The clearance of dying cells: table for two
Open accessAbstract
Phagocytic cells of the immune system must constantly survey for, recognize, and efficiently clear the billions of cellular corpses that arise as a result of development, stress, infection, or normal homeostasis. This process, termed efferocytosis, is critical for the prevention of autoimmune and inflammatory disorders, and persistence of dead cells in tissue is characteristic of many human autoimmune diseases, notably systemic lupus erythematosus. The most notable characteristic of the efferocytosis of apoptotic cells is its 'immunologically silent' response. Although the mechanisms by which phagocytes facilitate engulfment of dead cells has been a well-studied area, the pathways that coordinate to process the ingested corpse and direct the subsequent immune response is an area of growing interest. The recently described pathway of LC3 (microtubule-associated protein 1A/1B-light chain 3)-associated phagocytosis (LAP) has shed some light on this issue. LAP is triggered when an extracellular particle, such as a dead cell, engages an extracellular receptor during phagocytosis, induces the translocation of autophagy machinery, and ultimately LC3 to the cargo-containing phagosome, termed the LAPosome. In this review, we will examine efferocytosis and the impact of LAP on efferocytosis, allowing us to reimagine the impact of the autophagy machinery on innate host defense mechanisms.
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Apoptotic cells retain plasma membrane integrity and metabolic activity as the process proceeds to completion, allowing rapid clearance by macrophages or other phagocytic cells (efferocytosis).
“Apoptotic cells retain plasma membrane integrity and metabolic activity (to some degree) as the process proceeds to completion, which—in vivo—allows for the rapid clearance by macrophages or other cells with phagocytic activity (a process commonly known as efferocytosis) [35].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [35]
Defective efferocytosis or dysfunctional apoptotic-cell receptors, especially during non-resolving inflammation, leads to autoimmunity, tissue necrosis and pathological inflammation.
“Not surprisingly, when efferocytosis becomes defective or when apoptotic cell receptors become dysfunctional (predominantly during non-resolving inflammation), autoimmunity, tissue necrosis and pathological inflammation ensue187.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [187]
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2 retracted
Martinez, J., Malireddi, R. K. S., Lu, Q., Cunha, L. D., Pelletier, S., Gingras, S., Orchard, R., Guan, J.-L., Tan, H., Peng, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3192 · Cited by 758 · see citing works
Self-citationRetractedMartinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C. P., Fitzgerald, P., Hengartner, M. O., & Green, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113421108 · Cited by 655 · see citing works
Self-citationRetractedRepertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713 · see citing works
Autophagy and Viruses: Adversaries or Allies?
Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,441 · see citing works
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
Moy, R. H., & Cherry, S. R. (2013) · Journal of Innate Immunity · doi:10.1159/000350326 · Cited by 3,549 · see citing works
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481 · see citing works
Induction of autophagy and inhibition of tumorigenesis by beclin 1
Liang, X. H., Jackson, S., Seaman, M., Brown, K., Kempkes, B., Hibshoosh, H., & Levine, B. (1999) · Nature · doi:10.1038/45257 · Cited by 3,347 · see citing works
Pyroptosis: host cell death and inflammation
Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,185 · see citing works
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Geisler, S., Holmström, K. M., Skujat, D., Fiesel, F. C., Rothfuss, O. C., Kahle, P. J., & Springer, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2012 · Cited by 2,835 · see citing works
Caspase Functions in Cell Death and DiseasePreprint
McIlwain, D. R., Berger, T., & Mak, T. W. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008656 · Cited by 2,607 · see citing works
Mitochondria and cell death: outer membrane permeabilization and beyond
Tait, S. W. G., & Green, D. R. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2952 · Cited by 2,593 · see citing works
Self-citationRole of CD47 as a Marker of Self on Red Blood Cells
Oldenborg, P., Zheleznyak, A., Fang, Y., Lagenaur, C. F., Gresham, H. D., & Lindberg, F. P. (2000) · Science · doi:10.1126/science.288.5473.2051 · Cited by 1,975 · see citing works
ROCKs: multifunctional kinases in cell behaviour
Riento, K., & Ridley, A. J. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1128 · Cited by 1,941 · see citing works
RAGE Mediates a Novel Proinflammatory Axis
Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80801-6 · Cited by 1,864 · see citing works
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737 · see citing works
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654 · see citing works
Four deaths and a funeral: from caspases to alternative mechanisms
Leist, M., & Jäättelä, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085008 · Cited by 1,585 · see citing works
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., et al. (2008) · Nature · doi:10.1038/nature07416 · Cited by 1,542 · see citing works
Walport, M. J. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104123441506 · Cited by 1,480 · see citing works
Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473 · see citing works
Identification of a factor that links apoptotic cells to phagocytes
Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2002) · Nature · doi:10.1038/417182a · Cited by 1,401 · see citing works
Crosstalk between apoptosis.; necrosis and autophagy
Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.001 · Cited by 1,366 · see citing works
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., et al. (2007) · Nature · doi:10.1038/nature06421 · Cited by 1,347 · see citing works
Self-citationHuynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333 · see citing works
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature · doi:10.1038/nature09852 · Cited by 1,278 · see citing works
Self-citationMatsunaga, K., Saitoh, T., Tabata, K., Omori, H., Satoh, T., Kurotori, N., Maejima, I., Shirahama-Noda, K., Ichimura, T., Isobe, T., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1846 · Cited by 1,235 · see citing works
Apoptotic cell clearance: basic biology and therapeutic potential
Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3607 · Cited by 1,223 · see citing works
Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works
Self-citationBeclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
Itakura, E., Kishi, C., Inoue, K., & Mizushima, N. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-01-0080 · Cited by 1,176 · see citing works
Parkes, M., Barrett, J. C., Prescott, N. J., Tremelling, M., Anderson, C. A., Fisher, S. A., Roberts, R. G., Nimmo, E. R., Cummings, F. J. R., Soars, D., et al. (2007) · Nature Genetics · doi:10.1038/ng2061 · Cited by 1,144 · see citing works
Caspase‐1‐induced pyroptotic cell death
Miao, E. A., Rajan, J. V., & Aderem, A. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01044.x · Cited by 1,139 · see citing works
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120 · see citing works
Pickford, F., Masliah, E., Britschgi, M., Lucin, K. M., Narasimhan, R., Jaeger, P. A., Small, S. A., Spencer, B. J., Rockenstein, E. M., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 1,072 · see citing works
Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., & Evans, R. M. (2001) · Nature Medicine · doi:10.1038/83336 · Cited by 1,069 · see citing works
RIP3 mediates the embryonic lethality of caspase-8-deficient mice
Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., & Mocarski, E. S. (2011) · Nature · doi:10.1038/nature09857 · Cited by 1,057 · see citing works
Ambra1 regulates autophagy and development of the nervous system
Fimia, G. M., Stoykova, A., Romagnoli, A., Giunta, L., Bartolomeo, S. D., Nardacci, R., Corazzari, M., Fuoco, C., Uçar, A., Schwartz, P. J., et al. (2007) · Nature · doi:10.1038/nature05925 · Cited by 1,043 · see citing works
Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
Liang, C., Feng, P., Ku, B., Dotan, I., Canaani, D., Oh, B., & Jung, J. U. (2006) · Nature Cell Biology · doi:10.1038/ncb1426 · Cited by 1,025 · see citing works
Pyroptotic cell death defends against intracellular pathogens
Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021 · see citing works
Zhong, Y., Wang, Q. J., Li, X., Yan, Y., Backer, J. M., Chait, B. T., Heintz, N., & Yue, Z. (2009) · Nature Cell Biology · doi:10.1038/ncb1854 · Cited by 1,005 · see citing works
Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice
Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., & Nagata, S. (2004) · Science · doi:10.1126/science.1094359 · Cited by 992 · see citing works
A Unified Model for Apical Caspase Activation
Boatright, K. M., Renatus, M., Scott, F. L., Sperandio, S., Shin, H., Pedersen, I. M., Ricci, J., Edris, W. A., Sutherlin, D. P., Green, D. R., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00051-0 · Cited by 963 · see citing works
Self-citationPhagocytosis of apoptotic cells in homeostasis
Arandjelovic, S., & Ravichandran, K. S. (2015) · Nature Immunology · doi:10.1038/ni.3253 · Cited by 959 · see citing works
Huynh, M.-L. N., Fadok, V. A., & Henson, P. M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0211638 · Cited by 957 · see citing works
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
Joseph, S. B., McKilligin, E., Pei, L., Watson, M. A., Collins, A. R., Laffitte, B. A., Chen, M., Noh, G. J., Goodman, J., Hagger, G. N., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.112059299 · Cited by 950 · see citing works
Han, J., Zheng, H., Cui, Y., Sun, L., Ye, D., Hu, Z. Q., Xu, J., Cai, Z., Huang, W., Zhao, G., et al. (2009) · Nature Genetics · doi:10.1038/ng.472 · Cited by 938 · see citing works
Unveiling the roles of autophagy in innate and adaptive immunity
Levine, B., & Deretic, V. P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2161 · Cited by 903 · see citing works
Cargo recognition failure is responsible for inefficient autophagy in Huntington’s disease
Martinez-Vicente, M., Talloczy, Z., Wong, E., Tang, G., Koga, H., Kaushik, S., de Vries, R., Arias, E., Harris, S., Sulzer, D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2528 · Cited by 885 · see citing works
Autophagosome Formation in Mammalian Cells.
