GABAergic Control of Depression-Related Brain States

Diagnostic and Statistical Manual of Mental Disorders

Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works

Diagnostic and Statistical Manual of Mental Disorders.

Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,767 · see citing works

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies

Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works

The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function

Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00035-7 · Cited by 3,888 · see citing works

Antidepressant effects of ketamine in depressed patients

Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,499 · see citing works

A Neurotrophic Model for Stress-Related Mood Disorders

Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works

Stress signalling pathways that impair prefrontal cortex structure and function

Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works

Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111 · see citing works

The molecular neurobiology of depression

Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works

Causal Relationship Between Stressful Life Events and the Onset of Major Depression

Kendler, K. S., Karkowski, L. M., & Prescott, C. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.6.837 · Cited by 2,486 · see citing works

Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies

Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356 · see citing works

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) · Nature Genetics · doi:10.1038/ng.2711 · Cited by 2,263 · see citing works

Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression

Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · see citing works

Evidence-based health policy—lessons from the Global Burden of Disease Study

Murray, C. J. L., & Lopez, A. D. (1996) · Science · doi:10.1126/science.274.5288.740 · Cited by 2,178 · see citing works

CREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals

Shaywitz, A. J., & Greenberg, M. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.821 · Cited by 2,135 · see citing works

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works

Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study

Lichtenstein, P., Yip, B. H., Björk, C., Pawitan, Y., Cannon, T. D., Sullivan, P. F., & Hultman, C. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60072-6 · Cited by 2,125 · see citing works

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works

The brain reward circuitry in mood disorders

Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works

Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms

Pittenger, C., & Duman, R. S. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301574 · Cited by 1,795 · see citing works

Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression

Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

Duman, R. S., & Aghajanian, G. K. (2012) · Science · doi:10.1126/science.1222939 · Cited by 1,651 · cited 1× · see citing works

Epidemiology of Major Depressive Disorder: Results From the National Epidemiologic Survey on Alcoholism and Related Conditions

Hasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1097 · Cited by 1,645 · see citing works

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · cited 2× · see citing works

A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

Clelland, C. D., Choi, M., Romberg, C., Clemenson, G. D., Fragniere, A., Tyers, P., Jessberger, S., Saksida, L. M., Barker, R. A., Gage, F. H., et al. (2009) · Science · doi:10.1126/science.1173215 · Cited by 1,642 · see citing works

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation

Sahay, A., Scobie, K. N., Hill, A. S., O'Carroll, C. M., Kheirbek, M. A., Burghardt, N. S., Fenton, A. A., Dranovsky, A., & Hen, R. (2011) · Nature · doi:10.1038/nature09817 · Cited by 1,567 · see citing works

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

Tao, X., Finkbeiner, S., Arnold, D. B., Shaywitz, A. J., & Greenberg, M. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)81010-7 · Cited by 1,561 · see citing works

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A. (2011) · Nature · doi:10.1038/nature10287 · Cited by 1,473 · see citing works

Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression

Sheline, Y. I., Sanghavi, M., Mintun, M. A., & Gado, M. H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05034.1999 · Cited by 1,382 · see citing works

Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

Chen, Z.-Y., Jing, D., Bath, K. G., Ieraci, A., Khan, T., Siao, C.-J., Herrera, D. G., Toth, M., Yang, C., McEwen, B. S., et al. (2006) · Science · doi:10.1126/science.1129663 · Cited by 1,340 · see citing works

Parental olfactory experience influences behavior and neural structure in subsequent generations

Dias, B. G., & Ressler, K. J. (2014) · Nature Neuroscience · doi:10.1038/nn.3594 · Cited by 1,338 · see citing works

A Comparison of Nefazodone, the Cognitive Behavioral-Analysis System of Psychotherapy, and Their Combination for the Treatment of Chronic Depression

Keller, M. B., McCullough, J. P., Klein, D. N., Arnow, B., Dunner, D. L., Gelenberg, A. J., Markowitz, J. C., Nemeroff, C. B., Russell, J. M., Thase, M. E., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422001 · Cited by 1,331 · see citing works

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

Schmidt-Hieber, C., Jonas, P., & Bischofberger, J. (2004) · Nature · doi:10.1038/nature02553 · Cited by 1,292 · see citing works

Lasting epigenetic influence of early-life adversity on the BDNF gene

Roth, T. L., Lubin, F. D., Funk, A. J., & Sweatt, J. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.028 · Cited by 1,273 · see citing works

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression

David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267 · see citing works

GABA _A ‐receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits

Fritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244 · see citing works

The Biochemistry of Affective Disorders

Coppen, A. (1967) · British Journal of Psychiatry · doi:10.1192/bjp.113.504.1237 · Cited by 1,230 · see citing works

BDNF Regulates the Maturation of Inhibition and the Critical Period of Plasticity in Mouse Visual Cortex

Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198 · see citing works

Untreated Depression and Hippocampal Volume Loss

Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1516 · Cited by 1,180 · see citing works

Norepinephrine in Depressive Reactions

Bunney, W. E. (1965) · Archives of General Psychiatry · doi:10.1001/archpsyc.1965.01730060001001 · Cited by 1,154 · see citing works

The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress

Diorio, D., Viau, V, & Meaney, M. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03839.1993 · Cited by 1,151 · see citing works

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

Shimizu, E., Hashimoto, K., Okamura, N., Koike, K., Komatsu, N., Kumakiri, C., Nakazato, M., Watanabe, H., Shinoda, N., Okada, S.-I., et al. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00181-1 · Cited by 1,151 · see citing works

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

Drevets, W. C. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00203-8 · Cited by 1,146 · see citing works

Epigenetic transmission of the impact of early stress across generations

Franklin, T. B., Russig, H., Weiss, I. C., Gräff, J., Linder, N., Michalon, A., Vizi, S., & Mansuy, I. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.036 · Cited by 1,125 · cited 1× · see citing works

A mega-analysis of genome-wide association studies for major depressive disorder

Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke, S., Wray, N. R., Lewis, C. M., Hamilton, S. P., Weissman, M. M., Breen, G., Byrne, E. M., Blackwood, D. H. R., Boomsma, D. I., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.21 · Cited by 1,120 · see citing works

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

Maeng, S., Zarate, C. A., Du, J., Schloesser, R. J., McCammon, J., Chen, G., & Manji, H. K. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.028 · Cited by 1,103 · see citing works

Glutamate N-methyl-D-aspartate Receptor Antagonists Rapidly Reverse Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure

Li, N., Liu, R.-J., Dwyer, J. M., Banasr, M., Lee, B., Son, H., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.12.015 · Cited by 1,082 · see citing works

Course of illness, hippocampal function, and hippocampal volume in major depression

MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980 · see citing works

Early Life Programming and Neurodevelopmental Disorders

Bale, T. L., Baram, T. Z., Brown, A. S., Goldstein, J. M., Insel, T. R., McCarthy, M. M., Nemeroff, C. B., Reyes, T. M., Simerly, R. B., Susser, E. S., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.028 · Cited by 961 · see citing works

Molecular and neuronal substrate for the selective attenuation of anxiety

Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Rülicke, T., Bluethmann, H., Möhler, H., et al. (2000) · Science · doi:10.1126/science.290.5489.131 · Cited by 946 · see citing works

Gene Expression Deficits in a Subclass of GABA Neurons in the Prefrontal Cortex of Subjects with Schizophrenia

Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938 · see citing works

The GABAergic deficit hypothesis of major depressive disorder

Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934 · see citing works

Difference in treatment outcome in outpatients with anxious versus nonanxious depression: A STAR*D report

Fava, M., Rush, A. J., Alpert, J. E., Balasubramani, G. K., Wisniewski, S. R., Carmin, C. N., Biggs, M. M., Zisook, S., Leuchter, A., Howland, R., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06111868 · Cited by 927 · see citing works

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works

Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies

Koolschijn, P. C. M. P., van Haren, N. E. M., Lensvelt‐Mulders, G. J. L. M., Hulshoff Pol, H. E., & Kahn, R. S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20801 · Cited by 902 · see citing works

Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects

Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works

Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) Alters the Intracellular Trafficking and Activity-Dependent Secretion of Wild-Type BDNF in Neurosecretory Cells and Cortical Neurons

