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Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
Open accessAbstract
Pandemic influenza viruses often cause severe disease in middle-aged adults without preexisting comorbidities. The mechanism of illness associated with severe disease in this age group is not well understood. Here we find preexisting serum antibodies that cross-react with, but do not protect against, 2009 H1N1 influenza virus in middle-aged adults. Nonprotective antibody is associated with immune complex–mediated disease after infection. We detected high titers of serum antibody of low avidity for H1-2009 antigen, and low-avidity pulmonary immune complexes against the same protein, in severely ill individuals. Moreover, C4d deposition—a marker of complement activation mediated by immune complexes—was present in lung sections of fatal cases. Archived lung sections from middle-aged adults with confirmed fatal influenza 1957 H2N2 infection revealed a similar mechanism of illness. These observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics.
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Influenza-Associated Hospitalizations in the United States
Thompson, W. W. (2004) · JAMA · doi:10.1001/jama.292.11.1333 · Cited by 2,213
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.
de Jong, M. D., Simmons, C. P., Thanh, T. T., Hien, V. M., Smith, G. J. D., Chau, T. N. B., Hoang, D. M., Van Vinh Chau, N., Khanh, T. H., Dong, V. C., et al. (2006) · Nature Medicine · doi:10.1038/nm1477 · Cited by 1,858
1918 Influenza: the Mother of All Pandemics
Taubenberger, J. K., & Morens, D. M. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1201.050979 · Cited by 1,686
Morens, D. M., Taubenberger, J. K., & Fauci, A. S. (2008) · The Journal of Infectious Diseases · doi:10.1086/591708 · Cited by 1,625
1918 Influenza: the Mother of All Pandemics
Taubenberger, J. K., & Morens, D. M. (2006) · Emerging Infectious Diseases · doi:10.3201/eid1209.05-0979 · Cited by 1,590
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327
Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in Mexico
Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., Hernandez, M., Quiñones-Falconi, F., Bautista, E., Ramirez-Venegas, A., Rojas-Serrano, J., Ormsby, C. E., Corrales, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0904252 · Cited by 1,325
Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus
Hancock, K., Veguilla, V., Lu, X., Zhong, W., Butler, E. N., Sun, H., Liu, F., Dong, L., DeVos, J. R., Gargiullo, P. M., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0906453 · Cited by 1,259
In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Itoh, Y., Shinya, K., Kiso, M., Watanabe, T., Sakoda, Y., Hatta, M., Muramoto, Y., Tamura, D., Sakai-Tagawa, Y., Noda, T., et al. (2009) · Nature · doi:10.1038/nature08260 · Cited by 1,073
Critical Care Services and 2009 H1N1 Influenza in Australia and New Zealand
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0908481 · Cited by 1,001
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The co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722
Influenza A viruses: new research developments
Medina, R. A., & García-Sastre, A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2613 · Cited by 677
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Herold, S., Becker, C., Ridge, K. M., & Budinger, G. R. S. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186214 · Cited by 503
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Rice, T. W., Rubinson, L., Uyeki, T. M., Vaughn, F. L., John, B. B., Miller, R. R., Higgs, E., Randolph, A. G., Smoot, B. E., & Thompson, B. T. (2012) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182416f23 · Cited by 391
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Lin, G.-L., McGinley, J. P., Drysdale, S. B., & Pollard, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02147 · Cited by 351
Khurana, S., Verma, N., Yewdell, J. W., Hilbert, A. K., Castellino, F., Lattanzi, M., Del Giudice, G., Rappuoli, R., & Golding, H. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002336 · Cited by 356
Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients
Pierce, C. A., Preston-Hurlburt, P., Dai, Y., Aschner, C. B., Cheshenko, N., Galen, B., Garforth, S. J., Herrera, N. G., Jangra, R. K., Morano, N. C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abd5487 · Cited by 353
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Haynes, B. F., Corey, L., Fernandes, P., Gilbert, P. B., Hotez, P. J., Rao, S., Santos, M. R., Schuitemaker, H., Watson, M., & Arvin, A. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abe0948 · Cited by 261
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Bournazos, S., Wang, T. T., & Ravetch, J. V. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0045-2016 · Cited by 138
Khurana, S., Hahn, M., Coyle, E. M., King, L. R., Lin, T.-L., Treanor, J., Sant, A., & Golding, H. (2019) · Nature Communications · doi:10.1038/s41467-019-11296-5 · Cited by 101
Khurana, S., Frasca, D., Blomberg, B., & Golding, H. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002920 · Cited by 85
Myles, P. R., Semple, M. G., Lim, W. S., Openshaw, P. J. M., Gadd, E. M., Read, R. C., Taylor, B. L., Brett, S. J., McMenamin, J., Enstone, J. E., et al. (2012) · Thorax · doi:10.1136/thoraxjnl-2011-200266 · Cited by 82
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Metadata
- Authors
- Monsalvo, A. C., Batalle, J. P., Lopez, M. F., Krause, J. C., Klemenc, J., Hernandez, J. Z., Maskin, B., Bugna, J., Rubinstein, C., Aguilar, L., Dalurzo, L., Libster, R., Savy, V., Baumeister, E., Aguilar, L., Cabral, G., Font, J., Solari, L., Weller, K. P., Johnson, J., Echavarria, M., Edwards, K. M., Chappell, J. D., Crowe, J. E., Williams, J. V., Melendi, G. A., & Polack, F. P.
- Venue
- Nature Medicine
- Published
- 2010-12-05
- Volume
- 17
- Issue
- 2
- Pages
- 195-199
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2089483990
- Cited by
- 262
- References
- 30
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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