Mizushima, N., Ohsumi, Y., & Yoshimori, T. (2002) · Cell Structure and Function · doi:10.1247/csf.27.421 · Cited by 877 · see citing works
Autoimmunity and the Clearance of Dead Cells
Nagata, S., Hanayama, R., & Kawane, K. (2010) · Cell · doi:10.1016/j.cell.2010.02.014 · Cited by 877 · see citing works
Feoktistova, M., Geserick, P., Kellert, B., Panayotova‐Dimitrova, D., Langlais, C., Hupe, M., Cain, K., MacFarlane, M., Häcker, G. A., & Leverkus, M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.011 · Cited by 855 · see citing works
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
Park, D., Tosello‐Trampont, A., Elliott, M. R., Lu, M., Haney, L. B., Ma, Z., Klibanov, A. L., Mandell, J. W., & Ravichandran, K. S. (2007) · Nature · doi:10.1038/nature06329 · Cited by 848 · see citing works
Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21
Aita, V. M., Liang, X. H., Murty, V. V. V. S., Pincus, D. L., Yu, W., Cayanis, E., Kalachikov, S. M., Gilliam, T. C., & Levine, B. (1999) · Genomics · doi:10.1006/geno.1999.5851 · Cited by 800 · see citing works
Polson, H. E. J., de Lartigue, J., Rigden, D. J., Reedijk, M., Urbé, S., Clague, M. J., & Tooze, S. A. (2010) · Autophagy · doi:10.4161/auto.6.4.11863 · Cited by 712 · see citing works
WAVE, a novel WASP‐family protein involved in actin reorganization induced by Rac
Miki, H., Suetsugu, S., & Takenawa, T. (1998) · The EMBO Journal · doi:10.1093/emboj/17.23.6932 · Cited by 705 · see citing works
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908698106 · Cited by 691 · see citing works
Gal, A., Li, Y., Thompson, D. A., Weir, J., Orth, U., Jacobson, S. G., Apfelstedt-Sylla, E., & Vollrath, D. (2000) · Nature Genetics · doi:10.1038/81555 · Cited by 679 · see citing works
A-González, N., Bensinger, S. J., Hong, C., Beceiro, S., Bradley, M. N., Zelcer, N., Deniz, J. M., Ramírez, C. M., Díaz, M., Gallardo, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.018 · Cited by 674 · see citing works
Zizzo, G., Hilliard, B. A., Monestier, M., & Cohen, P. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200662 · Cited by 650 · see citing works
Cohen, P. L., Caricchio, R., Abraham, V., Camenisch, T. D., Jennette, J. C., Roubey, R. A. S., Earp, H. S., Matsushima, G. K., & Reap, E. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012094 · Cited by 637 · see citing works
Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis
Liao, X., Sluimer, J. C., Wang, Y., Subramanian, M., Brown, K., Pattison, J. S., Robbins, J., Martinez, J., & Tabas, I. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.022 · Cited by 627 · see citing works
Self-citationA Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
Llambi, F., Moldoveanu, T., Tait, S. W. G., Bouchier-Hayes, L., Temirov, J., McCormick, L. L., Dillon, C. P., & Green, D. R. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.001 · Cited by 596 · see citing works
Self-citationUnconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk, S. F., Tosello-Trampont, A.-C., Macara, I. G., Madhani, H., Fink, G. R., & Ravichandran, K. S. (2002) · Nature Cell Biology · doi:10.1038/ncb824 · Cited by 576 · see citing works
Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells
Suzuki, J., Denning, D. P., Imanishi, E., Horvitz, H. R., & Nagata, S. (2013) · Science · doi:10.1126/science.1236758 · Cited by 573 · see citing works
Activation of antibacterial autophagy by NADPH oxidases
Huang, J., Canadien, V., Lam, G. Y., Steinberg, B. E., Dinauer, M. C., Magalhaes, M. A. O., Glogauer, M., Grinstein, S., & Brumell, J. H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811045106 · Cited by 556 · see citing works
Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums
Ravichandran, K. S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 547 · see citing works
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T. R., Matsuda, F., & Nagata, S. (2014) · Science · doi:10.1126/science.1252809 · Cited by 528 · see citing works
Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion
Hochreiter-Hufford, A., & Ravichandran, K. S. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008748 · Cited by 503 · see citing works
Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family
McIntire, J. J., Umetsu, S. E., Akbari, O., Potter, M., Kuchroo, V. K., Barsh, G. S., Freeman, G. J., Umetsu, D. T., & DeKruyff, R. H. (2001) · Nature Immunology · doi:10.1038/ni739 · Cited by 501 · see citing works
Ezekowitz, R. A. B., Sastry, K., Bailly, P., & Warner, A. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.6.1785 · Cited by 501 · see citing works
Saitsu, H., Nishimura, T., Muramatsu, K., Kodera, H., Kumada, S., Sugai, K., Kasai-Yoshida, E., Sawaura, N., Nishida, H., Hoshino, A., et al. (2013) · Nature Genetics · doi:10.1038/ng.2562 · Cited by 474 · see citing works
CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
Truman, L. A., Ford, C. A., Pasikowska, M., Pound, J. D., Wilkinson, S. J., Dumitriu, I. E., Melville, L., Melrose, L. A., Ogden, C. A., Nibbs, R., et al. (2008) · Blood · doi:10.1182/blood-2008-06-162404 · Cited by 473 · see citing works
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
Kawane, K., Ohtani, M., Miwa, K., Kizawa, T., Kanbara, Y., Yoshioka, Y., Yoshikawa, H., & Nagata, S. (2006) · Nature · doi:10.1038/nature05245 · Cited by 467 · see citing works
Luciani, A., Villella, V. R., Esposito, S., Brunetti-Pierri, N., Medina, D., Settembre, C., Gavina, M., Pulze, L., Giardino, I., Pettoello-Mantovani, M., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2090 · Cited by 467 · see citing works
Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor
Park, S.-Y., Jung, M.-Y., Kim, H.-J., Lee, S., Kim, S.-Y., Lee, B.-H., Kwon, T.-H., Park, R. W., & Kim, I. T. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402242 · Cited by 464 · see citing works
Florey, O., Kim, S. E., Sandoval, C. P., Haynes, C. M., & Overholtzer, M. (2011) · Nature Cell Biology · doi:10.1038/ncb2363 · Cited by 459 · see citing works
Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis
Angelillo-Scherrer, A., de Frutos, P. G., Aparicio, C., Melis, E., Savi, P., Lupu, F., Arnout, J., Dewerchin, M., Hoylaerts, M. F., Herbert, J.-M., et al. (2001) · Nature Medicine · doi:10.1038/84667 · Cited by 441 · see citing works
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
Reddien, P. W., & Horvitz, H. R. (2000) · Nature Cell Biology · doi:10.1038/35004000 · Cited by 414 · see citing works
Mitochondrial cell death effectors
Brenner, D., & Mak, T. W. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.09.004 · Cited by 414 · see citing works
Matute, C., Torre, I., Pérez‐Cerdá, F., Pérez‐Samartín, A., Alberdi, E. M., Etxebarria, E., Arranz, A. M., Ravid, R., Antigüedad, A. R., Sánchez‐Gómez, M. V., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0579-07.2007 · Cited by 404 · see citing works
Aminophospholipid Asymmetry: A Matter of Life and Death
Balasubramanian, K., & Schroit, A. J. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142459 · Cited by 396 · see citing works
Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis
Rodríguez, D. A., Weinlich, R., Brown, S., Guy, C. S., Fitzgerald, P., Dillon, C. P., Oberst, A., Quarato, G., Low, J. A., Cripps, J. G., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.70 · Cited by 379 · see citing works
Self-citationHereditary Protein S Deficiency: Clinical Manifestations
Engesser, L., BROEKMANS, A. W., BRIËT, E., BROMMER, E. J. P., & Bertina, R. M. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-106-5-677 · Cited by 378 · see citing works
αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells
Albert, M. L., Kim, J.-I., & Birge, R. B. (2000) · Nature Cell Biology · doi:10.1038/35046549 · Cited by 377 · see citing works
Fadok, V. A., Bratton, D. L., Guthrie, L. A., & Henson, P. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6847 · Cited by 368 · see citing works
PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance
Mukundan, L., Odegaard, J. I., Morel, C. R., Heredia, J. E., Mwangi, J. W., Ricardo-Gonzalez, R. R., Goh, Y. P. S., Eagle, A. R., Dunn, S. E., Awakuni, J. U. H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2048 · Cited by 368 · see citing works
RIPK1 and RIPK3: critical regulators of inflammation and cell death
Newton, K. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.001 · Cited by 367 · see citing works
Gude, D., Alvarez, S. E., Paugh, S. W., Mitra, P., Yu, J., Griffiths, R., Barbour, S. E., Milstien, S., & Spiegel, S. (2008) · The FASEB Journal · doi:10.1096/fj.08-107169 · Cited by 364 · see citing works
Autophagy in human type 2 diabetes pancreatic beta cells
Masini, M., Bugliani, M., Lupi, R., Guerra, S. D., Boggi, U., Filipponi, F., Marselli, L., Masiello, P., & Marchetti, P. (2009) · Diabetologia · doi:10.1007/s00125-009-1347-2 · Cited by 360 · see citing works
Thorp, E., Cui, D., Schrijvers, D. M., Kuriakose, G., & Tabas, I. (2008) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.167197 · Cited by 357 · see citing works
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk
Raychaudhuri, S., Thomson, B. P., Remmers, E. F., Eyre, S., Hinks, A., Guiducci, C., Catanese, J. J., ., G. X., Stahl, E. A., Chen, R., et al. (2009) · Nature Genetics · doi:10.1038/ng.479 · Cited by 351 · see citing works
Holland, S. M. (2012) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2012.11.002 · Cited by 350 · see citing works
Henault, J., Martinez, J., Riggs, J. M., Tian, J., Mehta, P., Clarke, L., Sasai, M., Latz, E., Brinkmann, M. M., Iwasaki, A., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.014 · Cited by 348 · see citing works
Self-citationNoncanonical autophagy promotes the visual cycle
Kim, J.-Y., Zhao, H., Martinez, J., Doggett, T. A., Kolesnikov, A. V., Tang, P. H., Ablonczy, Z., Chan, C.-C., Zhou, Z., Green, D. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.012 · Cited by 347 · see citing works
Self-citationUric acid promotes an acute inflammatory response to sterile cell death in mice
Kono, H., Chen, C.-J., Ontiveros, F., & Rock, K. L. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40124 · Cited by 337 · see citing works
Role of Lysophosphatidylcholine (LPC) in Atherosclerosis
Matsumoto, T., Kobayashi, T., & Kamata, K. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707782793899 · Cited by 312 · see citing works
Enhanced autophagy ameliorates cardiac proteinopathy
Bhuiyan, M. S., Pattison, J. S., Osinska, H., James, J., Gulick, J., McLendon, P. M., Hill, J. A., Sadoshima, J., & Robbins, J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70877 · Cited by 298 · see citing works
Antidiabetic Action of a Liver X Receptor Agonist Mediated By Inhibition of Hepatic Gluconeogenesis
Cao, G., Yu, L., Broderick, C. L., Oldham, B. A., Beyer, T., Schmidt, R. J., Zhang, Y., Stayrook, K. R., Suen, C. S., Otto, K. A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210208200 · Cited by 298 · see citing works
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans
Hoeppner, D. J., Hengartner, M. O., & Schnabel, R. (2001) · Nature · doi:10.1038/35084103 · Cited by 295 · see citing works
Activation of NADPH Oxidase in Alzheimer’s Disease Brains
Shimohama, S., Tanino, H., Kawakami, N., Okamura, N., Kodama, H., Yamaguchi, T., Hayakawa, T., Nunomura, A., Chiba, S., Perry, G., et al. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2897 · Cited by 292 · see citing works
van den Eijnde, S. M., van den Hoff, M. J. B., Reutelingsperger, C. P. M., van Heerde, W. L., Henfling, M. E. R., Vermeij‐Keers, C., Schütte, B., Borgers, M. J., & Ramaekers, F. C. S. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.20.3631 · Cited by 289 · see citing works
Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation
Juncadella, I. J., Kadl, A., Sharma, A. K., Shim, Y. M., Hochreiter, A. E., Borish, L., & Ravichandran, K. S. (2012) · Nature · doi:10.1038/nature11714 · Cited by 287 · see citing works
Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy
Cullup, T., Kho, A. L., Dionisi‐Vici, C., Brandmeier, B., Smith, F., Urry, Z., Simpson, M. A., Yau, S., Bertini, E., McClelland, V. M., et al. (2012) · Nature Genetics · doi:10.1038/ng.2497 · Cited by 282 · see citing works
Kim, S. J., Elkon, K. B., & Ma, X. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.009 · Cited by 277 · see citing works
A role for Mer tyrosine kinase in αvβ5 integrin-mediated phagocytosis of apoptotic cells
Wu, Y., Singh, S., Georgescu, M.-M., & Birge, R. B. (2005) · Journal of Cell Science · doi:10.1242/jcs.01632 · Cited by 276 · see citing works
Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
Cui, G., Qin, X., Wu, L., Zhang, Y., Sheng, X., Yu, Q., Sheng, H., Xi, B., Zhang, J. Z., & Zang, Y. Q. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42974 · Cited by 271 · see citing works
Migration to Apoptotic “Find-me” Signals Is Mediated via the Phagocyte Receptor G2A
Peter, C., Waibel, M., Radu, C. G., Yang, L. V., Witte, O. N., Schulze-Osthoff, K., Wesselborg, S., & Lauber, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706586200 · Cited by 258 · see citing works
Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated Atherosclerosis in Mice
Ait-Oufella, H., Kinugawa, K., Zoll, J., Simon, T., Boddaert, J., Heeneman, S., Blanc-Brude, O., Barateau, V., Potteaux, S., Merval, R., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.662080 · Cited by 255 · see citing works
Autophagy is activated in systemic lupus erythematosus and required for plasmablast development
Clarke, A. J., Ellinghaus, U., Cortini, A., Stranks, A., Simon, A. K., Botto, M., & Vyse, T. J. (2015) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204343 · Cited by 252 · see citing works
Rubicon controls endosome maturation as a Rab7 effector
Sun, Q., Westphal, W., Wong, K. N., Tan, I., & Zhong, Q. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010554107 · Cited by 251 · see citing works
Ireland, J. M., & Unanue, E. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110640 · Cited by 249 · see citing works
Ishimoto, Y., Ohashi, K., Mizuno, K., & Nakano, T. (2000) · Journal of Biochemistry (Tokyo) · doi:10.1093/oxfordjournals.jbchem.a022622 · Cited by 248 · see citing works
Su, H.-P., Nakada‐Tsukui, K., Tosello‐Trampont, A., Li, Y., Bu, G., Henson, P. M., & Ravichandran, K. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109336200 · Cited by 245 · see citing works
Zhou, S., Lu, X., Lv, J., Yang, H.-Z., qin, L. X., Zhao, M., Su, Y., Li, Z., & Zhang, H. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.140111 · Cited by 240 · see citing works
Rho-Kinase and Myosin-II Control Phagocytic Cup Formation during CR, but Not FcγR, Phagocytosis
Olazabal, I. M., Caron, E., May, R. C., Schilling, K., Knecht, D. A., & Machesky, L. M. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01069-2 · Cited by 237 · see citing works
Christiansen-Weber, T. A., Voland, J. R., Wu, Y., Ngo, K., Roland, B. L., Nguyen, S., Peterson, P. A., & Fung‐Leung, W. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64614-7 · Cited by 236 · see citing works
Ulcerative colitis and autoimmunity induced by loss of myeloid αv integrins
Lacy‐Hulbert, A., Smith, A. M., Tissire, H., Barry, M., Crowley, D. G., Bronson, R. T., Roes, J., Savill, J., & Hynes, R. O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707421104 · Cited by 225 · see citing works
Means to an end: apoptosis and other cell death mechanisms
(2011) · Choice Reviews Online · doi:10.5860/choice.48-5678 · Cited by 224 · see citing works
Tian, Y., Bustos, V., Flajolet, M., & Greengard, P. (2011) · The FASEB Journal · doi:10.1096/fj.10-175158 · Cited by 223 · see citing works
Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome
Le, L. Q., Kabarowski, J. H. S., Weng, Z., Satterthwaite, A. B., Harvill, E. T., Jensen, E. R., Miller, J. F., & Witte, O. N. (2001) · Immunity · doi:10.1016/s1074-7613(01)00145-5 · Cited by 215 · see citing works