Chen, Z.-Y., Patel, P. D., Sant, G., Meng, C.-X., Teng, K. K., Hempstead, B. L., & Lee, F. S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0348-04.2004 · Cited by 874 · see citing works

Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies

Ruhé, H. G., Mason, N. S., & Schene, A. H. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001949 · Cited by 861 · see citing works

Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin

Essrich, C., Lorez, M., Benson, J. A., Fritschy, J., & Lüscher, B. (1998) · Nature Neuroscience · doi:10.1038/2798 · Cited by 856 · see citing works

Reduced Prefrontal Glutamate/Glutamine and γ-Aminobutyric Acid Levels in Major Depression Determined Using Proton Magnetic Resonance Spectroscopy

Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.193 · Cited by 846 · see citing works

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

Kang, H. J., Voleti, B., Hajszan, T., Rajkowska, G., Stockmeier, C. A., Licznerski, P., Lepack, A., Majik, M. S., Jeong, L. S., Banasr, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2886 · Cited by 808 · see citing works

Stress and hippocampal neurogenesis

Gould, E., & Tanapat, P. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00247-4 · Cited by 805 · see citing works

Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioral effects

Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA A receptors

Stell, B. M., Brickley, S. G., Tang, C., Farrant, M., & Módy, I. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2435457100 · Cited by 799 · see citing works

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works

A Swedish National Twin Study of Lifetime Major Depression

Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.109 · Cited by 794 · see citing works

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions

Trullas, R., & Skolnick, P. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90204-j · Cited by 785 · see citing works

Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover proliferation, and survival in the adult dentate gyrus

Sairanen, M., Lucas, G., Ernfors, P., Castrén, M., & Castrén, E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3741-04.2005 · Cited by 763 · see citing works

Glucocorticoid-sensitive hippocampal neurons are involved in terminating the adrenocortical stress response.

Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6174 · Cited by 758 · see citing works

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

Papouin, T., Ladépêche, L., Ruel, J., Sacchi, S., Labasque, M., Hanini, M., Groc, L., Pollegioni, L., Mothet, J., & Oliet, S. H. R. (2012) · Cell · doi:10.1016/j.cell.2012.06.029 · Cited by 752 · see citing works

The Genetics of Major Depression

Flint, J., & Kendler, K. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.01.027 · Cited by 724 · see citing works

Elevated anxiety and antidepressant-like responses in serotonin 5-HT 1A receptor mutant mice

Heisler, L. K., Chu, H.-M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., & Tecott, L. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15049 · Cited by 704 · see citing works

GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition

Jacob, T. C., Moss, S. J., & Jurd, R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2370 · Cited by 695 · see citing works

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

Shieh, P. B., Hu, S.-C., Bobb, K., Timmusk, T., & Ghosh, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)81011-9 · Cited by 693 · see citing works

Increased anxiety of mice lacking the serotonin 1A receptor

Parks, C. L., Robinson, P. S., Sibille, E. L., Shenk, T. E., & Tóth, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10734 · Cited by 691 · see citing works

Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease

Brickley, S. G., & Módy, I. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.012 · Cited by 674 · see citing works

Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine

Uzunova, V., Sheline, Y. I., Davis, J. M., Rasmusson, A. M., Uzunov, D. P., Costa, E., & Guidotti, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3239 · Cited by 672 · see citing works

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior

Carlén, M., Meletis, K., Siegle, J. H., Cardin, J. A., Futai, K., Vierling-Claassen, D., Rühlmann, C., Jones, S. R., Deisseroth, K., Sheng, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.31 · Cited by 669 · see citing works

Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation

Aimone, J. B., Deng, W., & Gage, F. H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.010 · Cited by 663 · see citing works

Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression

Choudary, P. V., Molnar, M., Evans, S. J., Tomita, H., Li, J., Vawter, M. P., Myers, R., Bunney, W. E., Akil, H., Watson, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507901102 · Cited by 653 · see citing works

The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior

Schmidt, H. D., & Duman, R. S. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee2aa8 · Cited by 649 · see citing works

Ovarian cycle–linked changes in GABAA receptors mediating tonic inhibition alter seizure susceptibility and anxiety

Maguire, J. L., Stell, B. M., Rafizadeh, M., & Mody, I. (2005) · Nature Neuroscience · doi:10.1038/nn1469 · Cited by 644 · see citing works

GABA Neurons of the VTA Drive Conditioned Place Aversion

Tan, K. R., Yvon, C., Turiault, M., Mirzabekov, J. J., Doehner, J., Labouèbe, G., Deisseroth, K. A., Tye, K. M., & Lüscher, C. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.015 · Cited by 635 · see citing works

Reduced Cortical γ-Aminobutyric Acid Levels in Depressed Patients Determined by Proton Magnetic Resonance Spectroscopy

Sanacora, G., Mason, G. F., Rothman, D. L., Behar, K. L., Hyder, F., Petroff, O. A. C., Berman, R. M., Charney, D. S., & Krystal, J. H. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1043 · Cited by 627 · see citing works

Early life experience alters response of adult neurogenesis to stress

Mirescu, C., Peters, J. D., & Gould, E. (2004) · Nature Neuroscience · doi:10.1038/nn1290 · Cited by 625 · see citing works

The GABA Excitatory/Inhibitory Shift in Brain Maturation and Neurological Disorders

Ben‐Ari, Y., Khalilov, I., Kahle, K. T., & Cherubini, E. (2012) · The Neuroscientist · doi:10.1177/1073858412438697 · Cited by 622 · see citing works

NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

Tashiro, A., Sandler, V. M., Toni, N., Zhao, C., & Gage, F. H. (2006) · Nature · doi:10.1038/nature05028 · Cited by 620 · see citing works

Gliogenesis and Glial Pathology in Depression

Rajkowska, G., & Miguel-Hidalgo, J. J. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780619326 · Cited by 612 · see citing works

Increased Levels of Glutamate in Brains from Patients with Mood Disorders

Hashimoto, K., Sawa, A., & Iyo, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.017 · Cited by 609 · see citing works

Activation of VTA GABA Neurons Disrupts Reward Consumption

van Zessen, R., Phillips, J. L., Budygin, E. A., & Stuber, G. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.016 · Cited by 609 · see citing works

The GABA system in anxiety and depression and its therapeutic potential

Möhler, H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.08.040 · Cited by 599 · see citing works

Dopaminergic neurons inhibit striatal output through non-canonical release of GABA

Tritsch, N. X., Ding, J. B., & Sabatini, B. L. (2012) · Nature · doi:10.1038/nature11466 · Cited by 576 · see citing works

Stress, hypercortisolism and corticosteroid receptors in depression: implicatons for therapy

Holsboer, F. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00352-9 · Cited by 575 · see citing works

Synapsins as mediators of BDNF-enhanced neurotransmitter release

Jovanovic, J. N., Czernik, A. J., Fienberg, A. A., Greengard, P., & Sihra, T. S. (2000) · Nature Neuroscience · doi:10.1038/73888 · Cited by 566 · see citing works

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

Yuen, E. Y., Wei, J., Liu, W., Zhong, P., Li, X., & Yan, Z. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.033 · Cited by 558 · see citing works

Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues

Crestani, F., Lorez, M., Baer, K., Essrich, C., Benke, D., Laurent, J. P., Belzung, C., Fritschy, J.-M., Lüscher, B., & Mohler, H. (1999) · Nature Neuroscience · doi:10.1038/12207 · Cited by 550 · see citing works

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

Kheirbek, M., Klemenhagen, K. C., Sahay, A., & Hen, R. (2012) · Nature Neuroscience · doi:10.1038/nn.3262 · Cited by 543 · see citing works

Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis

Cullinan, W. E., Herman, J. P., & Watson, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903320102 · Cited by 541 · see citing works

Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety

Gatt, J. M., Nemeroff, C. B., Dobson-Stone, C., Paul, R. H., Bryant, R. A., Schofield, P. R., Gordon, E., Kemp, A. H., & Williams, L. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.143 · Cited by 525 · see citing works

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

Preskorn, S., Baker, B., Kolluri, S., Menniti, F. S., Krams, M., & Landen, J. W. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31818a6cea · Cited by 522 · see citing works

Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice

Mihalek, R., Banerjee, P., Korpi, E. R., Quinlan, J. J., Firestone, L. L., Mi, Z.-P., Lagenaur, C. F., Tretter, V. E., Sieghart, W., Anagnostaras, S., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12905 · Cited by 520 · see citing works

