Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression
Open accessAbstract
Dendritic spines provide a compartment for assembly and functional organization of synaptic machinery that plays a fundamental role in neuronal communication and neuroplasticity. Studies in humans as well as in animal models have demonstrated abnormal spine architecture in several psychiatric disorders, including depression and other stress-related illnesses. The negative impact of stress on the density and organization of spines is thought to contribute to the behavioral deficits caused by stress exposure. Moreover, there is now evidence that medication-induced recovery involves changes in synaptic plasticity and dendrite morphology, including increased expression of pre- and postsynaptic plasticity-related proteins, as well as the density and function of axo-spinous synapses. Here we review the evidence from brain imaging and postmortem studies demonstrating that depression is accompanied by structural and functional alterations of cortical and limbic brain regions, including the prefrontal cortex, hippocampus and amygdala. In addition, we present more direct evidence from basic research studies that exposure to stress alters spine morphology, function and plasticity and that antidepressants, particularly new rapid acting agents, reverse these effects. Elucidation of the signaling pathways and molecular mechanisms that control spine synapse assembly and plasticity will contribute to a better understanding of the pathophysiology of depression and development of novel, more effective therapeutic agents.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In postmortem major depression patients, hippocampal volume is reduced and glial cell numbers are increased.
“Congruent to this finding, in a postmortem analysis of MD patients, reduced densities and mean sizes of frontal cortex neurons and reduced hippocampal volume with increased numbers of glial cells are reported (Licznerski and Duman, 2013).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Licznerski and Duman, 2013
The postmortem studies section reports reduced hippocampal volume in MDD and a 30–35% increase in glial cell density in hippocampal cell layers. It does not report an increase in the total number of hippocampal glial cells; greater density does not establish greater numbers. (LLM, conf=0.86)
Experimental — accuracy not yet measuredAnimal models confirm that medication-induced recovery involves changes in plasticity, dendritic morphology and density, and synaptic function.
“Studies from animal models confirm that medication-induced recovery involves changes in plasticity, dendritic morphology and density and function of synapses (for review seeLicznerski and Duman, 2013).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Licznerski and Duman, 2013
Section 5 (Typical Antidepressants; page not supplied) reviews animal studies showing antidepressant-related changes in dendritic branching, spine density and synaptic plasticity. Section 7 (Summary and Future Directions; page not supplied) says antidepressants may work at least in part by reversing stress-related synaptic deficits. The claim’s assertion that animal models confirm these changes as part of medication-induced recovery is stronger than the review’s qualified conclusion. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn postmortem major depression patients, densities and mean sizes of frontal cortex neurons are reduced.
“Congruent to this finding, in a postmortem analysis of MD patients, reduced densities and mean sizes of frontal cortex neurons and reduced hippocampal volume with increased numbers of glial cells are reported (Licznerski and Duman, 2013).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Licznerski and Duman, 2013
There is evidence of vmPFC gray matter loss in mood disorders.
“There is evidence of vmPFC gray matter loss in mood disorders7,115,116, which implies dendritic atrophy.”
From Stress weakens prefrontal networks: molecular insults to higher cognition (2015) · cites this paper as [115]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.
Zarate, C. A., Singh, J. B., Carlson, P. J., Brutsche, N. E., Ameli, R., Luckenbaugh, D. A., Charney, D. S., & Manji, H. K. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.8.856 · Cited by 3,766 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Self-citationNestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
Self-citationStructural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416 · see citing works
Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms
Citri, A., & Malenka, R. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301559 · Cited by 2,323 · see citing works
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · cited 2× · see citing works
“…the exact functional correlates of altered hippocampal morphology in MDD. Neuroimaging studies have also reported disrupted functional correlates of the amygdala in MDD patients (Sheline et al., 2001; Siegle et al., 2002), including abnormally elevated glucose metabolism (Drevets et al., 2008).”
Kessler, R. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90026-g · Cited by 2,207 · cited 3× · see citing works
“Clinical trials show that risk of developing depression is two times higher in females compared to males (Kessler et al., 1993), a phenomenon also observed in preclinical studies (Dalla et al.”
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016 · see citing works
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
McEwen, B. S. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.11.071 · Cited by 1,864 · see citing works
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834 · cited 1× · see citing works
“1), which contributes to disturbances in perception of emotional cues and associated memories (LaBar and Cabeza, 2006).”
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works
Self-citationMoghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793 · see citing works
Vyas, A., Mitra, R., Shankaranarayana Rao, B. S., & Chattarji, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06810.2002 · Cited by 1,662 · see citing works
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636 · see citing works
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 1× · see citing works
“Synaptic activation can lead to spine plasticity via the insertion of glutamate receptors and spine enlargement, followed by reorganization of the postsynaptic density, which in turn strengthens synaptic connections (Matsuzaki et al., 2001).”
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00041-4 · Cited by 1,477 · see citing works
The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393 · see citing works
Phillips, M. L., Ladouceur, C. D., & Drevets, W. C. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.65 · Cited by 1,383 · see citing works
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340 · see citing works
Dunkel Schetter, C., & Tanner, L. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3283503680 · Cited by 1,268 · cited 3× · see citing works
“Please cite this article in press as: Licznerski P, Duman RS. Remodeling of axo Neuroscience (2012), http://dx.doi.org/10.1016/j.neuroscience.2012.09.057 Chronic stress and depression during pregnancy may result in preterm birth and lower body weight (Dunkel Schetter and Tanner, 2012), which in turn may lead to impair…”
InfluentialPatterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233 · see citing works
Sen, S., Duman, R., & Sanacora, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.005 · Cited by 1,232 · see citing works
Self-citationSheline, Y. I., Barch, D. M., Donnelly, J. M., Ollinger, J. M., Snyder, A. Z., & Mintun, M. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01263-x · Cited by 1,191 · see citing works
Untreated Depression and Hippocampal Volume Loss
Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180 · see citing works
Stress- and Allostasis-Induced Brain Plasticity
McEwen, B. S., & Gianaros, P. J. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-052209-100430 · Cited by 1,171 · see citing works
Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131 · see citing works
mTOR signaling: At the crossroads of plasticity, memory and disease
Hoeffer, C. A., & Klann, E. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.003 · Cited by 1,128 · see citing works
Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works
Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works
Self-citationPubertal hormones organize the adolescent brain and behavior
Sisk, C. L., & Zehr, J. L. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.003 · Cited by 1,082 · see citing works
Lemaire, V., Koehl, M., Le Moal, M., & Abrous, D. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11032 · Cited by 1,044 · cited 2× · see citing works
“Moreover, PNS causes a lifespan reduction in neurogenesis accompanied by impairments in hippocampal-dependent spatial tasks (Lemaire et al., 2000; Odagiri et al., 2008), with passive avoidance being especially affected in female PNS progeny (Gue et al.”
