Cited by 1,857Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyIL-33, ST2, and ILC Pathways

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Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Acosta-Rodriguez, Eva V, Napolitani, Giorgio, Lanzavecchia, Antonio, Sallusto, Federica·2007·Nature Immunology

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Abstract

Interleukin 17 (IL-17)-producing CD4(+) helper T cells (T(H)-17 cells) have been linked to host defense and autoimmune diseases. In mice, the differentiation of T(H)-17 cells requires transforming growth factor-beta and IL-6 and the transcription factor RORgammat. We report here that for human naive CD4(+) T cells, RORgammat expression and T(H)-17 polarization were induced by IL-1beta and enhanced by IL-6 but were suppressed by transforming growth factor-beta and IL-12. Monocytes and conventional dendritic cells, but not monocyte-derived dendritic cells activated by microbial stimuli, efficiently induced T(H)-17 priming, and this function correlated with antigen-presenting cell production of IL-1beta and IL-6 but not IL-12. Our results identify cytokines, antigen-presenting cells and microbial products that promote the polarization of human T(H)-17 cells and emphasize an important difference in the requirements for the differentiation of T(H)-17 cells in humans and mice.

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Authors: Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F.
Affiliations: Institute for Research in Biomedicine (CH)
Corresponding author: Sallusto, Federica
ORCID: Napolitani, Giorgio
Lanzavecchia, Antonio
Sallusto, Federica
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2007-08-05
Volume: 8
Issue: 9
Pages: 942-949
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni1496
OpenAlex: W2012680181
Cited by: 1,857
References: 43
Citations by year: 2026: 43 · 2025: 35 · 2024: 39 · 2023: 47 · 2022: 46 · 2021: 65 · 2020: 63 · 2019: 59 · 2018: 57 · 2017: 93 · 2016: 97 · 2015: 115 · 2014: 119 · 2013: 126 · 2012: 145
FWCI: 67.88
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute for Health and Care Research
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Bundesamt für Gesundheit
National Institutes of Health
National Institute of Allergy and Infectious Diseases (U19AI057266)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: Th17 cells, IL-17, IL-1β, interleukin-6, TGF-beta, RORγ, CD4+ T cell differentiation, IL-12, antigen-presenting cells, dendritic cells, monocytes, T cell polarization
MeSH terms: Antigen-Presenting Cells, Cell Differentiation, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, T-Lymphocytes, Helper-Inducer, Humans, Receptors, Thyroid Hormone, Interleukin-6, T-Lymphocyte Subsets, Cytokines, Transforming Growth Factor beta, Receptors, Retinoic Acid, Interleukin-12, Cell Lineage, Reverse Transcriptase Polymerase Chain Reaction, Interleukin-17, Interleukin-1beta, Nuclear Receptor Subfamily 1, Group F, Member 3

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Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

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