Cited by 57Biosensors and Analytical DetectionAntifungal resistance and susceptibilityBacterial Identification and Susceptibility Testing

Advances in Candida detection platforms for clinical and point-of-care applications

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Safavieh, Mohammadali, Coarsey, Chad, Esiobu, Nwadiuto, Memic, Adnan, Vyas, Jatin Mahesh, Shafiee, Hadi, Asghar, Waseem·2017·Critical Reviews in Biotechnology

Abstract

Invasive candidiasis remains one of the most serious community and healthcare-acquired infections worldwide. Conventional Candida detection methods based on blood and plate culture are time-consuming and require at least 2-4 days to identify various Candida species. Despite considerable advances for candidiasis detection, the development of simple, compact and portable point-of-care diagnostics for rapid and precise testing that automatically performs cell lysis, nucleic acid extraction, purification and detection still remains a challenge. Here, we systematically review most prominent conventional and nonconventional techniques for the detection of various Candida species, including Candida staining, blood culture, serological testing and nucleic acid-based analysis. We also discuss the most advanced lab on a chip devices for candida detection.

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Crossref · 10.3109/07388551.2016.1167667

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  • Because it generally takes at least 2-4 days after blood culture collection to detect and identify Candida species, and because access to AFST may be limited or delayed, clinicians usually select initial antifungal treatment based on local species epidemiology, antifungal resistance patterns, and individual patient factors.

    “Because it generally takes at least 2–4 days after blood culture collection to detect and identify Candida species, and because access to AFST may be limited or delayed, clinicians usually select initial antifungal treatment based on local species epidemiology, antifungal resistance patterns, and individual patient factors [13–16].”

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Research works printed but not linked: 2

  1. [12]Murray PR Rosenthal KS Pfaller MA Opportunistic mycoses/candidiasis Medical microbiology 44 7 Philadelphia, PA Elsevier Saunders 2013 6776 6783
  2. [87]Medical microbiology 7 Philadelphia, PA Elsevier Saunders 2013

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Authors
Safavieh, M., Coarsey, C., Esiobu, N., Memic, A., Vyas, J. M., Shafiee, H., & Asghar, W.
Affiliations
  • Brigham and Women's Hospital (US)
  • Florida Atlantic University (US)
  • Massachusetts General Hospital (US)
Corresponding author
  • Shafiee, Hadi
  • Asghar, Waseem
Venue
Critical Reviews in Biotechnology
Published
2016-04-19
Volume
37
Issue
4
Pages
441-458
ISSN
  • 0738-8551 (ISSN-L)
  • 1549-7801
OpenAlex
W2336043212
Cited by
57
References
165
Citations by year
2026: 2 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 6 · 2021: 13 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 4
FWCI
0.41
Type
journal article
Language
en
Open access
Locations
  • Critical Reviews in Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (F1F32AI102590,R01AI118502)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Keywords
Candida detection, invasive candidiasis, point-of-care testing, lab-on-a-chip, blood culture, serological testing, nucleic acid detection, portable diagnostic device
MeSH terms
Point-of-Care Testing, Candida albicans, Candidiasis, Cross Infection, Humans, Point-of-Care Systems, Lab-On-A-Chip Devices

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