Woolley, C. S., Gould, E., & McEwen, B. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)90778-a · Cited by 1,020 · see citing works
Synaptic AMPA receptor plasticity and behavior
Kessels, H. W., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.015 · Cited by 993 · see citing works
Tanapat, P., Hastings, N. B., Reeves, A. J., & Gould, E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05792.1999 · Cited by 978 · see citing works
Liston, C., Miller, M. M., Goldwater, D. S., Radley, J. J., Rocher, A. B., Hof, P. R., Morrison, J. H., & McEwen, B. S. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1184-06.2006 · Cited by 968 · see citing works
Diazgranados, N., Ibrahim, L., Brutsche, N. E., Newberg, A., Kronstein, P., Khalife, S., Kammerer, W. A., Quezado, Z., Luckenbaugh, D. A., Salvadore, G., et al. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.90 · Cited by 963 · see citing works
Frontocingulate Dysfunction in Depression: Toward Biomarkers of Treatment Response
Pizzagalli, D. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.166 · Cited by 945 · see citing works
Freeman, E. W., Sammel, M. D., Lin, H., & Nelson, D. B. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.375 · Cited by 904 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01314-8 · Cited by 859 · see citing works
Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making
Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009) · Science · doi:10.1126/science.1171203 · Cited by 858 · see citing works
Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works
Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820 · see citing works
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817 · see citing works
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
Kang, H. J., Voleti, B., Hajszan, T., Rajkowska, G., Stockmeier, C. A., Licznerski, P., Lepack, A., Majik, M. S., Jeong, L. S., Banasr, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2886 · Cited by 808 · see citing works
Self-citationSubtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788 · see citing works
Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment
Warner‐Schmidt, J. L., & Duman, R. S. (2006) · Hippocampus · doi:10.1002/hipo.20156 · Cited by 787 · see citing works
Self-citationCotter, D., Mackay, D., Landau, S., Kerwin, R., & Everall, I. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.545 · Cited by 766 · see citing works
Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders
Hutsler, J. J., & Zhang, H. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.120 · Cited by 765 · see citing works
McKinnon, M. C., Yucel, K., Nazarov, A., & MacQueen, G. M. (2009) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0905 · Cited by 742 · see citing works
Dendritic Anomalies in Disorders Associated with Mental Retardation
Kaufmann, W. E. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.981 · Cited by 733 · see citing works
Cellular changes in the postmortem hippocampus in major depression
Stockmeier, C. A., Mahajan, G. J., Konick, L. C., Overholser, J. C., Jurjus, G. J., Meltzer, H. Y., Uylings, H. B. M., Friedman, L., & Rajkowska, G. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.022 · Cited by 732 · see citing works
Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia
Garey, L. J., Ong, W., Patel, T. S., Kanani, M., Davis, A., Mortimer, A. M., Barnes, T., & Hirsch, S. R. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.4.446 · Cited by 719 · see citing works
Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695 · see citing works
MacQueen, G., & Frodl, T. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.80 · Cited by 665 · see citing works
Neural plasticity to stress and antidepressant treatment
Duman, R. S., Malberg, J. E., & Thome, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00177-8 · Cited by 638 · see citing works
Self-citationCotter, D. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.386 · Cited by 634 · see citing works
Anatomical and Physiological Plasticity of Dendritic Spines
Alvarez, V. A., & Sabatini, B. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094222 · Cited by 629 · see citing works
Locally dynamic synaptic learning rules in pyramidal neuron dendrites
Harvey, C. D., & Svoboda, K. (2007) · Nature · doi:10.1038/nature06416 · Cited by 625 · see citing works
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines
Tanaka, J.-I., Horiike, Y., Matsuzaki, M., Miyazaki, T., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Science · doi:10.1126/science.1152864 · Cited by 615 · see citing works
Increased Levels of Glutamate in Brains from Patients with Mood Disorders
Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works
Bessa, J. M., Ferreira, D., Melo, I., Marques, F., Cerqueira, J. J., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.119 · Cited by 598 · cited 1× · see citing works
“Chronic administration of fluoxetine or the tricylic antidepressant imipramine is reported to rescue dendrite atrophy and spine loss in hippocampal CA3 and medial PFC layer II/III pyramidal neurons caused by chronic stress (Bessa et al., 2009).”
The New Neurobiology of Autism: Cortex, Connectivity, and Neuronal Organization
Minshew, N. J., & Williams, D. L. (2007) · Archives of Neurology · doi:10.1001/archneur.64.7.945 · Cited by 592 · see citing works
Drevets, W. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(02)00102-5 · Cited by 581 · see citing works
DiazGranados, N., Ibrahim, L. A., Brutsche, N. E., Ameli, R., Henter, I. D., Luckenbaugh, D. A., Machado-Vieira, R., & Zarate, C. A. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09m05327blu · Cited by 564 · see citing works
Wang, J.-W., David, D. J., Monckton, J. E., Battaglia, F., & Hen, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3632-07.2008 · Cited by 550 · see citing works
Neuroimaging Abnormalities in the Amygdala in Mood Disorders
DREVETS, W. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07098.x · Cited by 544 · see citing works
Chronic stress alters synaptic terminal structure in hippocampus
Magariños, A. M., Verdugo, J. M. G., & McEwen, B. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14002 · Cited by 543 · see citing works
Reduced volume of orbitofrontal cortex in major depression
Bremner, J. D., Vythilingam, M., Vermetten, E., Nazeer, A., Adil, J., Khan, S., Staib, L. H., & Charney, D. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01336-1 · Cited by 537 · see citing works
Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525 · see citing works
Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 522 · see citing works
Low glial numbers in the amygdala in major depressive disorder
Bowley, M. P., Drevets, W. C., Öngür, D., & Price, J. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01404-x · Cited by 503 · see citing works
Vesicular Glutamate Transporters 1 and 2 Target to Functionally Distinct Synaptic Release Sites
Fremeau, R. T., Kam, K., Qureshi, T., Johnson, J., Copenhagen, D. R., Storm‐Mathisen, J., Chaudhry, F. A., Nicoll, R. A., & Edwards, R. H. (2004) · Science · doi:10.1126/science.1097468 · Cited by 500 · see citing works
Dendritic spines and long-term plasticity
Segal, M. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1649 · Cited by 489 · see citing works
Vermetten, E., Vythilingam, M., Southwick, S. M., Charney, D. S., & Bremner, J. D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00634-6 · Cited by 487 · see citing works
Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys
Coe, C. L., Kramer, M., Czéh, B., Gould, E., Reeves, A. J., Kirschbaum, C., & Fuchs, E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00698-x · Cited by 477 · see citing works
Hippocampal volume, memory, and cortisol status in major depressive disorder: Effects of treatment
Vythilingam, M., Vermetten, E., Anderson, G. M., Luckenbaugh, D., Anderson, E. R., Snow, J., Staib, L. H., Charney, D. S., & Bremner, J. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.002 · Cited by 477 · see citing works
Reduced specificity of autobiographical memory and depression: The role of executive control.