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Song, J., Zhong, C., Bonaguidi, M. A., Sun, G. J., Hsu, D., Gu, Y., Meletis, K., Huang, Z. J., Ge, S., Enikolopov, G., et al. (2012) · Nature · doi:10.1038/nature11306 · Cited by 515 · see citing works

Increased Cortical GABA Concentrations in Depressed Patients Receiving ECT

Sanacora, G., Mason, G. F., Rothman, D. L., Hyder, F., Ciarcia, J. J., Ostroff, R. B., Berman, R., & Krystal, J. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.3.577 · Cited by 512 · see citing works

Altered Expression of Genes Involved in Inflammation and Apoptosis in Frontal Cortex in Major Depression

Shelton, R. C., Claiborne, J., Sidoryk-Wegrzynowicz, M., Reddy, R., Aschner, M., Lewis, D. A., & Mirnics, K. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.52 · Cited by 511 · see citing works

Anticholinergic Activity of 107 Medications Commonly Used by Older Adults

Chew, M. L., Mulsant, B. H., Pollock, B. G., Lehman, M. E., Greenspan, A. J., Mahmoud, R. A., Kirshner, M. A., Sorisio, D. A., Bies, R. R., & Gharabawi, G. M. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01737.x · Cited by 499 · see citing works

Increased Occipital Cortex GABA Concentrations in Depressed Patients After Therapy With Selective Serotonin Reuptake Inhibitors

Sanacora, G., Mason, G. F., Rothman, D. L., & Krystal, J. H. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.663 · Cited by 495 · see citing works

Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein

Nakagawa, S., Kim, J., Lee, R., Malberg, J. E., Chen, J., Steffen, C., Zhang, Y., Nestler, E. J., & Duman, R. S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03673.2002 · Cited by 486 · see citing works

Antidepressants recruit new neurons to improve stress response regulation

Surget, A., Tanti, A., Leonardo, E. D., Laugeray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.48 · Cited by 471 · see citing works

Neuroinflammation and comorbidity of pain and depression

Walker, A. K., Kavelaars, A., Heijnen, C. J., & Dantzer, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008144 · Cited by 460 · see citing works

Trophic actions of GABA on neuronal development

Represa, A., & Ben‐Ari, Y. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.03.010 · Cited by 456 · see citing works

Loss of Postsynaptic GABAA Receptor Clustering in Gephyrin-Deficient Mice

Kneussel, M., Brandstätter, J., Laube, B., Stahl, S., Müller, U., & Betz, H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-21-09289.1999 · Cited by 456 · see citing works

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

Taliaz, D., Stall, N., Dar, D. E., & Zangen, A. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.67 · Cited by 454 · see citing works

GABAAR Plasticity during Pregnancy: Relevance to Postpartum Depression

Maguire, J., & Mody, I. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.019 · Cited by 437 · see citing works

Reduced hippocampal volumes and memory loss in patients with early- and late-onset depression

Hickie, I., Naismith, S., Ward, P. B., Turner, K., Scott, E., Mitchell, P., Wilhelm, K., & Parker, G. (2005) · British Journal of Psychiatry · doi:10.1192/bjp.186.3.197 · Cited by 437 · see citing works

GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses

Lüscher, B., Fuchs, T. A. E., & Kilpatrick, C. L. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.024 · Cited by 432 · see citing works

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Rajkowska, G., O'Dwyer, G., Teleki, Z., Stockmeier, C. A., & Miguel-Hidalgo, J. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301234 · Cited by 430 · see citing works

Gephyrin: a master regulator of neuronal function?

Tyagarajan, S. K., & Fritschy, J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3670 · Cited by 425 · see citing works

Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression

Eisch, A. J., Bolaños, C. A., de Wit, J., Simonak, R. D., Pudiak, C. M., Barrot, M., Verhaagen, J., & Nestler, E. J. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.08.003 · Cited by 420 · see citing works

A negative regulator of MAP kinase causes depressive behavior

Duric, V., Banasr, M., Licznerski, P., Schmidt, H. D., Stockmeier, C. A., Simen, A. A., Newton, S. S., & Duman, R. S. (2010) · Nature Medicine · doi:10.1038/nm.2219 · Cited by 412 · see citing works

Mapping the depressed brain: A meta-analysis of structural and functional alterations in major depressive disorder

Sacher, J., Neumann, J., Fünfstück, T., Soliman, A., Villringer, A., & Schroeter, M. L. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.001 · Cited by 410 · see citing works

Glutamate and Depression: Clinical and Preclinical Studies

PAUL, I. A., & SKOLNICK, P. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.016 · Cited by 408 · cited 1× · see citing works

Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond

Krystal, J. H., Sanacora, G., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.026 · Cited by 406 · see citing works

Stress and development: Behavioral and biological consequences

Bremner, J., & Vermetten, E. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003042 · Cited by 405 · see citing works

Dysregulation in the Suicide Brain: mRNA Expression of Corticotropin-Releasing Hormone Receptors and GABA_AReceptor Subunits in Frontal Cortical Brain Region

Merali, Z., Du, L., Hrdina, P., Palkovits, M., Faludi, G., Poulter, M. O., & Anisman, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4734-03.2004 · Cited by 400 · see citing works

Global Brain Gene Expression Analysis Links Glutamatergic and GABAergic Alterations to Suicide and Major Depression

Sequeira, A., Mamdani, F., Ernst, C., Vawter, M. P., Bunney, W. E., Lebel, V., Rehal, S., Klempan, T., Gratton, A., Benkelfat, C., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006585 · Cited by 388 · see citing works

Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression

Guilloux, J.-P., Douillard-Guilloux, G., Kota, R., Wang, X., Gardier, A. M., Martinowich, K., Tseng, G. C., Lewis, D. A., & Sibille, E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.113 · Cited by 378 · see citing works

Lateralized Effects of Medial Prefrontal Cortex Lesions on Neuroendocrine and Autonomic Stress Responses in Rats

Sullivan, R. M., & Gratton, A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-07-02834.1999 · Cited by 377 · see citing works

Hippocampal volume in geriatric depression

Steffens, D. C., Byrum, C. E., McQuoid, D. R., Greenberg, D. L., Payne, M. E., Blitchington, T. F., MacFall, J. R., & Krishnan, K. R. R. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00829-5 · Cited by 375 · see citing works

Cholinergic signaling in the hippocampus regulates social stress resilience and anxiety- and depression-like behavior

Mineur, Y. S., Obayemi, A., Wigestrand, M. B., Fote, G. M., Calarco, C. A., Li, A. M., & Picciotto, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219731110 · Cited by 375 · see citing works

Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learning

Brown, M. T. C., Tan, K. R., O’Connor, E. C., Nikonenko, I., Müller, D., & Lüscher, C. (2012) · Nature · doi:10.1038/nature11657 · Cited by 368 · see citing works

Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression

Raison, C. L., Borisov, A. S., Majer, M., Drake, D. F., Pagnoni, G., Woolwine, B. J., Vogt, G. J., Massung, B., & Miller, A. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.010 · Cited by 367 · see citing works

GABA sets the tempo for activity-dependent adult neurogenesis

Ge, S., Pradhan, D. A., Ming, G., & Song, H. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.11.001 · Cited by 366 · see citing works

A Biological Function for the Neuronal Activity-Dependent Component of Bdnf Transcription in the Development of Cortical Inhibition

Hong, E. J., McCord, A. E., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.024 · Cited by 366 · see citing works

A neurotrophic hypothesis of depression: role of synaptogenesis in the actions of NMDA receptor antagonists

Duman, R. S., & Li, N. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0357 · Cited by 362 · see citing works

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Acute and Continuation Treatment of Major Depressive Disorder

Bauer, M., Whybrow, P. C., Angst, J., Versiani, M., Möller, H., & WFSBP Task Force on Treatment Guide (2002) · The World Journal of Biological Psychiatry · doi:10.3109/15622970209150599 · Cited by 340 · see citing works

A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment

Duman, C. H., Schlesinger, L., Kodama, M., Russell, D., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.047 · Cited by 338 · see citing works

Brain morphometric abnormalities in geriatric depression: Long-term neurobiological effects of illness duration

Bell-McGinty, S., Butters, M. A., Meltzer, C. C., Greer, P. J., Reynolds, C. F., & Becker, J. T. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1424 · Cited by 338 · see citing works

Reduced activation and expression of ERK1/2 MAP kinase in the post‐mortem brain of depressed suicide subjects

Dwivedi, Y., Rizavi, H. S., Roberts, R. C., Conley, R. C., Tamminga, C. A., & Pandey, G. N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00300.x · Cited by 333 · see citing works

Correlation between plasma levels of glutamate, alanine and serine with severity of depression

Mitani, H., Shirayama, Y., Yamada, T., Maeda, K., Ashby, C. R., & Kawahara, R. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.036 · Cited by 332 · see citing works

GABAA Receptor Promoter Hypermethylation in Suicide Brain: Implications for the Involvement of Epigenetic Processes

Poulter, M. O., Du, L., Weaver, I. C. G., Palkovits, M., Faludi, G., Merali, Z., Szyf, M., & Anisman, H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.028 · Cited by 331 · see citing works

The pharmacologic profile of mirtazapine.

de Boer, T. (1996) · PubMed · Cited by 330 · see citing works

Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography.

