Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders
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BACKGROUND: Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of rTMS/DMS on the brain are not yet fully understood. RESULTS: Here we studied the effects of deep-brain magnetic stimulation to brain on the molecular and cellular level. We examined the adult hippocampal neurogenesis and hippocampal synaptic plasticity of rodent under stress conditions with deep-brain magnetic stimulation treatment. We found that DMS promotes adult hippocampal neurogenesis significantly and facilitates the development of adult new-born neurons. Remarkably, DMS exerts anti-depression effects in the learned helplessness mouse model and rescues hippocampal long-term plasticity impaired by restraint stress in rats. Moreover, DMS alleviates the stress response in a mouse model for Rett syndrome and prolongs the life span of these animals dramatically. CONCLUSIONS: Deep-brain magnetic stimulation greatly facilitates adult hippocampal neurogenesis and maturation, also alleviates depression and stress-related responses in animal models.
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In preclinical depression-like models, impaired neurogenesis is observed in rodent models of depressive-like behavior.
“Hence, using proliferation and survival cell markers such as BrdU, Ki-67, or DCX, impaired neurogenesis was observed in rodent models of depressive-like behavior.”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Zhang et al. 2014b
The Background describes declining hippocampal neurogenesis as a hypothesis of depression, and the Results and discussion report depressive-like behavior in foot-shocked mice. The paper uses BrdU, Ki67, and DCX to assess neurogenesis after magnetic stimulation, but it does not report a marker-measured neurogenesis deficit in the depressive-like mice themselves; the reported decrease followed gamma irradiation. (LLM, conf=0.85)
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- Authors
- Zhang, Y., Mao, R.-R., Chen, Z.-F., Tian, M., Tong, D.-L., Gao, Z.-R., Huang, M., Li, X., Xu, X., Zhou, W.-H., Li, C.-Y., Wang, J., Xu, L., & Qiu, Z.
- Affiliations
- Chinese Academy of Sciences (CN)
- Kunming Institute of Zoology (CN)
- Children's Hospital of Fudan University (CN)
- Tianjin University (CN)
- Corresponding author
- Xu, Lin
- Qiu, Zilong
- Venue
- Molecular Brain
- Published
- 2014-02-11
- Volume
- 7
- Issue
- 1
- Pages
- 11-11
- ISSN
- 1756-6606 (ISSN-L)
- PMC
- PMC3928113
- OpenAlex
- W2141216091
- Cited by
- 69
- References
- 48
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 3 · 2014: 1
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Brain (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31100786, U1032605)
- Chinese Academy of Sciences (XDB02050400)
- National Institutes of Health
- National Key Research and Development Program of China (2013CB835103, 2011CBA00400)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult hippocampal neurogenesis, stress behavior, depression, learned helplessness, restraint stress, hippocampal synaptic plasticity, Rett syndrome, lifespan extension, neuropsychiatric disorders
- MeSH terms
- Aging, Animals, Anxiety, Behavior, Animal, Mental Disorders, Depression, Disease Models, Animal, Gene Expression Regulation, Hippocampus, Mice, Inbred C57BL, Neuronal Plasticity, Phenotype, Stress, Psychological, Synapses, Rett Syndrome, Rats, Sprague-Dawley, Dentate Gyrus, Cell Proliferation, Transcranial Magnetic Stimulation, Mice, Rats, Neurogenesis, Neural Stem Cells, Magnetic Fields
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