Dalgleish, T., Williams, J. M. G., Golden, A.-M. J., Perkins, N., Barrett, L. F., Barnard, P. J., Yeung, C. A., Murphy, V., Elward, R. L., Tchanturia, K., et al. (2007) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.136.1.23 · Cited by 475 · see citing works
Huizink, A. C., Mulder, E. J. H., & Buitelaar, J. K. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.1.115 · Cited by 473 · see citing works
Izquierdo, A., Wellman, C. L., & Holmes, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0474-06.2006 · Cited by 459 · see citing works
Regulation of Dendritic Spine Density in Cultured Rat Hippocampal Neurons by Steroid Hormones
Murphy, D., & Segal, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04059.1996 · Cited by 459 · see citing works
BDNF Val66Met Allele Is Associated with Reduced Hippocampal Volume in Healthy Subjects
Bueller, J. A., Aftab, M., Sen, S., Gomez‐Hassan, D. M., Burmeister, M., & Zubieta, J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.022 · Cited by 458 · see citing works
Vyas, A., Pillai, A. G., & Chattarji, S. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.013 · Cited by 445 · see citing works
Dumitriu, D., Hao, J., Hara, Y., Kaufmann, J., Janssen, W. G. M., Lou, W., Rapp, P. R., & Morrison, J. H. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6410-09.2010 · Cited by 439 · see citing works
Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression
Hickie, I., Naismith, S., Ward, P. B., Turner, K., Scott, E., Mitchell, P., Wilhelm, K., & Parker, G. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.186.3.197 · Cited by 437 · see citing works
Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430 · see citing works
A negative regulator of MAP kinase causes depressive behavior
Duric, V., Banasr, M., Licznerski, P., Schmidt, H. D., Stockmeier, C. A., Simen, A. A., Newton, S. S., & Duman, R. S. (2010) · Nature Medicine · doi:10.1038/nm.2219 · Cited by 412 · see citing works
Self-citationBeneyto, M., Kristiansen, L. V., Oni-Orisan, A., McCullumsmith, R. E., & Meador-Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301312 · Cited by 408 · see citing works
McEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., & Fuchs, E. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.80 · Cited by 406 · see citing works
Liu, R.-J., Lee, F. S., Li, X.-Y., Bambico, F., Duman, R. S., & Aghajanian, G. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.030 · Cited by 403 · see citing works
Self-citationVolumetric Analysis of the Prefrontal Cortex, Amygdala, and Hippocampus in Major Depression
Hastings, R. S., Parsey, R. V., Oquendo, M. A., Arango, V., & Mann, J. J. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300371 · Cited by 378 · see citing works
Repeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 374 · see citing works
Krucker, T., Siggins, G. R., & Halpain, S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100139797 · Cited by 374 · see citing works
Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines
Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373 · see citing works
Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo
Liston, C., & Gan, W.-B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110444108 · Cited by 352 · see citing works
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works
Self-citationStress Burden and the Lifetime Incidence of Psychiatric Disorder inYoung Adults
Turner, R. J., & Lloyd, D. A. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.5.481 · Cited by 337 · see citing works
Silva-Gómez, A. B., Rojas, D., Juárez, I., & Flores, G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03042-7 · Cited by 336 · see citing works
Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory
Yuen, E. Y., Liu, W., Karatsoreos, I. N., Ren, Y., Feng, J., McEwen, B. S., & Yan, Z. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.50 · Cited by 324 · see citing works
Rex, C. S., Lin, C.-Y., Kramár, E. A., Chen, L. Y., Gall, C. M., & Lynch, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4037-06.2007 · Cited by 324 · see citing works
Enlargement of the Amygdala in Patients with a First Episode of Major Depression
Frodl, T., Meisenzahl, E., Zetzsche, T., Bottlender, R., Born, C., Groll, C., Jäger, M., Leinsinger, G., Hahn, K., & Möller, H.-J. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01359-2 · Cited by 316 · see citing works
Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior
Pawlak, R., Magariños, A. M., Melchor, J. P., McEwen, B. S., & Strickland, S. (2003) · Nature Neuroscience · doi:10.1038/nn998 · Cited by 305 · see citing works
Neurobiological and clinical effects of the antidepressant tianeptine
Kasper, S., & McEwen, B. S. (2008) · CNS Drugs · doi:10.2165/00023210-200822010-00002 · Cited by 302 · see citing works
Prolonged behavioral stress enhances synaptic connectivity in the basolateral amygdala
Vyas, A., Jadhav, S., & Chattarji, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.003 · Cited by 299 · see citing works
Effects of chronic stress on dendritic arborization in the central and extended amygdala
Vyas, A., Bernal, S., & Chattarji, S. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04162-8 · Cited by 291 · see citing works
The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
Groc, L., Choquet, D., & Chaouloff, F. (2008) · Nature Neuroscience · doi:10.1038/nn.2150 · Cited by 280 · see citing works
Murmu, M. S., Salomon, S., Biala, Y., Weinstock, M., Braun, K., & Bock, J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05024.x · Cited by 278 · see citing works
Chen, Y., Dubé, C. M., Rice, C. J., & Baram, T. Z. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0225-08.2008 · Cited by 276 · see citing works
Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures
Vaidya, V. A., Siuciak, J. A., Du, F., & Duman, R. S. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00289-9 · Cited by 276 · see citing works
Self-citationLate-Preterm Birth and Its Association With Cognitive and Socioemotional Outcomes at 6 Years of Age
Talge, N. M., Holzman, C., Wang, J., Lucia, V. C., Gardiner, J. C., & Breslau, N. (2010) · PEDIATRICS · doi:10.1542/peds.2010-1536 · Cited by 275 · see citing works
Grigoriadis, S., & Robinson, G. E. (2007) · Annals of Clinical Psychiatry · doi:10.1080/10401230701653294 · Cited by 274 · see citing works
Activity-induced targeting of profilin and stabilization of dendritic spine morphology
Ackermann, M., & Matus, A. I. (2003) · Nature Neuroscience · doi:10.1038/nn1135 · Cited by 274 · see citing works
Glucocorticoids Enhance the Excitability of Principal Basolateral Amygdala Neurons
Duvarci, S., & Paré, D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0680-07.2007 · Cited by 249 · see citing works
Hashimoto, R., Numakawa, T., Ohnishi, T., Kumamaru, E., Yagasaki, Y., Ishimoto, T., Mori, T., Nemoto, K., Adachi, N., Izumi, A., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl244 · Cited by 247 · see citing works
Gonadal hormone modulation of dendrites in the mammalian CNS
Cooke, B. M., & Woolley, C. S. (2005) · Journal of Neurobiology · doi:10.1002/neu.20143 · Cited by 244 · see citing works
Lin, Y., & Koleske, A. J. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153204 · Cited by 241 · see citing works
Hajszán, T., MacLusky, N. J., & Leranth, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03968.x · Cited by 239 · see citing works
The Influence of Gonadal Hormones on Neuronal Excitability, Seizures, and Epilepsy in the Female