Uzunov, D. P., Cooper, T. B., Costa, E., & Guidotti, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12599 · Cited by 330 · see citing works

GABA-cAMP Response Element-Binding Protein Signaling Regulates Maturation and Survival of Newly Generated Neurons in the Adult Hippocampus

Jagasia, R., Steib, K., Englberger, E., Herold, S., Faus-Keßler, T., Saxe, M., Gage, F. H., Song, H., & Lie, D. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1054-09.2009 · Cited by 328 · see citing works

Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory

Yuen, E. Y., Liu, W., Karatsoreos, I. N., Ren, Y., Feng, J., McEwen, B. S., & Yan, Z. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.50 · Cited by 324 · see citing works

Hippocampal atrophy in first episode depression: A meta-analysis of magnetic resonance imaging studies

Cole, J., Costafreda, S. G., McGuffin, P., & Fu, C. H. Y. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.05.057 · Cited by 319 · see citing works

GABA _A Receptor Subtypes: Therapeutic Potential in Down Syndrome, Affective Disorders, Schizophrenia, and Autism

Rudolph, U., & Möhler, H. (2014) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135947 · Cited by 319 · see citing works

Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance

Lagace, D. C., Donovan, M. H., DeCarolis, N. A., Farnbauch, L. A., Malhotra, S., Berton, O., Nestler, E. J., Krishnan, V., & Eisch, A. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910072107 · Cited by 314 · see citing works

BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2

Aguado, F., Carmona, M. A., Pozas, E., Aguiló, A., Martinez-Guijarro, F. J., Alcántara, S., Borrell, V., Yuste, R., Ibáñez, C. F., & Soriano, E. (2003) · Development · doi:10.1242/dev.00351 · Cited by 304 · see citing works

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

Lee, H. H. C., Deeb, T. Z., Walker, J., Davies, P. A., & Moss, S. J. (2011) · Nature Neuroscience · doi:10.1038/nn.2806 · Cited by 303 · see citing works

A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia

Clerc, G. E., Ruimy, P., & Verdeau-Pailles, J. (1994) · International Clinical Psychopharmacology · doi:10.1097/00004850-199409000-00001 · Cited by 301 · see citing works

Low plasma BDNF is associated with suicidal behavior in major depression

Kim, Y.-K., Lee, H.-P., Won, S.-D., Park, E.-Y., Lee, H.-Y., Lee, B.-H., Lee, S.-W., Yoon, D., Han, C., Kim, D.-J., et al. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.024 · Cited by 300 · cited 1× · see citing works

Regulation of Adult Neurogenesis by Psychotropic Drugs and Stress

Duman, R. S., Malberg, J. E., & Nakagawa, S. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29244-2 · Cited by 300 · see citing works

Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression

Klempan, T. A., Sequeira, A., Canetti, L., Lalovic, A., Ernst, C., ffrench-Mullen, J., & Turecki, G. (2009) · Molecular Psychiatry · doi:10.1038/sj.mp.4002110 · Cited by 294 · see citing works

Inhibition of glycogen synthase kinase-3 is necessary for the rapid antidepressant effect of ketamine in mice

Beurel, E., Song, L., & Jope, R. S. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.47 · Cited by 288 · see citing works

Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression

Gourley, S. L., Wu, F. J., Kiraly, D. D., Ploski, J. E., Kedves, A. T., Duman, R. S., & Taylor, J. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.016 · Cited by 287 · see citing works

BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission

Waterhouse, E. G., An, J. J., Orefice, L. L., Baydyuk, M., Liao, G.-Y., Zheng, K., Lu, B., & Xu, B. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0709-12.2012 · Cited by 287 · see citing works

Neurogenesis and affective disorders

Samuels, B. A., & Hen, R. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07614.x · Cited by 286 · see citing works

Comparative efficacy of selective serotonin reuptake inhibitors and tricyclics in the treatment of melancholia

Roose, S. P., Glassman, A. H., Attia, E., & Woodring, S. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.12.1735 · Cited by 286 · see citing works

Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [¹¹C]ABP688 PET and Postmortem Study

Deschwanden, A., Karolewicz, B., Feyissa, A. M., Treyer, V., Ametamey, S. M., Johayem, A., Burger, C., Auberson, Y. P., Sovago, J., Stockmeier, C. A., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.09111607 · Cited by 278 · see citing works

Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants

Yu, H., Wang, D.-D., Wang, Y., Liu, T., Lee, F. S., & Chen, Z.-Y. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5048-11.2012 · Cited by 275 · see citing works

Brain-Derived Neurotrophic Factor Signaling and Subgenual Anterior Cingulate Cortex Dysfunction in Major Depressive Disorder

Tripp, A., Oh, H., Guilloux, J.-P., Martinowich, K., Lewis, D. A., & Sibille, E. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12020248 · Cited by 273 · see citing works

Etiology of depression comorbidity in combat-related PTSD: a review of the literature

Stander, V. A., Thomsen, C. J., & Highfill-McRoy, R. M. (2014) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.12.002 · Cited by 271 · see citing works

Maternal Care and DNA Methylation of a Glutamic Acid Decarboxylase 1 Promoter in Rat Hippocampus

Zhang, T., Hellstrom, I. C., Bagot, R. C., Wen, X., Diorio, J. C., & Meaney, M. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1039-10.2010 · Cited by 269 · see citing works

A Discrete GABAergic Relay Mediates Medial Prefrontal Cortical Inhibition of the Neuroendocrine Stress Response

Radley, J. J., Gosselink, K. L., & Sawchenko, P. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5924-08.2009 · Cited by 268 · see citing works

Age-Dependent Reductions in the Level of Glial Fibrillary Acidic Protein in the Prefrontal Cortex in Major Depression

Si, X., Miguel-Hidalgo, J. J., O'Dwyer, G., Stockmeier, C. A., & Rajkowska, G. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300525 · Cited by 268 · see citing works

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

Zattoni, M., Mura, M. L., Deprez, F., Schwendener, R. A., Engelhardt, B., Frei, K., & Fritschy, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6210-10.2011 · Cited by 267 · see citing works

Evidence of Cortical Inhibitory Deficits in Major Depressive Disorder

Levinson, A. J., Fitzgerald, P. B., Favalli, G., Blumberger, D. M., Daigle, M., & Daskalakis, Z. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.025 · Cited by 261 · see citing works

Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper

Grønli, J., Bramham, C., Murison, R., Kanhema, T., Fiske, E., Bjorvatn, B., Ursin, R., & Portas, C. M. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.11.021 · Cited by 260 · see citing works

GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine

Liu, R.-J., Fuchikami, M., Dwyer, J. M., Lepack, A. E., Duman, R. S., & Aghajanian, G. K. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.128 · Cited by 256 · see citing works

Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA_AReceptors

Sarkar, J., Wakefield, S., MacKenzie, G., Moss, S. J., & Maguire, J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2560-11.2011 · Cited by 254 · see citing works

Stress Impairs GABAergic Network Function in the Hippocampus by Activating Nongenomic Glucocorticoid Receptors and Affecting the Integrity of the Parvalbumin-Expressing Neuronal Network

Hu, W., Zhang, M., Czéh, B., Flügge, G., & Zhang, W. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.31 · Cited by 246 · see citing works

Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

Pinna, G., Costa, E., & Guidotti, A. (2006) · Psychopharmacology · doi:10.1007/s00213-005-0213-2 · Cited by 245 · see citing works

Neurosteroid Synthesis-Mediated Regulation of GABAAReceptors: Relevance to the Ovarian Cycle and Stress

Maguire, J. L., & Módy, I. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4945-06.2007 · Cited by 244 · see citing works

The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?

