The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
Open accessAbstract
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex–mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition—a marker of complement activation mediated by immune complexes—was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.
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Cites
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Cited by
Liu, L., Wei, Q., Lin, Q., Fang, J., Wang, H., Kwok, H., Tang, H., Nishiura, K., Peng, J., Tan, Z., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123158 · Cited by 830
The co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722
Influenza A viruses: new research developments
Medina, R. A., & García-Sastre, A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2613 · Cited by 677
Zhang, B., Zhou, X., Zhu, C., Song, Y., Feng, F., Qiu, Y., Feng, J., Jia, Q., Song, Q., Zhu, B., et al. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00157 · Cited by 528
Influenza virus-induced lung injury: pathogenesis and implications for treatment
Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 503
Metadata
- Authors
- Monsalvo, A. C., Batalle, J. P., Lopez, M. F., Krause, J. C., Klemenc, J., Hernandez, J. Z., Maskin, B., Bugna, J., Rubinstein, C., Aguilar, L., Dalurzo, L., Libster, R., Savy, V., Baumeister, E., Aguilar, L., Cabral, G., Font, J., Solari, L., Weller, K. P., Johnson, J., Echavarria, M., Edwards, K. M., Chappell, J. D., Crowe, J. E., Williams, J. V., Melendi, G. A., & Polack, F. P.
- Venue
- Nature Medicine
- Published
- 2010-12-05
- Volume
- 17
- Issue
- 2
- Pages
- 195-199
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2089483990
- Cited by
- 262
- References
- 30
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Monsalvo, A. C., Batalle, J. P., Lopez, M. F., Krause, J. C., Klemenc, J., Hernandez, J. Z., Maskin, B., Bugna, J., Rubinstein, C., Aguilar, L., Dalurzo, L., Libster, R., Savy, V., Baumeister, E., Aguilar, L., Cabral, G., Font, J., Solari, L., Weller, K. P., . . . Polack, F. P. (2011). Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes. Nature Medicine. https://doi.org/10.1038/nm.2262
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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