Scharfman, H., & MacLusky, N. (2006) · Epilepsia · doi:10.1111/j.1528-1167.2006.00672.x · Cited by 238 · see citing works
Morozov, A., Muzzio, I. A., Bourtchouladze, R., Van-Strien, N., Lapidus, K. A. B., Yin, D., Winder, D. G., Adams, J. P., Sweatt, J. D., & Kandel, E. R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00404-5 · Cited by 237 · see citing works
Magariños, A. M., Li, C. J., Gal Toth, J., Bath, K. G., Jing, D., Lee, F. S., & McEwen, B. S. (2011) · Hippocampus · doi:10.1002/hipo.20744 · Cited by 232 · see citing works
Effect of Estrogen-Serotonin Interactions on Mood and Cognition
Amin, Z., Canli, T., & Epperson, C. N. (2005) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582305277152 · Cited by 228 · see citing works
Enlarged amygdala volume and reduced hippocampal volume in young women with major depression
Lange, C., & Irle, E. (2004) · Psychological Medicine · doi:10.1017/s0033291703001806 · Cited by 225 · see citing works
Evidence for reduced experience-dependent dendritic spine plasticity in the aging prefrontal cortex
Bloss, E. B., Janssen, W. G., Ohm, D. T., Yuk, F. J., Wadsworth, S., Saardi, K. M., McEwen, B. S., & Morrison, J. H. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0839-11.2011 · Cited by 219 · see citing works
Glial and glutamatergic markers in depression, alcoholism, and their comorbidity
Miguel-Hidalgo, J. J., Waltzer, R., Whittom, A. A., Austin, M. C., Rajkowska, G., & Stockmeier, C. A. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.003 · Cited by 218 · see citing works
A History of Corticosterone Exposure Regulates Fear Extinction and Cortical NR2B, GluR2/3, and BDNF
Gourley, S. L., Kedves, A. T., Olausson, P., & Taylor, J. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.123 · Cited by 218 · see citing works
Structural basis for the role of inhibition in facilitating adult brain plasticity
Chen, J. L., Lin, W. C., Cha, J. W., So, P. T., Kubota, Y., & Nedivi, E. (2011) · Nature Neuroscience · doi:10.1038/nn.2799 · Cited by 214 · see citing works
Malykhin, N. V., Carter, R., Seres, P., & Coupland, N. J. (2010) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100002 · Cited by 212 · see citing works
Remodeling of Hippocampal Spine Synapses in the Rat Learned Helplessness Model of Depression
Hajszán, T., Dow, A. L., Warner‐Schmidt, J. L., Szigeti‐Buck, K., Sallam, N. L., Párducz, Á., Leranth, C., & Duman, R. S. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.031 · Cited by 212 · see citing works
Self-citationCaetano, S. C., Hatch, J. P., Brambilla, P., Sassi, R. B., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J., Keshavan, M. S., & Soares, J. C. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.08.002 · Cited by 206 · see citing works
Tham, M. W., Woon, P. S., Sum, M. Y., Lee, T.-S. W., & Sim, K. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.013 · Cited by 206 · see citing works
Hao, J., Janssen, W. G. M., Tang, Y. C., Roberts, J. A., McKay, H. M., Lasley, B. L., Allen, P. B., Greengard, P., Rapp, P. R., Kordower, J. H., et al. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10837 · Cited by 199 · see citing works
Stewart, M. G., Davies, H. A., Sandi, C., Kraev, I. V., Rogachevsky, V. V., Peddie, C. J., Rodriguez, J. J., Cordero, M. I., Donohue, H. S., Gabbott, P. L. A., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.031 · Cited by 197 · see citing works
Tang, Y. C. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg121 · Cited by 197 · see citing works
Estrogen Promotes Stress Sensitivity in a Prefrontal Cortex-Amygdala Pathway
Shansky, R. M., Hamo, C., Hof, P. R., Lou, W., McEwen, B. S., & Morrison, J. H. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq003 · Cited by 191 · see citing works
Salvadore, G., Nugent, A. C., Lemaître, H., Luckenbaugh, D. A., Tinsley, R., Cannon, D. M., Neumeister, A., Zarate, C. A., & Drevets, W. C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.011 · Cited by 188 · see citing works
The Mental Retardation Protein PAK3 Contributes to Synapse Formation and Plasticity in Hippocampus
Boda, B., Alberi, S., Nikonenko, I., Nodé-Langlois, R., Jourdain, P., Moosmayer, M., Jourdain, L., & Müller, D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2931-04.2004 · Cited by 183 · see citing works
Local Protein Synthesis and Spine Morphogenesis: Fragile X Syndrome and Beyond
Grossman, A. W., Aldridge, G. M., Weiler, I. J., & Greenough, W. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1790-06.2006 · Cited by 177 · see citing works
Bock, J., Gruss, M., Becker, S., & Braun, K. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh181 · Cited by 175 · see citing works
Females do not express learned helplessness like males do
Dalla, C., Edgecomb, C., Whetstone, A. S., & Shors, T. J. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301533 · Cited by 174 · see citing works
Martínez‐Téllez, R. I., Hernández‐Torres, E., Gamboa, C., & Flores, G. (2009) · Synapse · doi:10.1002/syn.20664 · Cited by 174 · see citing works
Age-related alterations in hippocampal spines and deficiencies in spatial memory in mice
Halbach, O. V. B. U., Zacher, C., Gass, P., & Unsicker, K. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20759 · Cited by 173 · see citing works
Developmental Delay in Moderately Preterm-Born Children at School Entry
Kerstjens, J. M., de Winter, A. F., Bocca-Tjeertes, I. F. A., Vergert, E. M. T., Reijneveld, S. A., & Bos, A. F. (2011) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.12.041 · Cited by 171 · see citing works
Maciąg, D., Hughes, J., O'Dwyer, G., Pride, Y., Stockmeier, C. A., Sanacora, G., & Rajkowska, G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.027 · Cited by 170 · see citing works
mTOR activation is required for the antidepressant effects of mGluR2/3 blockade
Dwyer, J. M., Lepack, A. E., & Duman, R. S. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001702 · Cited by 169 · see citing works
Self-citationTordera, R. M., Totterdell, S., Wojcik, S. M., Brose, N., Elizalde, N., Lasheras, B., & del Rı́o, J. A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05259.x · Cited by 169 · see citing works
Norrholm, S. D., & Ouimet, C. C. (2001) · Synapse · doi:10.1002/syn.10006 · Cited by 164 · see citing works
Shansky, R., & Morrison, J. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.062 · Cited by 163 · see citing works
Yuan, P., Zhou, R., Wang, Y., Li, X., Li, J., Chen, G., Guitart, X., & Manji, H. K. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.10.017 · Cited by 160 · see citing works
Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome
Liu, Z., Chuang, D., & Smith, C. B. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000520 · Cited by 159 · see citing works
Du, J., Gray, N. A., Falke, C. A., Chen, W., Yuan, P., Szabo, S. T., Einat, H., & Manji, H. K. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1258-04.2004 · Cited by 157 · see citing works
Rigucci, S., Serafini, G., Pompili, M., Kotzalidis, G., & Tatarelli, R. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970903131571 · Cited by 154 · see citing works
Chen, F., Madsen, T. M., Wegener, G., & Nyengaard, J. R. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.12.007 · Cited by 153 · see citing works
Chronic Stress- and Sex-Specific Neuromorphological and Functional Changes in Limbic Structures
McLaughlin, K. J., Baran, S. E., & Conrad, C. D. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8079-7 · Cited by 152 · see citing works