Petrik, D., Lagace, D. C., & Eisch, A. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.003 · Cited by 241 · see citing works

Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats

Garcia, L. S. B., Comim, C. M., Valvassori, S. S., Réus, G. Z., Stertz, L., Kapczinski, F. P., Gavioli, E. C., & Quevedo, J. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.01.004 · Cited by 238 · see citing works

Altered chloride homeostasis removes synaptic inhibitory constraint of the stress axis

Hewitt, S. A., Cusulin, J. I. W., Kurz, E. U., & Bains, J. S. (2009) · Nature Neuroscience · doi:10.1038/nn.2274 · Cited by 237 · see citing works

Serotonin is required for exercise-induced adult hippocampal neurogenesis

Klempin, F., Beis, D., Mosienko, V., Kempermann, G., Bader, M., & Alenina, N. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5855-12.2013 · Cited by 235 · see citing works

TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellum

Rico, B., Xu, B., & Reichardt, L. F. (2002) · Nature Neuroscience · doi:10.1038/nn808 · Cited by 230 · see citing works

Increased Brain GABA Concentrations Following Acute Administration of a Selective Serotonin Reuptake Inhibitor

Bhagwagar, Z., Wylezinska, M., Taylor, M. J., Jezzard, P., Matthews, P. M., & Cowen, P. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.368 · Cited by 227 · see citing works

Glial and glutamatergic markers in depression, alcoholism, and their comorbidity

Miguel-Hidalgo, J. J., Waltzer, R., Whittom, A. A., Austin, M. C., Rajkowska, G., & Stockmeier, C. A. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.06.003 · Cited by 218 · see citing works

GABA-related transcripts in the dorsolateral prefrontal cortex in mood disorders

Sibille, E., Morris, H. M., Kota, R. S., & Lewis, D. A. (2011) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001616 · Cited by 217 · see citing works

Imaging phenotypes of major depressive disorder: genetic correlates

Savitz, J. B., & Drevets, W. C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.082 · Cited by 216 · see citing works

Contribution of the Ventral Subiculum to Inhibitory Regulation of the Hypothalamo‐Pituitary‐Adrenocortical Axis

Herman, J. P., Cullinan, W. E., Morano, M. I., Akil, H., & Watson, S. J. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00784.x · Cited by 214 · see citing works

Alterations in Somatostatin mRNA Expression in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia or Schizoaffective Disorder

Morris, H. M., Hashimoto, T., & Lewis, D. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm186 · Cited by 213 · see citing works

Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala

Murray, E. A., Wise, S. P., & Drevets, W. C. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.041 · Cited by 208 · see citing works

Regulation of GABAergic synapse formation and plasticity by GSK3β-dependent phosphorylation of gephyrin

Tyagarajan, S. K., Ghosh, H., Yévenes, G. E., Nikonenko, I., Ebeling, C., Schwerdel, C., Sidler, C., Zeilhofer, H. U., Gerrits, B., Müller, D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011824108 · Cited by 204 · see citing works

Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression

Karolewicz, B., Maciag, D., O'Dwyer, G., Stockmeier, C. A., Feyissa, A. M., & Rajkowska, G. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990587 · Cited by 203 · see citing works

GABAergic Control of Adult Hippocampal Neurogenesis in Relation to Behavior Indicative of Trait Anxiety and Depression States

Earnheart, J. C., Schweizer, C., Crestani, F., Iwasato, T., Itohara, S., Mohler, H., & Lüscher, B. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3609-06.2007 · Cited by 203 · see citing works

Anterior Cingulate Cortexγ-Aminobutyric Acid in Depressed Adolescents: Relationship to Anhedonia

Gabbay, V. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.131 · Cited by 201 · see citing works

Brain-Derived Neurotrophic Factor Modulation of GABAergic Synapses by Postsynaptic Regulation of Chloride Transport

Wardle, R. A., & Poo, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08722.2003 · Cited by 201 · see citing works

Role of BDNF epigenetics in activity-dependent neuronal plasticity

Karpova, N. N. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.002 · Cited by 200 · see citing works

Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex

Sakata, K., Woo, N. H., Martinowich, K., Greene, J. S., Schloesser, R. J., Shen, L., & Lu, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811431106 · Cited by 200 · see citing works

Reelin and glutamic acid decarboxylase 67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia

Dong, E., Agís‐Balboa, R. C., Simonini, M. V., Grayson, D. R., Costa, E., & Guidotti, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505394102 · Cited by 198 · see citing works

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments

Duman, R. S., Sanacora, G., & Krystal, J. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.013 · Cited by 1,026 · see citing works

Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model

Price, R. B., & Duman, R. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0615-x · Cited by 721 · see citing works

PV Interneurons: Critical Regulators of E/I Balance for Prefrontal Cortex-Dependent Behavior and Psychiatric Disorders

Ferguson, B. R., & Gao, W.-J. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00037 · Cited by 594 · see citing works

Influence of glutamate and GABA transport on brain excitatory/inhibitory balance

Sears, S. M. S., & Hewett, S. J. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221989263 · Cited by 348 · see citing works

Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives

Fee, C., Banasr, M., & Sibille, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.024 · Cited by 329 · see citing works

Trial of SAGE-217 in Patients with Major Depressive Disorder

Gunduz-Bruce, H., Silber, C., Kaul, I., Rothschild, A. J., Riesenberg, R., Sankoh, A. J., Li, H., Lasser, R., Zorumski, C. F., Rubinow, D. R., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1815981 · Cited by 232 · see citing works

Differences in excitatory and inhibitory neurotransmitter levels between depressed patients and healthy controls: A systematic review and meta-analysis

Godfrey, K. E. M., Gardner, A. C., Kwon, S., Chea, W., & Muthukumaraswamy, S. D. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.08.015 · Cited by 207 · see citing works

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

Fuchs, T., Jefferson, S. J., Hooper, A., Yee, P.-H., Maguire, J., & Luscher, B. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.188 · Cited by 204 · see citing works

Prefrontal cortex GABAergic deficits and circuit dysfunction in the pathophysiology and treatment of chronic stress and depression

Ghosal, S., Hare, B. D., & Duman, R. S. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.09.012 · Cited by 203 · see citing works

Dietary fiber and its associations with depression and inflammation

Swann, O. G., Kilpatrick, M., Breslin, M., & Oddy, W. H. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuz072 · Cited by 185 · see citing works

Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder

Sarawagi, A., Soni, N. D., & Patel, A. B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.637863 · Cited by 172 · see citing works

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder

Cutler, A. J., Mattingly, G. W., & Maletic, V. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02514-2 · Cited by 147 · see citing works

Long-Term Stress Disrupts the Structural and Functional Integrity of GABAergic Neuronal Networks in the Medial Prefrontal Cortex of Rats

Czéh, B., Vardya, I., Varga, Z., Febbraro, F., Csabai, D., Martis, L., Højgaard, K., Henningsen, K., Bouzinova, E. V., Miseta, A., et al. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00148 · Cited by 129 · see citing works

Sensory processing sensitivity and serotonin gene variance: Insights into mechanisms shaping environmental sensitivity

Homberg, J. R., Schubert, D., Asan, E., & Aron, E. N. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.029 · Cited by 121 · see citing works

Can we ‘seize’ the gut microbiota to treat epilepsy?

