinck, T. J., Ellisman, M. H., Stauderman, K. A., & Cahalan, M. D. (2005) · Nature · doi:10.1038/nature04147 · Cited by 1,389
Orai1 is an essential pore subunit of the CRAC channel
Prakriya, M., Feske, S., Gwack, Y., Srikanth, S., Rao, A., & Hogan, P. G. (2006) · Nature · doi:10.1038/nature05122 · Cited by 1,343
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CRACM1 Is a Plasma Membrane Protein Essential for Store-Operated Ca 2+ Entry
Vig, M., Peinelt, C., Beck, A., Koomoa, D. L., Rabah, D., Koblan-Huberson, M., Kraft, S., Turner, H., Fleig, A., Penner, R., et al. (2006) · Science · doi:10.1126/science.1127883 · Cited by 1,321
Self-citationMalek, T. R. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090357 · Cited by 1,079
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Ion Channels in Innate and Adaptive Immunity
Feske, S., Wulff, H., & Skolnik, E. Y. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112212 · Cited by 768
Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI
Hogan, P. G., Lewis, R. S., & Rao, A. (2010) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132550 · Cited by 760
Trebak, M., & Kinet, J.-P. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-018-0110-7 · Cited by 508
Self-citationCytokine dysregulation in autism spectrum disorders (ASD): Possible role of the environment
Goines, P. E., & Ashwood, P. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.07.006 · Cited by 314
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Metadata
- Authors
- Vig, M., & Kinet, J.-P.
- Venue
- Nature Immunology
- Published
- 2008-12-17
- Volume
- 10
- Issue
- 1
- Pages
- 21-27
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- OpenAlex
- W2061519511
- Cited by
- 493
- References
- 92
- FWCI
- 12.78
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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