Soetanto, A., Wilson, R. S., Talbot, K., Un, A., Schneider, J. A., Sobiesk, M., Kelly, J., Leurgans, S., Bennett, D. A., & Arnold, S. E. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.48 · Cited by 148 · see citing works
Rajkowska, G., Miguel-Hidalgo, J. J., Dubey, P., Stockmeier, C. A., & Krishnan, K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.013 · Cited by 146 · see citing works
Stress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator
Bennur, S., Rao, B. S. S., Pawlak, R., Strickland, S., McEwen, B. S., & Chattarji, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.075 · Cited by 145 · see citing works
Prenatal programming of postnatal endocrine responses by glucocorticoids
Bertram, C. E., & Hanson, M. A. (2002) · Reproduction · doi:10.1530/rep.0.1240459 · Cited by 144 · see citing works
Sunanda, Rao, M. S. R., & Raju, T. R. (1995) · Brain Research · doi:10.1016/0006-8993(95)00822-8 · Cited by 143 · see citing works
Hercher, C., Turecki, G., & Mechawar, N. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.01.006 · Cited by 142 · see citing works
Donohue, H. S., Gabbott, P. L. A., Davies, H. A., Rodríguez, J. J., Cordero, M. I., Sandi, C., Medvedev, N. I., Popov, V. I., Colyer, F. M., Peddie, C. J., et al. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.072 · Cited by 139 · see citing works
NMDA Receptor Blockade Alters Stress-Induced Dendritic Remodeling in Medial Prefrontal Cortex
Martin, K. P., & Wellman, C. L. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr021 · Cited by 138 · see citing works
Schmitz, C., Rhodes, M. E., Bludau, M., Kaplan, S., Ong, P., Ueffing, I., Vehoff, J., Korr, H., & Frye, C. A. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001118 · Cited by 136 · see citing works
Ishiwata, H., Shiga, T., & Okado, N. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.048 · Cited by 133 · see citing works
Neuronal and morphological bases of cognitive decline in aged rhesus monkeys
Hara, Y., Rapp, P. R., & Morrison, J. H. (2011) · AGE · doi:10.1007/s11357-011-9278-5 · Cited by 130 · see citing works
Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus
Thome, J., Pesold, B., Baader, M., Hu, M., Gewirtz, J. C., Duman, R. S., & Henn, F. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01229-x · Cited by 128 · see citing works
Self-citationThe extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers
Chen, G., & Manji, H. K. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000218604.63463.cd · Cited by 126 · see citing works
Lateral amygdaloid nucleus expansion in adult rats is associated with exposure to prenatal stress
Salm, A. K., Pavelko, M., Krouse, E. M., Webster, W., Kraszpulski, M., & Birkle, D. L. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.11.005 · Cited by 125 · cited 2× · see citing works
“PNS exposure of rats leads to an enlarged amygdala volume in adulthood (Salm et al., 2004) and may also cause dysregulation in BDNF in adult rats that could contribute to alterations of dendrite and spine morphology (discussed above in a separate paragraph) (Fumagalli et al.”
Chowdhury, G. M. I., Behar, K. L., Cho, W., Thomas, M. A., Rothman, D. L., & Sanacora, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.006 · Cited by 125 · see citing works
Mychasiuk, R., Gibb, R. L., & Kolb, B. E. (2011) · Synapse · doi:10.1002/syn.21512 · Cited by 125 · see citing works
Çavuş, I., & Duman, R. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00236-1 · Cited by 124 · see citing works
Self-citationBalschun, D., Moechars, D., Callaerts‐Vegh, Z., Vermaercke, B., Acker, N. V., Andries, L. J., & D’Hooge, R. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp133 · Cited by 123 · see citing works
Fumagalli, F., Bedogni, F., Pérez, J., Racagni, G., & Riva, M. A. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03592.x · Cited by 119 · see citing works
Memory impairment in patients with late-onset major depression: The effect of antidepressant therapy
Gallassi, R., Di Sarro, R., Morreale, A., & Amore, M. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.01.018 · Cited by 118 · see citing works
Eriksson, E., Sundblad, C., Lisjo, P. I., Modigh, K., & Andersch, B. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90058-f · Cited by 118 · see citing works
Rigucci, S., Serafini, G., Pompili, M., Kotzalidis, G. D., & Tatarelli, R. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903131571 · Cited by 117 · see citing works
Sex differences in learning deficits induced by prenatal stress in juvenile rats
Gué, M., Bravard, A., Meunier, J., Veyrier, R., Gaillet, S., Récasens, M., & Maurice, T. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00250-x · Cited by 116 · see citing works
Koike, H., Iijima, M., & Chaki, S. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.034 · Cited by 114 · see citing works
Hippocampal volumetrics in depression: The importance of the posterior tail
Maller, J. J., Daskalakis, Z. J., & Fitzgerald, P. B. (2007) · Hippocampus · doi:10.1002/hipo.20339 · Cited by 114 · see citing works
Chepenik, L. G., Fredericks, C. A., Papademetris, X., Spencer, L., Lacadie, C., Wang, F., Pittman, B. P., Duncan, J. S., Staib, L. H., Duman, R. S., et al. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.107 · Cited by 112 · see citing works
Self-citationSexually dimorphic aging of dendritic morphology in CA1 of hippocampus
Markham, J. A., McKian, K. P., Stroup, T. S., & Juraska, J. M. (2004) · Hippocampus · doi:10.1002/hipo.20034 · Cited by 112 · see citing works
Savitz, J. B., Nugent, A. C., Bogers, W., Liu, A., Sills, R., Luckenbaugh, D. A., Bain, E., Price, J. L., Zarate, C. A., Manji, H. K., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.025 · Cited by 109 · see citing works
Poeggel, G., Helmeke, C., Abraham, A., Schwabe, T., Friedrich, P., & Braun, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434663100 · Cited by 107 · see citing works
NMDA Receptor-Dependent Regulation of Axonal and Dendritic Branching
Lee, L., Lo, F., & Erzurumlu, R. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4902-04.2005 · Cited by 106 · see citing works
Muhammad, A., & Kolb, B. E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.015 · Cited by 104 · see citing works
Chen, F., Madsen, T. M., Wegener, G., & Nyengaard, J. R. (2009) · Hippocampus · doi:10.1002/hipo.20718 · Cited by 103 · see citing works
Dwivedi, Y., Rizavi, H. S., Zhang, H., Roberts, R. C., Conley, R. R., & Pandey, G. N. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990575 · Cited by 101 · see citing works
Michelsen, K. A., van den Hove, D. L., Schmitz, C., Segers, O., Prickaerts, J., & Steinbusch, H. W. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-107 · Cited by 100 · see citing works
Lee, L. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9022-4 · Cited by 100 · see citing works
Hajek, T., Kopecek, M., & Höschl, C. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.580005 · Cited by 99 · see citing works
Flagged first, then by citations
2 of the 256 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Tsai SJ Hong CJ Liou YJ 2010 Effects of BDNF polymorphisms on antidepressant action Psychiatry Investig 7 236 242 PMC3022309 21253406
Cited by
Sorted by citations
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works
Self-citationThe chronic mild stress (CMS) model of depression: History, evaluation and usage