De Caro, C., Iannone, L. F., Citraro, R., Striano, P., De Sarro, G., Constanti, A., Cryan, J. F., & Russo, E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.002 · Cited by 110 · see citing works

Steroid Hormone Sensitivity in Reproductive Mood Disorders: On the Role of the GABAA Receptor Complex and Stress During Hormonal Transitions

Schweizer-Schubert, S., Gordon, J. L., Eisenlohr-Moul, T. A., Meltzer-Brody, S. E., Schmalenberger, K. M., Słopień, R., Zietlow, A., Ehlert, U., & Ditzen, B. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2020.479646 · Cited by 118 · see citing works

Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience

Lüscher, B., & Möhler, H. (2019) · F1000Research · doi:10.12688/f1000research.18758.1 · Cited by 105 · see citing works

An Overview of the Heterogeneity of Major Depressive Disorder: Current Knowledge and Future Prospective

Athira, K. V., Bandopadhyay, S., Samudrala, P. K., Naidu, V. G. M., Lahkar, M., & Chakravarty, S. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191001142934 · Cited by 103 · see citing works

Modulation of microglial activation by antidepressants

Mariani, N., Everson, J., Pariante, C. M., & Borsini, A. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811211069110 · Cited by 92 · see citing works

Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents

Ghosal, S., Duman, C. H., Liu, R.-J., Wu, M., Terwilliger, R., Girgenti, M. J., Wohleb, E., Fogaca, M. V., Teichman, E. M., Hare, B., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104669 · Cited by 89 · see citing works

Novel Benzodiazepine-Like Ligands with Various Anxiolytic, Antidepressant, or Pro-Cognitive Profiles

Prévot, T. D., Li, G., Vidojević, A., Misquitta, K. A., Fee, C., Santrač, A., Knutson, D. E., Stephen, M. R., Kodali, R., Zahn, N. M., et al. (2019) · Complex Psychiatry · doi:10.1159/000496086 · Cited by 83 · see citing works

GABAergic Regulation of Adult Hippocampal Neurogenesis

Sibbe, M., & Kulik, Á. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0072-3 · Cited by 81 · see citing works

A developmental reduction of the excitation:inhibition ratio in association cortex during adolescence

Larsen, B., Cui, Z., Adebimpe, A., Pines, A., Alexander-Bloch, A., Bertolero, M., Calkins, M. E., Gur, R. E., Gur, R. C., Mahadevan, A. S., et al. (2022) · Science Advances · doi:10.1126/sciadv.abj8750 · Cited by 80 · see citing works

Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis

Catavero, C. M., Bao, H., & Song, J. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2668-y · Cited by 75 · see citing works

Thalamic Gamma Aminobutyric Acid Level Changes in Major Depressive Disorder After a 12-Week Iyengar Yoga and Coherent Breathing Intervention

Streeter, C. C., Gerbarg, P. L., Brown, R. P., Scott, T. M., Nielsen, G. H., Owen, L., Sakai, O., Sneider, J. T., Nyer, M., & Silveri, M. M. (2020) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2019.0234 · Cited by 70 · see citing works

Novel rapid-acting glutamatergic modulators: Targeting the synaptic plasticity in depression

Wang, Y., Wang, X., Feng, S., Chen, N., Wang, Z., & Zhang, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105761 · Cited by 68 · see citing works

Large-scale functional network overlap is a general property of brain functional organization: Reconciling inconsistent fMRI findings from general-linear-model-based analyses

Xu, J., Potenza, M. N., Calhoun, V. D., Zhang, R., Yip, S. W., Wall, J. T., Pearlson, G. D., Worhunsky, P. D., Garrison, K. A., & Moran, J. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.035 · Cited by 68 · see citing works

The impact of accelerated high frequency rTMS on brain neurochemicals in treatment-resistant depression: Insights from 1H MR spectroscopy

Baeken, C., Lefaucheur, J., & Schuerbeek, P. V. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.06.243 · Cited by 66 · see citing works

Periaqueductal Gray Glutamatergic Transmission Governs Chronic Stress-Induced Depression

Ho, Y., Lin, T.-B., Hsieh, M., Lai, C., Chou, D., Chau, Y., Chen, G., & Peng, H. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.199 · Cited by 62 · see citing works

Serial Prefrontal Pathways Are Positioned to Balance Cognition and Emotion in Primates

Joyce, M. K. P., García‐Cabezas, M. Á., John, Y. J., & Barbas, H. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0860-20.2020 · Cited by 60 · see citing works

From stress to depression: development of extracellular matrix-dependent cognitive impairment following social stress

Koskinen, M.-K., van Mourik, Y., Smit, A. B., Riga, D., & Spijker, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-73173-2 · Cited by 61 · see citing works

Rodent ketamine depression-related research: Finding patterns in a literature of variability

Polis, A. J., Fitzgerald, P. J., Hale, P. J., & Watson, B. O. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112153 · Cited by 62 · see citing works

From bugs to brain: unravelling the GABA signalling networks in the brain–gut–microbiome axis

Belelli, D., Lambert, J. J., Wan, M. L. Y., Monteiro, A. R., Nutt, D., & Swinny, J. D. (2024) · Brain · doi:10.1093/brain/awae413 · Cited by 67 · see citing works

SAGE-217, a novel GABAA receptor positive allosteric modulator: clinical pharmacology and tolerability in randomized phase i dose-finding studies.

Hoffmann, E., Nomikos, G. G., Kaul, I., Raines, S., Wald, J., Bullock, A., Sankoh, A. J., Doherty, J., Kanes, S. J., & Colquhoun, H. (2020) · Clinical Pharmacokinetics · doi:10.1007/s40262-019-00801-0 · Cited by 59 · see citing works

Biogenic Amines and the Amino Acids GABA and Glutamate: Relationships with Pain and Depression

Benson, C. A., Mifflin, K. A., Kerr, B. J., Jesudasan, S. J. B., Dursun, S. M., & Baker, G. B. (2015) · Modern trends in psychiatry · doi:10.1159/000435933 · Cited by 56 · see citing works

High‐dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression

Field, D. T., Cracknell, R., Eastwood, J., Scarfe, P., Williams, C. M., Zheng, Y., & Tavassoli, T. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2852 · Cited by 55 · see citing works

Resveratrol Attenuates Chronic Unpredictable Mild Stress-Induced Alterations in the SIRT1/PGC1α/SIRT3 Pathway and Associated Mitochondrial Dysfunction in Mice

Tabassum, S., Misrani, A. A., Huang, H., Zhang, Z.-Y., Li, Q.-W., & Long, C. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03395-8 · Cited by 55 · see citing works

Neurobiology of the rapid-acting antidepressant effects of ketamine: impact and opportunities

Shinohara, R., Aghajanian, G. K., & Abdallah, C. G. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.006 · Cited by 54 · see citing works

Chronic Stress Exposure Reduces Parvalbumin Expression in the Rat Hippocampus through an Imbalance of Redox Mechanisms: Restorative Effect of the Antipsychotic Lurasidone

Rossetti, A. C., Paladini, M. S., Colombo, M., Gruca, P., Łasoń, M., Tota-Glowczyk, K., Papp, M., Riva, M. A., & Molteni, R. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy046 · Cited by 53 · see citing works

Ketogenic diet for depression: A potential dietary regimen to maintain euthymia?

Włodarczyk, A., Cubała, W. J., & Stawicki, M. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110257 · Cited by 51 · see citing works

GABA System in Depression: Impact on Pathophysiology and Psychopharmacology

Vecchia, A. D., Arone, A., Piccinni, A., Mucci, F., & Marazziti, D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666211115124149 · Cited by 52 · see citing works

Prefrontal Cortical Reactivity and Connectivity Markers Distinguish Youth Depression from Healthy Youth

Dhami, P., Atluri, S., Lee, J. C., Knyahnytska, Y., Croarkin, P. E., Blumberger, D. M., Daskalakis, Z. J., & Farzan, F. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa004 · Cited by 49 · see citing works

The role of the excitation:inhibition functional balance in the mPFC in the onset of antidepressants

Yin, Y., Wang, Y., Liu, W., Yao, J.-Q., Yuan, J., Li, Z.-H., Ran, Y., Zhang, L., & Li, Y. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108573 · Cited by 48 · see citing works

Chronic stress affects the number of GABAergic neurons in the orbitofrontal cortex of rats

Varga, Z., Csabai, D., Miseta, A., Wiborg, O., & Czéh, B. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.030 · Cited by 48 · see citing works

Disinhibition, an emerging pharmacology of learning and memory

Möhler, H., & Rudolph, U. (2017) · F1000Research · doi:10.12688/f1000research.9947.1 · Cited by 44 · see citing works

