CoChat
Sign Up
Cited by 198

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Regulation of T cell development by the deubiquitinating enzyme CYLD

Reiley, William W, Zhang, Minying, Jin, Wei, Losiewicz, Mandy, Donohue, Keri B, Norbury, Christopher C, Sun, Shao-Cong·2006·Nature Immunology
DOI 10.1038/ni1315
Open this paper in CoChat — free account

Abstract

T cell receptor signaling is essential for the generation and maturation of T lymphocyte precursors. Here we identify the deubiquitinating enzyme CYLD as a positive regulator of proximal T cell receptor signaling in thymocytes. CYLD physically interacted with active Lck and promoted recruitment of active Lck to its substrate, Zap70. CYLD also removed both Lys 48- and Lys 63-linked polyubiquitin chains from Lck. Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells.

Overview

Integrity signals

Registry

Crossref · 10.1038/ni1315

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 48

  1. Germain, R.N. T-cell development and the CD4–CD8 lineage decision. Nat. Rev. Immunol. 2, 309–322 (2002). · DOI
  2. Starr, T.K., Jameson, S.C. & Hogquist, K.A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21, 139–176 (2003). · DOI · Paper page
  3. Zamoyska, R. & Lovatt, M. Signalling in T-lymphocyte development: integration of signalling pathways is the key. Curr. Opin. Immunol. 16, 191–196 (2004). · DOI
  4. Palacios, E.H. & Weiss, A. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene 23, 7990–8000 (2004). · DOI
  5. Gallegos, A.M. & Bevan, M.J. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J. Exp. Med. 200, 1039–1049 (2004). · DOI
  6. Kane, L.P., Lin, J. & Weiss, A. Signal transduction by the TCR for antigen. Curr. Opin. Immunol. 12, 242–249 (2000). · DOI · Paper page
  7. Duplay, P., Thome, M., Herve, F. & Acuto, O. p56lck interacts via its src homology 2 domain with the Zap70 kinase. J. Exp. Med. 179, 1163–1172 (1994). · DOI
  8. Thome, M., Duplay, P., Guttinger, M. & Acuto, O. Syk and Zap70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/ζ complex. J. Exp. Med. 181, 1997–2006 (1995). · DOI
  9. Straus, D.B., Chan, A.C., Patai, B. & Weiss, A. SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction. J. Biol. Chem. 271, 9976–9981 (1996). · DOI
  10. Pelosi, M. et al. Tyrosine 319 in the interdomain B of Zap70 is a binding site for the Src homology 2 domain of Lck. J. Biol. Chem. 274, 14229–14237 (1999). · DOI
  11. Trobridge, P.A., Forbush, K.A. & Levin, S.D. Positive and negative selection of thymocytes depends on Lck interaction with the CD4 and CD8 coreceptors. J. Immunol. 166, 809–818 (2001). · DOI
  12. Bignell, G.R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat. Genet. 25, 160–165 (2000). · DOI
  13. Brooke, H.G. Epithelioma adenoides cysticum. Br. J. Dermatol. 4, 269–287 (1892).
  14. Spiegler, E. Ueber endotheliome der haut. Arch. Derm. Syph. 50, 163–176 (1899). · DOI
  15. Biggs, P.J. et al. Familial cylindromatosis (turban tumour syndrome) gene localised to chromosome 16q12-q13: evidence for its role as a tumour suppressor gene. Nat. Genet. 11, 441–443 (1995). · DOI
  16. Biggs, P.J., Chapman, P., Lakhani, S.R., Burn, J. & Stratton, M.R. The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas. Oncogene 12, 1375–1377 (1996).
  17. Brummelkamp, T.R., Nijman, S.M., Dirac, A.M. & Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature 424, 797–801 (2003). · DOI
  18. Kovalenko, A. et al. The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination. Nature 424, 801–805 (2003). · DOI
  19. Trompouki, E. et al. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature 424, 793–796 (2003). · DOI
  20. Kim, J.H., Park, K.C., Chung, S.S., Bang, O. & Chung, CH. Deubiquitinating enzymes as cellular regulators. J. Biochem. 134, 9–18 (2003). · DOI
  21. Amerik, A.Y. & Hochstrasser, M. Mechanism and function of deubiquitinating enzymes. Biochim. Biophys. Acta 1695, 189–207 (2004). · DOI
  22. Regamey, A. et al. The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor κB activation by tumor necrosis factor. J. Exp. Med. 198, 1959–1964 (2003). · DOI