Willner, P. (2017) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.08.002 · Cited by 959 · see citing works
Stress weakens prefrontal networks: molecular insults to higher cognition
Arnsten, A. F. T. (2015) · Nature Neuroscience · doi:10.1038/nn.4087 · Cited by 752 · see citing works
Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 457 · see citing works
Neuroplasticity Underlying the Comorbidity of Pain and Depression
Doan, L., Manders, T. R., & Wang, J. (2015) · Neural Plasticity · doi:10.1155/2015/504691 · Cited by 284 · see citing works
Biological Sex Differences in Depression: A Systematic Review
Labaka, A., Goñi‐Balentziaga, O., Lebeña, A., & Pérez-Tejada, J. (2018) · Biological Research For Nursing · doi:10.1177/1099800418776082 · Cited by 276 · see citing works
Hippocampal Sirtuin 1 signaling mediates depression-like behavior
Abe-Higuchi, N., Uchida, S., Yamagata, H., Higuchi, F., Hobara, T., Hara, K., Kobayashi, A., & Watanabe, Y. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.01.009 · Cited by 247 · see citing works
Biological hypotheses and biomarkers of bipolar disorder
Sigitova, E., Fišar, Z., Hroudová, J., Cikánková, T., & Raboch, J. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12476 · Cited by 247 · see citing works
Sex differences in antidepressant efficacy
LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 225 · see citing works
Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide
Gulbins, A., Schumacher, F., Becker, K. A., Wilker, B., Soddemann, M., Boldrin, F., Müller, C. P., Edwards, M. J., Goodman, M. D., Caldwell, C. C., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0090-9 · Cited by 230 · see citing works
∆FosB: A transcriptional regulator of stress and antidepressant responses
Nestler, E. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.10.034 · Cited by 220 · see citing works
Bassett, B., Subramaniyam, S., Yang, F., Varney, S., Pan, H., Carneiro, A. M. D., & Chung, C. Y. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.11.009 · Cited by 217 · see citing works
Fogaça, M. V., Campos, A. C., Coelho, L. D., Duman, R. S., & Guimarães, F. S. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.001 · Cited by 208 · see citing works
Self-citationStructural and functional plasticity of dendritic spines – root or result of behavior?
Gipson, C. D., & Olive, M. F. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12324 · Cited by 192 · see citing works
Identifying fast-onset antidepressants using rodent models
Ramaker, M. J., & Dulawa, S. C. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.36 · Cited by 181 · see citing works
Peripheral administration of lactate produces antidepressant-like effects
Carrard, A., Elsayed, M. G. A., Margineanu, M. B., Boury‐Jamot, B., Fragnière, L., Meylan, E. M., Petit, J.-M., Fiumelli, H., Magistretti, P. J., & Martin, J.-L. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.179 · Cited by 170 · see citing works
Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes.
Woo, E., Sansing, L. H., Arnsten, A. F. T., & Datta, D. (2021) · Chronic Stress · doi:10.1177/24705470211029254 · Cited by 159 · see citing works
Hippocampal MicroRNA-124 Enhances Chronic Stress Resilience in Mice
Higuchi, F., Uchida, S., Yamagata, H., Abe-Higuchi, N., Hobara, T., Hara, K., Kobayashi, A., Shintaku, T., Itoh, Y., Suzuki, T., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0319-16.2016 · Cited by 158 · see citing works
Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine
Wohleb, E. S., Gerhard, D. M., Thomas, A., & Duman, R. S. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160309114549 · Cited by 151 · see citing works
Self-citationPathophysiological Bases of Comorbidity: Traumatic Brain Injury and Post-Traumatic Stress Disorder
Kaplan, G. B., Leite‐Morris, K. A., Wang, L., Rumbika, K. K., Heinrichs, S. C., Zeng, X., Wu, L., Arena, D. T., & Teng, Y. D. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2016.4953 · Cited by 146 · see citing works
Quiroz, J. A., Tamburri, P., Deptula, D., Banken, L., Beyer, U., Rabbia, M., Parkar, N., Fontoura, P., & Santarelli, L. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0838 · Cited by 133 · see citing works
BDNF Impact on Biological Markers of Depression—Role of Physical Exercise and Training
Murawska‐Ciałowicz, E., Wiatr, M., Ciałowicz, M., de Assis, G. G., Borowicz, W., Rocha‐Rodrigues, S., Paprocka‐Borowicz, M., & Marques, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18147553 · Cited by 140 · see citing works
Zhang, Y., Shao, F., Wang, Q., Xie, X., & Wang, W. (2017) · Neural Plasticity · doi:10.1155/2017/9382797 · Cited by 125 · see citing works
Chronically Restricted or Disrupted Sleep as a Causal Factor in the Development of Depression
Meerlo, P., Havekes, R., & Steiger, A. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_367 · Cited by 119 · see citing works
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Pantazopoulos, H., & Berretta, S. (2015) · Neural Plasticity · doi:10.1155/2016/9847696 · Cited by 118 · see citing works
Borrow, A. P., & Cameron, N. M. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.05.009 · Cited by 120 · see citing works
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.07.007 · Cited by 114 · see citing works
Synaptic regulation of affective behaviors; role of BDNF
Ninan, I. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.011 · Cited by 111 · see citing works
McKlveen, J. M., Moloney, R. D., Scheimann, J. R., Myers, B., & Herman, J. P. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.032 · Cited by 109 · see citing works
Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression
Qiao, H., An, S.-C., Ren, W., & Ma, X. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.040 · Cited by 105 · see citing works
Oluboka, O. J., Katzman, M. A., Habert, J., McIntosh, D., MacQueen, G. M., Milev, R. V., McIntyre, R. S., & Blier, P. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx081 · Cited by 104 · see citing works
Csabai, D., Wiborg, O., & Czéh, B. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00024 · Cited by 100 · see citing works
Sanaeifar, F., Pourranjbar, S., Pourranjbar, M., Ramezani, S., Mehr, S. R., Wadan, A. S., & Khazeifard, F. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112539 · Cited by 106 · see citing works
McNamara, R. K. (2015) · World Journal of Psychiatry · doi:10.5498/wjp.v5.i1.15 · Cited by 88 · see citing works
Musazzi, L., Treccani, G., & Popoli, M. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00060 · Cited by 83 · see citing works
Ng, L. H. L., Huang, Y., Han, L., Chang, R. C.-C., Chan, Y. S., & Lai, C. S. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0321-5 · Cited by 82 · see citing works
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2020) · Molecular Brain · doi:10.1186/s13041-020-00627-z · Cited by 85 · see citing works
Datta, D., & Arnsten, A. (2019) · Brain Sciences · doi:10.3390/brainsci9050113 · Cited by 78 · see citing works
Licznerski, P., Duric, V., Banasr, M., Alavian, K. N., Ota, K. T., Kang, H. J., Jonas, E. A., Ursano, R., Krystal, J. H., Duman, R. S., et al. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002282 · Cited by 79 · see citing works
Self-citationBarthas, F., Humo, M., Gilsbach, R., Waltisperger, E., Karatas, M., Leman, S., Hein, L., Belzung, C., Boutillier, A., Barrot, M., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.01.019 · Cited by 80 · see citing works
The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice.
