Contributions of humoral and cellular immunity to vaccine-induced protection in humans

Amanna, Ian J.; Slifka, Mark K.

doi:10.1016/j.virol.2010.12.016

Cited by 263Immune responses and vaccinationsT-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Contributions of humoral and cellular immunity to vaccine-induced protection in humans

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Amanna, Ian J., Slifka, Mark K.·2011·Virology

DOI 10.1016/j.virol.2010.12.016PMC PMC3238379

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Abstract

Vaccines play a vital role in protecting the host against infectious disease. The most effective licensed vaccines elicit long-term antigen-specific antibody responses by plasma cells in addition to the development of persisting T cell and B cell memory. The relative contributions of these different immune cell subsets are context-dependent and vary depending on the attributes of the vaccine (i.e., live/attenuated, inactivated, and subunit) as well as the biology of the pathogen in question. For relatively simple vaccines against bacterial antigens (e.g., tetanus toxin) or invariant viruses, the immunological correlates of protection are well-characterized. For more complex vaccines against viruses, especially those that mutate or cause latent infections, it is more difficult to define the specific correlates of immunity. This often requires observational/natural history studies, clinical trials, or experimental evaluation in relevant animal models in order for immunological correlates to be determined or extrapolated. In this review, we will discuss the relative contributions of virus-specific T cell and B cell responses to vaccine-mediated protection against disease.

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Protection afforded by currently licensed vaccines is primarily based on induction of a humoral immune response.
“Protection afforded by currently licensed vaccines is primarily based on induction of a humoral immune response (Amanna & Slifka, 2011).”
From mRNA mediates passive vaccination against infectious agents, toxins, and tumors (2017) · cites this paper as Amanna & Slifka, 2011
The section “Persisting antibody following vaccination; the first line of defense against infection” says antibody responses are the probable basis of efficacy for many of today’s most successful vaccines. But the Abstract and Conclusions say the relative contribution of humoral immunity depends on the vaccine and pathogen, and that protection often also involves cellular immunity. The claim extends the antibody-based account to currently licensed vaccines generally. (LLM, conf=0.85)
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Fine PEM Mulholland K Plotkin SA Orenstein WA Offit PA 2008 Community Immunity 5 Vaccines 17 36 Saunders/Elsevier Philadelphia, PA
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Gomez PL Robinson JM Rogalewicz J Plotkin SA Orenstein WA Offit PA 2008 Vaccine manufacturing 5 Vaccines 45 58 Saunders/Elsevier Philadelphia, PA
Siegrist C-A Plotkin SA Orenstein WA Offit PA 2008 Vaccine Immunology 5 Vaccines 1725 Saunders/Elsevier
Strebel PM Papania MJ Dayan GH Halsey NA Plotkin SA Orenstein WA Offit PA 2008 Measles vaccines Vaccines 353 398 Saunders/Elsevier Philadelphia, PA
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“Protection afforded by currently licensed vaccines is primarily based on induction of a humoral immune response (Amanna & Slifka, 2011).”
Background
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Authors: Amanna, I. J., & Slifka, M. K.
Affiliations: Najít Technologies (United States) (US)
Oregon Health & Science University (US)
ORCID: Amanna, Ian J.
Slifka, Mark K.
Venue: Virology
Publisher: Elsevier BV
Published: 2011-03
Volume: 411
Issue: 2
Pages: 206-215
ISSN: 0042-6822 (ISSN-L)
DOI: 10.1016/j.virol.2010.12.016
PMC: PMC3238379
OpenAlex: W2043944957
Cited by: 263
References: 169
Citations by year: 2026: 16 · 2025: 18 · 2024: 19 · 2023: 25 · 2022: 29 · 2021: 23 · 2020: 14 · 2019: 15 · 2018: 19 · 2017: 14 · 2016: 14 · 2015: 8 · 2014: 11 · 2013: 20 · 2012: 11
FWCI: 1.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 869 d)
Locations: Virology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases, National Institutes of Health (R43 AI079898, UO1 AI082196, U54 AI081680)
ONPRC (RR00163)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: vaccine-induced immunity, humoral immunity, cell-mediated immunity, T cell response, B cell response, immunological correlates of protection, vaccine types, virus-specific immunity, memory B cells, plasma cells
MeSH terms: B-Lymphocytes, Humans, Immunity, Cellular, T-Lymphocytes, Viral Vaccines, Immunity, Humoral

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Contributions of humoral and cellular immunity to vaccine-induced protection in humans

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