A negative regulator of MAP kinase causes depressive behavior
Open accessAbstract
The lifetime prevalence (∼16%) and the economic burden ($100 billion annually) associated with major depressive disorder (MDD) make it one of the most common and debilitating neurobiological illnesses. To date, the exact cellular and molecular mechanisms underlying the pathophysiology of MDD have not been identified. Here we use whole-genome expression profiling of postmortem tissue and show significantly increased expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1, encoded by DUSP1, but hereafter called MKP-1) in the hippocampal subfields of subjects with MDD compared to matched controls. MKP-1, also known as dual-specificity phosphatase-1 (DUSP1), is a member of a family of proteins that dephosphorylate both threonine and tyrosine residues and thereby serves as a key negative regulator of the MAPK cascade, a major signaling pathway involved in neuronal plasticity, function and survival. We tested the role of altered MKP-1 expression in rat and mouse models of depression and found that increased hippocampal MKP-1 expression, as a result of stress or viral-mediated gene transfer, causes depressive behaviors. Conversely, chronic antidepressant treatment normalizes stress-induced MKP-1 expression and behavior, and mice lacking MKP-1 are resilient to stress. These postmortem and preclinical studies identify MKP-1 as a key factor in MDD pathophysiology and as a new target for therapeutic interventions.
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Stress and depression disrupt brain-derived neurotrophic factor-tropomyosin-related kinase B receptor signaling, including reductions of the downstream extracellular signal-regulated kinase and Akt pathways in the hippocampus and prefrontal cortex.
“Stress and depression also disrupt BDNF–tropomyosinrelated kinase B (TrkB) receptor signaling, including reductions of the downstream extracellular signal–regulated kinase (ERK) and Akt pathways in the hippocampus and PFC (24, 34).”
From Synaptic Dysfunction in Depression: Potential Therapeutic Targets (2012) · cites this paper as [34]
The paper’s main-text discussion of MAP kinase signaling (page not provided) reports reduced ERK2 and BDNF expression in hippocampal subfields of subjects with major depressive disorder, supporting the hippocampal ERK portion of the claim. It does not report reduced Akt signaling or demonstrate disrupted BDNF–TrkB receptor signaling in both the hippocampus and prefrontal cortex; it says stress did not alter Mkp-1 expression in the cortex. (LLM, conf=0.87)
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Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515 · see citing works
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087 · see citing works
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016 · see citing works
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works
The Economic Burden of Depression in the United States: How Did It Change Between 1990 and 2000?
Greenberg, P. E., Kessler, R. C., Birnbaum, H. G., Leong, S. A., Lowe, S. W., Berglund, P. A., & Corey-Lisle, P. K. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n1211 · Cited by 1,280 · see citing works
Gold, P. W., & Chrousos, G. P. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001032 · Cited by 1,274 · see citing works
Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
Watanabe, Y., Gould, E., & McEwen, B. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91597-8 · Cited by 1,212 · see citing works
Untreated Depression and Hippocampal Volume Loss
Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180 · see citing works
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works
The stress system in the human brain in depression and neurodegeneration
Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
Cellular changes in the postmortem hippocampus in major depression
Stockmeier, C. A., Mahajan, G. J., Konick, L. C., Overholser, J. C., Jurjus, G. J., Meltzer, H. Y., Uylings, H. B. M., Friedman, L., & Rajkowska, G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.022 · Cited by 732 · see citing works
Self-citationFunctional anatomical abnormalities in limbic and prefrontal cortical structures in major depression
Drevets, W. C. (2000) · Progress in Brain Research · doi:10.1016/s0079-6123(00)26027-5 · Cited by 659 · see citing works
Schmidt, H. D., & Duman, R. S. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 649 · see citing works
Self-citationOxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase
Keyse, S. M., & Emslie, E. (1992) · Nature · doi:10.1038/359644a0 · Cited by 640 · see citing works
Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors
Banasr, M., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.008 · Cited by 606 · see citing works
Self-citationKarege, F., Vaudan, G., Schwald, M., Perroud, N., & La Harpe, R. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.020 · Cited by 600 · see citing works