Huang, H.-J., Chen, X.-R., Han, Q.-Q., Wang, J., Pilot, A., Yu, R., Liu, Q., Li, B., Wu, G.-C., Wang, Y.-Q., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.013 · Cited by 74 · see citing works
Weger, M., Alpern, D., Cherix, A., Ghosal, S., Grosse, J., Russeil, J., Rolf Gruetter, A., de Kloet, E. R., Deplancke, B., & Sandi, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-75326-9 · Cited by 71 · see citing works
Banasr, M., Sanacora, G., & Esterlis, I. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.004 · Cited by 65 · see citing works
Page, C. E., Epperson, C. N., Novick, A. M., Duffy, K. A., & Thompson, S. M. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02625-2 · Cited by 80 · see citing works
Smell and Autoimmunity: A Comprehensive Review
Perricone, C., Shoenfeld, N., Agmon‐Levin, N., Carolis, C. D., Perricone, R., & Shoenfeld, Y. (2012) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-012-8343-x · Cited by 62 · see citing works
Jia, M., Li, C., Zheng, Y., Ding, X., Chen, M., Ding, J., Du, R., Lu, M., & Hu, G. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx062 · Cited by 63 · see citing works
The Neurotrophic Hypothesis of Depression Revisited: New Insights and Therapeutic Implications
Jaggar, M., Fanibunda, S. E., Ghosh, S. K., Duman, R. S., & Vaidya, V. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813333-0.00006-8 · Cited by 58 · see citing works
Self-citationCui, Q., Hu, Z., Hu, Y., Chen, X., Wang, J., Mao, L., Lu, X., Ni, M., Chen, J., & Wang, F. (2020) · The EMBO Reports · doi:10.15252/embr.201947857 · Cited by 56 · see citing works
Fang, J.-L., Luo, Y., Jin, S., Yuan, K., & Guo, Y. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103757 · Cited by 55 · see citing works
Barfield, E. T., & Gourley, S. L. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.10.015 · Cited by 53 · see citing works
Haim, A., Albin-Brooks, C., Sherer, M. L., Mills, E., & Leuner, B. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.05.005 · Cited by 52 · see citing works
Cerebrospinal Fluid Aβ42 Levels: When Physiological Become Pathological State
Martorana, A., Lorenzo, F. D., Belli, L., Sancesario, G., Toniolo, S., Sallustio, F., Sancesario, G. M., & Koch, G. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12476 · Cited by 51 · see citing works
García‐Rojo, G., Fresno, C., Vilches, N., Díaz‐Véliz, G., Mora, S., Aguayo, F. I., Pacheco, A., Parra-Fiedler, N. A., Parra, C. S., Rojas, P. S., et al. (2016) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyw108 · Cited by 50 · see citing works
Mechanisms of SSRI Therapy and Discontinuation
Sharp, T., & Collins, H. (2023) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2023_452 · Cited by 45 · see citing works
Jonckheere, J., Deloulme, J., Dall’Igna, G., Chauliac, N., Pelluet, A., Nguon, A.-S., Lentini, C., Brocard, J., Denarier, É., Brugière, S., et al. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.08.001 · Cited by 45 · see citing works
Kuwajima, M., Špaček, J., & Harris, K. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.061 · Cited by 45 · see citing works
Récamier-Carballo, S., Estrada-Camarena, E. M., & López‐Rubalcava, C. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000324 · Cited by 41 · see citing works
Hamdaoui, Y. E., Zheng, F., Fritz, N., Ye, L., Tran, M. A., Schwickert, K., Schirmeister, T., Braeuning, A., Lichtenstein, D., Hellmich, U. A., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01804-3 · Cited by 43 · see citing works
Ploski, J. E., & Vaidya, V. A. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.009 · Cited by 42 · see citing works
Stem Cell Factor (SCF) is a putative biomarker of antidepressant response
Benedetti, F., Poletti, S., Hoogenboezem, T. A., Locatelli, C., Ambrée, O., de Wit, H., Wijkhuijs, A. J. M., Mazza, E. B., Bulgarelli, C., Vai, B., et al. (2016) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-016-9672-y · Cited by 42 · see citing works
BDNF signaling: Harnessing stress to battle mood disorder
Licznerski, P., & Jonas, E. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803645115 · Cited by 39 · see citing works
Self-citationMcOmish, C. E., Pavey, G., Gibbons, A. S., Hopper, S., Udawela, M., Scarr, E., & Dean, B. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.004 · Cited by 38 · see citing works
Chen, F., du Jardin, K. G., Waller, J. A., Sánchez, C., Nyengaard, J. R., & Wegener, G. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.018 · Cited by 37 · see citing works
In vitroandin vivoregulation of synaptogenesis by the novel antidepressant spadin
Devader, C., Khayachi, A., Veyssière, J., Maati, H. M. O., Roulot, M., Moréno, S., Borsotto, M., Martin, S., Heurteaux, C., & Mazella, J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13083 · Cited by 36 · see citing works
Molecular and genetic basis of depression
ROY, M., Tapadia, M. G., Joshi, S., & Koch, B. (2014) · Journal of Genetics · doi:10.1007/s12041-014-0449-x · Cited by 37 · see citing works
Singh, L., Singh, A. P., & Bhatti, R. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00261-z · Cited by 35 · see citing works
Xu, C., Ma, X.-M., Chen, H.-B., Zhou, M.-H., Qiao, H., & An, S.-C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.020 · Cited by 34 · see citing works
Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity
Ren, F., & Guo, R. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s268012 · Cited by 31 · see citing works
Wang, P., Ouyang, H., Bi, G., Liang, F., Wu, C., Wu, C., Jiang, X., Zhou, W., Li, D., Zhang, S., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156340 · Cited by 33 · see citing works
Bertolini, F., Robertson, L., Bisson, J. I., Meader, N., Churchill, R. C., Ostuzzi, G., Stein, D. J., Williams, T., & Barbui, C. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013443.pub2 · Cited by 35 · see citing works
Ortiz, R., Niciu, M. J., Lukkahati, N., Saligan, L. N., Nugent, A. C., Luckenbaugh, D. A., Machado‐Vieira, R., & Zarate, C. A. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.09.015 · Cited by 32 · see citing works
Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience
Pereira, C. M., Castro, F. C. D. A. Q., Barcelos, R. M., Chiepe, K. C. M. B., Rossoni, J. V., Ambrósio, R. P., Chiarelli-Neto, O., & Pesarico, A. P. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.1006836 · Cited by 32 · see citing works
High-throughput sequencing of the synaptome in major depressive disorder
Pirooznia, M., Wang, T., Avramopoulos, D., Potash, J. B., Zandi, P. P., & Goes, F. S. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.98 · Cited by 29 · see citing works