Apoptotic human cells inhibit migration of granulocytes via release of lactoferrin
Bournazou, I., Pound, J. D., Duffin, R., Bournazos, S., Melville, L. A., Brown, S. B., Rossi, A. G., & Gregory, C. D. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36226 · Cited by 212 · see citing works
Microglia function during brain development: New insights from animal models
Bilimoria, P. M., & Stevens, B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.11.032 · Cited by 204 · see citing works
Constitutive exposure of phosphatidylserine on viable cells
Segawa, K., Suzuki, J., & Nagata, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114799108 · Cited by 203 · see citing works
GENETIC DISORDERS OF PROGRAMMED CELL DEATH IN THE IMMUNE SYSTEM
Bidère, N., Su, H. C., & Lenardo, M. J. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090513 · Cited by 197 · see citing works
and the IBSEN study group, Franke, A., Balschun, T. C., Sina, C., Ellinghaus, D., Häsler, R., Gabriele Mayr, B., Albrecht, M., Wittig, M., Buchert, E., et al. (2010) · Nature Genetics · doi:10.1038/ng.553 · Cited by 194 · see citing works
The Chemokine Fractalkine Inhibits Fas-Mediated Cell Death of Brain Microglia
Boehme, S. A., Lio, F. M., Maciejewski-Lenoir, D., Bacon, K. B., & Conlon, P. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.1.397 · Cited by 192 · see citing works
Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma
Gerber, E. E., Gallo, E. M., Fontana, S. C., Davis, E. C., Wigley, F. M., Huso, D. L., & Dietz, H. C. (2013) · Nature · doi:10.1038/nature12614 · Cited by 190 · see citing works
Yan, S. S., Wu, Z., Zhang, H. P., Furtado, G. D. C., Chen, X., Yan, S. F., Schmidt, A. M., Brown, C., Stern, A., Lafaille, J. J., et al. (2003) · Nature Medicine · doi:10.1038/nm831 · Cited by 182 · see citing works
Rodriguez‐Manzanet, R., Sanjuán, M. A. F., Wu, H. Y., Quintana, F. J., Xiao, S., Anderson, A. C., Weiner, H. L., Green, D. R., & Kuchroo, V. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910359107 · Cited by 182 · see citing works
Self-citationPhagocytic activity of neuronal progenitors regulates adult neurogenesis
Lu, Z., Elliott, M. R., Chen, Y., Walsh, J. T., Klibanov, A. L., Ravichandran, K. S., & Kipnis, J. (2011) · Nature Cell Biology · doi:10.1038/ncb2299 · Cited by 180 · see citing works
Kim, J., & Kang, T. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44818 · Cited by 179 · see citing works
Babaev, V. R., Yancey, P. G., Ryzhov, S. V., Kon, V., Breyer, M. D., Magnuson, M. A., Fazio, S., & Linton, M. F. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000173413.31789.1a · Cited by 178 · see citing works
Rőszer, T., Menéndez-Gutierrez, M. P., Lefterova, M. I., Alameda, D., Núñez, V., Lazar, M. A., Fischer, T., & Ricote, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002230 · Cited by 176 · see citing works
Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo
Elliott, M. R., Zheng, S., Park, D., Woodson, R. I., Reardon, M. A., Juncadella, I. J., Kinchen, J. M., Zhang, J., Lysiak, J. J., & Ravichandran, K. S. (2010) · Nature · doi:10.1038/nature09356 · Cited by 175 · see citing works
The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo
Laurin, M., Fradet, N., Blangy, A., Hall, A., Vuori, K., & Côté, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805546105 · Cited by 167 · see citing works
Functional Variant in the Autophagy-Related 5 Gene Promotor is Associated with Childhood Asthma
Martin, L. J., Gupta, J., Jyothula, S., Kovacic, M. B., Myers, J. M. B., Patterson, T. L., Ericksen, M. B., He, H., Gibson, A. M., Baye, T. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033454 · Cited by 166 · see citing works
Yang, C., Lee, J., Rodgers, M. A., Min, C., Lee, J., Kim, H. J., Lee, K.-H., Kim, C., Oh, B., Zandi, E., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.01.018 · Cited by 163 · see citing works
Garris, C., Wu, L., Acharya, S., Arac, A., Blaho, V. A., Huang, Y., Moon, B.-S., Axtell, R. C., Ho, P. P.-K., Steinberg, G. K., et al. (2013) · Nature Immunology · doi:10.1038/ni.2730 · Cited by 161 · see citing works
Nanki, T., Imai, T., Nagasaka, K., Urasaki, Y., Nonomura, Y., Taniguchi, K., Hayashida, K., Hasegawa, J., Yoshie, O., & Miyasaka, N. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10622 · Cited by 158 · see citing works
The Phosphatidylserine Receptor TIM-4 Does Not Mediate Direct Signaling
Park, D., Hochreiter, A. E., & Ravichandran, K. S. (2009) · Current Biology · doi:10.1016/j.cub.2009.01.042 · Cited by 158 · see citing works
Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease
Henckaerts, L., Cleynen, I., Brinar, M., John, J. M., Steen, K. V., Rutgeerts, P. J., & Vermeire, S. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21486 · Cited by 156 · see citing works
Opposite Effects of Rho Family GTPases on Engulfment of Apoptotic Cells by Macrophages
Nakaya, M., Tanaka, M., Okabe, Y., Hanayama, R., & Nagata, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510972200 · Cited by 155 · see citing works
Kim, M. S., Jeong, E. G., Ahn, C. H., Kim, S. S., Lee, S. H., & Yoo, N. J. (2008) · Human Pathology · doi:10.1016/j.humpath.2007.11.013 · Cited by 154 · see citing works
Sun, Q., Zhang, J., Fan, W., Wong, K. N., Ding, X., Chen, S., & Zhong, Q. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.126425 · Cited by 153 · see citing works
Membrane recruitment of Rac1 triggers phagocytosis
Castellano, F., Montcourrier, P., & Chavrier, P. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.17.2955 · Cited by 153 · see citing works
Coordinate regulation of neutrophil homeostasis by liver X receptors in mice
Hong, C., Kidani, Y., A-González, N., Phung, T., Ito, A., Rong, X., Ericson, K. R., Mikkola, H. K. A., Beaven, S. W., Miller, L. S., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58393 · Cited by 152 · see citing works
Xiao, S., Brooks, C. R., Zhu, C. Y., Wu, C., Sweere, J. M., Petecka, S., Yeste, A., Quintana, F. J., Ichimura, T., Sobel, R. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120914109 · Cited by 143 · see citing works
Metabolic Connections during Apoptotic Cell Engulfment
Han, C. Z., & Ravichandran, K. S. (2011) · Cell · doi:10.1016/j.cell.2011.12.006 · Cited by 143 · see citing works
CD46 Plays a Key Role in Tailoring Innate Immune Recognition of Apoptotic and Necrotic Cells
Elward, K., Griffiths, M., Mizuno, M., Harris, C. L., Neal, J. W., Morgan, B. P., & Gasque, P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506579200 · Cited by 142 · see citing works
Autophagy in Autoimmune Disease
Yang, Z., Goronzy, J., & Weyand, C. (2015) · Journal of molecular medicine · doi:10.1007/s00109-015-1297-8 · Cited by 141 · see citing works
Heat-shock proteins can promote as well as regulate autoimmunity
Rajaiah, R., & Moudgil, K. D. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.12.004 · Cited by 141 · see citing works
Cell death in development: shaping the embryo
Penaloza, C. G., Lin, L., Lockshin, R. A., & Zakeri, Z. F. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0214-1 · Cited by 136 · see citing works
Dangerous attraction: phagocyte recruitment and danger signals of apoptotic and necrotic cells
Peter, C., Wesselborg, S., i, M. H., & Lauber, K. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0472-1 · Cited by 130 · see citing works
The Two Faces of Receptor Interacting Protein Kinase-1
Weinlich, R., & Green, D. R. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.11.001 · Cited by 127 · see citing works
Self-citationTwo-Step Engulfment of Apoptotic Cells
Toda, S., Hanayama, R., & Nagata, S. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05993-11 · Cited by 124 · see citing works
Leverrier, Y., Lorenzi, R., Blundell, M. P., Brickell, P. M., Kinnon, C., Ridley, A. J., & Thrasher, A. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4831 · Cited by 119 · see citing works