Extracellular-signal-regulated kinase signalling in neurons
Grewal, S., York, R. D., & Stork, P. A. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00010-0 · Cited by 555 · see citing works
Targeting dual-specificity phosphatases: Manipulating MAP kinase signalling and immune responses
Jeffrey, K. L., Camps, M., Rommel, C., & Mackay, C. R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2289 · Cited by 533 · see citing works
The Role of the Extracellular Signal-Regulated Kinase Signaling Pathway in Mood Modulation
Einat, H., Yuan, P., Gould, T. D., Li, J., Du, J., Zhang, L., Manji, H. K., & Chen, G. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07311.2003 · Cited by 475 · see citing works
Banasr, M., Chowdhury, G. M. I., Terwilliger, R., Newton, S. S., Duman, R. S., Behar, K. L., & Sanacora, G. (2010) · Molecular Psychiatry · doi:10.1038/mp.2008.106 · Cited by 458 · see citing works
Self-citationSocial and economic burden of mood disorders
Simon, G. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00420-7 · Cited by 430 · see citing works
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works
Self-citationDwivedi, Y., Rizavi, H. S., Roberts, R. C., Conley, R. C., Tamminga, C. A., & Pandey, G. N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00300.x · Cited by 333 · see citing works
Magariños, A. M., Deslandes, A., & McEwen, B. S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00163-6 · Cited by 330 · see citing works
Neumeister, A., Wood, S. E., Bonne, O. B., Nugent, A. C., Luckenbaugh, D. A., Young, T. A., Bain, E., Charney, D. S., & Drevets, W. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.016 · Cited by 276 · see citing works
Fukunaga, K., & Miyamoto, E. (1998) · Molecular Neurobiology · doi:10.1007/bf02740604 · Cited by 256 · see citing works
Wu, J., Flach, R. J. R., Anderson, E. J., Hong, E., Lee, M., Choi, C. S., Neufer, P. D., Shulman, G. I., Kim, J. K., & Bennett, A. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.010 · Cited by 212 · see citing works
Dorfman, K. S., Carrasco, D., Gruda, M. C., Ryan, C., Lira, S. A., & Bravo, R. (1996) · PubMed · Cited by 207 · see citing works
Hsiung, S., Adlersberg, M., Arango, V., Mann, J. J., Tamir, H., & Liu, K. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01987.x · Cited by 156 · see citing works
Laderoute, K. R., Mendonca, H. L., Calaoagan, J. M., Knapp, A. M., Giaccia, A. J., & Stork, P. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.18.12890 · Cited by 126 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., & Pandey, G. N. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001744 · Cited by 123 · see citing works
Suicide Brain Is Associated with Decreased Expression of Neurotrophins
Dwivedi, Y., Mondal, A. C., Rizavi, H. S., & Conley, R. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.014 · Cited by 120 · see citing works
Engel, S. R., Creson, T. K., Hao, Y., Shen, Y., Maeng, S., Nekrasova, T., Landreth, G. E., Manji, H. K., & Chen, G. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002135 · Cited by 118 · see citing works
A role for the extracellular signal-regulated kinase signal pathway in depressive-like behavior
Qi, X., Lin, W., Wang, D., Pan, Y., Wang, W., & Sun, M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.051 · Cited by 84 · see citing works
Seta, K. A., Kim, R., Kim, H., Millhorn, D. E., & Beitner‐Johnson, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103346200 · Cited by 74 · see citing works
Creson, T. K., Hao, Y., Engel, S. R., Shen, Y., Hamidi, A., Zhuo, M., Manji, H. K., & Chen, G. (2009) · Bipolar Disorders · doi:10.1111/j.1399-5618.2009.00697.x · Cited by 18 · see citing works
Limbic control of endocrine glands in aged rats
Verkhratsky, N. S. (1995) · Experimental Gerontology · doi:10.1016/0531-5565(94)00056-9 · Cited by 5 · see citing works
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Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works
Self-citationSynaptic Dysfunction in Depression: Potential Therapeutic Targets
Duman, R. S., & Aghajanian, G. K. (2012) · Science · doi:10.1126/science.1222939 · Cited by 1,651 · see citing works
Self-citationDuman, R. S., & Voleti, B. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.004 · Cited by 714 · see citing works
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Self-citationIwata, M., Ota, K. T., Li, X.-Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.11.026 · Cited by 387 · see citing works
Self-citationDuman, R. S., Deyama, S., & Fogaça, M. V. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14630 · Cited by 321 · see citing works
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Vialou, V., Feng, J., Robison, A. J., & Nestler, E. J. (2013) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010611-134540 · Cited by 277 · see citing works
Cobb, J. A., O’Neill, K., Milner, J., Mahajan, G. J., Lawrence, T. J., May, W. L., Miguel-Hidalgo, J., Rajkowska, G., & Stockmeier, C. A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.044 · Cited by 254 · see citing works