McNamara, R., & Almeida, D. M. (2019) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000199 · Cited by 23 · see citing works
Lyttle, K., Ohmura, Y., Konno, K., Yoshida, T., Izumi, T., Watanabe, M., & Yoshioka, M. (2015) · Brain Research · doi:10.1016/j.brainres.2015.04.058 · Cited by 26 · see citing works
Pooley, J., Flynn, B., Grøntved, L., Baek, S., Guertin, M. J., Kershaw, Y. M., Birnie, M. T., Pellatt, A., Rivers, C. A., Schiltz, R., et al. (2017) · Endocrinology · doi:10.1210/en.2016-1929 · Cited by 27 · see citing works
Yu, H. M., Zhong, J., Niu, B., Zhong, Q., Xiao, J., Xie, J., Lin, M., Zhou, Z., Xu, J., & Wang, H. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy092 · Cited by 26 · see citing works
Trophic factors as potential therapies for treatment of major mental disorders
Dremencov, E., Ježová, D., Barak, S., Gaburjáková, J., Gaburjáková, M., Kútna, V., & Ovsepian, S. V. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136194 · Cited by 25 · see citing works
Qian, X., Zhong, Z., Lu, S., & Zhang, Y. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148541 · Cited by 26 · see citing works
Waller, J. A., Chen, F., & Sánchez, C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.12.012 · Cited by 25 · see citing works
Li, Y. Y., Ni, X. K., You, Y. F., Qing, Y. H., Wang, P. R., Yao, J., Ren, K. M., Zhang, L., Liu, Z. W., Song, T. J., et al. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.634113 · Cited by 25 · see citing works
Effects of gravity changes on gene expression of BDNF and serotonin receptors in the mouse brain
Ishikawa, C., Li, H., Ogura, R., Yoshimura, Y., Kudo, T., Shirakawa, M., Shiba, D., Takahashi, S., Morita, H., & Shiga, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177833 · Cited by 23 · see citing works
Özkay, Ü. D., Söztutar, E., Can, Ö. D., Üçel, U. İ., Öztürk, Y., & Ulupınar, E. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000153 · Cited by 23 · see citing works
Gao, S., Zhang, T., Jin, L., Dong, L., Fan, G., Song, Y., Lucassen, P. J., Yu, R., & Swaab, D. F. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy254 · Cited by 22 · see citing works
Aleksandrova, L. R., Wang, Y. T., & Phillips, A. G. (2017) · Chronic Stress · doi:10.1177/2470547017743511 · Cited by 21 · see citing works
Talking to the Synapse: How Antidepressants Can Target Glial Cells to Reshape Brain Circuits
Benedetto, B. D., Rupprecht, R., & Czéh, B. (2013) · Current Drug Targets · doi:10.2174/1389450111314110011 · Cited by 20 · see citing works
Takashima, Y., Fannon, M. J., Galinato, M. H., Steiner, N. L., An, M., Zemljic‐Harpf, A. E., Somkuwar, S. S., Head, B. P., & Mandyam, C. D. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1615-3 · Cited by 19 · see citing works
Hernández, A. D., Zamudio, S., Martı́nez-Mota, L., González-González, R., & Juan, E. R. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.03.057 · Cited by 19 · see citing works
Progesterone and fluoxetine treatments of postpartum depressive‐like behavior in rat model
Hu, Z., Du, X., Yang, Y., Botchway, B. O. A., & Fang, M. (2019) · Cell Biology International · doi:10.1002/cbin.11123 · Cited by 19 · see citing works
Sasaki, T., Oga, T., Nakagaki, K., Sakai, K., Sumida, K., Hoshino, K., Miyawaki, I., Saito, K., Suto, F., & Ichinohe, N. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.023 · Cited by 19 · see citing works
Risk of Dementia in Posttraumatic Stress Disorder
Elias, A., Rowe, C. C., & Hopwood, M. (2020) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988720957088 · Cited by 18 · see citing works
Integration of multiscale dendritic spine structure and function data into systems biology models
Mancuso, J. J., Cheng, J., Yin, Z., Gilliam, J. C., Xia, X., Li, X., & Wong, S. T. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00130 · Cited by 18 · see citing works
Stress Response and Perinatal Reprogramming: Unraveling (Mal)adaptive Strategies
Musazzi, L., & Marrocco, J. (2016) · Neural Plasticity · doi:10.1155/2016/6752193 · Cited by 18 · see citing works
Guerini, E., Schadt, S., Greig, G., Haas, R., Husser, C., Zell, M., Funk, C., Härtung, T., Gloge, A., & Mallalieu, N. L. (2016) · Xenobiotica · doi:10.3109/00498254.2016.1169334 · Cited by 17 · see citing works
Kouba, B. R., Torrá, A. C. N. C., Camargo, A., & Rodrigues, A. L. S. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01115-0 · Cited by 16 · see citing works
Cognitive performance of juvenile monkeys after chronic fluoxetine treatment
Golub, M. S., Hackett, E. P., Hogrefe, C. E., Leranth, C., Elsworth, J. D., & Roth, R. H. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.04.008 · Cited by 16 · see citing works
Kaur, H., Sarmah, D., Datta, A., Borah, A., Yavagal, D. R., & Bhattacharya, P. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10461-6 · Cited by 15 · see citing works
Proteomic Markers for Depression
Silva-Costa, L. C., Carlson, P. T., Guest, P. C., de Almeida, V., & Martins‐de‐Souza, D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-05542-4_10 · Cited by 15 · see citing works
Ambrogini, P., Lattanzi, D., Pagliarini, M., Palma, M. D., Sartini, S., Cuppini, R., Fuxé, K., & Borroto‐Escuela, D. O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087467 · Cited by 14 · see citing works
Pérez-Valenzuela, E., Hudson, R., Uzuneser, T. C., Felice, M. D., Szkudlarek, H. J., Rushlow, W. J., & Laviolette, S. R. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230912101441 · Cited by 13 · see citing works
- Authors
- Licznerski, P., & Duman, R. S.
- Affiliations
- Yale University (US)
- Corresponding author
- Duman, R.S.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 251
- Pages
- 33-50
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3566360
- OpenAlex
- W2065851490
- Cited by
- 157
- References
- 256
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 12 · 2021: 12 · 2020: 9 · 2019: 15 · 2018: 16 · 2017: 15 · 2016: 18 · 2015: 21 · 2014: 7 · 2013: 2 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH093897, R37MH045481)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- depression, dendritic spines, synaptic plasticity, stress, antidepressants, rapid-acting antidepressants, prefrontal cortex, hippocampus, amygdala, limbic system, neuroplasticity, dendritic spine morphology
- MeSH terms
- Animals, Brain, Depression, Humans, Neuronal Plasticity, Neurons, Stress, Physiological, Synapses, Brain-Derived Neurotrophic Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review