Apoptotic Cells Induce a Phosphatidylserine-Dependent Homeostatic Response from Phagocytes
Kiss, R. S., Elliott, M. R., Ma, Z., Marcel, Y. L., & Ravichandran, K. S. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.043 · Cited by 119 · see citing works
Phagocytic Clearance in Neurodegeneration
Sokolowski, J. D., & Mandell, J. W. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.12.051 · Cited by 117 · see citing works
Requirement of Adaptor Protein GULP during Stabilin-2-mediated Cell Corpse Engulfment
Park, S., Kang, K.-B., Thapa, N., Kim, S.-Y., Lee, S.-J., & Kim, I. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709105200 · Cited by 105 · see citing works
Tian, L., Choi, S., Murakami, Y., Allen, J. N., Morse, H. C., Qi, C., Krzewski, K., & Coligan, J. E. (2014) · Nature Communications · doi:10.1038/ncomms4146 · Cited by 98 · see citing works
Apoptotic mechanisms involved in neurodegenerative diseases: Experimental and therapeutic approaches
Camins, A., Pallàs, M., & Silvestre, J. S. (2008) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2008.30.1.1090962 · Cited by 95 · see citing works
Suh, C., Hilliard, B. A., Li, S., Merrill, J. T., & Cohen, P. L. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3088 · Cited by 93 · see citing works
Essential role of Gas6 for glomerular injury in nephrotoxic nephritis
Yanagita, M., Ishimoto, Y., Arai, H., Nagai, K., Ito, T., Nakano, T., Salant, D. J., Fukatsu, A., Doi, T., & Kita, T. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14861 · Cited by 93 · see citing works
Acharya, M., Mukhopadhyay, S., Païdassi, H., Jamil, T., Chow, C., Kissler, S., Stuart, L. M., Hynes, R. O., & Lacy‐Hulbert, A. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43796 · Cited by 91 · see citing works
Decreased expression of Beclin-1 and LC3 in human lung cancer
Jiang, Z., Shao, L., Wang, W., Yan, X., & Liu, R. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-0734-1 · Cited by 90 · see citing works
The CX3C chemokine fractalkine in allergic asthma and rhinitis
Rimaniol, A.-C., Till, S. J., Garcia, G., Capel, F., Godot, V., Balabanian, K., Durand-Gasselin, I., Varga, E. M., Simonneau, G., Emilie, D., et al. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.041 · Cited by 87 · see citing works
Bhattacharya, A., Parillon, X., Zeng, S., Han, S., & Eissa, N. T. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.575860 · Cited by 87 · see citing works
Phagocytosis of apoptotic cells by liver: A morphological study
Dini, L., Pagliara, P., & Carlà, E. C. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10107 · Cited by 87 · see citing works
BAI1 regulates spatial learning and synaptic plasticity in the hippocampus
Zhu, D., Li, C., Swanson, A. M., Villalba, R. M., Guo, J., Zhang, Z., Matheny, S. L., Murakami, T., Stephenson, J. R., Daniel, S. M., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74603 · Cited by 86 · see citing works
Inhibition of eosinophil migration by lactoferrin
Bournazou, I., Mackenzie, K. J., Duffin, R., Rossi, A. G., & Gregory, C. D. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.86 · Cited by 84 · see citing works
Macrophage-restricted molecules: role in differentiation and activation
Gordon, S. (1999) · Immunology Letters · doi:10.1016/s0165-2478(98)00116-3 · Cited by 81 · see citing works
Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity
Xu, J., Wagoner, G., Douglas, J. C., & Drew, P. D. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008600 · Cited by 81 · see citing works
Phagocytosis of apoptotic cells
Hart, S. P., Dransfield, I., & Rossi, A. G. (2008) · Methods · doi:10.1016/j.ymeth.2007.11.009 · Cited by 81 · see citing works
Vasheghani, F., Monemdjou, R., Fahmi, H., Zhang, Y., Perez, G., Blati, M., St-Arnaud, R., Pelletier, J.-P., Beier, F., Martel-Pelletier, J., et al. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.12.012 · Cited by 80 · see citing works
Molecular targeting of atherosclerotic plaques by a stabilin-2-specific peptide ligand
Lee, G. Y., Kim, J.-H., Oh, G. T., Lee, B.-H., Kwon, I. C., & Kim, I. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.07.010 · Cited by 78 · see citing works
G2A Deficiency in Mice Promotes Macrophage Activation and Atherosclerosis
Bolick, D. T., Skaflen, M. D., Johnson, L. E., Kwon, S., Howatt, D. A., Daugherty, A., Ravichandran, K. S., & Hedrick, C. C. (2008) · Circulation Research · doi:10.1161/circresaha.108.181131 · Cited by 78 · see citing works
Essential role of Gas6 for glomerular injury in nephrotoxic nephritis
Yanagita, M., Ishimoto, Y., Arai, H., Nagai, K., Ito, T., Nakano, T., Salant, D. J., Fukatsu, A., Doi, T., & Kita, T. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214861 · Cited by 78 · see citing works
Burning Down the House: Cellular Actions during Pyroptosis
LaRock, C. N., & Cookson, B. T. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003793 · Cited by 77 · see citing works
The Relationship between Metabolism and the Autophagy Machinery during the Innate Immune Response
Martinez, J., Verbist, K., Wang, R., & Green, D. R. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.012 · Cited by 67 · see citing works
Self-citationContribution of Pannexin1 to Experimental Autoimmune Encephalomyelitis
Lutz, S. E., González‐Fernández, E., Ventura, J. C. C., Pérez‐Samartín, A., Tarassishin, L., Negoro, H., Patel, N. K., Suadicani, S. O., Lee, S. C., Matute, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066657 · Cited by 65 · see citing works
The Role of the NADPH Oxidase NOX2 in Prion Pathogenesis
Sorce, S., Nuvolone, M., Keller, A., Falsig, J., Varol, A., Schwarz, P., Bieri, M., Budka, H., & Aguzzi, A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004531 · Cited by 62 · see citing works
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance
Nakaya, M., Tajima, M., Kosako, H., Nakaya, T., Hashimoto, A. S., Watari, K., Nishihara, H., Ohba, M., Komiya, S., Tani, N., et al. (2013) · Nature Communications · doi:10.1038/ncomms2540 · Cited by 54 · see citing works
A model to die for: signaling to apoptotic cell removal in worm, fly and mouse
Kinchen, J. M. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0509-5 · Cited by 50 · see citing works
DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4
Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.223388 · Cited by 49 · see citing works
Activation of Liver X Receptor Alleviates Ocular Inflammation in Experimental Autoimmune Uveitis
Yang, H., Zheng, S., Qiu, Y., Yang, Y., Wang, C., Yang, P., Li, Q., & Lei, B. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13323 · Cited by 49 · see citing works
Ueyama, T., Nakakita, J., Nakamura, T., Kobayashi, T., Kobayashi, T., Son, J., Sakuma, M., Sakaguchi, H., Leto, T. L., & Saito, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237289 · Cited by 44 · see citing works
Wei, H., Gan, B., Wu, X., & Guan, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806375200 · Cited by 42 · see citing works
ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability
Magné, J., Saliba‐Gustafsson, P., Jin, H. H., Mäegdefessel, L., Hultenby, K. R., Wernerson, A. M., Eriksson, P. O., Franco‐Cereceda, A., Kovanen, P. T., Gonçalves, I., et al. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304840 · Cited by 42 · see citing works
Roles of ICAM-3 and CD 14 in the recognition and phagocytosis of apoptotic cells by macrophages
Gregory, C. D., Devitt, A., & Moffatt, O. (1998) · Biochemical Society Transactions · doi:10.1042/bst0260644 · Cited by 42 · see citing works
Baker, O. J., Camden, J. M., Rome, D. E., Seye, C. I., & Weisman, G. A. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.05.009 · Cited by 39 · see citing works
Clearance of dead cells: mechanisms, immune responses and implication in the development of diseases
Krysko, D. V., & Vandenabeele, P. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0524-6 · Cited by 39 · see citing works