The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice

Yan, T., Xu, M., Wu, B., Liao, Z., Liu, Z., Zhao, X. D., Kai-shun, B., & Jia, Y. (2016) · Food & Function · doi:10.1039/c6fo00328a · Cited by 42 · see citing works

Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition

Lüscher, B., Feng, M., & Jefferson, S. J. (2020) · Advances in pharmacology · doi:10.1016/bs.apha.2020.03.002 · Cited by 41 · see citing works

Absence seizures and their relationship to depression and anxiety: Evidence for bidirectionality

Gruenbaum, B. F., Sandhu, M. R. S., Bertasi, R. A. O., Bertasi, T. G. O., Schonwald, A., Kurup, A., Gruenbaum, S. E., Freedman, I. G., Funaro, M. C., Blumenfeld, H., et al. (2021) · Epilepsia · doi:10.1111/epi.16862 · Cited by 40 · see citing works

Magnetic resonance (MR) spectroscopic measurement of γ-aminobutyric acid (GABA) in major depression before and after electroconvulsive therapy

Knudsen, M. K., Near, J., Blicher, A. B., Videbech, P., & Blicher, J. U. (2018) · Acta Neuropsychiatrica · doi:10.1017/neu.2018.22 · Cited by 38 · see citing works

Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior

Goubert, E., Altvater, M., Rovira, M.-N., Khalilov, I., Mazzarino, M., Sebastiani, A., Schaefer, M. K. E., Rivera, C., & Pellegrino, C. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00012 · Cited by 33 · see citing works

Increase in Seizure Susceptibility After Repetitive Concussion Results from Oxidative Stress, Parvalbumin-Positive Interneuron Dysfunction and Biphasic Increases in Glutamate/GABA Ratio

MacMullin, P., Hodgson, N., Damar, U., Lee, H. H. C., Hameed, M. Q., Dhamne, S. C., Hyde, D. E., Conley, G. M., Morriss, N. J., Qiu, J., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa157 · Cited by 35 · see citing works

Identification of key genes, pathways and miRNA/mRNA regulatory networks of CUMS-induced depression in nucleus accumbens by integrated bioinformatics analysis

Ma, K., Zhang, H., Wei, G., Dong, Z., Zhao, H., Han, X., Song, X., Zhang, H., Zong, X., Baloch, Z., et al. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s200264 · Cited by 32 · see citing works

Exercise Ameliorates Fluoride-induced Anxiety- and Depression-like Behavior in Mice: Role of GABA

Cao, Q., Wang, J., Hao, Y., Fang-ye, Z., Fu, R., Yu, Y., Wang, J., Niu, R., Bian, S., & Sun, Z. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02678-2 · Cited by 34 · see citing works

Age- and sex-specific effects of stress on parvalbumin interneurons in preclinical models: Relevance to sex differences in clinical neuropsychiatric and neurodevelopmental disorders

Woodward, E. M., & Coutellier, L. D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.031 · Cited by 34 · see citing works

Regulatory Effects and Mechanisms of L-Theanine on Neurotransmitters via Liver–Brain Axis Under a High Protein Diet

Xu, W., Song, Y., Xiao, W., & Gong, Z. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03608-0 · Cited by 33 · see citing works

Repeated Isoflurane Exposures Impair Long-Term Potentiation and Increase Basal GABAergic Activity in the Basolateral Amygdala

Long, R. P., II, Aroniadou‐Anderjaska, V., Prager, E. M., Pidoplichko, V. I., Figueiredo, T. H., & Braga, M. F. M. (2016) · Neural Plasticity · doi:10.1155/2016/8524560 · Cited by 34 · see citing works

Hippocampal PGC-1α-mediated positive effects on parvalbumin interneurons are required for the antidepressant effects of running exercise

Wang, J., Tang, J., Liang, X., Luo, Y., Zhu, P., Li, Y., Xiao, K., Jiang, L. H., Yang, H., Xie, Y., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01339-1 · Cited by 31 · see citing works

Cell Type-Specific Gene Expression of Alpha 5 Subunit-Containing Gamma-Aminobutyric Acid Subtype A Receptors in Human and Mouse Frontal Cortex

Hu, X., Rocco, B. R., Fee, C., & Sibille, E. L. (2018) · Complex Psychiatry · doi:10.1159/000495840 · Cited by 30 · see citing works

Stearoylethanolamide interferes with retrograde endocannabinoid signalling and supports the blood-brain barrier integrity under acute systemic inflammation

Kasatkina, L. A., Heinemann, Á., Hudz, Y. A., Thomas, D., & Sturm, E. M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.113783 · Cited by 30 · see citing works

Benefits of animal models to understand the pathophysiology of depressive disorders

Czéh, B., & Simon, M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110049 · Cited by 30 · see citing works

Deciphering the mechanistic impact of acupuncture on the neurovascular unit in acute ischemic stroke: Insights from basic research in a narrative review

Jiang, H., Zhang, C., Lin, M., Yin, Y., Deng, S., Liu, W., Zhuo, B., Tian, G., Du, Y., & Meng, Z. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102536 · Cited by 32 · see citing works

A Role for the Amygdala in Impairments of Affective Behaviors Following Mild Traumatic Brain Injury

McCorkle, T. A., Barson, J. R., & Raghupathi, R. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.601275 · Cited by 24 · see citing works

mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress

Xu, H., Wang, J., Jing, H., Ellenbroek, B. A., Shao, F., & Wang, W. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108412 · Cited by 24 · see citing works

Tianeptine antagonizes the reduction of PV+ and GAD67 cells number in dorsal hippocampus of socially isolated rats

Perić, I., Stanisavljević, A., Inta, D., Gass, P., Lang, U. E., Borgwardt, S., & Filipović, D. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.013 · Cited by 19 · see citing works

Scn1a haploinsufficiency in the prefrontal cortex leads to cognitive impairment and depressive phenotype

Riga, M. S., Pérez-Fernández, M., Miquel-Rio, L., Paz, V., Campa, L., Martínez‐Losa, M., Esteban, F. J., Callado, L. F., Meana, J. J., Artigas, F., et al. (2024) · Brain · doi:10.1093/brain/awae167 · Cited by 21 · see citing works

Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice

Jefferson, S. J., Feng, M., Chon, U., Guo, Y., Kim, Y., & Lüscher, B. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100238 · Cited by 19 · see citing works

Pilot validation of blood-based biomarkers during pregnancy and postpartum in women with prior or current depression

Redei, E. E., Ciolino, J. D., Wert, S. L., Yang, A., Kim, S., Clark, C. T., Zumpf, K. B., & Wisner, K. L. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01188-4 · Cited by 20 · see citing works

The involvement of GABAergic system in the antidepressant-like effect of agmatine

Neis, V. B., Rosado, A. F., Olescowicz, G., Moretti, M., da Rosa, P. B., Platt, N., & Rodrigues, A. L. S. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-01910-5 · Cited by 19 · see citing works

Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex

Cho, Y., Hwang, H., Rahman, M. A., Chung, C., & Rhim, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-63819-6 · Cited by 17 · see citing works

Alterations in the Occipital Cortex of Drug-Naïve Adults With Major Depressive Disorder: A Surface-Based Analysis of Surface Area and Cortical Thickness

Lee, J. S., Kang, W., Kang, Y., Kim, A., Han, K., Tae, W., & Ham, B. (2021) · Psychiatry Investigation · doi:10.30773/pi.2021.0099 · Cited by 18 · see citing works

Cortical GABA Levels Are Reduced in Post-Acute COVID-19 Syndrome

Marinković, K., White, D. R., Myers, A. A., Parker, K. S., Arienzo, D., & Mason, G. F. (2023) · Brain Sciences · doi:10.3390/brainsci13121666 · Cited by 16 · see citing works

From antioxidant to neuromodulator: The role of ascorbate in the management of major depression disorder

Ferreira, N. R., Vitorino, C., & Fortuna, A. C. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115300 · Cited by 16 · see citing works

Sex-specific GABAergic microcircuits that switch vulnerability into resilience to stress and reverse the effects of chronic stress exposure

Jiang, T., Feng, M., Hutsell, A., & Lüscher, B. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02835-8 · Cited by 14 · see citing works

Molecular Biological Aspects of Depressive Disorders: A Modern View

Ushakova, V. M., Morozova, A. Y., Reznik, A. M., Kostyuk, G. P., & Chekhonin, V. P. (2020) · Molecular Biology · doi:10.1134/s0026893320050118 · Cited by 15 · see citing works

