The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Synovial fibroblasts spread rheumatoid arthritis to unaffected joints
Open accessAbstract
Active rheumatoid arthritis originates from few joints but subsequently affects the majority of joints. Thus far, the pathways of the progression of the disease are largely unknown. As rheumatoid arthritis synovial fibroblasts (RASFs) which can be found in RA synovium are key players in joint destruction and are able to migrate in vitro, we evaluated the potential of RASFs to spread the disease in vivo. To simulate the primary joint of origin, we implanted healthy human cartilage together with RASFs subcutaneously into severe combined immunodeficient (SCID) mice. At the contralateral flank, we implanted healthy cartilage without cells. RASFs showed an active movement to the naive cartilage via the vasculature independent of the site of application of RASFs into the SCID mouse, leading to a marked destruction of the target cartilage. These findings support the hypothesis that the characteristic clinical phenomenon of destructive arthritis spreading between joints is mediated, at least in part, by the transmigration of activated RASFs.
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Cites
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Self-citationHow severe must repetitive loading be to kill chondrocytes in articular cartilage?
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The Pathogenesis of Rheumatoid Arthritis
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Pang, X., He, X., Qiu, Z., Zhang, H., Xie, R., Liu, Z., Gu, Y., Zhao, N., Xiang, Q., & Cui, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01259-6 · Cited by 1,275
Immunopathogenesis of Rheumatoid Arthritis
Firestein, G. S., & McInnes, I. B. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.006 · Cited by 1,301
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Lin, Y.-J., Anzaghe, M., & Schülke, S. (2020) · Cells · doi:10.3390/cells9040880 · Cited by 932
Osteoimmunology: The conceptual framework unifying the immune and skeletal systems
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The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting
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Role of Ion Channels and Transporters in Cell Migration
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Dysregulated bioenergetics: a key regulator of joint inflammation
Biniecka, M., Canavan, M., McGarry, T., Gao, W., McCormick, J., Cregan, S., Gallagher, L., Smith, T., Phelan, J. J., Ryan, J., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-208476 · Cited by 236
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Arthritis and the role of endogenous glucocorticoids
Macfarlane, E., Seibel, M. J., & Zhou, H. (2020) · Bone Research · doi:10.1038/s41413-020-00112-2 · Cited by 64
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Metadata
- Authors
- Lefèvre, S., Knedla, A., Tennie, C., Kampmann, A., Wunrau, C., Dinser, R., Korb, A., Schnäker, E.-M., Tarner, I. H., Robbins, P. D., Evans, C. H., Stürz, H., Steinmeyer, J., Gay, S., Schölmerich, J., Pap, T., Müller-Ladner, U., & Neumann, E.
- Venue
- Nature Medicine
- Published
- 2009-11-08
- Volume
- 15
- Issue
- 12
- Pages
- 1414-1420
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1997131908
- Cited by
- 717
- References
- 3
- FWCI
- 33.82
- Type
- journal article
- Language
- en
- Open access
- green
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