Martin, S., Rieckmann, P., Melchers, I., Wagner, R., Bertrams, J., Voskuyl, A. E., Roep, B. O., Zielasek, J., Heidenthal, E., Weichselbraun, I., et al. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.4.1951 · Cited by 37 · see citing works
Essential role for UVRAG in autophagy and maintenance of cardiac function
Song, Z., An, L. K., Ye, Y., Wu, J., Zou, Y., He, L., & Zhu, H. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt223 · Cited by 37 · see citing works
Adaptor protein GULP is involved in stabilin-1-mediated phagocytosis
Park, S., Kim, S.-Y., Kang, K.-B., & Kim, I. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.101 · Cited by 37 · see citing works
Prix Fixe: Efferocytosis as a Four-Course Meal
Martinez, J. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_467 · Cited by 33 · see citing works
Self-citationLC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains
Satoh, J., Motohashi, N., Kino, Y., Ishida, T., Yagishita, S., Jinnai, K., Arai, N., Nakamagoe, K., Tamaoka, A., Saito, Y., et al. (2014) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-9-68 · Cited by 33 · see citing works
Abreu, J. R. F., Dontje, W., Krausz, S., de Launay, D., van Hennik, P. B., van Stalborch, A.-M. D., ten Klooster, J. P., Sanders, M. E., Reedquist, K. A., Vervoordeldonk, M. J., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2900 · Cited by 33 · see citing works
Association of UVRAG polymorphisms with susceptibility to non‐segmental vitiligo in a Korean sample
Jeong, T., Shin, M. K., Uhm, Y., Kim, H., Chung, J., & Lee, M. (2010) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.01039.x · Cited by 32 · see citing works
Dagkalis, A., Wallace, C. A., Hing, B. W. Q., Liversidge, J., & Crane, I. J. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03046.x · Cited by 32 · see citing works
Kim, H., Nam, J., Jeon, J., An, J.-M., Jung, J., Bae, C.-B., & Suh, C. (2012) · Journal of Clinical Immunology · doi:10.1007/s10875-012-9765-1 · Cited by 30 · see citing works
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Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works
Self-citationThe gasdermins, a protein family executing cell death and inflammation
Broz, P., Pelegrín, P., & Shao, F. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0228-2 · Cited by 1,641 · see citing works
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works
The clearance of dead cells by efferocytosis
Boada-Romero, E., Martinez, J., Heckmann, B. L., & Green, D. R. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0232-1 · Cited by 893 · see citing works
Self-citationPancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure
Eizirik, D. L., Pasquali, L., & Cnop, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0355-7 · Cited by 854 · see citing works
Doherty, J., & Baehrecke, E. H. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0201-5 · Cited by 626 · see citing works
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Berglund, E., Maaskola, J., Schultz, N., Friedrich, S., Marklund, M., Bergenstråhle, J., Tarish, F., Tanoglidi, A., Vicković, S., Larsson, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04724-5 · Cited by 550 · see citing works
Drugging the efferocytosis process: concepts and opportunities
Mehrotra, P., & Ravichandran, K. S. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00470-y · Cited by 459 · see citing works
Efferocytosis Signaling in the Regulation of Macrophage Inflammatory Responses
Elliott, M. R., Koster, K. M., & Murphy, P. S. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601520 · Cited by 440 · see citing works
Cell death in the gut epithelium and implications for chronic inflammation
Patankar, J. V., & Becker, C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0326-4 · Cited by 421 · see citing works
An, Y., Zhang, H., Wang, C., Jiao, F., Xu, H., Wang, X., Luan, W., Ma, F., Ni, L., Tang, X., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802805rr · Cited by 409 · see citing works
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I., et al. (2016) · Aging · doi:10.18632/aging.100991 · Cited by 357 · see citing works
The concept of intrinsic versus extrinsic apoptosis
Lossi, L. (2022) · Biochemical Journal · doi:10.1042/bcj20210854 · Cited by 355 · see citing works
Moretti, J., Roy, S., Bozec, D., Martinez, J., Chapman, J. R., Ueberheide, B. M., Lamming, D. W., Chen, Z. J., Horng, T., Yeretssian, G., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.034 · Cited by 329 · see citing works
Self-citationArterial ageing: from endothelial dysfunction to vascular calcification
Tesauro, M., Mauriello, A., Rovella, V., Annicchiarico‐Petruzzelli, M., Cardillo, C., Melino, G., & Daniele, N. D. (2017) · Journal of Internal Medicine · doi:10.1111/joim.12605 · Cited by 324 · see citing works
Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
Plaza-Zabala, A., Sierra-Torre, V., & Sierra, A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030598 · Cited by 323 · see citing works
The Dynamics of Apoptotic Cell Clearance
Elliott, M. R., & Ravichandran, K. S. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.06.029 · Cited by 314 · see citing works
Кологривова, И. В., Штатолкина, М. А., Суслова, Т. Е., & Ryabov, V. V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.664457 · Cited by 319 · see citing works
Phagocytosis in the Brain: Homeostasis and Disease
Galloway, D. A., Phillips, A. E. M., Owen, D. R., & Moore, C. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00790 · Cited by 304 · see citing works
Phagocytosis of Apoptotic Cells in Resolution of Inflammation
Kourtzelis, I., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00553 · Cited by 301 · see citing works
Flores, A. M., Hosseini-Nassab, N., Jarr, K.-U., Ye, J., Zhu, X., Wirka, R. C., Koh, A. L., Tsantilas, P., Wang, Y., Nanda, V., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-019-0619-3 · Cited by 289 · see citing works
The immune response to secondary necrotic cells
Sachet, M., Liang, Y. Y., & Oehler, R. (2017) · Apoptosis · doi:10.1007/s10495-017-1413-z · Cited by 282 · see citing works
Ferroptosis and Necroptosis in the Kidney
Belavgeni, A., Meyer, C., Stumpf, J., Hugo, C., & Linkermann, A. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.03.016 · Cited by 279 · see citing works
Tipping the immunostimulatory and inhibitory DAMP balance to harness immunogenic cell death
Hayashi, K., Nikolos, F., Lee, Y. C., Jain, A., Tsouko, E., Gao, H., Kasabyan, A., Leung, H. E., Osipov, A., Jung, S. Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19970-9 · Cited by 275 · see citing works
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Loving, B. A., & Bruce, K. D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00393 · Cited by 255 · see citing works
Blame the signaling: Role of cAMP for the resolution of inflammation
Tavares, L. P., Negreiros-Lima, G. L., Lima, K. M., Silva, P., Pinho, V., Teixeira, M. M., & Sousa, L. P. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105030 · Cited by 205 · see citing works
Henson, P. M. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125315 · Cited by 208 · see citing works
Kim, S. M., Nguyen, T. T., Ravi, A., Kubiniok, P., Finicle, B. T., Jayashankar, V., Malacrida, L., Hou, J., Robertson, J., Gao, D., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1215 · Cited by 199 · see citing works
Advances in mechanism and regulation of PANoptosis: Prospects in disease treatment
Zhu, P., Ke, Z.-R., Chen, J.-X., Li, S., Ma, T., & Fan, X.-L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1120034 · Cited by 194 · see citing works
I mmunosenescence and Inflammaging: Risk Factors of Severe COVID-19 in Older People
Pietrobon, A. J., Teixeira, F. M. E., & Sato, M. N. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.579220 · Cited by 185 · see citing works
Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?