GABA A Receptor Family: Overview on Structural Characterization

Amundarain, M. J., Ribeiro, R. P., Costabel, M. D., & Giorgetti, A. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0336 · Cited by 16 · see citing works

Glutamic acid decarboxylase 67 haplodeficiency in mice: consequences of postweaning social isolation on behavior and changes in brain neurochemical systems

Nullmeier, S., Elmers, C., D’Hanis, W., Sandhu, K. V., Stork, O., Yanagawa, Y., Panther, P., & Schwegler, H. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02087-6 · Cited by 14 · see citing works

Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala

Meis, S., Endres, T., Munsch, T., & Leßmann, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20174310 · Cited by 14 · see citing works

Roles of Testosterone and Estradiol in Mediation of Acute Neuroendocrine and Electroencephalographic Effects of Sevoflurane During the Sensitive Period in Rats

Li, N., Xu, N., Lin, Y., Lei, L., Ju, L.-S., Morey, T. E., Gravenstein, N. L., Zhang, J., & Martynyuk, A. E. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.545973 · Cited by 13 · see citing works

Potential biomarkers of emotional stress induced neurodegeneration

Zafar, T. (2020) · eNeurologicalSci · doi:10.1016/j.ensci.2020.100292 · Cited by 13 · see citing works

Neurological mechanism-based analysis of the role and characteristics of physical activity in the improvement of depressive symptoms

Wang, N., Zhu, S., Chen, S., Zou, J., Zeng, P., & Tan, S. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0147 · Cited by 12 · see citing works

Age‐related decline in GABAergic intracortical inhibition can be counteracted by long‐term learning of balance skills

Kuhn, Y., Egger, S., Bugnon, M., Lehmann, N., Taubert, M., & Taube, W. (2024) · The Journal of Physiology · doi:10.1113/jp285706 · Cited by 12 · see citing works

Mechanisms of action of the ketogenic diet in depression

Włodarczyk, A., & Cubała, W. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.038 · Cited by 12 · see citing works

Influence of BDNF Val66Met polymorphism on excitatory-inhibitory balance and plasticity in human motor cortex

Cash, R. F. H., Udupa, K., Gunraj, C. A., Mazzella, F., Daskalakis, Z. J., Wong, A. H. C., Kennedy, J. L., & Chen, R. E. (2021) · Clinical Neurophysiology · doi:10.1016/j.clinph.2021.07.029 · Cited by 12 · see citing works

Chronic Stress Alters Synaptic Inhibition/Excitation Balance of Pyramidal Neurons But Not PV Interneurons in the Infralimbic and Prelimbic Cortices of C57BL/6J Mice

Rodrigues, D., Santa, C., Manadas, B. J., & Monteiro, P. (2024) · eNeuro · doi:10.1523/eneuro.0053-24.2024 · Cited by 10 · see citing works

Dietary fibre intake and its associations with depressive symptoms in a prospective adolescent cohort

Swann, O. G., Breslin, M. C., Kilpatrick, M., O’Sullivan, T. A., Mori, T. A., Beilin, L. J., Lin, A. P., & Oddy, W. H. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520003426 · Cited by 9 · see citing works

An electrophysiological model of major depression: Relevance to clinical subtyping and pharmacological management

Cerda, I. H., & Fitzgerald, P. J. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114054 · Cited by 9 · see citing works

Impact of environmental enrichment on the GABAergic neurons and glucocorticoid receptors in the hippocampus and nucleus accumbens of Wistar rats: Pro-resilient effects

Begega, A., Jove, C. I., López, M., & Moreno‐Fernández, R. D. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110699 · Cited by 8 · see citing works

MicroRNA signatures in neuroplasticity, neuroinflammation and neurotransmission in association with depression

Choudhary, A., Kumar, A., Jindal, M., Rhuthuparna, M., & Munshi, A. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01065-4 · Cited by 8 · see citing works

A Load to Find Clinically Useful Biomarkers for Depression

Perković, M. N., Šagud, M., Tudor, L., Konjevod, M., Štrac, D. Š., & Pivac, N. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-33-6044-0_11 · Cited by 7 · see citing works

Metabolomic profiling relates tianeptine effectiveness with hippocampal GABA, myo-inositol, cholesterol, and fatty acid metabolism restoration in socially isolated rats

Perić, I., Lješević, M., Beskoski, V. P., Nikolic, M. R., & Filipović, D. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06180-y · Cited by 8 · see citing works

Somatostatin-positive GABAergic interneuron: new targets for depression

Zhang, C., Liu, X., & Yuan, T.-F. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.11 · Cited by 8 · see citing works

Investigating low intensity focused ultrasound pulsation in anhedonic depression—A randomized controlled trial

Rotstein, N. M., Cohen, Z. D., Welborn, A., Zbozinek, T. D., Akre, S., Jones, K. G., Null, K. E., Pontanares, J., Sanchez, K. L., Flanagan, D. C., et al. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1478534 · Cited by 7 · see citing works

Kynurenine pathway dysregulation in major depressive disorder: the convergence of excitotoxicity, neuroinflammation, and oxidative stress

O’Regan, G., Plummer, Z., Christie, B. R., Shultz, S. R., & Allen, J. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03717-2 · Cited by 10 · see citing works

The Antidepressant Action of Fluoxetine Involves the Inhibition of Dlx5/6 in Cortical GABAergic Neurons through a TrkB-Dependent Pathway

Aouci, R., Fontaine, A., Vion, A., Belz, L., Levi, G., & Narboux‐Nême, N. (2024) · Cells · doi:10.3390/cells13151262 · Cited by 7 · see citing works

In silico Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties

Malyshev, A. V., Sukhanova, I. A., Zlobin, A. S., Gedzun, V. R., Pavshintsev, V. V., Васильева, Е. В., Zalevsky, A. O., Doronin, I. I., Mitkin, N. A., Golovin, A. V., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.705590 · Cited by 7 · see citing works

TOB is an effector of the hippocampus-mediated acute stress response

Youssef, M., Hamada, H. T., Lai, S., Kiyama, Y., El‐Tabbal, M., Kiyonari, H., Nakano, K., Kühn, B., & Yamamoto, T. S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02078-7 · Cited by 7 · see citing works

Молекулярно-биологические аспекты депрессивных состояний: современный взгляд на проблему

Ushakova, V. M., Морозова, А. Ю., Reznik, A. M., Kostyuk, G. P., & Chekhonin, V. P. (2020) · Molecular Biology · doi:10.31857/s0026898420050110 · Cited by 8 · see citing works

Current Neuropharmacological Interventions in Autism: Potential Drug Targets from Pre-clinical and Clinical Findings

Sharma, R., Tiwari, A., Rahi, S., & Mehan, S. (2020) · Current Psychopharmacologye · doi:10.2174/1389203721999200820165117 · Cited by 6 · see citing works

Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons

Chen, H., He, T., Li, M., Wang, C., Chen, G., Wang, W., Yu, B., Huang, J., Cui, L., Guo, P., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1070478 · Cited by 6 · see citing works

Changes in the brain directly following alcohol consumption—a study of healthy male individuals, with the use of proton magnetic resonance spectroscopy (1HMRS) and diffusion (DWI)

Urbanik, A., Kozub, J., Karcz, P., & Ostrogórska, M. (2020) · Alcohol and Alcoholism · doi:10.1093/alcalc/agaa119 · Cited by 6 · see citing works

The GABAergic deficit hypothesis of major depressive disorder

Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934 · see citing works

GABA System in Depression: Impact on Pathophysiology and Psychopharmacology

Vecchia, A. D., Arone, A., Piccinni, A., Mucci, F., & Marazziti, D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666211115124149 · Cited by 52 · see citing works

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants

Pehrson, A. L., & Sánchez, C. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s62912 · Cited by 143 · see citing works

GABA, glutamate and beyond : in vivo measures and models of neurochemistry and network dynamics in healthy subjects and clinical populations

Shaw, A. D. (2014) · ORCA Online Research @Cardiff (Cardiff University)

GABAergic dysfunction in mood disorders

Brambilla, P., Pérez, J., Barale, F., Schettini, G., & Soares, J. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001362 · Cited by 567 · see citing works