  23. Reiley, W., Zhang, M. & Sun, S.-C. Tumor suppressor negatively regulates Jnk signaling pathway downstream of TNFR members. J. Biol. Chem. 279, 55161–55167 (2004). · DOI
  24. Yoshida, H., Jono, H., Kai, H. & Li, J.D. The tumor suppressor CYLD acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 and TRAF7. J. Biol. Chem. 280, 41111–41121 (2005). · DOI
  25. Tarakhovsky, A., Muller, W. & Rajewsky, K. Lymphocyte populations and immune responses in CD5-deficient mice. Eur. J. Immunol. 24, 1678–1684 (1994). · DOI
  26. Azzam, H.S. et al. Fine tuning of TCR signaling by CD5. J. Immunol. 166, 5464–5472 (2001). · DOI
  27. Fischer, A.M., Katayama, C.D., Pages, G., Pouyssegur, J. & Hedrick, S.M. The role of Erk1 and Erk2 in multiple stages of T cell development. Immunity 23, 431–443 (2005). · DOI
  28. Liu, X. & Bosselut, R. Duration of TCR signaling controls CD4–CD8 lineage differentiation in vivo. Nat. Immunol. 5, 280–288 (2004). · DOI
  29. Giannini, A. & Bijlmakers, M.J. Regulation of the Src family kinase Lck by Hsp90 and ubiquitination. Mol. Cell. Biol. 24, 5667–5676 (2004). · DOI
  30. Rao, N. et al. Negative regulation of Lck by Cbl ubiquitin ligase. Proc. Natl. Acad. Sci. USA 99, 3794–3799 (2002). · DOI
  31. Galan, J.M. & Haguenauer-Tsapis, R. Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J. 16, 5847–5854 (1997). · DOI
  32. Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346–351 (2001). · DOI · Paper page
  33. Fischer, J.A. Deubiquitinating enzymes: their roles in development, differentiation, and disease. Int. Rev. Cytol. 229, 43–72 (2003). · DOI
  34. D'Andrea, A. & Pellman, D. Deubiquitinating enzymes: a new class of biological regulators. Crit. Rev. Biochem. Mol. Biol. 33, 337–352 (1998). · DOI
  35. Chung, C.H. & Back, S.H. Deubiquitinating enzymes: their diversity and emerging roles. Biochem. Biophys. Res. Commun. 266, 633–640 (1999). · DOI
  36. Liu, Y.C. Ubiquitin ligases and the immune response. Annu. Rev. Immunol. 22, 81–127 (2004). · DOI
  37. Murphy, M.A. et al. Tissue hyperplasia and enhanced T-cell signalling via Zap70 in c-Cbl-deficient mice. Mol. Cell. Biol. 18, 4872–4882 (1998). · DOI
  38. Naramura, M., Kole, H.K., Hu, R.J. & Gu, H. Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc. Natl. Acad. Sci. USA 95, 15547–15552 (1998). · DOI
  39. Heissmeyer, V. et al. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5, 255–265 (2004). · DOI
  40. Fang, D. & Liu, Y.C. Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells. Nat. Immunol. 2, 870–875 (2001). · DOI
  41. Hawash, I.Y., Kesavan, K.P., Magee, A.I., Geahlen, R.L. & Harrison, M.L. The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl. J. Biol. Chem. 277, 5683–5691 (2002). · DOI
  42. Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W. & Roder, J.C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424–8428 (1993). · DOI
  43. Ettenberg, S.A. et al. cbl-b inhibits epidermal growth factor receptor signaling. Oncogene 18, 1855–1866 (1999). · DOI
  44. Xiao, G. et al. Retroviral oncoprotein Tax induces processing of NF-κB2/p100 in T cells: evidence for the involvement of IKKα. EMBO J. 20, 6805–6815 (2001). · DOI
  45. Waterfield, M., Zhang, M., Norman, L.P. & Sun, S.C. NF-κB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase. Mol. Cell 11, 685–694 (2003). · DOI
  46. Racoosin, E.L. & Swanson, J.A. Macrophage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages. J. Exp. Med. 170, 1635–1648 (1989). · DOI
  47. Uhlik, M. et al. NF-κB-inducing kinase and IκB kinase participate in human T-cell leukemia virus I Tax-mediated NF-κB activation. J. Biol. Chem. 273, 21132–21136 (1998). · DOI
  48. Sun, S.-C., Ganchi, P.A., Ballard, D.W. & Greene, W.C. NF-κB controls expression of inhibitor IκBα: evidence for an inducible autoregulatory pathway. Science 259, 1912–1915 (1993). · DOI

Cited by

Sorted by citations

Metadata

Authors
Reiley, W. W., Zhang, M., Jin, W., Losiewicz, M., Donohue, K. B., Norbury, C. C., & Sun, S.-C.
Venue
Nature Immunology
Publisher
Springer Science and Business Media LLC
Published
2006-02-26
Volume
7
Issue
4
Pages
411-417
ISSN
  • 1529-2908
  • 1529-2916
DOI
10.1038/ni1315
Cited by
198
References
2
Language
en
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review