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Gold, P. W., Machado-Vieira, R., & Pavlatou, M. G. (2015) · Neural Plasticity · doi:10.1155/2015/581976 · Cited by 259 · see citing works
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Abe-Higuchi, N., Uchida, S., Yamagata, H., Higuchi, F., Hobara, T., Hara, K., Kobayashi, A., & Watanabe, Y. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.009 · Cited by 247 · see citing works
Alboni, S., van Dijk, R. M., Poggini, S., Milior, G., Perrotta, M., Drenth, T., Brunello, N., Wolfer, D. P., Limatola, C., Amrein, I., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2015.142 · Cited by 207 · see citing works
Descalzi, G., Mitsi, V., Purushothaman, I., Gaspari, S., Avrampou, K., Loh, Y.-H. E., Shen, L., & Zachariou, V. (2017) · Science Signaling · doi:10.1126/scisignal.aaj1549 · Cited by 188 · see citing works
Menke, A., Arloth, J., Pütz, B., Weber, P., Klengel, T., Mehta, D., Gonik, M., Rex-Haffner, M., Rubel, J., Uhr, M., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.331 · Cited by 177 · see citing works
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Self-citationJefsen, O. H., Elfving, B., Wegener, G., & Müller, H. K. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881120959614 · Cited by 127 · see citing works
Kim, Y.-K., Kim, O. Y., & Song, J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01270 · Cited by 109 · see citing works
Son, H., Banasr, M., Choi, M., Chae, S. Y., Licznerski, P., Lee, B., Voleti, B., Li, N., Lepack, A., Fournier, N. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201191109 · Cited by 103 · see citing works
Self-citationWoodburn, S. C., Bollinger, J. L., & Wohleb, E. S. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100312 · Cited by 100 · see citing works
Ota, K. T., & Duman, R. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.022 · Cited by 94 · see citing works
Self-citationLicznerski, P., Duric, V., Banasr, M., Alavian, K. N., Ota, K. T., Kang, H. J., Jonas, E. A., Ursano, R., Krystal, J. H., Duman, R. S., et al. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002282 · Cited by 79 · see citing works
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Wei, L., Simen, A., Mane, S., & Kaffman, A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.239 · Cited by 71 · see citing works
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Hauger, R. L., Olivares-Reyes, J. A., Dautzenberg, F. M., Lohr, J. B., Braun, S., & Oakley, R. H. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.11.007 · Cited by 71 · see citing works
Zhang, Y., Mao, R.-R., Chen, Z.-F., Tian, M., Tong, D.-L., Gao, Z.-R., Huang, M., Li, X., Xu, X., Zhou, W.-H., et al. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-11 · Cited by 69 · see citing works
Limon, A., Mamdani, F., Hjelm, B. E., Vawter, M. P., & Sequeira, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.010 · Cited by 63 · see citing works
Schiweck, C., Claes, S., Van Oudenhove, L., Lafit, G., Vaessen, T., de Beeck, G. O., Berghmans, R., Wijkhuijs, A., Müller, N., Arolt, V., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00979-z · Cited by 59 · see citing works
Patrício, P., Mateus-Pinheiro, A., Irmler, M., Alves, N. D., Machado-Santos, A. R., Morais, M., Correia, J. S., Korostynski, M., Piechota, M., Stoffel, R., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.176 · Cited by 57 · see citing works
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- Authors
- Duric, V., Banasr, M., Licznerski, P., Schmidt, H. D., Stockmeier, C. A., Simen, A. A., Newton, S. S., & Duman, R. S.
- Affiliations
- Yale University (US)
- University of Mississippi Medical Center (US)
- Corresponding author
- Duman, Ronald S
- ORCID
- Venue
- Nature Medicine
- Published
- 2010-10-17
- Volume
- 16
- Issue
- 11
- Pages
- 1328-1332
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC3066515
- OpenAlex
- W2060035717
- Cited by
- 412
- References
- 41
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 14 · 2023: 19 · 2022: 19 · 2021: 34 · 2020: 40 · 2019: 21 · 2018: 22 · 2017: 30 · 2016: 31 · 2015: 32 · 2014: 24 · 2013: 24 · 2012: 31
- FWCI
- 22.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p20rr017701-10)
- National Institute of Mental Health (R01MH067996, MH67996, 2P01 MH25642, MH-45481, R37MH045481, P01MH025642, R01MH045481)
- National Center for Research Resources (P20-RR-017701, P20 RR 17701)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- MKP-1, major depressive disorder, depression, MAPK signaling, hippocampus, stress resilience, chronic antidepressant treatment, viral gene delivery, neuroplasticity, therapeutic target
- MeSH terms
- Dependovirus, Animals, Antidepressive Agents, Behavior, Animal, Depression, Disease Models, Animal, Female, Humans, Male, Postmortem Changes, Gene Expression Regulation, Enzymologic, Rats, Sprague-Dawley, Mice, Knockout, Oligonucleotide Array Sequence Analysis, Mice, Rats, Dual Specificity Phosphatase 1
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