Janda, E., Boi, L., & Carta, A. R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00144 · Cited by 175 · see citing works
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
De Maeyer, R. P. H., van de Merwe, R. C., Louie, R., Bracken, O. V., Devine, O. P., Goldstein, D. R., Uddin, M., Akbar, A. N., & Gilroy, D. W. (2020) · Nature Immunology · doi:10.1038/s41590-020-0646-0 · Cited by 182 · see citing works
Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation
Kim, E. H., Wong, S., & Martinez, J. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0179-3 · Cited by 176 · see citing works
Self-citationThe role of neutrophil death in chronic inflammation and cancer
Brostjan, C., & Oehler, R. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-0255-6 · Cited by 174 · see citing works
Citrobacter rodentium–host–microbiota interactions: immunity, bioenergetics and metabolism
Mullineaux-Sanders, C., Sanchez‐Garrido, J., Hopkins, E. G. D., Shenoy, A. R., Barry, R. E., & Frankel, G. M. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0252-z · Cited by 170 · see citing works
Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications
Fucikova, J. P., Palová-Jelínková, L., Bartůňková, J., & Špíšek, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02393 · Cited by 172 · see citing works
PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment
Gao, J., Xiong, A., Liu, J., Li, X., Wang, J., Zhang, L., Liu, Y., Xiong, Y., Li, G., & He, X. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-024-00765-9 · Cited by 172 · see citing works
Horiguchi, H., Loftus, T. J., Hawkins, R. B., Raymond, S. L., Stortz, J. A., Hollen, M. K., Weiss, B. P., Miller, E. S., Bihorac, A., Larson, S. D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00595 · Cited by 164 · see citing works
Macrophages in vascular inflammation and atherosclerosis
Cochain, C., & Zernecke, A. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1941-y · Cited by 164 · see citing works
Günther, J., & Seyfert, H. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0701-1 · Cited by 160 · see citing works
Zheng, Y., Han, Y., Sun, Q., & Li, Z. (2022) · Exploration · doi:10.1002/exp.20210166 · Cited by 151 · see citing works
Peroxisome proliferator-activated receptor agonists and antagonists: a patent review (2014-present)
Takada, I., & Makishima, M. (2019) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2020.1703952 · Cited by 146 · see citing works
Different types of cell death and their shift in shaping disease
Shen, S., Shao, Y., & Li, C. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01581-0 · Cited by 146 · see citing works
Lysosomal Cholesterol Hydrolysis Couples Efferocytosis to Anti-Inflammatory Oxysterol Production
Viaud, M., Ivanov, S., Vujić, N., Duta-Mare, M., Aira, L., Barouillet, T., Garcia, E., Orange, F., Dugail, I., Hainault, I., et al. (2018) · Circulation Research · doi:10.1161/circresaha.117.312333 · Cited by 120 · see citing works
Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms
Tajbakhsh, A., Rezaee, M., Kovanen, P. T., & Sahebkar, A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.003 · Cited by 134 · see citing works
The Role of Efferocytosis in Autoimmune Diseases
Abdolmaleki, F., Farahani, N., Hayat, S. M. G., Pirro, M., Bianconi, V., Barreto, G. E., & Sahebkar, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01645 · Cited by 125 · see citing works
TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease
Lu, J., Zhou, W., Dou, F., Wang, C., & Yu, Z. (2021) · The EMBO Reports · doi:10.15252/embr.202052013 · Cited by 121 · see citing works
Immune aging in diabetes and its implications in wound healing
Moura, J., Madureira, P., Leal, E. C., Fonseca, A. C., & Carvalho, E. (2019) · Clinical Immunology · doi:10.1016/j.clim.2019.02.002 · Cited by 116 · see citing works
The Origins and Functions of Tissue-Resident Macrophages in Kidney Development
Munro, D. A. D., & Hughes, J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00837 · Cited by 118 · see citing works
Endoplasmic Reticulum Stress Signaling and Neuronal Cell Death
Merighi, A., & Lossi, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315186 · Cited by 116 · see citing works
Interplay between Cell Death and Cell Proliferation Reveals New Strategies for Cancer Therapy
Loftus, L. V., Amend, S. R., & Pienta, K. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094723 · Cited by 112 · see citing works
Campana, L., Starkey Lewis, P. J., Pellicoro, A., Aucott, R. L., Man, J., O’Duibhir, E., Mok, S. E., Ferreira-Gonzalez, S., Livingstone, E., Greenhalgh, S. N., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701247 · Cited by 107 · see citing works
Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway
Perry, J. S. A., Morioka, S., Medina, C. B., Etchegaray, J. I., Barron, B. J., Raymond, M. H., Lucas, C. D., Önengüt-Gümüşcü, S., Delpire, E. J., & Ravichandran, K. S. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0431-1 · Cited by 105 · see citing works
GSDME and its role in cancer: From behind the scenes to the front of the stage
Schutter, E. D., Croes, L., Ibrahim, J., Pauwels, P., de Beeck, K. O., Vandenabeele, P., & Camp, G. V. (2020) · International Journal of Cancer · doi:10.1002/ijc.33390 · Cited by 100 · see citing works
Immune responses in the Parkinson's disease brain
Weiss, F. C., Labrador‐Garrido, A., Dzamko, N. L., & Halliday, G. M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105700 · Cited by 97 · see citing works
Kyrmizi, I., Ferreira, H., Carvalho, A., Figueroa, J. A. L., Zarmpas, P., Cunha, C., Akoumianaki, T., Stylianou, K., Deepe, G. S., Samonis, G., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0167-x · Cited by 96 · see citing works
Cellular Uptake Pathways of Nanoparticles: Process of Endocytosis and Factors Affecting their Fate
Varma, S. K., Dey, S., & Palanisamy, D. (2021) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201022666210714145356 · Cited by 85 · see citing works
Exosomes and Other Extracellular Vesicles in HPV Transmission and Carcinogenesis
Guenat, D., Hermetet, F., Prétet, J., & Mougin, C. (2017) · Viruses · doi:10.3390/v9080211 · Cited by 80 · see citing works
Maxed out macs: physiologic cell clearance as a function of macrophage phagocytic capacity
Zent, C. S., & Elliott, M. R. (2016) · FEBS Journal · doi:10.1111/febs.13961 · Cited by 79 · see citing works
Contribution of Macrophage Efferocytosis to Liver Homeostasis and Disease
Horst, A., Tiegs, G., & Diehl, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02670 · Cited by 66 · see citing works
The role of regulated necrosis in endocrine diseases
Tonnus, W., Belavgeni, A., Beuschlein, F., Eisenhofer, G., Faßnacht, M., Kroiß, M., Krone, N. P., Reincke, M., Bornstein, S. R., & Linkermann, A. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00499-w · Cited by 72 · see citing works
Non-professional phagocytosis: a general feature of normal tissue cells
Seeberg, J. C., Loibl, M., Moser, F., Schwegler, M., Büttner-Herold, M. J., Daniel, C., Engel, F. B., Hartmann, A., Schlötzer-Schrehardt, U. M., Goppelt‐Struebe, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48370-3 · Cited by 70 · see citing works
Ethanol-Induced Neurodegeneration and Glial Activation in the Developing Brain
Saito, M., Chakraborty, G., Hui, M., Masiello, K., & Saito, M. (2016) · Brain Sciences · doi:10.3390/brainsci6030031 · Cited by 69 · see citing works
Autophagy-activating strategies to promote innate defense against mycobacteria
Kim, Y. S., Silwal, P., Kim, S. Y., Yoshimori, T., & Jo, E. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0290-7 · Cited by 70 · see citing works
Optogenetic activators of apoptosis, necroptosis, and pyroptosis
Shkarina, K., Hasel, E., Santos, J. C., Ramos, S., Leptin, M., & Brož, P. (2022) · The Journal of Cell Biology · doi:10.1083/jcb.202109038 · Cited by 69 · see citing works
Stepanov, Y. V., Golovynska, I., Zhang, R., Golovynskyi, S., Stepanova, L. I., Gorbach, O. I., Dovbynchuk, T., Garmanchuk, L., Ohulchanskyy, T. Y., & Qu, J. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-01022-7 · Cited by 68 · see citing works
The mTOR–lysosome axis at the centre of ageing
Carosi, J. M., Fourrier, C., Bensalem, J., & Sargeant, T. J. (2021) · FEBS Open Bio · doi:10.1002/2211-5463.13347 · Cited by 66 · see citing works
Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis
Torres, A., Gubbiotti, M. A., & Iozzo, R. V. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.753632 · Cited by 63 · see citing works
Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
Wang, L., Li, H., Tang, Y., & Yao, P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.585285 · Cited by 62 · see citing works
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Du, X., Huo, X., Yang, Y., Hu, Z., Botchway, B. O. A., Jiang, Y., & Fang, M. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.08.082 · Cited by 63 · see citing works
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Karaji, N., & Sattentau, Q. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01863 · Cited by 61 · see citing works
LAP it up, fuzz ball: a short history of LC3-associated phagocytosis
Martinez, J. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.09.011 · Cited by 59 · see citing works
Self-citationThe role of P2Y receptors in regulating immunity and metabolism
Lovászi, M., Haas, C. B., Antonioli, L., Pacher, P., & Haskó, G. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114419 · Cited by 57 · see citing works
Validation of Induced Microglia-Like Cells (iMG Cells) for Future Studies of Brain Diseases
Banerjee, A., Lu, Y., Do, K., Mize, T. J., Wu, X., Chen, X., & Chen, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.629279 · Cited by 55 · see citing works
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Anderton, H., & Alqudah, S. (2022) · Biochemical Journal · doi:10.1042/bcj20210606 · Cited by 61 · see citing works
The Role of BCL-2 Family Members in Acute Kidney Injury
Borkan, S. C. (2016) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2016.04.001 · Cited by 56 · see citing works
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Jung, M., Weigert, A., Mertens, C., Rehwald, C., & Brüne, B. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01171 · Cited by 54 · see citing works
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Singh, A. P., Chen, W., Zheng, X., Mody, H. R., Carpenter, T. J., Zong, A., & Heald, D. (2021) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12598 · Cited by 56 · see citing works
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Shi, J., Wu, X., Wang, Z., Li, F., Meng, Y., Moore, R. M., Cui, J. G., Xue, C., Croce, K. R., Yurdagul, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35604-8 · Cited by 54 · see citing works
Liu, P., Bao, H., Jin, C., Zhou, J., Hua, F., Li, K., Lv, X., Cui, B., Hu, Z., & Zhang, X. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012338 · Cited by 55 · see citing works
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Andoh, M., & Koyama, R. (2021) · Cells · doi:10.3390/cells10102555 · Cited by 52 · see citing works
Belizário, J. E., Neyra, J. M., & Rodrigues, M. F. S. D. (2018) · Innate Immunity · doi:10.1177/1753425918800200 · Cited by 51 · see citing works
Blume, Z. I., Lambert, J. M., Lovel, A. G., & Mitchell, D. M. (2020) · Developmental Dynamics · doi:10.1002/dvdy.163 · Cited by 51 · see citing works
Asare, P. F., Roscioli, E., Hurtado, P. R., Tran, H. B., Mah, C. Y., & Hodge, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01298 · Cited by 50 · see citing works
Ishtiaq, S. M., Arshad, M. I., & Khan, J. A. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108298 · Cited by 49 · see citing works
Clearance of apoptotic cells by neutrophils in inflammation and cancer
Ramos, C., & Oehler, R. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01809-7 · Cited by 49 · see citing works
Wei, D., Jiang, M., Lin, P., Yang, H., Dang, Y., Qiao, Y., Liao, D., Luo, D., & Chen, G. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4660 · Cited by 48 · see citing works
Myeloid Populations in Systemic Autoimmune Diseases
Morell, M. H., Varela, N., & Marañón, C. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-017-8606-7 · Cited by 47 · see citing works
Regulated cell death pathways in the sodium iodate model: Insights and implications for AMD
Upadhyay, M., & Bonilha, V. L. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109728 · Cited by 48 · see citing works
Félix, F. B., Vago, J. P., Fernandes, D. D. O., Martins, D. G., Zaidan, I., Gonçalves, W. A., Costa, W. C., Araújo, J. M. D., Queiroz‐Junior, C. M., Campolina-Silva, G. H., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.662308 · Cited by 44 · see citing works
Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance
Pinney, J. J., Rivera‐Escalera, F., Chu, C. C., Whitehead, H. E., VanDerMeid, K. R., Nelson, A. M., Barbeau, M. C., Zent, C. S., & Elliott, M. R. (2020) · Blood · doi:10.1182/blood.2020005571 · Cited by 44 · see citing works
Megakaryocyte emperipolesis: a new frontier in cell-in-cell interaction
Cunin, P., & Nigrovic, P. A. (2019) · Platelets · doi:10.1080/09537104.2019.1693035 · Cited by 44 · see citing works
Biomaterials delivery strategies to repair spinal cord injury by modulating macrophage phenotypes
Xia, Y., Yang, R., Wang, H., Hou, Y., Li, Y., Zhu, J., Xu, F., & Fu, C. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221143059 · Cited by 44 · see citing works
Leishmania donovani Induces Autophagy in Human Blood–Derived Neutrophils
Pitale, D. M., Gendalur, N. S., Descoteaux, A., & Shaha, C. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801053 · Cited by 41 · see citing works
Episodic β‐cell death and dedifferentiation during diet‐induced obesity and dysglycemia in male mice
Tersey, S. A., Levasseur, E. M., Syed, F., Farb, T. B., Orr, K. S., Nelson, J. B., Shaw, J. L., Bokvist, K. B., Mather, K. J., & Mirmira, R. G. (2018) · The FASEB Journal · doi:10.1096/fj.201800150rr · Cited by 40 · see citing works
Kim, T., James, B. T., Kahn, M. C., Blanco‐Duque, C., Abdurrob, F., Islam, R., Lavoie, N., Kellis, M., & Tsai, L. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adf4601 · Cited by 41 · see citing works
Biomarkers and Associated Immune Mechanisms for Early Detection and Therapeutic Management of Sepsis
Trzeciak, A. J., Pietropaoli, A. P., & Kim, M. (2020) · Immune Network · doi:10.4110/in.2020.20.e23 · Cited by 51 · see citing works
Crbn modulates calcium influx by regulating Orai1 during efferocytosis
Moon, H., Min, C., Kim, G., Kim, D., Kim, K., Lee, S.-A., Moon, B., Yang, S., Lee, J., Yang, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19272-0 · Cited by 41 · see citing works
- Authors
- Green, D. R., Oguin, T. H., & Martinez, J.
- Affiliations
- St. Jude Children's Research Hospital (US)
- National Institutes of Health (US)
- Corresponding author
- Martinez, J
- Venue
- Cell Death & Differentiation
- Published
- 2016-03-18
- Volume
- 23
- Issue
- 6
- Pages
- 915-926
- ISSN
- 1350-9047 (ISSN-L)
- 1476-5403
- PMC
- PMC4987729
- OpenAlex
- W2297172779
- Cited by
- 314
- References
- 207
- Citations by year
- 2026: 18 · 2025: 26 · 2024: 30 · 2023: 32 · 2022: 40 · 2021: 41 · 2020: 35 · 2019: 28 · 2018: 26 · 2017: 26 · 2016: 12
- FWCI
- 2.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell Death and Differentiation (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI040646)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- efferocytosis, LC3-associated phagocytosis, autophagy machinery, phagocytes, systemic lupus erythematosus, autoimmune disease, innate immunity
- MeSH terms
- Autophagy-Related Proteins, Animals, Autoimmune Diseases, Humans, Inflammation, Microtubule-Associated Proteins, Phagocytes, Phagocytosis, Signal Transduction, Cytokines, Apoptosis, Reactive Oxygen Species
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